[Study on the animal model for severe acute respiratory syndrome].
Identifieur interne : 001122 ( Ncbi/Checkpoint ); précédent : 001121; suivant : 001123[Study on the animal model for severe acute respiratory syndrome].
Auteurs : Bo-Hua Liu [République populaire de Chine] ; Dong-Lai Wu ; Da-Wei Zhan ; E-De Qin ; Qing-Yu Zhu ; Cui-E Wang ; Qing-Wen Meng ; Wen-Ming Peng ; Xun-Nan Yin ; Yin-Hui Yang ; Yun-Tao Guan ; Wei-Guo Han ; Chang-Wen Li ; Yong-Gang Liu ; Mou-Ping Wang ; Quan-Gui Liu ; Hui-Ying Shi ; Zhi-Fen DingSource :
- Wei sheng wu xue bao = Acta microbiologica Sinica [ 0001-6209 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Syndrome respiratoire aigu sévère.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Humains, Macaca fascicularis, Macaca mulatta, Modèles animaux de maladie humaine, Poulets, RT-PCR, Rat Wistar, Rats, Réplication virale.
English descriptors
- KwdEn :
- MESH :
Abstract
To screen small animals susceptible to SARS-CoV, five species of animals, including guinea pig, hamster, albino hamster, chicken and rat, were experimentally infected with SARS-CoV strain BJ-01 by different routes. On the basis of this, further cynomolgus and rhesus macaques were selected and experimentally inoculated SARS-CoV, the quality they serve as animal model for SARS was evaluated. The results showed that, all five species of small animals chosed were not susceptible to SARS-CoV, no characterized changes in clinical sign and histopathology were observed after infection, but from the lung samples of large rat and pig guinea, the genomic RNA of SARS-CoV could be detected by RT-PCR at day 14 post infection, this suggested that SARS-CoV could replicate in these animals. After inoculated with SARS-CoV, all inoculated cynomolgus and rhesus macaques had developed interstitial pneumonia of differing severity. These changes on histopathology were similar to that seen in SARS patients, but the pathological lesions were less severe than that of human. Except interstitial pneumonia, no other characterized pathological changes were observed. This suggested cynomolgus and rhesus macaques were not the ideal animal model for SARS in fact, but they could serve as animal model for SARS when a more ideal animal model is absent.
PubMed: 16110944
Affiliations:
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pubmed:16110944Le document en format XML
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<term>Macaca mulatta</term>
<term>Rats</term>
<term>Rats, Wistar</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>Syndrome respiratoire aigu sévère (virologie)</term>
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<front><div type="abstract" xml:lang="en">To screen small animals susceptible to SARS-CoV, five species of animals, including guinea pig, hamster, albino hamster, chicken and rat, were experimentally infected with SARS-CoV strain BJ-01 by different routes. On the basis of this, further cynomolgus and rhesus macaques were selected and experimentally inoculated SARS-CoV, the quality they serve as animal model for SARS was evaluated. The results showed that, all five species of small animals chosed were not susceptible to SARS-CoV, no characterized changes in clinical sign and histopathology were observed after infection, but from the lung samples of large rat and pig guinea, the genomic RNA of SARS-CoV could be detected by RT-PCR at day 14 post infection, this suggested that SARS-CoV could replicate in these animals. After inoculated with SARS-CoV, all inoculated cynomolgus and rhesus macaques had developed interstitial pneumonia of differing severity. These changes on histopathology were similar to that seen in SARS patients, but the pathological lesions were less severe than that of human. Except interstitial pneumonia, no other characterized pathological changes were observed. This suggested cynomolgus and rhesus macaques were not the ideal animal model for SARS in fact, but they could serve as animal model for SARS when a more ideal animal model is absent.</div>
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