[Study on the animal model for severe acute respiratory syndrome].
Identifieur interne : 001122 ( Ncbi/Checkpoint ); précédent : 001121; suivant : 001123[Study on the animal model for severe acute respiratory syndrome].
Auteurs : Bo-Hua Liu [République populaire de Chine] ; Dong-Lai Wu ; Da-Wei Zhan ; E-De Qin ; Qing-Yu Zhu ; Cui-E Wang ; Qing-Wen Meng ; Wen-Ming Peng ; Xun-Nan Yin ; Yin-Hui Yang ; Yun-Tao Guan ; Wei-Guo Han ; Chang-Wen Li ; Yong-Gang Liu ; Mou-Ping Wang ; Quan-Gui Liu ; Hui-Ying Shi ; Zhi-Fen DingSource :
- Wei sheng wu xue bao = Acta microbiologica Sinica [ 0001-6209 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Syndrome respiratoire aigu sévère.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Humains, Macaca fascicularis, Macaca mulatta, Modèles animaux de maladie humaine, Poulets, RT-PCR, Rat Wistar, Rats, Réplication virale.
English descriptors
- KwdEn :
- MESH :
Abstract
To screen small animals susceptible to SARS-CoV, five species of animals, including guinea pig, hamster, albino hamster, chicken and rat, were experimentally infected with SARS-CoV strain BJ-01 by different routes. On the basis of this, further cynomolgus and rhesus macaques were selected and experimentally inoculated SARS-CoV, the quality they serve as animal model for SARS was evaluated. The results showed that, all five species of small animals chosed were not susceptible to SARS-CoV, no characterized changes in clinical sign and histopathology were observed after infection, but from the lung samples of large rat and pig guinea, the genomic RNA of SARS-CoV could be detected by RT-PCR at day 14 post infection, this suggested that SARS-CoV could replicate in these animals. After inoculated with SARS-CoV, all inoculated cynomolgus and rhesus macaques had developed interstitial pneumonia of differing severity. These changes on histopathology were similar to that seen in SARS patients, but the pathological lesions were less severe than that of human. Except interstitial pneumonia, no other characterized pathological changes were observed. This suggested cynomolgus and rhesus macaques were not the ideal animal model for SARS in fact, but they could serve as animal model for SARS when a more ideal animal model is absent.
PubMed: 16110944
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002580
- to stream PubMed, to step Curation: 002580
- to stream PubMed, to step Checkpoint: 002877
- to stream Ncbi, to step Merge: 001122
- to stream Ncbi, to step Curation: 001122
Links to Exploration step
pubmed:16110944Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Study on the animal model for severe acute respiratory syndrome].</title><author><name sortKey="Liu, Bo Hua" sort="Liu, Bo Hua" uniqKey="Liu B" first="Bo-Hua" last="Liu">Bo-Hua Liu</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology and Epidemiology, AMMS, Beijing 100071, China. bhl726915@sohu.com</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, AMMS, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wu, Dong Lai" sort="Wu, Dong Lai" uniqKey="Wu D" first="Dong-Lai" last="Wu">Dong-Lai Wu</name></author><author><name sortKey="Zhan, Da Wei" sort="Zhan, Da Wei" uniqKey="Zhan D" first="Da-Wei" last="Zhan">Da-Wei Zhan</name></author><author><name sortKey="Qin, E De" sort="Qin, E De" uniqKey="Qin E" first="E-De" last="Qin">E-De Qin</name></author><author><name sortKey="Zhu, Qing Yu" sort="Zhu, Qing Yu" uniqKey="Zhu Q" first="Qing-Yu" last="Zhu">Qing-Yu Zhu</name></author><author><name sortKey="Wang, Cui E" sort="Wang, Cui E" uniqKey="Wang C" first="Cui-E" last="Wang">Cui-E Wang</name></author><author><name sortKey="Meng, Qing Wen" sort="Meng, Qing Wen" uniqKey="Meng Q" first="Qing-Wen" last="Meng">Qing-Wen Meng</name></author><author><name sortKey="Peng, Wen Ming" sort="Peng, Wen Ming" uniqKey="Peng W" first="Wen-Ming" last="Peng">Wen-Ming Peng</name></author><author><name sortKey="Yin, Xun Nan" sort="Yin, Xun Nan" uniqKey="Yin X" first="Xun-Nan" last="Yin">Xun-Nan Yin</name></author><author><name sortKey="Yang, Yin Hui" sort="Yang, Yin Hui" uniqKey="Yang Y" first="Yin-Hui" last="Yang">Yin-Hui Yang</name></author><author><name sortKey="Guan, Yun Tao" sort="Guan, Yun Tao" uniqKey="Guan Y" first="Yun-Tao" last="Guan">Yun-Tao Guan</name></author><author><name sortKey="Han, Wei Guo" sort="Han, Wei Guo" uniqKey="Han W" first="Wei-Guo" last="Han">Wei-Guo Han</name></author><author><name sortKey="Li, Chang Wen" sort="Li, Chang Wen" uniqKey="Li C" first="Chang-Wen" last="Li">Chang-Wen Li</name></author><author><name sortKey="Liu, Yong Gang" sort="Liu, Yong Gang" uniqKey="Liu Y" first="Yong-Gang" last="Liu">Yong-Gang Liu</name></author><author><name sortKey="Wang, Mou Ping" sort="Wang, Mou Ping" uniqKey="Wang M" first="Mou-Ping" last="Wang">Mou-Ping Wang</name></author><author><name sortKey="Liu, Quan Gui" sort="Liu, Quan Gui" uniqKey="Liu Q" first="Quan-Gui" last="Liu">Quan-Gui Liu</name></author><author><name sortKey="Shi, Hui Ying" sort="Shi, Hui Ying" uniqKey="Shi H" first="Hui-Ying" last="Shi">Hui-Ying Shi</name></author><author><name sortKey="Ding, Zhi Fen" sort="Ding, Zhi Fen" uniqKey="Ding Z" first="Zhi-Fen" last="Ding">Zhi-Fen Ding</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:16110944</idno><idno type="pmid">16110944</idno><idno type="wicri:Area/PubMed/Corpus">002580</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002580</idno><idno type="wicri:Area/PubMed/Curation">002580</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002580</idno><idno type="wicri:Area/PubMed/Checkpoint">002877</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002877</idno><idno type="wicri:Area/Ncbi/Merge">001122</idno><idno type="wicri:Area/Ncbi/Curation">001122</idno><idno type="wicri:Area/Ncbi/Checkpoint">001122</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Study on the animal model for severe acute respiratory syndrome].</title><author><name sortKey="Liu, Bo Hua" sort="Liu, Bo Hua" uniqKey="Liu B" first="Bo-Hua" last="Liu">Bo-Hua Liu</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Microbiology and Epidemiology, AMMS, Beijing 100071, China. bhl726915@sohu.com</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, AMMS, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wu, Dong Lai" sort="Wu, Dong Lai" uniqKey="Wu D" first="Dong-Lai" last="Wu">Dong-Lai Wu</name></author><author><name sortKey="Zhan, Da Wei" sort="Zhan, Da Wei" uniqKey="Zhan D" first="Da-Wei" last="Zhan">Da-Wei Zhan</name></author><author><name sortKey="Qin, E De" sort="Qin, E De" uniqKey="Qin E" first="E-De" last="Qin">E-De Qin</name></author><author><name sortKey="Zhu, Qing Yu" sort="Zhu, Qing Yu" uniqKey="Zhu Q" first="Qing-Yu" last="Zhu">Qing-Yu Zhu</name></author><author><name sortKey="Wang, Cui E" sort="Wang, Cui E" uniqKey="Wang C" first="Cui-E" last="Wang">Cui-E Wang</name></author><author><name sortKey="Meng, Qing Wen" sort="Meng, Qing Wen" uniqKey="Meng Q" first="Qing-Wen" last="Meng">Qing-Wen Meng</name></author><author><name sortKey="Peng, Wen Ming" sort="Peng, Wen Ming" uniqKey="Peng W" first="Wen-Ming" last="Peng">Wen-Ming Peng</name></author><author><name sortKey="Yin, Xun Nan" sort="Yin, Xun Nan" uniqKey="Yin X" first="Xun-Nan" last="Yin">Xun-Nan Yin</name></author><author><name sortKey="Yang, Yin Hui" sort="Yang, Yin Hui" uniqKey="Yang Y" first="Yin-Hui" last="Yang">Yin-Hui Yang</name></author><author><name sortKey="Guan, Yun Tao" sort="Guan, Yun Tao" uniqKey="Guan Y" first="Yun-Tao" last="Guan">Yun-Tao Guan</name></author><author><name sortKey="Han, Wei Guo" sort="Han, Wei Guo" uniqKey="Han W" first="Wei-Guo" last="Han">Wei-Guo Han</name></author><author><name sortKey="Li, Chang Wen" sort="Li, Chang Wen" uniqKey="Li C" first="Chang-Wen" last="Li">Chang-Wen Li</name></author><author><name sortKey="Liu, Yong Gang" sort="Liu, Yong Gang" uniqKey="Liu Y" first="Yong-Gang" last="Liu">Yong-Gang Liu</name></author><author><name sortKey="Wang, Mou Ping" sort="Wang, Mou Ping" uniqKey="Wang M" first="Mou-Ping" last="Wang">Mou-Ping Wang</name></author><author><name sortKey="Liu, Quan Gui" sort="Liu, Quan Gui" uniqKey="Liu Q" first="Quan-Gui" last="Liu">Quan-Gui Liu</name></author><author><name sortKey="Shi, Hui Ying" sort="Shi, Hui Ying" uniqKey="Shi H" first="Hui-Ying" last="Shi">Hui-Ying Shi</name></author><author><name sortKey="Ding, Zhi Fen" sort="Ding, Zhi Fen" uniqKey="Ding Z" first="Zhi-Fen" last="Ding">Zhi-Fen Ding</name></author></analytic><series><title level="j">Wei sheng wu xue bao = Acta microbiologica Sinica</title><idno type="ISSN">0001-6209</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chickens</term><term>Disease Models, Animal</term><term>Humans</term><term>Macaca fascicularis</term><term>Macaca mulatta</term><term>Rats</term><term>Rats, Wistar</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Severe Acute Respiratory Syndrome (pathology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Macaca fascicularis</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Poulets</term><term>RT-PCR</term><term>Rat Wistar</term><term>Rats</term><term>Réplication virale</term><term>Syndrome respiratoire aigu sévère (anatomopathologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chickens</term><term>Disease Models, Animal</term><term>Humans</term><term>Macaca fascicularis</term><term>Macaca mulatta</term><term>Rats</term><term>Rats, Wistar</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Macaca fascicularis</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Poulets</term><term>RT-PCR</term><term>Rat Wistar</term><term>Rats</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To screen small animals susceptible to SARS-CoV, five species of animals, including guinea pig, hamster, albino hamster, chicken and rat, were experimentally infected with SARS-CoV strain BJ-01 by different routes. On the basis of this, further cynomolgus and rhesus macaques were selected and experimentally inoculated SARS-CoV, the quality they serve as animal model for SARS was evaluated. The results showed that, all five species of small animals chosed were not susceptible to SARS-CoV, no characterized changes in clinical sign and histopathology were observed after infection, but from the lung samples of large rat and pig guinea, the genomic RNA of SARS-CoV could be detected by RT-PCR at day 14 post infection, this suggested that SARS-CoV could replicate in these animals. After inoculated with SARS-CoV, all inoculated cynomolgus and rhesus macaques had developed interstitial pneumonia of differing severity. These changes on histopathology were similar to that seen in SARS patients, but the pathological lesions were less severe than that of human. Except interstitial pneumonia, no other characterized pathological changes were observed. This suggested cynomolgus and rhesus macaques were not the ideal animal model for SARS in fact, but they could serve as animal model for SARS when a more ideal animal model is absent.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Ding, Zhi Fen" sort="Ding, Zhi Fen" uniqKey="Ding Z" first="Zhi-Fen" last="Ding">Zhi-Fen Ding</name><name sortKey="Guan, Yun Tao" sort="Guan, Yun Tao" uniqKey="Guan Y" first="Yun-Tao" last="Guan">Yun-Tao Guan</name><name sortKey="Han, Wei Guo" sort="Han, Wei Guo" uniqKey="Han W" first="Wei-Guo" last="Han">Wei-Guo Han</name><name sortKey="Li, Chang Wen" sort="Li, Chang Wen" uniqKey="Li C" first="Chang-Wen" last="Li">Chang-Wen Li</name><name sortKey="Liu, Quan Gui" sort="Liu, Quan Gui" uniqKey="Liu Q" first="Quan-Gui" last="Liu">Quan-Gui Liu</name><name sortKey="Liu, Yong Gang" sort="Liu, Yong Gang" uniqKey="Liu Y" first="Yong-Gang" last="Liu">Yong-Gang Liu</name><name sortKey="Meng, Qing Wen" sort="Meng, Qing Wen" uniqKey="Meng Q" first="Qing-Wen" last="Meng">Qing-Wen Meng</name><name sortKey="Peng, Wen Ming" sort="Peng, Wen Ming" uniqKey="Peng W" first="Wen-Ming" last="Peng">Wen-Ming Peng</name><name sortKey="Qin, E De" sort="Qin, E De" uniqKey="Qin E" first="E-De" last="Qin">E-De Qin</name><name sortKey="Shi, Hui Ying" sort="Shi, Hui Ying" uniqKey="Shi H" first="Hui-Ying" last="Shi">Hui-Ying Shi</name><name sortKey="Wang, Cui E" sort="Wang, Cui E" uniqKey="Wang C" first="Cui-E" last="Wang">Cui-E Wang</name><name sortKey="Wang, Mou Ping" sort="Wang, Mou Ping" uniqKey="Wang M" first="Mou-Ping" last="Wang">Mou-Ping Wang</name><name sortKey="Wu, Dong Lai" sort="Wu, Dong Lai" uniqKey="Wu D" first="Dong-Lai" last="Wu">Dong-Lai Wu</name><name sortKey="Yang, Yin Hui" sort="Yang, Yin Hui" uniqKey="Yang Y" first="Yin-Hui" last="Yang">Yin-Hui Yang</name><name sortKey="Yin, Xun Nan" sort="Yin, Xun Nan" uniqKey="Yin X" first="Xun-Nan" last="Yin">Xun-Nan Yin</name><name sortKey="Zhan, Da Wei" sort="Zhan, Da Wei" uniqKey="Zhan D" first="Da-Wei" last="Zhan">Da-Wei Zhan</name><name sortKey="Zhu, Qing Yu" sort="Zhu, Qing Yu" uniqKey="Zhu Q" first="Qing-Yu" last="Zhu">Qing-Yu Zhu</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Bo Hua" sort="Liu, Bo Hua" uniqKey="Liu B" first="Bo-Hua" last="Liu">Bo-Hua Liu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001122 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001122 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= pubmed:16110944
|texte= [Study on the animal model for severe acute respiratory syndrome].
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:16110944" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |