Symptom combinations associated with outcome and therapeutic effects in a cohort of cases with SARS.
Identifieur interne : 001799 ( Ncbi/Checkpoint ); précédent : 001798; suivant : 001800Symptom combinations associated with outcome and therapeutic effects in a cohort of cases with SARS.
Auteurs : Shao Li [République populaire de Chine] ; Ruiqin Wang ; Yulong Zhang ; Xuegong Zhang ; A Joseph Layon ; Yanda Li ; Mingzhe ChenSource :
- The American journal of Chinese medicine [ 0192-415X ] ; 2006.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Antibactériens (usage thérapeutique), Antiviraux (usage thérapeutique), Arthralgie (traitement médicamenteux), Association de médicaments, Association thérapeutique, Chine, Durée du séjour (), Femelle, Glucocorticoïdes (usage thérapeutique), Houttuynia, Humains, Hémofiltration, Mâle, Médecine traditionnelle chinoise, Oxygénothérapie, Oxyhémoglobines (analyse), Phytothérapie, Ribavirine (usage thérapeutique), Sujet âgé, Syndrome respiratoire aigu sévère (mortalité), Syndrome respiratoire aigu sévère (traitement médicamenteux), Thymosine (usage thérapeutique), Virus du SRAS, Études de cohortes.
- MESH :
- analyse : Oxyhémoglobines.
- mortalité : Syndrome respiratoire aigu sévère.
- traitement médicamenteux : Arthralgie, Syndrome respiratoire aigu sévère.
- usage thérapeutique : Antibactériens, Antiviraux, Glucocorticoïdes, Ribavirine, Thymosine.
- Adolescent, Adulte, Adulte d'âge moyen, Association de médicaments, Association thérapeutique, Chine, Durée du séjour, Femelle, Houttuynia, Humains, Hémofiltration, Mâle, Médecine traditionnelle chinoise, Oxygénothérapie, Phytothérapie, Sujet âgé, Virus du SRAS, Études de cohortes.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Anti-Bacterial Agents (therapeutic use), Antiviral Agents (therapeutic use), Arthralgia (drug therapy), China, Cohort Studies, Combined Modality Therapy, Drug Therapy, Combination, Female, Glucocorticoids (therapeutic use), Hemofiltration, Houttuynia, Humans, Length of Stay (statistics & numerical data), Male, Medicine, Chinese Traditional, Middle Aged, Oxygen Inhalation Therapy, Oxyhemoglobins (analysis), Phytotherapy, Ribavirin (therapeutic use), SARS Virus, Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (mortality), Thymosin (therapeutic use).
- MESH :
- chemical , analysis : Oxyhemoglobins.
- chemical , therapeutic use : Anti-Bacterial Agents, Antiviral Agents, Glucocorticoids, Ribavirin, Thymosin.
- geographic : China.
- drug therapy : Arthralgia, Severe Acute Respiratory Syndrome.
- mortality : Severe Acute Respiratory Syndrome.
- statistics & numerical data : Length of Stay.
- Adolescent, Adult, Aged, Cohort Studies, Combined Modality Therapy, Drug Therapy, Combination, Female, Hemofiltration, Houttuynia, Humans, Male, Medicine, Chinese Traditional, Middle Aged, Oxygen Inhalation Therapy, Phytotherapy, SARS Virus.
Abstract
Severe acute respiratory syndrome (SARS) is an infectious disease and some of its symptoms were clinically indistinguishable of those from similar diseases. This study aimed to find the symptom combinations associated with adverse outcome and the therapeutic effects in a cohort of patients with probable SARS retrospectively. In 2003, 123 SARS cases in Beijing were subjected to a strictly western medicine (WM) treatment, or a combined treatment (WM plus Herba houttuyniae injection, addition of individualized herbal treatments when necessary), of which 115 were followed till death or discharge; 8 were transferred and lost to follow-up. In both treatment groups, clinical manifestations were evaluated daily; development of signs and symptoms, and their possible relationship with outcome, were assessed. The relationships between these sign/symptom complexes and outcome under two treatment protocols were evaluated and differences were noted. Dynamic symptom combinations, dividing into the early, the medium-term and the durational symptom clusters, were identified as likely being related to the adverse outcomes of SARS (p < 0.05, p < 0.01). Compared with a strictly WM treatment, the combined treatment resulted in a longer hospital stay (p = 0.028), a non-statistically significant mortality rate decrease (combined treatment: 9.6% versus WM: 11.1%), and a significant improvement of arthralgia and myalgia (p < 0.05) in the early symptom cluster. Additionally, the combined protocol improved arterial oxyhemoglobin saturation significantly at day 22 (p < 0.05). In conclusion, the progress and outcome of SARS may be associated with specific temporal patterns of development in combination of several non-specific signs and symptom complexes, which are also helpful for evaluating the therapeutic effects on SARS patients.
DOI: 10.1142/S0192415X06004417
PubMed: 17163583
Affiliations:
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<term>Arthralgia (drug therapy)</term>
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<term>Cohort Studies</term>
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<term>Length of Stay (statistics & numerical data)</term>
<term>Male</term>
<term>Medicine, Chinese Traditional</term>
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<term>Oxygen Inhalation Therapy</term>
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<term>Syndrome respiratoire aigu sévère (mortalité)</term>
<term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term>
<term>Thymosine (usage thérapeutique)</term>
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<term>Études de cohortes</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is an infectious disease and some of its symptoms were clinically indistinguishable of those from similar diseases. This study aimed to find the symptom combinations associated with adverse outcome and the therapeutic effects in a cohort of patients with probable SARS retrospectively. In 2003, 123 SARS cases in Beijing were subjected to a strictly western medicine (WM) treatment, or a combined treatment (WM plus Herba houttuyniae injection, addition of individualized herbal treatments when necessary), of which 115 were followed till death or discharge; 8 were transferred and lost to follow-up. In both treatment groups, clinical manifestations were evaluated daily; development of signs and symptoms, and their possible relationship with outcome, were assessed. The relationships between these sign/symptom complexes and outcome under two treatment protocols were evaluated and differences were noted. Dynamic symptom combinations, dividing into the early, the medium-term and the durational symptom clusters, were identified as likely being related to the adverse outcomes of SARS (p < 0.05, p < 0.01). Compared with a strictly WM treatment, the combined treatment resulted in a longer hospital stay (p = 0.028), a non-statistically significant mortality rate decrease (combined treatment: 9.6% versus WM: 11.1%), and a significant improvement of arthralgia and myalgia (p < 0.05) in the early symptom cluster. Additionally, the combined protocol improved arterial oxyhemoglobin saturation significantly at day 22 (p < 0.05). In conclusion, the progress and outcome of SARS may be associated with specific temporal patterns of development in combination of several non-specific signs and symptom complexes, which are also helpful for evaluating the therapeutic effects on SARS patients.</div>
</front>
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<tree><noCountry><name sortKey="Chen, Mingzhe" sort="Chen, Mingzhe" uniqKey="Chen M" first="Mingzhe" last="Chen">Mingzhe Chen</name>
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<name sortKey="Li, Yanda" sort="Li, Yanda" uniqKey="Li Y" first="Yanda" last="Li">Yanda Li</name>
<name sortKey="Wang, Ruiqin" sort="Wang, Ruiqin" uniqKey="Wang R" first="Ruiqin" last="Wang">Ruiqin Wang</name>
<name sortKey="Zhang, Xuegong" sort="Zhang, Xuegong" uniqKey="Zhang X" first="Xuegong" last="Zhang">Xuegong Zhang</name>
<name sortKey="Zhang, Yulong" sort="Zhang, Yulong" uniqKey="Zhang Y" first="Yulong" last="Zhang">Yulong Zhang</name>
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<country name="République populaire de Chine"><noRegion><name sortKey="Li, Shao" sort="Li, Shao" uniqKey="Li S" first="Shao" last="Li">Shao Li</name>
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