Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome.
Identifieur interne : 000B02 ( Ncbi/Checkpoint ); précédent : 000B01; suivant : 000B03Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome.
Auteurs : Wei-Kung Wang [Taïwan] ; Shey-Ying Chen ; I-Jung Liu ; Chuan-Liang Kao ; Hui-Ling Chen ; Bor-Liang Chiang ; Jann-Tay Wang ; Wang-Hwei Sheng ; Po-Ren Hsueh ; Chao-Fu Yang ; Pan-Chyr Yang ; Shan-Chwen ChangSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- sang : Interleukine-6, Interleukine-8.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Antiviraux, Ribavirine.
- Adulte, Adulte d'âge moyen, Charge virale, Facteurs temps, Femelle, Humains, Mâle, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Interleukin-6, Interleukin-8.
- chemical , therapeutic use : Antiviral Agents, Ribavirin.
- drug therapy : Severe Acute Respiratory Syndrome.
- Adult, Female, Humans, Male, Middle Aged, SARS Virus, Time Factors, Viral Load.
Abstract
Although viral replication and overwhelming immune responses are believed to contribute to the progression of severe acute respiratory syndrome (SARS), little is known about the temporal relationship between viral load, ribavirin, proinflammatory cytokines, and clinical progression. We report that ribavirin was not effective in reducing the SARS coronavirus load in 3 of 8 probable cases studied and that elevated levels of interleukin (IL)-6 and IL-8 subsequent to the peak viral load were found in 8 and 6 cases, respectively. The nadir lymphocyte count during lymphopenia, the peak level of lactate dehydrogenase, and the peak density of pulmonary infiltrates lag further behind the peak viral load by a median of 4, 5, and 3.5 days, respectively. These findings provide important information for therapeutic strategies to treat SARS.
DOI: 10.1086/423808
PubMed: 15472864
Affiliations:
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pubmed:15472864Le document en format XML
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<front><div type="abstract" xml:lang="en">Although viral replication and overwhelming immune responses are believed to contribute to the progression of severe acute respiratory syndrome (SARS), little is known about the temporal relationship between viral load, ribavirin, proinflammatory cytokines, and clinical progression. We report that ribavirin was not effective in reducing the SARS coronavirus load in 3 of 8 probable cases studied and that elevated levels of interleukin (IL)-6 and IL-8 subsequent to the peak viral load were found in 8 and 6 cases, respectively. The nadir lymphocyte count during lymphopenia, the peak level of lactate dehydrogenase, and the peak density of pulmonary infiltrates lag further behind the peak viral load by a median of 4, 5, and 3.5 days, respectively. These findings provide important information for therapeutic strategies to treat SARS.</div>
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