In vitro inhibition of SARS virus replication by human interferons.
Identifieur interne : 000E35 ( Ncbi/Checkpoint ); précédent : 000E34; suivant : 000E36In vitro inhibition of SARS virus replication by human interferons.
Auteurs : Helena Dahl [Suède] ; Annika Linde ; Orjan Stranneg RdSource :
- Scandinavian journal of infectious diseases [ 0036-5548 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antiviraux, Interféron alpha, Interféron bêta.
- physiologie : Virus du SRAS.
- Animaux, Cellules Vero, Humains, Protéines recombinantes, Réplication virale, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antiviral Agents, Interferon-alpha, Interferon-beta.
- drug effects : SARS Virus, Virus Replication.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Humans, Interferon alpha-2, Recombinant Proteins, Vero Cells.
Abstract
Four different types of human interferon, interferon-beta (IFN-beta), recombinant IFN-alpha2a and IFN-alpha2b and natural IFN-alpha were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-beta was found to be the most highly active antiviral agent, followed by natural IFN-alpha, whereas the 2 recombinant IFN-alpha2 species were poorly active in the system used. These results suggest that IFN-beta as well as natural IFN-alpha may be used for the treatment of SARS.
DOI: 10.1080/00365540410021144
PubMed: 15764169
Affiliations:
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pubmed:15764169Le document en format XML
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<author><name sortKey="Linde, Annika" sort="Linde, Annika" uniqKey="Linde A" first="Annika" last="Linde">Annika Linde</name>
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<series><title level="j">Scandinavian journal of infectious diseases</title>
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<term>Humans</term>
<term>Interferon alpha-2</term>
<term>Interferon-alpha (pharmacology)</term>
<term>Interferon-beta (pharmacology)</term>
<term>Recombinant Proteins</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (physiology)</term>
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<term>Virus Replication (drug effects)</term>
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<term>Antiviraux (pharmacologie)</term>
<term>Cellules Vero</term>
<term>Humains</term>
<term>Interféron alpha (pharmacologie)</term>
<term>Interféron bêta (pharmacologie)</term>
<term>Protéines recombinantes</term>
<term>Réplication virale ()</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (physiologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term>
<term>Interferon-alpha</term>
<term>Interferon-beta</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term>
<term>Virus Replication</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term>
<term>Interféron alpha</term>
<term>Interféron bêta</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term>
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<term>Interferon alpha-2</term>
<term>Recombinant Proteins</term>
<term>Vero Cells</term>
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<term>Cellules Vero</term>
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<term>Protéines recombinantes</term>
<term>Réplication virale</term>
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<front><div type="abstract" xml:lang="en">Four different types of human interferon, interferon-beta (IFN-beta), recombinant IFN-alpha2a and IFN-alpha2b and natural IFN-alpha were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-beta was found to be the most highly active antiviral agent, followed by natural IFN-alpha, whereas the 2 recombinant IFN-alpha2 species were poorly active in the system used. These results suggest that IFN-beta as well as natural IFN-alpha may be used for the treatment of SARS.</div>
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<country name="Suède"><region name="Svealand"><name sortKey="Dahl, Helena" sort="Dahl, Helena" uniqKey="Dahl H" first="Helena" last="Dahl">Helena Dahl</name>
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