Clinical presentations and outcome of severe acute respiratory syndrome in children
Identifieur interne : 006557 ( Main/Merge ); précédent : 006556; suivant : 006558Clinical presentations and outcome of severe acute respiratory syndrome in children
Auteurs : Kle Hon [République populaire de Chine] ; Cw Leung [Hong Kong] ; Wtf Cheng [République populaire de Chine] ; Pks Chan [République populaire de Chine] ; Wcw Chu [République populaire de Chine] ; Yw Kwan [Hong Kong] ; Am Li [République populaire de Chine] ; Nc Fong [Hong Kong] ; Pc Ng [République populaire de Chine] ; Mc Chiu [Hong Kong] ; Ck Li [Hong Kong] ; Js Tam [République populaire de Chine] ; Tf Fok [République populaire de Chine]Source :
- Lancet (London, England) [ 0140-6736 ] ; 2003.
Abstract
Hong Kong has been severely affected by severe acute respiratory syndrome (SARS). Contact in households and healthcare settings is thought to be important for transmission, putting children at particular risk. Most data so far, however, have been for adults. We prospectively followed up the first ten children with SARS managed during the early phase of the epidemic in Hong Kong. All the children had been in close contact with infected adults. Persistent fever, cough, progressive radiographic changes of chest and lymphopenia were noted in all patients. The children were treated with high-dose ribavirin, oral prednisolone, or intravenous methylprednisolone, with no short-term adverse effects. Four teenagers required oxygen therapy and two needed assisted ventilation. None of the younger children required oxygen supplementation. Compared with adults and teenagers, SARS seems to have a less aggressive clinical course in younger children.
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DOI: 10.1016/S0140-6736(03)13364-8
PubMed: 12767737
PubMed Central: 7112484
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Tin</settlement></placeName></affiliation></author><author><name sortKey="Chan, Pks" sort="Chan, Pks" uniqKey="Chan P" first="Pks" last="Chan">Pks Chan</name><affiliation wicri:level="4"><nlm:aff id="aff2">Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chu, Wcw" sort="Chu, Wcw" uniqKey="Chu W" first="Wcw" last="Chu">Wcw Chu</name><affiliation wicri:level="4"><nlm:aff id="aff3">Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, 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Li</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Fong, Nc" sort="Fong, Nc" uniqKey="Fong N" first="Nc" last="Fong">Nc Fong</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Princess Margaret 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sortKey="Leung, Cw" sort="Leung, Cw" uniqKey="Leung C" first="Cw" last="Leung">Cw Leung</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital</wicri:regionArea><wicri:noRegion>Princess Margaret Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Wtf" sort="Cheng, Wtf" uniqKey="Cheng W" first="Wtf" last="Cheng">Wtf Cheng</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chan, Pks" sort="Chan, Pks" uniqKey="Chan P" first="Pks" last="Chan">Pks Chan</name><affiliation wicri:level="4"><nlm:aff id="aff2">Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chu, Wcw" sort="Chu, Wcw" uniqKey="Chu W" first="Wcw" last="Chu">Wcw Chu</name><affiliation wicri:level="4"><nlm:aff id="aff3">Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Kwan, Yw" sort="Kwan, Yw" uniqKey="Kwan Y" first="Yw" last="Kwan">Yw Kwan</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital</wicri:regionArea><wicri:noRegion>Princess Margaret Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Li, Am" sort="Li, Am" uniqKey="Li A" first="Am" last="Li">Am Li</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Fong, Nc" sort="Fong, Nc" uniqKey="Fong N" first="Nc" last="Fong">Nc Fong</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital</wicri:regionArea><wicri:noRegion>Princess Margaret Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Pc" sort="Ng, Pc" uniqKey="Ng P" first="Pc" last="Ng">Pc Ng</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chiu, Mc" sort="Chiu, Mc" uniqKey="Chiu M" first="Mc" last="Chiu">Mc Chiu</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital</wicri:regionArea><wicri:noRegion>Princess Margaret Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Li, Ck" sort="Li, Ck" uniqKey="Li C" first="Ck" last="Li">Ck Li</name><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong</nlm:aff><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital</wicri:regionArea><wicri:noRegion>Princess Margaret Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Tam, Js" sort="Tam, Js" uniqKey="Tam J" first="Js" last="Tam">Js Tam</name><affiliation wicri:level="4"><nlm:aff id="aff2">Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Fok, Tf" sort="Fok, Tf" uniqKey="Fok T" first="Tf" last="Fok">Tf Fok</name><affiliation wicri:level="4"><nlm:aff id="aff1">Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Special Adminstrative Region</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="ISSN">0140-6736</idno><idno type="eISSN">1474-547X</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>Hong Kong has been severely affected by severe acute respiratory syndrome (SARS). Contact in households and healthcare settings is thought to be important for transmission, putting children at particular risk. Most data so far, however, have been for adults. We prospectively followed up the first ten children with SARS managed during the early phase of the epidemic in Hong Kong. All the children had been in close contact with infected adults. Persistent fever, cough, progressive radiographic changes of chest and lymphopenia were noted in all patients. The children were treated with high-dose ribavirin, oral prednisolone, or intravenous methylprednisolone, with no short-term adverse effects. Four teenagers required oxygen therapy and two needed assisted ventilation. None of the younger children required oxygen supplementation. Compared with adults and teenagers, SARS seems to have a less aggressive clinical course in younger children.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name></author><author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name></author><author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Hui, D" uniqKey="Hui D">D Hui</name></author><author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cairo, M" uniqKey="Cairo M">M Cairo</name></author><author><name sortKey="Brancho, F" uniqKey="Brancho F">F Brancho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Dw" uniqKey="Smith D">DW Smith</name></author><author><name sortKey="Frankel, Lr" uniqKey="Frankel L">LR Frankel</name></author><author><name sortKey="Mathers, Lh" uniqKey="Mathers L">LH Mathers</name></author><author><name sortKey="Tang, At" uniqKey="Tang A">AT Tang</name></author><author><name sortKey="Ariagno, Rl" uniqKey="Ariagno R">RL Ariagno</name></author><author><name sortKey="Prober, Cg" uniqKey="Prober C">CG Prober</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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