SrasV1, Main, Merge, bibRecord, 005F81

In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds

Identifieur interne : 005F81 ( Main/Merge ); précédent : 005F80; suivant : 005F82

In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds

Auteurs : F. Chen [Hong Kong] ; K. H. Chan [Hong Kong] ; Y. Jiang [Hong Kong] ; R. Y. T. Kao [Hong Kong] ; H. T. Lu [Hong Kong] ; K. W. Fan [Hong Kong] ; V. C. C. Cheng [Hong Kong] ; W. H. W. Tsui [Hong Kong] ; I. F. N. Hung [Hong Kong] ; T. S. W. Lee [Hong Kong] ; Y. Guan [Hong Kong] ; J. S. M. Peiris [Hong Kong] ; K. Y. Yuen [Hong Kong]

Source :

Journal of clinical virology [ 1386-6532 ] ; 2004.

RBID : Pascal:04-0464714

Descripteurs français

Pascal (Inist)
- Coronavirus, In vitro, Test sensibilité médicamenteuse, Sensibilité, Isolat clinique, Antiviral, Grave, Malade état grave, Aigu, Syndrome respiratoire aigu sévère, Voie respiratoire, Epidémie, Microbiologie, Virologie, Forme grave, Virus syndrome respiratoire aigu sévère.

English descriptors

KwdEn :
- Acute, Antiviral, Clinical isolate, Coronavirus, Critically ill, Drug susceptibility test, Epidemic, In vitro, Microbiology, Respiratory tract, Sensitivity, Severe, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Virology.

Abstract

Effective antiviral agents are urgently needed to combat the possible return of severe acute respiratory syndrome (SARS). Commercial antiviral agents and pure chemical compounds extracted from traditional Chinese medicinal herbs were screened against 10 clinical isolates of SARS coronavirus by neutralisation tests with confirmation by plaque reduction assays. Interferon-beta-la, leukocytic interferon-alpha, ribavirin, lopinavir, rimantadine, baicalin and glycyrrhizin showed antiviral activity. The two interferons were only active if the cell lines were pre-incubated with the drugs 16 h before viral inoculation. Results were confirmed by plaque reduction assays. Antiviral activity varied with the use of different cell lines. Checkerboard assays for synergy were performed showing combinations of interferon beta-1a or leukocytic interferon-alpha with ribavirin are synergistic. Since the clinical and toxicity profiles of these agents are well known, they should be considered either singly or in combination for prophylaxis or treatment of SARS in randomised placebo controlled trials in future epidemics.

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Pascal:04-0464714

Le document en format XML

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<sZ>13 aut.</sZ>
</inist:fA14>
<country>Hong Kong</country>
<wicri:noRegion>Division of Infectious Diseases, Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of clinical virology</title>
<title level="j" type="abbreviated">J. clin. virol.</title>
<idno type="ISSN">1386-6532</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of clinical virology</title>
<title level="j" type="abbreviated">J. clin. virol.</title>
<idno type="ISSN">1386-6532</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term>
<term>Antiviral</term>
<term>Clinical isolate</term>
<term>Coronavirus</term>
<term>Critically ill</term>
<term>Drug susceptibility test</term>
<term>Epidemic</term>
<term>In vitro</term>
<term>Microbiology</term>
<term>Respiratory tract</term>
<term>Sensitivity</term>
<term>Severe</term>
<term>Severe acute respiratory syndrome</term>
<term>Severe acute respiratory syndrome virus</term>
<term>Virology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
<term>In vitro</term>
<term>Test sensibilité médicamenteuse</term>
<term>Sensibilité</term>
<term>Isolat clinique</term>
<term>Antiviral</term>
<term>Grave</term>
<term>Malade état grave</term>
<term>Aigu</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Voie respiratoire</term>
<term>Epidémie</term>
<term>Microbiologie</term>
<term>Virologie</term>
<term>Forme grave</term>
<term>Virus syndrome respiratoire aigu sévère</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Effective antiviral agents are urgently needed to combat the possible return of severe acute respiratory syndrome (SARS). Commercial antiviral agents and pure chemical compounds extracted from traditional Chinese medicinal herbs were screened against 10 clinical isolates of SARS coronavirus by neutralisation tests with confirmation by plaque reduction assays. Interferon-beta-la, leukocytic interferon-alpha, ribavirin, lopinavir, rimantadine, baicalin and glycyrrhizin showed antiviral activity. The two interferons were only active if the cell lines were pre-incubated with the drugs 16 h before viral inoculation. Results were confirmed by plaque reduction assays. Antiviral activity varied with the use of different cell lines. Checkerboard assays for synergy were performed showing combinations of interferon beta-1a or leukocytic interferon-alpha with ribavirin are synergistic. Since the clinical and toxicity profiles of these agents are well known, they should be considered either singly or in combination for prophylaxis or treatment of SARS in randomised placebo controlled trials in future epidemics.</div>
</front>
</TEI>
<affiliations><list><country><li>Hong Kong</li>
</country>
</list>
<tree><country name="Hong Kong"><noRegion><name sortKey="Chen, F" sort="Chen, F" uniqKey="Chen F" first="F." last="Chen">F. Chen</name>
</noRegion>
<name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K. H." last="Chan">K. H. Chan</name>
<name sortKey="Cheng, V C C" sort="Cheng, V C C" uniqKey="Cheng V" first="V. C. C." last="Cheng">V. C. C. Cheng</name>
<name sortKey="Fan, K W" sort="Fan, K W" uniqKey="Fan K" first="K. W." last="Fan">K. W. Fan</name>
<name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name>
<name sortKey="Hung, I F N" sort="Hung, I F N" uniqKey="Hung I" first="I. F. N." last="Hung">I. F. N. Hung</name>
<name sortKey="Jiang, Y" sort="Jiang, Y" uniqKey="Jiang Y" first="Y." last="Jiang">Y. Jiang</name>
<name sortKey="Kao, R Y T" sort="Kao, R Y T" uniqKey="Kao R" first="R. Y. T." last="Kao">R. Y. T. Kao</name>
<name sortKey="Lee, T S W" sort="Lee, T S W" uniqKey="Lee T" first="T. S. W." last="Lee">T. S. W. Lee</name>
<name sortKey="Lu, H T" sort="Lu, H T" uniqKey="Lu H" first="H. T." last="Lu">H. T. Lu</name>
<name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name>
<name sortKey="Tsui, W H W" sort="Tsui, W H W" uniqKey="Tsui W" first="W. H. W." last="Tsui">W. H. W. Tsui</name>
<name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name>
</country>
</tree>
</affiliations>
</record>

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In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds

In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds

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