Structure-based preliminary analysis of immunity and virulence of SARS coronavirus.
Identifieur interne : 005415 ( Main/Merge ); précédent : 005414; suivant : 005416Structure-based preliminary analysis of immunity and virulence of SARS coronavirus.
Auteurs : Yan Li [République populaire de Chine] ; Chunqing Luo ; Wei Li ; Zhao Xu ; Changqing Zeng ; Shenli Bi ; Jun Yu ; Jun Wu ; Huanming YangSource :
- Viral immunology [ 0882-8245 ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Biologie informatique (), Humains, Motifs d'acides aminés, Protéines virales (), Protéines virales (génétique), Protéines virales (immunologie), Souris, Superantigènes (), Superantigènes (immunologie), Syndrome respiratoire aigu sévère (immunologie), Toxines biologiques (), Toxines biologiques (immunologie), Virulence, Virus du SRAS (immunologie), Virus du SRAS (pathogénicité).
- MESH :
- génétique : Protéines virales.
- immunologie : Protéines virales, Superantigènes, Syndrome respiratoire aigu sévère, Toxines biologiques, Virus du SRAS.
- pathogénicité : Virus du SRAS.
- Animaux, Biologie informatique, Humains, Motifs d'acides aminés, Protéines virales, Souris, Superantigènes, Toxines biologiques, Virulence.
English descriptors
- KwdEn :
- Amino Acid Motifs, Animals, Computational Biology (methods), Humans, Mice, SARS Virus (immunology), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (immunology), Superantigens (chemistry), Superantigens (immunology), Toxins, Biological (chemistry), Toxins, Biological (immunology), Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (immunology), Virulence.
- MESH :
- chemical , chemistry : Superantigens, Toxins, Biological, Viral Proteins.
- chemical , genetics : Viral Proteins.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome, Superantigens, Toxins, Biological, Viral Proteins.
- methods : Computational Biology.
- pathogenicity : SARS Virus.
- Amino Acid Motifs, Animals, Humans, Mice, Virulence.
Abstract
The research on SARS-associated coronavirus (SARS-CoV) has not stopped since its discovery, but the pathogenesis of SARS is still unclear. To explore the possible molecular mechanisms of the invasion and virulence of SARS-CoV, we investigated the structural basis of the viral proteins using computational biology. Forty-five motifs relating to superantigens, toxins and other bioactive molecules were detected in the proteins of SARS-CoV. The results showed that the distribution of the motifs varied in different proteins. Enzyme-like motifs were located in the R protein, while ICAM- 1-like and toxin-like molecules were located in the spike, envelop, nucleocapsid, PUP1, PUP 2 and PUP 4 proteins. Comparison of SARS-CoV with other viruses (OC43, PEDV, HRSV, HHerpV and HAdenoV) showed that each group of motifs was different for each type of virus. Data suggest that the proteins of SARS-CoV with toxic motifs might play crucial roles in targeting host cells and interfering with the immune system. This study provides new information for drug and vaccine design, as well as therapeutic strategies against SARS.
DOI: 10.1089/vim.2004.17.528
PubMed: 15671749
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Yu</name></author><author><name sortKey="Wu, Jun" sort="Wu, Jun" uniqKey="Wu J" first="Jun" last="Wu">Jun Wu</name></author><author><name sortKey="Yang, Huanming" sort="Yang, Huanming" uniqKey="Yang H" first="Huanming" last="Yang">Huanming Yang</name></author></analytic><series><title level="j">Viral immunology</title><idno type="ISSN">0882-8245</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Motifs</term><term>Animals</term><term>Computational Biology (methods)</term><term>Humans</term><term>Mice</term><term>SARS Virus (immunology)</term><term>SARS Virus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Superantigens (chemistry)</term><term>Superantigens (immunology)</term><term>Toxins, Biological (chemistry)</term><term>Toxins, Biological (immunology)</term><term>Viral Proteins 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Motifs</term><term>Animals</term><term>Humans</term><term>Mice</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Biologie informatique</term><term>Humains</term><term>Motifs d'acides aminés</term><term>Protéines virales</term><term>Souris</term><term>Superantigènes</term><term>Toxines biologiques</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The research on SARS-associated coronavirus (SARS-CoV) has not stopped since its discovery, but the pathogenesis of SARS is still unclear. To explore the possible molecular mechanisms of the invasion and virulence of SARS-CoV, we investigated the structural basis of the viral proteins using computational biology. Forty-five motifs relating to superantigens, toxins and other bioactive molecules were detected in the proteins of SARS-CoV. The results showed that the distribution of the motifs varied in different proteins. Enzyme-like motifs were located in the R protein, while ICAM- 1-like and toxin-like molecules were located in the spike, envelop, nucleocapsid, PUP1, PUP 2 and PUP 4 proteins. Comparison of SARS-CoV with other viruses (OC43, PEDV, HRSV, HHerpV and HAdenoV) showed that each group of motifs was different for each type of virus. Data suggest that the proteins of SARS-CoV with toxic motifs might play crucial roles in targeting host cells and interfering with the immune system. 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