Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy.
Identifieur interne : 000344 ( Ncbi/Checkpoint ); précédent : 000343; suivant : 000345Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy.
Auteurs : Yossef Kliger [Israël] ; Erez Y. LevanonSource :
- BMC microbiology [ 1471-2180 ] ; 2003.
Descripteurs français
- KwdFr :
- Agents antiVIH (pharmacologie), Antiviraux (pharmacologie), Conception de médicament, Conformation des protéines, Données de séquences moléculaires, Fragments peptidiques (pharmacologie), Protéine d'enveloppe gp41 du VIH (pharmacologie), Protéines de fusion virale (), Protéines de fusion virale (génétique), Protéines de fusion virale (métabolisme), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), Virus du SRAS ().
- MESH :
- génétique : Protéines de fusion virale.
- métabolisme : Protéines de fusion virale.
- pharmacologie : Agents antiVIH, Antiviraux, Fragments peptidiques, Protéine d'enveloppe gp41 du VIH.
- Conception de médicament, Conformation des protéines, Données de séquences moléculaires, Protéines de fusion virale, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Virus du SRAS.
English descriptors
- KwdEn :
- Anti-HIV Agents (pharmacology), Antiviral Agents (pharmacology), Drug Design, Enfuvirtide, HIV Envelope Protein gp41 (pharmacology), HIV-1 (chemistry), HIV-1 (drug effects), Molecular Sequence Data, Peptide Fragments (pharmacology), Protein Conformation, SARS Virus (chemistry), SARS Virus (drug effects), Viral Fusion Proteins (chemistry), Viral Fusion Proteins (genetics), Viral Fusion Proteins (metabolism).
- MESH :
- chemical , chemistry : Viral Fusion Proteins.
- chemical , genetics : Viral Fusion Proteins.
- chemical , metabolism : Viral Fusion Proteins.
- chemical , pharmacology : Anti-HIV Agents, Antiviral Agents, HIV Envelope Protein gp41, Peptide Fragments.
- chemistry : HIV-1, SARS Virus.
- drug effects : HIV-1, SARS Virus.
- Drug Design, Enfuvirtide, Molecular Sequence Data, Protein Conformation.
Abstract
Severe acute respiratory syndrome (SARS) is a febrile respiratory illness. The disease has been etiologically linked to a novel coronavirus that has been named the SARS-associated coronavirus (SARS-CoV), whose genome was recently sequenced. Since it is a member of the Coronaviridae, its spike protein (S2) is believed to play a central role in viral entry by facilitating fusion between the viral and host cell membranes. The protein responsible for viral-induced membrane fusion of HIV-1 (gp41) differs in length, and has no sequence homology with S2.
DOI: 10.1186/1471-2180-3-20
PubMed: 14499001
Affiliations:
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pubmed:14499001Le document en format XML
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a febrile respiratory illness. The disease has been etiologically linked to a novel coronavirus that has been named the SARS-associated coronavirus (SARS-CoV), whose genome was recently sequenced. Since it is a member of the Coronaviridae, its spike protein (S2) is believed to play a central role in viral entry by facilitating fusion between the viral and host cell membranes. The protein responsible for viral-induced membrane fusion of HIV-1 (gp41) differs in length, and has no sequence homology with S2.</div>
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