Severe acute respiratory syndrome (SARS): epidemiology and clinical features
Identifieur interne : 005B40 ( Main/Merge ); précédent : 005B39; suivant : 005B41Severe acute respiratory syndrome (SARS): epidemiology and clinical features
Auteurs : D S C. Hui [Hong Kong] ; M C H. Chan [Hong Kong] ; A K Wu [Hong Kong] ; P C Ng [Hong Kong]Source :
- Postgraduate Medical Journal [ 0032-5473 ] ; 2004-07.
English descriptors
- KwdEn :
- Teeft :
- Adult sars patients, Alternative diagnosis, Amoy, Amoy gardens, Amoy gardens outbreak, Aspirate, Case definitions, Chan, Chinese university, Clin chem, Clinical course, Clinical criteria, Clinical features, Coronavirus, Creatine kinase, Dehydrogenase, Detection rate, Difficulty breathing, Disease control, Distress syndrome, Engl, Epidemiological criteria, February, Healthcare, Healthcare workers, Hong kong, Index case, Infectious disease, July, Lactate dehydrogenase, Lancet, Local transmission, Major outbreak, Myalgia, Nasopharyngeal, Nasopharyngeal aspirate, Novel coronavirus, Opacity, Organisation, Outbreak, Pneumonia, Probable case, Probable sars cases, Prognostic, Radiographic, Real time, Respiratory syndrome, Same floor, Sars, Sars coronavirus, Sars outbreak, Sars patients, Sore throat, Southern china, Symptom onset, Syndrome, Viral, Viral load, Wales hospital, Wong, World health organisation.
Abstract
Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease with a significant morbidity and mortality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache, and dyspnoea. Older subjects may present without the typical febrile response. Common laboratory features include lymphopenia, thrombocytopenia, raised alanine transaminases, lactate dehydrogenase, and creatine kinase. The constellation of compatible clinical and laboratory findings, together with certain characteristic radiological features and lack of clinical response to broad spectrum antibiotics, should arouse suspicion of SARS. Measurement of serum RNA by real time reverse transcriptase-polymerase chain reaction technique has a detection rate of 75%–80% in the first week of the illness.
Url:
- https://api.istex.fr/ark:/67375/NVC-QT6FK3J5-H/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1743054
DOI: 10.1136/pgmj.2004.020263
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Hui</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chan, M C H" sort="Chan, M C H" uniqKey="Chan M" first="M C H" last="Chan">M C H. Chan</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Wu, A K" sort="Wu, A K" uniqKey="Wu A" first="A K" last="Wu">A K Wu</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Ng, P C" sort="Ng, P C" uniqKey="Ng P" first="P C" last="Ng">P C Ng</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Postgraduate Medical Journal</title><title level="j" type="abbrev">Postgrad Med J</title><idno type="ISSN">0032-5473</idno><idno type="eISSN">1469-0756</idno><imprint><publisher>The Fellowship of Postgraduate Medicine</publisher><date type="published" when="2004-07">2004-07</date><biblScope unit="volume">80</biblScope><biblScope unit="issue">945</biblScope><biblScope unit="page" from="373">373</biblScope></imprint><idno type="ISSN">0032-5473</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0032-5473</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>RT-PCR, reverse transcriptase-polymerase chain reaction</term><term>SARS</term><term>SARS CoV, SARS coronavirus</term><term>SARS, severe acute respiratory syndrome</term><term>WHO, World Health Organisation</term><term>severe acute respiratory syndrome</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adult sars patients</term><term>Alternative diagnosis</term><term>Amoy</term><term>Amoy gardens</term><term>Amoy gardens outbreak</term><term>Aspirate</term><term>Case definitions</term><term>Chan</term><term>Chinese university</term><term>Clin chem</term><term>Clinical course</term><term>Clinical criteria</term><term>Clinical features</term><term>Coronavirus</term><term>Creatine kinase</term><term>Dehydrogenase</term><term>Detection rate</term><term>Difficulty breathing</term><term>Disease control</term><term>Distress syndrome</term><term>Engl</term><term>Epidemiological criteria</term><term>February</term><term>Healthcare</term><term>Healthcare workers</term><term>Hong kong</term><term>Index case</term><term>Infectious disease</term><term>July</term><term>Lactate dehydrogenase</term><term>Lancet</term><term>Local transmission</term><term>Major outbreak</term><term>Myalgia</term><term>Nasopharyngeal</term><term>Nasopharyngeal aspirate</term><term>Novel coronavirus</term><term>Opacity</term><term>Organisation</term><term>Outbreak</term><term>Pneumonia</term><term>Probable case</term><term>Probable sars cases</term><term>Prognostic</term><term>Radiographic</term><term>Real time</term><term>Respiratory syndrome</term><term>Same floor</term><term>Sars</term><term>Sars coronavirus</term><term>Sars outbreak</term><term>Sars patients</term><term>Sore throat</term><term>Southern china</term><term>Symptom onset</term><term>Syndrome</term><term>Viral</term><term>Viral load</term><term>Wales hospital</term><term>Wong</term><term>World health organisation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease with a significant morbidity and mortality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache, and dyspnoea. Older subjects may present without the typical febrile response. Common laboratory features include lymphopenia, thrombocytopenia, raised alanine transaminases, lactate dehydrogenase, and creatine kinase. The constellation of compatible clinical and laboratory findings, together with certain characteristic radiological features and lack of clinical response to broad spectrum antibiotics, should arouse suspicion of SARS. Measurement of serum RNA by real time reverse transcriptase-polymerase chain reaction technique has a detection rate of 75%–80% in the first week of the illness.</div></front></TEI><double doi="10.1136/pgmj.2004.020263"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Severe acute respiratory syndrome (SARS): epidemiology and clinical features</title><author><name sortKey="Hui, D S C" sort="Hui, D S C" uniqKey="Hui D" first="D S C" last="Hui">D S C. Hui</name></author><author><name sortKey="Chan, M C H" sort="Chan, M C H" uniqKey="Chan M" first="M C H" last="Chan">M C H. Chan</name></author><author><name sortKey="Wu, A K" sort="Wu, A K" uniqKey="Wu A" first="A K" last="Wu">A K Wu</name></author><author><name sortKey="Ng, P C" sort="Ng, P C" uniqKey="Ng P" first="P C" last="Ng">P C Ng</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6CFD64E1D78EB9A60B801759E9A167E0B9424AA3</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1136/pgmj.2004.020263</idno><idno type="url">https://api.istex.fr/ark:/67375/NVC-QT6FK3J5-H/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000739</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000739</idno><idno type="wicri:Area/Istex/Curation">000739</idno><idno type="wicri:Area/Istex/Checkpoint">001D72</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001D72</idno><idno type="wicri:doubleKey">0032-5473:2004:Hui D:severe:acute:respiratory</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Severe acute respiratory syndrome (SARS): epidemiology and clinical features</title><author><name sortKey="Hui, D S C" sort="Hui, D S C" uniqKey="Hui D" first="D S C" last="Hui">D S C. Hui</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chan, M C H" sort="Chan, M C H" uniqKey="Chan M" first="M C H" last="Chan">M C H. Chan</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Wu, A K" sort="Wu, A K" uniqKey="Wu A" first="A K" last="Wu">A K Wu</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Ng, P C" sort="Ng, P C" uniqKey="Ng P" first="P C" last="Ng">P C Ng</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Postgraduate Medical Journal</title><title level="j" type="abbrev">Postgrad Med J</title><idno type="ISSN">0032-5473</idno><idno type="eISSN">1469-0756</idno><imprint><publisher>The Fellowship of Postgraduate Medicine</publisher><date type="published" when="2004-07">2004-07</date><biblScope unit="volume">80</biblScope><biblScope unit="issue">945</biblScope><biblScope unit="page" from="373">373</biblScope></imprint><idno type="ISSN">0032-5473</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0032-5473</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>RT-PCR, reverse transcriptase-polymerase chain reaction</term><term>SARS</term><term>SARS CoV, SARS coronavirus</term><term>SARS, severe acute respiratory syndrome</term><term>WHO, World Health Organisation</term><term>severe acute respiratory syndrome</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adult sars patients</term><term>Alternative diagnosis</term><term>Amoy</term><term>Amoy gardens</term><term>Amoy gardens outbreak</term><term>Aspirate</term><term>Case definitions</term><term>Chan</term><term>Chinese university</term><term>Clin chem</term><term>Clinical course</term><term>Clinical criteria</term><term>Clinical features</term><term>Coronavirus</term><term>Creatine kinase</term><term>Dehydrogenase</term><term>Detection rate</term><term>Difficulty breathing</term><term>Disease control</term><term>Distress syndrome</term><term>Engl</term><term>Epidemiological criteria</term><term>February</term><term>Healthcare</term><term>Healthcare workers</term><term>Hong kong</term><term>Index case</term><term>Infectious disease</term><term>July</term><term>Lactate dehydrogenase</term><term>Lancet</term><term>Local transmission</term><term>Major outbreak</term><term>Myalgia</term><term>Nasopharyngeal</term><term>Nasopharyngeal aspirate</term><term>Novel coronavirus</term><term>Opacity</term><term>Organisation</term><term>Outbreak</term><term>Pneumonia</term><term>Probable case</term><term>Probable sars cases</term><term>Prognostic</term><term>Radiographic</term><term>Real time</term><term>Respiratory syndrome</term><term>Same floor</term><term>Sars</term><term>Sars coronavirus</term><term>Sars outbreak</term><term>Sars patients</term><term>Sore throat</term><term>Southern china</term><term>Symptom onset</term><term>Syndrome</term><term>Viral</term><term>Viral load</term><term>Wales hospital</term><term>Wong</term><term>World health organisation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease with a significant morbidity and mortality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache, and dyspnoea. Older subjects may present without the typical febrile response. Common laboratory features include lymphopenia, thrombocytopenia, raised alanine transaminases, lactate dehydrogenase, and creatine kinase. The constellation of compatible clinical and laboratory findings, together with certain characteristic radiological features and lack of clinical response to broad spectrum antibiotics, should arouse suspicion of SARS. Measurement of serum RNA by real time reverse transcriptase-polymerase chain reaction technique has a detection rate of 75%–80% in the first week of the illness.</div></front></TEI></ISTEX><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Severe acute respiratory syndrome (SARS): epidemiology and clinical features</title><author><name sortKey="Hui, D" sort="Hui, D" uniqKey="Hui D" first="D" last="Hui">D. Hui</name></author><author><name sortKey="Chan, M" sort="Chan, M" uniqKey="Chan M" first="M" last="Chan">M. Chan</name></author><author><name sortKey="Wu, A" sort="Wu, A" uniqKey="Wu A" first="A" last="Wu">A. Wu</name></author><author><name sortKey="Ng, P" sort="Ng, P" uniqKey="Ng P" first="P" last="Ng">P. Ng</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15254300</idno><idno type="pmc">1743054</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1743054</idno><idno type="RBID">PMC:1743054</idno><idno type="doi">10.1136/pgmj.2004.020263</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">001962</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001962</idno><idno type="wicri:Area/Pmc/Curation">001962</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001962</idno><idno type="wicri:Area/Pmc/Checkpoint">001475</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001475</idno><idno type="wicri:Area/Ncbi/Merge">000950</idno><idno type="wicri:Area/Ncbi/Curation">000950</idno><idno type="wicri:Area/Ncbi/Checkpoint">000950</idno><idno type="wicri:doubleKey">0032-5473:2004:Hui D:severe:acute:respiratory</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Severe acute respiratory syndrome (SARS): epidemiology and clinical features</title><author><name sortKey="Hui, D" sort="Hui, D" uniqKey="Hui D" first="D" last="Hui">D. Hui</name></author><author><name sortKey="Chan, M" sort="Chan, M" uniqKey="Chan M" first="M" last="Chan">M. Chan</name></author><author><name sortKey="Wu, A" sort="Wu, A" uniqKey="Wu A" first="A" last="Wu">A. Wu</name></author><author><name sortKey="Ng, P" sort="Ng, P" uniqKey="Ng P" first="P" last="Ng">P. Ng</name></author></analytic><series><title level="j">Postgraduate Medical Journal</title><idno type="ISSN">0032-5473</idno><idno type="eISSN">1469-0756</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p> Severe acute respiratory syndrome (SARS) is a newly emerged infectious disease with a significant morbidity and mortality. The major clinical features include persistent fever, chills/rigor, myalgia, malaise, dry cough, headache, and dyspnoea. Older subjects may present without the typical febrile response. Common laboratory features include lymphopenia, thrombocytopenia, raised alanine transaminases, lactate dehydrogenase, and creatine kinase. The constellation of compatible clinical and laboratory findings, together with certain characteristic radiological features and lack of clinical response to broad spectrum antibiotics, should arouse suspicion of SARS. Measurement of serum RNA by real time reverse transcriptase-polymerase chain reaction technique has a detection rate of 75%–80% in the first week of the illness. </p></div></front></TEI></PMC></double></record>Pour manipuler ce document sous Unix (Dilib)
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