Alignment using genetic programming with causal trees for identification of protein functions
Identifieur interne : 004C59 ( Main/Merge ); précédent : 004C58; suivant : 004C60Alignment using genetic programming with causal trees for identification of protein functions
Auteurs : Chun-Min Hung [République populaire de Chine] ; Yueh-Min Huang [République populaire de Chine] ; Ming-Shi Chang [République populaire de Chine]Source :
- Nonlinear Analysis, Theory, Methods & Applications [ 0362-546X ] ; 2005.
Abstract
A hybrid evolutionary model is used to propose a hierarchical homology of protein sequences to identify protein functions systematically. The proposed model offers considerable potentials, considering the inconsistency of existing methods for predicting novel proteins. Because some novel proteins might align without meaningful conserved domains, maximizing the score of sequence alignment is not the best criterion for predicting protein functions. This work presents a decision model that can minimize the cost of making a decision for predicting protein functions using the hierarchical homologies. Particularly, the model has three characteristics: (i) it is a hybrid evolutionary model with multiple fitness functions that uses genetic programming to predict protein functions on a distantly related protein family, (ii) it incorporates modified robust point matching to accurately compare all feature points using the moment invariant and thin-plate spline theorems, and (iii) the hierarchical homologies holding up a novel protein sequence in the form of a causal tree can effectively demonstrate the relationship between proteins. This work describes the comparisons of nucleocapsid proteins from the putative polyprotein SARS virus and other coronaviruses in other hosts using the model.
Url:
DOI: 10.1016/j.na.2005.09.048
PubMed: NONE
PubMed Central: 7117053
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PMC:7117053Le document en format XML
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first="Chun-Min" last="Hung">Chun-Min Hung</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yueh Min" sort="Huang, Yueh Min" uniqKey="Huang Y" first="Yueh-Min" last="Huang">Yueh-Min Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Ming Shi" sort="Chang, Ming Shi" uniqKey="Chang M" first="Ming-Shi" last="Chang">Ming-Shi Chang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nonlinear Analysis, Theory, Methods & Applications</title><idno type="ISSN">0362-546X</idno><idno type="eISSN">0362-546X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A hybrid evolutionary model is used to propose a hierarchical homology of protein sequences to identify protein functions systematically. The proposed model offers considerable potentials, considering the inconsistency of existing methods for predicting novel proteins. Because some novel proteins might align without meaningful conserved domains, maximizing the score of sequence alignment is not the best criterion for predicting protein functions. This work presents a decision model that can minimize the cost of making a decision for predicting protein functions using the hierarchical homologies. Particularly, the model has three characteristics: (i) it is a hybrid evolutionary model with multiple fitness functions that uses genetic programming to predict protein functions on a distantly related protein family, (ii) it incorporates modified robust point matching to accurately compare all feature points using the moment invariant and thin-plate spline theorems, and (iii) the hierarchical homologies holding up a novel protein sequence in the form of a causal tree can effectively demonstrate the relationship between proteins. This work describes the comparisons of nucleocapsid proteins from the putative polyprotein SARS virus and other coronaviruses in other hosts using the model.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Delcoigne, A" uniqKey="Delcoigne A">A. Delcoigne</name></author><author><name sortKey="Hansen, P" uniqKey="Hansen P">P. Hansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krogh, A" uniqKey="Krogh A">A. Krogh</name></author><author><name sortKey="Mian, S" uniqKey="Mian S">S. Mian</name></author><author><name sortKey="Haussler, D" uniqKey="Haussler D">D. Haussler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krogh, A" uniqKey="Krogh A">A. Krogh</name></author><author><name sortKey="Brown, M" uniqKey="Brown M">M. Brown</name></author><author><name sortKey="Mian, I S" uniqKey="Mian I">I.S. Mian</name></author><author><name sortKey="Sjolander, K" uniqKey="Sjolander K">K. Sjolander</name></author><author><name sortKey="Haussler, D" uniqKey="Haussler D">D. Haussler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Judea, P" uniqKey="Judea P">P. Judea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cai, D" uniqKey="Cai D">D. Cai</name></author><author><name sortKey="Delcher, A" uniqKey="Delcher A">A. Delcher</name></author><author><name sortKey="Kao, B" uniqKey="Kao B">B. Kao</name></author><author><name sortKey="Kasif, S" uniqKey="Kasif S">S. Kasif</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, P Y" uniqKey="Chou P">P.Y. Chou</name></author><author><name sortKey="Fasman, G D" uniqKey="Fasman G">G.D. Fasman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, T F" uniqKey="Smith T">T.F. Smith</name></author><author><name sortKey="Waterman, M S" uniqKey="Waterman M">M.S. Waterman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Willett, P" uniqKey="Willett P">P. Willett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z R" uniqKey="Yang Z">Z.R. Yang</name></author><author><name sortKey="Thomson, R" uniqKey="Thomson R">R. Thomson</name></author><author><name sortKey="Hodgman, T C" uniqKey="Hodgman T">T.C. Hodgman</name></author><author><name sortKey="Dry, J" uniqKey="Dry J">J. Dry</name></author><author><name sortKey="Doyle, A K" uniqKey="Doyle A">A.K. Doyle</name></author><author><name sortKey="Narayanan, A" uniqKey="Narayanan A">A. Narayanan</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreiseitl, S" uniqKey="Dreiseitl S">S. Dreiseitl</name></author><author><name sortKey="Ohno Machado, L" uniqKey="Ohno Machado L">L. Ohno-Machado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coolen, A C C" uniqKey="Coolen A">A.C.C. Coolen</name></author><author><name sortKey="Prete, V D" uniqKey="Prete V">V.D. Prete</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jason, H T B" uniqKey="Jason H">H.T.B. Jason</name></author><author><name sortKey="Michael, P Y" uniqKey="Michael P">P.Y. Michael</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ressom, H" uniqKey="Ressom H">H. Ressom</name></author><author><name sortKey="Reynolds, R" uniqKey="Reynolds R">R. Reynolds</name></author><author><name sortKey="Varghese, R S" uniqKey="Varghese R">R.S. Varghese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reichard, K" uniqKey="Reichard K">K. Reichard</name></author><author><name sortKey="Kaufmann, M" uniqKey="Kaufmann M">M. Kaufmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Durbin, R" uniqKey="Durbin R">R. Durbin</name></author><author><name sortKey="Eddy, S" uniqKey="Eddy S">S. Eddy</name></author><author><name sortKey="Krogh, A" uniqKey="Krogh A">A. Krogh</name></author><author><name sortKey="Mitchison, G" uniqKey="Mitchison G">G. Mitchison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mittelman, D" uniqKey="Mittelman D">D. Mittelman</name></author><author><name sortKey="Sadreyev, R" uniqKey="Sadreyev R">R. Sadreyev</name></author><author><name sortKey="Grishin, N" uniqKey="Grishin N">N. Grishin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rychlewski, L" uniqKey="Rychlewski L">L. Rychlewski</name></author><author><name sortKey="Jaroszewski, L" uniqKey="Jaroszewski L">L. Jaroszewski</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Godzik, A" uniqKey="Godzik A">A. Godzik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yona, G" uniqKey="Yona G">G. Yona</name></author><author><name sortKey="Levitt, M" uniqKey="Levitt M">M. Levitt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sadreyev, R" uniqKey="Sadreyev R">R. Sadreyev</name></author><author><name sortKey="Grishin, N" uniqKey="Grishin N">N. Grishin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altschul, S F" uniqKey="Altschul S">S.F. Altschul</name></author><author><name sortKey="Gish, W" uniqKey="Gish W">W. Gish</name></author><author><name sortKey="Miller, W" uniqKey="Miller W">W. Miller</name></author><author><name sortKey="Myers, E W" uniqKey="Myers E">E.W. Myers</name></author><author><name sortKey="Lipman, D J" uniqKey="Lipman D">D.J. Lipman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altschul, S F" uniqKey="Altschul S">S.F. Altschul</name></author><author><name sortKey="Madden, T L" uniqKey="Madden T">T.L. Madden</name></author><author><name sortKey="Schaffer, A A" uniqKey="Schaffer A">A.A. Schaffer</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Miller, W" uniqKey="Miller W">W. Miller</name></author><author><name sortKey="Lipman, D J" uniqKey="Lipman D">D.J. Lipman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, J D" uniqKey="Thompson J">J.D. Thompson</name></author><author><name sortKey="Higgins, D G" uniqKey="Higgins D">D.G. Higgins</name></author><author><name sortKey="Gibson, T J" uniqKey="Gibson T">T.J. Gibson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Koza, J R" uniqKey="Koza J">J.R. Koza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gold, S" uniqKey="Gold S">S. Gold</name></author><author><name sortKey="Rangarajan, A" uniqKey="Rangarajan A">A. Rangarajan</name></author><author><name sortKey="Lu, C P" uniqKey="Lu C">C.P. Lu</name></author><author><name sortKey="Pappu, S" uniqKey="Pappu S">S. Pappu</name></author><author><name sortKey="Mjolsness, E" uniqKey="Mjolsness E">E. Mjolsness</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, C C" uniqKey="Holmes C">C.C. Holmes</name></author><author><name sortKey="Denison, D" uniqKey="Denison D">D. Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Q" uniqKey="Zheng Q">Q. Zheng</name></author><author><name sortKey="Chellappa, R" uniqKey="Chellappa R">R. Chellappa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steven, L S" uniqKey="Steven L">L.S. Steven</name></author><author><name sortKey="David, B S" uniqKey="David B">B.S. David</name></author><author><name sortKey="Simon, K" uniqKey="Simon K">K. Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, M K" uniqKey="Hu M">M.K. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dresher, M" uniqKey="Dresher M">M. Dresher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wahba, G" uniqKey="Wahba G">G. Wahba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riesz, F" uniqKey="Riesz F">F. Riesz</name></author><author><name sortKey="Sz Nagy, B" uniqKey="Sz Nagy B">B. Sz-Nagy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sinkhorn, R" uniqKey="Sinkhorn R">R. Sinkhorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peterson, C" uniqKey="Peterson C">C. Peterson</name></author><author><name sortKey="Soderberg, B" uniqKey="Soderberg B">B. Soderberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuille, A L" uniqKey="Yuille A">A.L. Yuille</name></author><author><name sortKey="Kosowsky, J J" uniqKey="Kosowsky J">J.J. Kosowsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rangarajan, A" uniqKey="Rangarajan A">A. Rangarajan</name></author><author><name sortKey="Gold, S" uniqKey="Gold S">S. Gold</name></author><author><name sortKey="Mjolsness, E" uniqKey="Mjolsness E">E. Mjolsness</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldberg, D E" uniqKey="Goldberg D">D.E. Goldberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koza, J R" uniqKey="Koza J">J.R. Koza</name></author><author><name sortKey="Bennett, F H" uniqKey="Bennett F">F.H. Bennett</name></author><author><name sortKey="Andre, D" uniqKey="Andre D">D. Andre</name></author><author><name sortKey="Keane, M A" uniqKey="Keane M">M.A. Keane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kushchu, I" uniqKey="Kushchu I">I. Kushchu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, M L" uniqKey="Wong M">M.L. Wong</name></author><author><name sortKey="Lam, W" uniqKey="Lam W">W. Lam</name></author><author><name sortKey="Leung, K S" uniqKey="Leung K">K.S. Leung</name></author><author><name sortKey="Ngan, P S" uniqKey="Ngan P">P.S. Ngan</name></author><author><name sortKey="Cheng, J C Y" uniqKey="Cheng J">J.C.Y. Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bojarczuk, C C" uniqKey="Bojarczuk C">C.C. Bojarczuk</name></author><author><name sortKey="Lopes, H S" uniqKey="Lopes H">H.S Lopes</name></author><author><name sortKey="Freitas, A A" uniqKey="Freitas A">A.A. Freitas</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fields, B N" uniqKey="Fields B">B.N. Fields</name></author><author><name sortKey="Knipe, D M" uniqKey="Knipe D">D.M. Knipe</name></author><author><name sortKey="Howley, P M" uniqKey="Howley P">P.M. Howley</name></author><author><name sortKey="Griffin, D E" uniqKey="Griffin D">D.E. Griffin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, P" uniqKey="Hall P">P. Hall</name></author><author><name sortKey="Titterington, D M" uniqKey="Titterington D">D.M. Titterington</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double doi="10.1016/j.na.2005.09.048"><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Alignment using genetic programming with causal trees for identification of protein functions.</title><author><name sortKey="Hung, Chun Min" sort="Hung, Chun Min" uniqKey="Hung C" first="Chun-Min" last="Hung">Chun-Min Hung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yueh Min" sort="Huang, Yueh Min" uniqKey="Huang Y" first="Yueh-Min" last="Huang">Yueh-Min Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Ming Shi" sort="Chang, Ming Shi" uniqKey="Chang M" first="Ming-Shi" last="Chang">Ming-Shi Chang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:32288048</idno><idno type="pmid">32288048</idno><idno type="doi">10.1016/j.na.2005.09.048</idno><idno type="wicri:Area/PubMed/Corpus">002108</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002108</idno><idno type="wicri:Area/PubMed/Curation">002108</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002108</idno><idno type="wicri:Area/PubMed/Checkpoint">002313</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002313</idno><idno type="wicri:Area/Ncbi/Merge">003974</idno><idno type="wicri:Area/Ncbi/Curation">003974</idno><idno type="wicri:Area/Ncbi/Checkpoint">003974</idno><idno type="wicri:doubleKey">0362-546X:2006:Hung C:alignment:using:genetic</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Alignment using genetic programming with causal trees for identification of protein functions.</title><author><name sortKey="Hung, Chun Min" sort="Hung, Chun Min" uniqKey="Hung C" first="Chun-Min" last="Hung">Chun-Min Hung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yueh Min" sort="Huang, Yueh Min" uniqKey="Huang Y" first="Yueh-Min" last="Huang">Yueh-Min Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Ming Shi" sort="Chang, Ming Shi" uniqKey="Chang M" first="Ming-Shi" last="Chang">Ming-Shi Chang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nonlinear analysis, theory, methods & applications</title><idno type="ISSN">0362-546X</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A hybrid evolutionary model is used to propose a hierarchical homology of protein sequences to identify protein functions systematically. The proposed model offers considerable potentials, considering the inconsistency of existing methods for predicting novel proteins. Because some novel proteins might align without meaningful conserved domains, maximizing the score of sequence alignment is not the best criterion for predicting protein functions. This work presents a decision model that can minimize the cost of making a decision for predicting protein functions using the hierarchical homologies. Particularly, the model has three characteristics: (i) it is a hybrid evolutionary model with multiple fitness functions that uses genetic programming to predict protein functions on a distantly related protein family, (ii) it incorporates modified robust point matching to accurately compare all feature points using the moment invariant and thin-plate spline theorems, and (iii) the hierarchical homologies holding up a novel protein sequence in the form of a causal tree can effectively demonstrate the relationship between proteins. This work describes the comparisons of nucleocapsid proteins from the putative polyprotein SARS virus and other coronaviruses in other hosts using the model.</div></front></TEI></PubMed><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Alignment using genetic programming with causal trees for identification of protein functions</title><author><name sortKey="Hung, Chun Min" sort="Hung, Chun Min" uniqKey="Hung C" first="Chun-Min" last="Hung">Chun-Min Hung</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yueh Min" sort="Huang, Yueh Min" uniqKey="Huang Y" first="Yueh-Min" last="Huang">Yueh-Min Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Ming Shi" sort="Chang, Ming Shi" uniqKey="Chang M" first="Ming-Shi" last="Chang">Ming-Shi Chang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7117053</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117053</idno><idno type="RBID">PMC:7117053</idno><idno type="doi">10.1016/j.na.2005.09.048</idno><idno type="pmid">NONE</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">001305</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001305</idno><idno type="wicri:Area/Pmc/Curation">001305</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001305</idno><idno type="wicri:Area/Pmc/Checkpoint">001397</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001397</idno><idno type="wicri:Area/Ncbi/Merge">003C93</idno><idno type="wicri:Area/Ncbi/Curation">003C93</idno><idno type="wicri:Area/Ncbi/Checkpoint">003C93</idno><idno type="wicri:doubleKey">0362-546X:2005:Hung C:alignment:using:genetic</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Alignment using genetic programming with causal trees for identification of protein functions</title><author><name sortKey="Hung, Chun Min" sort="Hung, Chun Min" uniqKey="Hung C" first="Chun-Min" last="Hung">Chun-Min Hung</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yueh Min" sort="Huang, Yueh Min" uniqKey="Huang Y" first="Yueh-Min" last="Huang">Yueh-Min Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Engineering Science, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Ming Shi" sort="Chang, Ming Shi" uniqKey="Chang M" first="Ming-Shi" last="Chang">Ming-Shi Chang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan, ROC</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Biochemistry, National Cheng Kung University, No.1, Ta-Hsueh Road, Tainan 701, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nonlinear Analysis, Theory, Methods & Applications</title><idno type="ISSN">0362-546X</idno><idno type="eISSN">0362-546X</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A hybrid evolutionary model is used to propose a hierarchical homology of protein sequences to identify protein functions systematically. The proposed model offers considerable potentials, considering the inconsistency of existing methods for predicting novel proteins. Because some novel proteins might align without meaningful conserved domains, maximizing the score of sequence alignment is not the best criterion for predicting protein functions. This work presents a decision model that can minimize the cost of making a decision for predicting protein functions using the hierarchical homologies. Particularly, the model has three characteristics: (i) it is a hybrid evolutionary model with multiple fitness functions that uses genetic programming to predict protein functions on a distantly related protein family, (ii) it incorporates modified robust point matching to accurately compare all feature points using the moment invariant and thin-plate spline theorems, and (iii) the hierarchical homologies holding up a novel protein sequence in the form of a causal tree can effectively demonstrate the relationship between proteins. This work describes the comparisons of nucleocapsid proteins from the putative polyprotein SARS virus and other coronaviruses in other hosts using the model.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Delcoigne, A" uniqKey="Delcoigne A">A. Delcoigne</name></author><author><name sortKey="Hansen, P" uniqKey="Hansen P">P. Hansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krogh, A" uniqKey="Krogh A">A. Krogh</name></author><author><name sortKey="Mian, S" uniqKey="Mian S">S. Mian</name></author><author><name sortKey="Haussler, D" uniqKey="Haussler D">D. Haussler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krogh, A" uniqKey="Krogh A">A. Krogh</name></author><author><name sortKey="Brown, M" uniqKey="Brown M">M. Brown</name></author><author><name sortKey="Mian, I S" uniqKey="Mian I">I.S. Mian</name></author><author><name sortKey="Sjolander, K" uniqKey="Sjolander K">K. Sjolander</name></author><author><name sortKey="Haussler, D" uniqKey="Haussler D">D. Haussler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Judea, P" uniqKey="Judea P">P. Judea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cai, D" uniqKey="Cai D">D. Cai</name></author><author><name sortKey="Delcher, A" uniqKey="Delcher A">A. Delcher</name></author><author><name sortKey="Kao, B" uniqKey="Kao B">B. Kao</name></author><author><name sortKey="Kasif, S" uniqKey="Kasif S">S. Kasif</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chou, P Y" uniqKey="Chou P">P.Y. Chou</name></author><author><name sortKey="Fasman, G D" uniqKey="Fasman G">G.D. Fasman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, T F" uniqKey="Smith T">T.F. Smith</name></author><author><name sortKey="Waterman, M S" uniqKey="Waterman M">M.S. Waterman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Willett, P" uniqKey="Willett P">P. Willett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z R" uniqKey="Yang Z">Z.R. Yang</name></author><author><name sortKey="Thomson, R" uniqKey="Thomson R">R. Thomson</name></author><author><name sortKey="Hodgman, T C" uniqKey="Hodgman T">T.C. Hodgman</name></author><author><name sortKey="Dry, J" uniqKey="Dry J">J. Dry</name></author><author><name sortKey="Doyle, A K" uniqKey="Doyle A">A.K. Doyle</name></author><author><name sortKey="Narayanan, A" uniqKey="Narayanan A">A. Narayanan</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreiseitl, S" uniqKey="Dreiseitl S">S. Dreiseitl</name></author><author><name sortKey="Ohno Machado, L" uniqKey="Ohno Machado L">L. Ohno-Machado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coolen, A C C" uniqKey="Coolen A">A.C.C. Coolen</name></author><author><name sortKey="Prete, V D" uniqKey="Prete V">V.D. Prete</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jason, H T B" uniqKey="Jason H">H.T.B. Jason</name></author><author><name sortKey="Michael, P Y" uniqKey="Michael P">P.Y. Michael</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ressom, H" uniqKey="Ressom H">H. Ressom</name></author><author><name sortKey="Reynolds, R" uniqKey="Reynolds R">R. Reynolds</name></author><author><name sortKey="Varghese, R S" uniqKey="Varghese R">R.S. Varghese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reichard, K" uniqKey="Reichard K">K. Reichard</name></author><author><name sortKey="Kaufmann, M" uniqKey="Kaufmann M">M. Kaufmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Durbin, R" uniqKey="Durbin R">R. Durbin</name></author><author><name sortKey="Eddy, S" uniqKey="Eddy S">S. Eddy</name></author><author><name sortKey="Krogh, A" uniqKey="Krogh A">A. Krogh</name></author><author><name sortKey="Mitchison, G" uniqKey="Mitchison G">G. Mitchison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mittelman, D" uniqKey="Mittelman D">D. Mittelman</name></author><author><name sortKey="Sadreyev, R" uniqKey="Sadreyev R">R. Sadreyev</name></author><author><name sortKey="Grishin, N" uniqKey="Grishin N">N. Grishin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rychlewski, L" uniqKey="Rychlewski L">L. Rychlewski</name></author><author><name sortKey="Jaroszewski, L" uniqKey="Jaroszewski L">L. Jaroszewski</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Godzik, A" uniqKey="Godzik A">A. Godzik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yona, G" uniqKey="Yona G">G. Yona</name></author><author><name sortKey="Levitt, M" uniqKey="Levitt M">M. Levitt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sadreyev, R" uniqKey="Sadreyev R">R. Sadreyev</name></author><author><name sortKey="Grishin, N" uniqKey="Grishin N">N. Grishin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altschul, S F" uniqKey="Altschul S">S.F. Altschul</name></author><author><name sortKey="Gish, W" uniqKey="Gish W">W. Gish</name></author><author><name sortKey="Miller, W" uniqKey="Miller W">W. Miller</name></author><author><name sortKey="Myers, E W" uniqKey="Myers E">E.W. Myers</name></author><author><name sortKey="Lipman, D J" uniqKey="Lipman D">D.J. Lipman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altschul, S F" uniqKey="Altschul S">S.F. Altschul</name></author><author><name sortKey="Madden, T L" uniqKey="Madden T">T.L. Madden</name></author><author><name sortKey="Schaffer, A A" uniqKey="Schaffer A">A.A. Schaffer</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Miller, W" uniqKey="Miller W">W. Miller</name></author><author><name sortKey="Lipman, D J" uniqKey="Lipman D">D.J. Lipman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, J D" uniqKey="Thompson J">J.D. Thompson</name></author><author><name sortKey="Higgins, D G" uniqKey="Higgins D">D.G. Higgins</name></author><author><name sortKey="Gibson, T J" uniqKey="Gibson T">T.J. Gibson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Koza, J R" uniqKey="Koza J">J.R. Koza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gold, S" uniqKey="Gold S">S. Gold</name></author><author><name sortKey="Rangarajan, A" uniqKey="Rangarajan A">A. Rangarajan</name></author><author><name sortKey="Lu, C P" uniqKey="Lu C">C.P. Lu</name></author><author><name sortKey="Pappu, S" uniqKey="Pappu S">S. Pappu</name></author><author><name sortKey="Mjolsness, E" uniqKey="Mjolsness E">E. Mjolsness</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, C C" uniqKey="Holmes C">C.C. Holmes</name></author><author><name sortKey="Denison, D" uniqKey="Denison D">D. Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Q" uniqKey="Zheng Q">Q. Zheng</name></author><author><name sortKey="Chellappa, R" uniqKey="Chellappa R">R. Chellappa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steven, L S" uniqKey="Steven L">L.S. Steven</name></author><author><name sortKey="David, B S" uniqKey="David B">B.S. David</name></author><author><name sortKey="Simon, K" uniqKey="Simon K">K. Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hu, M K" uniqKey="Hu M">M.K. Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dresher, M" uniqKey="Dresher M">M. Dresher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wahba, G" uniqKey="Wahba G">G. Wahba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riesz, F" uniqKey="Riesz F">F. Riesz</name></author><author><name sortKey="Sz Nagy, B" uniqKey="Sz Nagy B">B. Sz-Nagy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sinkhorn, R" uniqKey="Sinkhorn R">R. Sinkhorn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peterson, C" uniqKey="Peterson C">C. Peterson</name></author><author><name sortKey="Soderberg, B" uniqKey="Soderberg B">B. Soderberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuille, A L" uniqKey="Yuille A">A.L. Yuille</name></author><author><name sortKey="Kosowsky, J J" uniqKey="Kosowsky J">J.J. Kosowsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rangarajan, A" uniqKey="Rangarajan A">A. Rangarajan</name></author><author><name sortKey="Gold, S" uniqKey="Gold S">S. Gold</name></author><author><name sortKey="Mjolsness, E" uniqKey="Mjolsness E">E. Mjolsness</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldberg, D E" uniqKey="Goldberg D">D.E. Goldberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koza, J R" uniqKey="Koza J">J.R. Koza</name></author><author><name sortKey="Bennett, F H" uniqKey="Bennett F">F.H. Bennett</name></author><author><name sortKey="Andre, D" uniqKey="Andre D">D. Andre</name></author><author><name sortKey="Keane, M A" uniqKey="Keane M">M.A. Keane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kushchu, I" uniqKey="Kushchu I">I. Kushchu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, M L" uniqKey="Wong M">M.L. Wong</name></author><author><name sortKey="Lam, W" uniqKey="Lam W">W. Lam</name></author><author><name sortKey="Leung, K S" uniqKey="Leung K">K.S. Leung</name></author><author><name sortKey="Ngan, P S" uniqKey="Ngan P">P.S. Ngan</name></author><author><name sortKey="Cheng, J C Y" uniqKey="Cheng J">J.C.Y. Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bojarczuk, C C" uniqKey="Bojarczuk C">C.C. Bojarczuk</name></author><author><name sortKey="Lopes, H S" uniqKey="Lopes H">H.S Lopes</name></author><author><name sortKey="Freitas, A A" uniqKey="Freitas A">A.A. Freitas</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fields, B N" uniqKey="Fields B">B.N. Fields</name></author><author><name sortKey="Knipe, D M" uniqKey="Knipe D">D.M. Knipe</name></author><author><name sortKey="Howley, P M" uniqKey="Howley P">P.M. Howley</name></author><author><name sortKey="Griffin, D E" uniqKey="Griffin D">D.E. Griffin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, P" uniqKey="Hall P">P. Hall</name></author><author><name sortKey="Titterington, D M" uniqKey="Titterington D">D.M. Titterington</name></author></analytic></biblStruct></listBibl></div1></back></TEI></PMC></double></record>Pour manipuler ce document sous Unix (Dilib)
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