Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study
Identifieur interne : 000E87 ( Ncbi/Checkpoint ); précédent : 000E86; suivant : 000E88Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study
Auteurs : Kc Allen Chan ; Nelson Ls Tang ; David Sc Hui ; Grace Ty Chung ; Alan Kl Wu ; Stephen Sc Chim ; Rossa Wk Chiu ; Nelson Lee ; Kw Choi ; Ym Sung ; Paul Ks Chan ; Yk Tong ; St Lai ; Wc Yu ; Owen Tsang ; Ym Dennis LoSource :
- BMC Infectious Diseases [ 1471-2334 ] ; 2005.
Abstract
It has been postulated that genetic predisposition may influence the susceptibility to SARS-coronavirus infection and disease outcomes. A recent study has suggested that the deletion allele (D allele) of the
One hundred and forty genetically unrelated Chinese SARS patients and 326 healthy volunteers were recruited. The ACE I/D genotypes were determined by polymerase chain reaction and agarose gel electrophoresis.
There is no significant difference in the genotypic distributions and the allelic frequencies of the ACE I/D polymorphism between the SARS patients and the healthy control subjects. Moreover, there is also no evidence that ACE I/D polymorphism is associated with the progression to ARDS or the requirement of intensive care in the SARS patients. In multivariate logistic analysis, age is the only factor associated with the development of ARDS while age and male sex are independent factors associated with the requirement of intensive care.
The ACE I/D polymorphism is not directly related to increased susceptibility to SARS-coronavirus infection and is not associated with poor outcomes after SARS-coronavirus infection.
Url:
DOI: 10.1186/1471-2334-5-26
PubMed: 15819995
PubMed Central: 1090578
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000288
- to stream Pmc, to step Curation: 000288
- to stream Pmc, to step Checkpoint: 001400
- to stream Ncbi, to step Merge: 000E87
- to stream Ncbi, to step Curation: 000E87
Links to Exploration step
PMC:1090578Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study</title><author><name sortKey="Chan, Kc Allen" sort="Chan, Kc Allen" uniqKey="Chan K" first="Kc Allen" last="Chan">Kc Allen Chan</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Tang, Nelson Ls" sort="Tang, Nelson Ls" uniqKey="Tang N" first="Nelson Ls" last="Tang">Nelson Ls Tang</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Hui, David Sc" sort="Hui, David Sc" uniqKey="Hui D" first="David Sc" last="Hui">David Sc Hui</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Medicine and Therapeutics,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chung, Grace Ty" sort="Chung, Grace Ty" uniqKey="Chung G" first="Grace Ty" last="Chung">Grace Ty Chung</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Wu, Alan Kl" sort="Wu, Alan Kl" uniqKey="Wu A" first="Alan Kl" last="Wu">Alan Kl Wu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Medicine and Therapeutics,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chim, Stephen Sc" sort="Chim, Stephen Sc" uniqKey="Chim S" first="Stephen Sc" last="Chim">Stephen Sc Chim</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chiu, Rossa Wk" sort="Chiu, Rossa Wk" uniqKey="Chiu R" first="Rossa Wk" last="Chiu">Rossa Wk Chiu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Lee, Nelson" sort="Lee, Nelson" uniqKey="Lee N" first="Nelson" last="Lee">Nelson Lee</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Medicine and Therapeutics,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Choi, Kw" sort="Choi, Kw" uniqKey="Choi K" first="Kw" last="Choi">Kw Choi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Medicine and Therapeutics,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Sung, Ym" sort="Sung, Ym" uniqKey="Sung Y" first="Ym" last="Sung">Ym Sung</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chan, Paul Ks" sort="Chan, Paul Ks" uniqKey="Chan P" first="Paul Ks" last="Chan">Paul Ks Chan</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Microbiology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Tong, Yk" sort="Tong, Yk" uniqKey="Tong Y" first="Yk" last="Tong">Yk Tong</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Lai, St" sort="Lai, St" uniqKey="Lai S" first="St" last="Lai">St Lai</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.415229.9</institution-id><institution-id institution-id-type="ISNI">0000000417997070</institution-id><institution>Department of Medicine and Geriatrics,</institution><institution>Princess Margaret Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Yu, Wc" sort="Yu, Wc" uniqKey="Yu W" first="Wc" last="Yu">Wc Yu</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.415229.9</institution-id><institution-id institution-id-type="ISNI">0000000417997070</institution-id><institution>Department of Medicine and Geriatrics,</institution><institution>Princess Margaret Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Tsang, Owen" sort="Tsang, Owen" uniqKey="Tsang O" first="Owen" last="Tsang">Owen Tsang</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.415229.9</institution-id><institution-id institution-id-type="ISNI">0000000417997070</institution-id><institution>Department of Medicine and Geriatrics,</institution><institution>Princess Margaret Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Lo, Ym Dennis" sort="Lo, Ym Dennis" uniqKey="Lo Y" first="Ym Dennis" last="Lo">Ym Dennis Lo</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15819995</idno><idno type="pmc">1090578</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1090578</idno><idno type="RBID">PMC:1090578</idno><idno type="doi">10.1186/1471-2334-5-26</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000288</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000288</idno><idno type="wicri:Area/Pmc/Curation">000288</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000288</idno><idno type="wicri:Area/Pmc/Checkpoint">001400</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001400</idno><idno type="wicri:Area/Ncbi/Merge">000E87</idno><idno type="wicri:Area/Ncbi/Curation">000E87</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study</title><author><name sortKey="Chan, Kc Allen" sort="Chan, Kc Allen" uniqKey="Chan K" first="Kc Allen" last="Chan">Kc Allen Chan</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Tang, Nelson Ls" sort="Tang, Nelson Ls" uniqKey="Tang N" first="Nelson Ls" last="Tang">Nelson Ls Tang</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Hui, David Sc" sort="Hui, David Sc" uniqKey="Hui D" first="David Sc" last="Hui">David Sc Hui</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Medicine and Therapeutics,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chung, Grace Ty" sort="Chung, Grace Ty" uniqKey="Chung G" first="Grace Ty" last="Chung">Grace Ty Chung</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Wu, Alan Kl" sort="Wu, Alan Kl" uniqKey="Wu A" first="Alan Kl" last="Wu">Alan Kl Wu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Medicine and Therapeutics,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chim, Stephen Sc" sort="Chim, Stephen Sc" uniqKey="Chim S" first="Stephen Sc" last="Chim">Stephen Sc Chim</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chiu, Rossa Wk" sort="Chiu, Rossa Wk" uniqKey="Chiu R" first="Rossa Wk" last="Chiu">Rossa Wk Chiu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Lee, Nelson" sort="Lee, Nelson" uniqKey="Lee N" first="Nelson" last="Lee">Nelson Lee</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Medicine and Therapeutics,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Choi, Kw" sort="Choi, Kw" uniqKey="Choi K" first="Kw" last="Choi">Kw Choi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Medicine and Therapeutics,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Sung, Ym" sort="Sung, Ym" uniqKey="Sung Y" first="Ym" last="Sung">Ym Sung</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Chan, Paul Ks" sort="Chan, Paul Ks" uniqKey="Chan P" first="Paul Ks" last="Chan">Paul Ks Chan</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Microbiology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Tong, Yk" sort="Tong, Yk" uniqKey="Tong Y" first="Yk" last="Tong">Yk Tong</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Lai, St" sort="Lai, St" uniqKey="Lai S" first="St" last="Lai">St Lai</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.415229.9</institution-id><institution-id institution-id-type="ISNI">0000000417997070</institution-id><institution>Department of Medicine and Geriatrics,</institution><institution>Princess Margaret Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Yu, Wc" sort="Yu, Wc" uniqKey="Yu W" first="Wc" last="Yu">Wc Yu</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.415229.9</institution-id><institution-id institution-id-type="ISNI">0000000417997070</institution-id><institution>Department of Medicine and Geriatrics,</institution><institution>Princess Margaret Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Tsang, Owen" sort="Tsang, Owen" uniqKey="Tsang O" first="Owen" last="Tsang">Owen Tsang</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.415229.9</institution-id><institution-id institution-id-type="ISNI">0000000417997070</institution-id><institution>Department of Medicine and Geriatrics,</institution><institution>Princess Margaret Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author><author><name sortKey="Lo, Ym Dennis" sort="Lo, Ym Dennis" uniqKey="Lo Y" first="Ym Dennis" last="Lo">Ym Dennis Lo</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>The Centre for Emerging Infectious Diseases,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.415197.f</institution-id><institution-id institution-id-type="ISNI">0000000417647206</institution-id><institution>Department of Chemical Pathology,</institution><institution>The Chinese University of Hong Kong, Prince of Wales Hospital,</institution></institution-wrap>Hong Kong</nlm:aff></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>It has been postulated that genetic predisposition may influence the susceptibility to SARS-coronavirus infection and disease outcomes. A recent study has suggested that the deletion allele (D allele) of the <italic>angiotensin converting enzyme</italic> (<italic>ACE</italic>) gene is associated with hypoxemia in SARS patients. Moreover, the <italic>ACE</italic> D allele has been shown to be more prevalent in patients suffering from adult respiratory distress syndrome (ARDS) in a previous study. Thus, we have investigated the association between ACE insertion/deletion (I/D) polymorphism and the progression to ARDS or requirement of intensive care in SARS patients.</p></sec><sec><title>Method</title><p>One hundred and forty genetically unrelated Chinese SARS patients and 326 healthy volunteers were recruited. The ACE I/D genotypes were determined by polymerase chain reaction and agarose gel electrophoresis.</p></sec><sec><title>Results</title><p>There is no significant difference in the genotypic distributions and the allelic frequencies of the ACE I/D polymorphism between the SARS patients and the healthy control subjects. Moreover, there is also no evidence that ACE I/D polymorphism is associated with the progression to ARDS or the requirement of intensive care in the SARS patients. In multivariate logistic analysis, age is the only factor associated with the development of ARDS while age and male sex are independent factors associated with the requirement of intensive care.</p></sec><sec><title>Conclusion</title><p>The ACE I/D polymorphism is not directly related to increased susceptibility to SARS-coronavirus infection and is not associated with poor outcomes after SARS-coronavirus infection.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tsui, Pt" uniqKey="Tsui P">PT Tsui</name></author><author><name sortKey="Kwok, Ml" uniqKey="Kwok M">ML Kwok</name></author><author><name sortKey="Yuen, H" uniqKey="Yuen H">H Yuen</name></author><author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name></author><author><name sortKey="Hedley, Aj" uniqKey="Hedley A">AJ Hedley</name></author><author><name sortKey="Ho, Lm" uniqKey="Ho L">LM Ho</name></author><author><name sortKey="Chau, P" uniqKey="Chau P">P Chau</name></author><author><name sortKey="Wong, Io" uniqKey="Wong I">IO Wong</name></author><author><name sortKey="Thach, Tq" uniqKey="Thach T">TQ Thach</name></author><author><name sortKey="Ghani, Ac" uniqKey="Ghani A">AC Ghani</name></author><author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name></author><author><name sortKey="Fraser, C" uniqKey="Fraser C">C Fraser</name></author><author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name></author><author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name></author><author><name sortKey="Anderson, Rm" uniqKey="Anderson R">RM Anderson</name></author><author><name sortKey="Tsang, T" uniqKey="Tsang T">T Tsang</name></author><author><name sortKey="Leung, Py" uniqKey="Leung P">PY Leung</name></author><author><name sortKey="Wong, V" uniqKey="Wong V">V Wong</name></author><author><name sortKey="Chan, Jc" uniqKey="Chan J">JC Chan</name></author><author><name sortKey="Tsui, E" uniqKey="Tsui E">E Tsui</name></author><author><name sortKey="Lo, Sv" uniqKey="Lo S">SV Lo</name></author><author><name sortKey="Lam, Th" uniqKey="Lam T">TH Lam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Mh" uniqKey="Chan M">MH Chan</name></author><author><name sortKey="Wong, Vw" uniqKey="Wong V">VW Wong</name></author><author><name sortKey="Wong, Ck" uniqKey="Wong C">CK Wong</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Suen, Mw" uniqKey="Suen M">MW Suen</name></author><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author><author><name sortKey="Chung, Ss" uniqKey="Chung S">SS Chung</name></author><author><name sortKey="Lam, Cw" uniqKey="Lam C">CW Lam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, Eko" uniqKey="Ng E">EKO Ng</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Chan, Kca" uniqKey="Chan K">KCA Chan</name></author><author><name sortKey="Hung, Ec" uniqKey="Hung E">EC Hung</name></author><author><name sortKey="Chiu, Rwk" uniqKey="Chiu R">RWK Chiu</name></author><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name></author><author><name sortKey="Chim, Ssc" uniqKey="Chim S">SSC Chim</name></author><author><name sortKey="Tong, Yk" uniqKey="Tong Y">YK Tong</name></author><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author><author><name sortKey="Tam, Js" uniqKey="Tam J">JS Tam</name></author><author><name sortKey="Lo, Ymd" uniqKey="Lo Y">YMD Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chim, Ssc" uniqKey="Chim S">SSC Chim</name></author><author><name sortKey="Tsui, Sk" uniqKey="Tsui S">SK Tsui</name></author><author><name sortKey="Chan, Kca" uniqKey="Chan K">KCA Chan</name></author><author><name sortKey="Au, Tc" uniqKey="Au T">TC Au</name></author><author><name sortKey="Hung, Ec" uniqKey="Hung E">EC Hung</name></author><author><name sortKey="Tong, Yk" uniqKey="Tong Y">YK Tong</name></author><author><name sortKey="Chiu, Rwk" uniqKey="Chiu R">RWK Chiu</name></author><author><name sortKey="Ng, Ek" uniqKey="Ng E">EK Ng</name></author><author><name sortKey="Chan, Pks" uniqKey="Chan P">PKS Chan</name></author><author><name sortKey="Chu, Cm" uniqKey="Chu C">CM Chu</name></author><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author><author><name sortKey="Tam, Js" uniqKey="Tam J">JS Tam</name></author><author><name sortKey="Fung, Kp" uniqKey="Fung K">KP Fung</name></author><author><name sortKey="Waye, Mm" uniqKey="Waye M">MM Waye</name></author><author><name sortKey="Lee, Cy" uniqKey="Lee C">CY Lee</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Lo, Ymd" uniqKey="Lo Y">YMD Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ng, Mh" uniqKey="Ng M">MH Ng</name></author><author><name sortKey="Lau, Km" uniqKey="Lau K">KM Lau</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Cheng, Sh" uniqKey="Cheng S">SH Cheng</name></author><author><name sortKey="Chan, Wy" uniqKey="Chan W">WY Chan</name></author><author><name sortKey="Hui, Pk" uniqKey="Hui P">PK Hui</name></author><author><name sortKey="Zee, B" uniqKey="Zee B">B Zee</name></author><author><name sortKey="Leung, Cb" uniqKey="Leung C">CB Leung</name></author><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, M" uniqKey="Lin M">M Lin</name></author><author><name sortKey="Tseng, Hk" uniqKey="Tseng H">HK Tseng</name></author><author><name sortKey="Trejaut, Ja" uniqKey="Trejaut J">JA Trejaut</name></author><author><name sortKey="Lee, Hl" uniqKey="Lee H">HL Lee</name></author><author><name sortKey="Loo, Jh" uniqKey="Loo J">JH Loo</name></author><author><name sortKey="Chu, Cc" uniqKey="Chu C">CC Chu</name></author><author><name sortKey="Chen, Pj" uniqKey="Chen P">PJ Chen</name></author><author><name sortKey="Su, Yw" uniqKey="Su Y">YW Su</name></author><author><name sortKey="Lim, Kh" uniqKey="Lim K">KH Lim</name></author><author><name sortKey="Tsai, Zu" uniqKey="Tsai Z">ZU Tsai</name></author><author><name sortKey="Lin, Ry" uniqKey="Lin R">RY Lin</name></author><author><name sortKey="Lin, Rs" uniqKey="Lin R">RS Lin</name></author><author><name sortKey="Huang, Ch" uniqKey="Huang C">CH Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiu, Rwk" uniqKey="Chiu R">RWK Chiu</name></author><author><name sortKey="Tang, Nl" uniqKey="Tang N">NL Tang</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Chung, Gt" uniqKey="Chung G">GT Chung</name></author><author><name sortKey="Chim, Ssc" uniqKey="Chim S">SSC Chim</name></author><author><name sortKey="Chan, Kca" uniqKey="Chan K">KCA Chan</name></author><author><name sortKey="Sung, Ym" uniqKey="Sung Y">YM Sung</name></author><author><name sortKey="Chan, Ly" uniqKey="Chan L">LY Chan</name></author><author><name sortKey="Tong, Yk" uniqKey="Tong Y">YK Tong</name></author><author><name sortKey="Lee, Ws" uniqKey="Lee W">WS Lee</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Lo, Ymd" uniqKey="Lo Y">YMD Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Itoyama, S" uniqKey="Itoyama S">S Itoyama</name></author><author><name sortKey="Keicho, N" uniqKey="Keicho N">N Keicho</name></author><author><name sortKey="Quy, T" uniqKey="Quy T">T Quy</name></author><author><name sortKey="Phi, Nc" uniqKey="Phi N">NC Phi</name></author><author><name sortKey="Long, Ht" uniqKey="Long H">HT Long</name></author><author><name sortKey="Ha Le, D" uniqKey="Ha Le D">D Ha le</name></author><author><name sortKey="Ban, Vv" uniqKey="Ban V">VV Ban</name></author><author><name sortKey="Ohashi, J" uniqKey="Ohashi J">J Ohashi</name></author><author><name sortKey="Hijikata, M" uniqKey="Hijikata M">M Hijikata</name></author><author><name sortKey="Matsushita, I" uniqKey="Matsushita I">I Matsushita</name></author><author><name sortKey="Kawana, A" uniqKey="Kawana A">A Kawana</name></author><author><name sortKey="Yanai, H" uniqKey="Yanai H">H Yanai</name></author><author><name sortKey="Kirikae, T" uniqKey="Kirikae T">T Kirikae</name></author><author><name sortKey="Kuratsuji, T" uniqKey="Kuratsuji T">T Kuratsuji</name></author><author><name sortKey="Sasazuki, T" uniqKey="Sasazuki T">T Sasazuki</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bernard, Gr" uniqKey="Bernard G">GR Bernard</name></author><author><name sortKey="Artigas, A" uniqKey="Artigas A">A Artigas</name></author><author><name sortKey="Brigham, Kl" uniqKey="Brigham K">KL Brigham</name></author><author><name sortKey="Carlet, J" uniqKey="Carlet J">J Carlet</name></author><author><name sortKey="Falke, K" uniqKey="Falke K">K Falke</name></author><author><name sortKey="Hudson, L" uniqKey="Hudson L">L Hudson</name></author><author><name sortKey="Lamy, M" uniqKey="Lamy M">M Lamy</name></author><author><name sortKey="Legall, Jr" uniqKey="Legall J">JR Legall</name></author><author><name sortKey="Morris, A" uniqKey="Morris A">A Morris</name></author><author><name sortKey="Spragg, R" uniqKey="Spragg R">R Spragg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marshall, Rp" uniqKey="Marshall R">RP Marshall</name></author><author><name sortKey="Webb, S" uniqKey="Webb S">S Webb</name></author><author><name sortKey="Bellingan, Gj" uniqKey="Bellingan G">GJ Bellingan</name></author><author><name sortKey="Montgomery, He" uniqKey="Montgomery H">HE Montgomery</name></author><author><name sortKey="Chaudhari, B" uniqKey="Chaudhari B">B Chaudhari</name></author><author><name sortKey="Mcanulty, Rj" uniqKey="Mcanulty R">RJ McAnulty</name></author><author><name sortKey="Humphries, Se" uniqKey="Humphries S">SE Humphries</name></author><author><name sortKey="Hill, Mr" uniqKey="Hill M">MR Hill</name></author><author><name sortKey="Laurent, Gj" uniqKey="Laurent G">GJ Laurent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, B" uniqKey="Zhao B">B Zhao</name></author><author><name sortKey="Moochhala, Sm" uniqKey="Moochhala S">SM Moochhala</name></author><author><name sortKey="Tham, S" uniqKey="Tham S">S Tham</name></author><author><name sortKey="Lu, J" uniqKey="Lu J">J Lu</name></author><author><name sortKey="Chia, M" uniqKey="Chia M">M Chia</name></author><author><name sortKey="Byrne, C" uniqKey="Byrne C">C Byrne</name></author><author><name sortKey="Hu, Q" uniqKey="Hu Q">Q Hu</name></author><author><name sortKey="Lee, Lk" uniqKey="Lee L">LK Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costerousse, O" uniqKey="Costerousse O">O Costerousse</name></author><author><name sortKey="Allegrini, J" uniqKey="Allegrini J">J Allegrini</name></author><author><name sortKey="Lopez, M" uniqKey="Lopez M">M Lopez</name></author><author><name sortKey="Alhenc Gelas, F" uniqKey="Alhenc Gelas F">F Alhenc-Gelas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koh, Wp" uniqKey="Koh W">WP Koh</name></author><author><name sortKey="Yuan, Jm" uniqKey="Yuan J">JM Yuan</name></author><author><name sortKey="Sun, Cl" uniqKey="Sun C">CL Sun</name></author><author><name sortKey="Van Den Berg, D" uniqKey="Van Den Berg D">D van den Berg</name></author><author><name sortKey="Seow, A" uniqKey="Seow A">A Seow</name></author><author><name sortKey="Lee, Hp" uniqKey="Lee H">HP Lee</name></author><author><name sortKey="Yu, Mc" uniqKey="Yu M">MC Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tse, Gm" uniqKey="Tse G">GM Tse</name></author><author><name sortKey="To, Kf" uniqKey="To K">KF To</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Lo, Aw" uniqKey="Lo A">AW Lo</name></author><author><name sortKey="Ng, Kc" uniqKey="Ng K">KC Ng</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name></author><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Wong, Hc" uniqKey="Wong H">HC Wong</name></author><author><name sortKey="Mak, Sm" uniqKey="Mak S">SM Mak</name></author><author><name sortKey="Chan, Kf" uniqKey="Chan K">KF Chan</name></author><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Sung, Jj" uniqKey="Sung J">JJ Sung</name></author><author><name sortKey="Ng, Hk" uniqKey="Ng H">HK Ng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colhoun, Hm" uniqKey="Colhoun H">HM Colhoun</name></author><author><name sortKey="Mckeigue, Pm" uniqKey="Mckeigue P">PM McKeigue</name></author><author><name sortKey="Davey Smith, G" uniqKey="Davey Smith G">G Davey Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daly, Ak" uniqKey="Daly A">AK Daly</name></author><author><name sortKey="Day, Cp" uniqKey="Day C">CP Day</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Chan, Kc Allen" sort="Chan, Kc Allen" uniqKey="Chan K" first="Kc Allen" last="Chan">Kc Allen Chan</name><name sortKey="Chan, Paul Ks" sort="Chan, Paul Ks" uniqKey="Chan P" first="Paul Ks" last="Chan">Paul Ks Chan</name><name sortKey="Chim, Stephen Sc" sort="Chim, Stephen Sc" uniqKey="Chim S" first="Stephen Sc" last="Chim">Stephen Sc Chim</name><name sortKey="Chiu, Rossa Wk" sort="Chiu, Rossa Wk" uniqKey="Chiu R" first="Rossa Wk" last="Chiu">Rossa Wk Chiu</name><name sortKey="Choi, Kw" sort="Choi, Kw" uniqKey="Choi K" first="Kw" last="Choi">Kw Choi</name><name sortKey="Chung, Grace Ty" sort="Chung, Grace Ty" uniqKey="Chung G" first="Grace Ty" last="Chung">Grace Ty Chung</name><name sortKey="Hui, David Sc" sort="Hui, David Sc" uniqKey="Hui D" first="David Sc" last="Hui">David Sc Hui</name><name sortKey="Lai, St" sort="Lai, St" uniqKey="Lai S" first="St" last="Lai">St Lai</name><name sortKey="Lee, Nelson" sort="Lee, Nelson" uniqKey="Lee N" first="Nelson" last="Lee">Nelson Lee</name><name sortKey="Lo, Ym Dennis" sort="Lo, Ym Dennis" uniqKey="Lo Y" first="Ym Dennis" last="Lo">Ym Dennis Lo</name><name sortKey="Sung, Ym" sort="Sung, Ym" uniqKey="Sung Y" first="Ym" last="Sung">Ym Sung</name><name sortKey="Tang, Nelson Ls" sort="Tang, Nelson Ls" uniqKey="Tang N" first="Nelson Ls" last="Tang">Nelson Ls Tang</name><name sortKey="Tong, Yk" sort="Tong, Yk" uniqKey="Tong Y" first="Yk" last="Tong">Yk Tong</name><name sortKey="Tsang, Owen" sort="Tsang, Owen" uniqKey="Tsang O" first="Owen" last="Tsang">Owen Tsang</name><name sortKey="Wu, Alan Kl" sort="Wu, Alan Kl" uniqKey="Wu A" first="Alan Kl" last="Wu">Alan Kl Wu</name><name sortKey="Yu, Wc" sort="Yu, Wc" uniqKey="Yu W" first="Wc" last="Yu">Wc Yu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E87 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000E87 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= PMC:1090578
|texte= Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:15819995" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |