Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models.
Identifieur interne : 000F66 ( Ncbi/Checkpoint ); précédent : 000F65; suivant : 000F67Interferon alfacon1 is an inhibitor of SARS-corona virus in cell-based models.
Auteurs : Jason Paragas [États-Unis] ; Lawrence M. Blatt ; Chris Hartmann ; John W. Huggins ; Tim P. EndySource :
- Antiviral research [ 0166-3542 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- pharmacocinétique : Interféron de type I.
- pharmacologie : Antiviraux, Interféron de type I.
- Effet cytopathogène viral, Humains, Interféron alpha, Modèles biologiques, Protéines recombinantes, Tests de sensibilité microbienne, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacokinetics : Interferon Type I.
- chemical , pharmacology : Antiviral Agents, Interferon Type I.
- drug effects : SARS Virus.
- Cytopathogenic Effect, Viral, Humans, Interferon-alpha, Microbial Sensitivity Tests, Models, Biological, Recombinant Proteins.
Abstract
Preliminary data examining interferon alfacon1 treatment of SARS-CoV (severe acute respiratory syndrome-corona virus)-infected patients suggests this therapy is well tolerated and of therapeutic benefit. We report herein that interferon alfacon1, has potent in vitro antiviral activity against SARS-CoV. In a cytopathic effect protection (CPE) assay, interferon alfacon1 inhibited the generation of CPE in a dose-dependent manner with an IC50 of 0.001 microg/ml, a clinically achievable level. Furthermore, interferon alfacon1 also demonstrated significant antiviral activity in yield reduction and plaque reduction assays. The in vitro antiviral activity of interferon alfacon1 against SARS-CoV suggests continued evaluation of interferon alfacon1 as a therapeutic treatment for patients infected with SARS-CoV.
DOI: 10.1016/j.antiviral.2005.01.002
PubMed: 15911026
Affiliations:
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Jason.paragas@det.amedd.army.mil</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Virology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, MD 21702-5011</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Blatt, Lawrence M" sort="Blatt, Lawrence M" uniqKey="Blatt L" first="Lawrence M" last="Blatt">Lawrence M. Blatt</name></author><author><name sortKey="Hartmann, Chris" sort="Hartmann, Chris" uniqKey="Hartmann C" first="Chris" last="Hartmann">Chris Hartmann</name></author><author><name sortKey="Huggins, John W" sort="Huggins, John W" uniqKey="Huggins J" first="John W" last="Huggins">John W. Huggins</name></author><author><name sortKey="Endy, Tim P" sort="Endy, Tim P" uniqKey="Endy T" first="Tim P" last="Endy">Tim P. Endy</name></author></analytic><series><title level="j">Antiviral research</title><idno type="ISSN">0166-3542</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (pharmacology)</term><term>Cytopathogenic Effect, Viral</term><term>Humans</term><term>Interferon Type I (pharmacokinetics)</term><term>Interferon Type I (pharmacology)</term><term>Interferon-alpha</term><term>Microbial Sensitivity Tests</term><term>Models, Biological</term><term>Recombinant Proteins</term><term>SARS Virus (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (pharmacologie)</term><term>Effet cytopathogène viral</term><term>Humains</term><term>Interféron alpha</term><term>Interféron de type I (pharmacocinétique)</term><term>Interféron de type I (pharmacologie)</term><term>Modèles biologiques</term><term>Protéines recombinantes</term><term>Tests de sensibilité microbienne</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Interferon Type I</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Interferon Type I</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Interféron de type I</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Interféron de type I</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cytopathogenic Effect, Viral</term><term>Humans</term><term>Interferon-alpha</term><term>Microbial Sensitivity Tests</term><term>Models, Biological</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Effet cytopathogène viral</term><term>Humains</term><term>Interféron alpha</term><term>Modèles biologiques</term><term>Protéines recombinantes</term><term>Tests de sensibilité microbienne</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Preliminary data examining interferon alfacon1 treatment of SARS-CoV (severe acute respiratory syndrome-corona virus)-infected patients suggests this therapy is well tolerated and of therapeutic benefit. We report herein that interferon alfacon1, has potent in vitro antiviral activity against SARS-CoV. In a cytopathic effect protection (CPE) assay, interferon alfacon1 inhibited the generation of CPE in a dose-dependent manner with an IC50 of 0.001 microg/ml, a clinically achievable level. Furthermore, interferon alfacon1 also demonstrated significant antiviral activity in yield reduction and plaque reduction assays. The in vitro antiviral activity of interferon alfacon1 against SARS-CoV suggests continued evaluation of interferon alfacon1 as a therapeutic treatment for patients infected with SARS-CoV.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Blatt, Lawrence M" sort="Blatt, Lawrence M" uniqKey="Blatt L" first="Lawrence M" last="Blatt">Lawrence M. Blatt</name><name sortKey="Endy, Tim P" sort="Endy, Tim P" uniqKey="Endy T" first="Tim P" last="Endy">Tim P. Endy</name><name sortKey="Hartmann, Chris" sort="Hartmann, Chris" uniqKey="Hartmann C" first="Chris" last="Hartmann">Chris Hartmann</name><name sortKey="Huggins, John W" sort="Huggins, John W" uniqKey="Huggins J" first="John W" last="Huggins">John W. Huggins</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Paragas, Jason" sort="Paragas, Jason" uniqKey="Paragas J" first="Jason" last="Paragas">Jason Paragas</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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