Synthetic biology with artificially expanded genetic information systems. From personalized medicine to extraterrestrial life.
Identifieur interne : 006237 ( Main/Merge ); précédent : 006236; suivant : 006238Synthetic biology with artificially expanded genetic information systems. From personalized medicine to extraterrestrial life.
Auteurs : Steven A. Benner [États-Unis] ; Daniel Hutter ; A Michael SismourSource :
- Nucleic acids research. Supplement (2001) ; 2003.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- MESH :
- geographic : United States.
- therapy : HIV Infections, Hepatitis C.
- virology : Severe Acute Respiratory Syndrome.
- Clinical Medicine, Extraterrestrial Environment, Humans, United States Food and Drug Administration.
Abstract
Over 15 years ago, the Benner group noticed that the DNA alphabet need not be limited to the four standard nucleotides known in natural DNA. Rather, twelve nucleobases forming six base pairs joined by mutually exclusive hydrogen bonding patterns are possible within the geometry of the Watson-Crick pair (Fig. 1). Synthesis and studies on these compounds have brought us to the threshold of a synthetic biology, an artificial chemical system that does basic processes needed for life (in particular, Darwinian evolution), but with unnatural chemical structures. At the same time, the artificial genetic information systems (AEGIS) that we have developed have been used in FDA-approved commercial tests for managing HIV and hepatitis C infections in individual patients, and in a tool that seeks the virus for severe acute respiratory syndrome (SARS). AEGIS also supports the next generation of robotic probes to search for genetic molecules on Mars, Europa, and elsewhere where NASA probes will travel.
DOI: 10.1093/nass/3.1.125
PubMed: 14510412
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pubmed:14510412Le document en format XML
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Supplement (2001)</title><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical Medicine</term><term>Extraterrestrial Environment</term><term>HIV Infections (therapy)</term><term>Hepatitis C (therapy)</term><term>Humans</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>United States</term><term>United States Food and Drug Administration</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Environnement extraterrestre</term><term>Food and Drug Administration (USA)</term><term>Humains</term><term>Hépatite C ()</term><term>Infections à VIH ()</term><term>Médecine clinique</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>United States</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>HIV Infections</term><term>Hepatitis C</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Clinical Medicine</term><term>Extraterrestrial Environment</term><term>Humans</term><term>United States Food and Drug Administration</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Environnement extraterrestre</term><term>Food and Drug Administration (USA)</term><term>Humains</term><term>Hépatite C</term><term>Infections à VIH</term><term>Médecine clinique</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Over 15 years ago, the Benner group noticed that the DNA alphabet need not be limited to the four standard nucleotides known in natural DNA. Rather, twelve nucleobases forming six base pairs joined by mutually exclusive hydrogen bonding patterns are possible within the geometry of the Watson-Crick pair (Fig. 1). Synthesis and studies on these compounds have brought us to the threshold of a synthetic biology, an artificial chemical system that does basic processes needed for life (in particular, Darwinian evolution), but with unnatural chemical structures. At the same time, the artificial genetic information systems (AEGIS) that we have developed have been used in FDA-approved commercial tests for managing HIV and hepatitis C infections in individual patients, and in a tool that seeks the virus for severe acute respiratory syndrome (SARS). AEGIS also supports the next generation of robotic probes to search for genetic molecules on Mars, Europa, and elsewhere where NASA probes will travel.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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