Augmentation of immune responses to SARS coronavirus by a combination of DNA and whole killed virus vaccines
Identifieur interne : 004C36 ( Main/Merge ); précédent : 004C35; suivant : 004C37Augmentation of immune responses to SARS coronavirus by a combination of DNA and whole killed virus vaccines
Auteurs : Alexander N. Zakhartchouk [Canada] ; Qiang Liu [Canada] ; Martin Petric [Canada] ; Lorne A. Babiuk [Canada]Source :
- Vaccine [ 0264-410X ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Vaccins antiviraux, Vaccins inactivés.
- immunologie : Vaccins antiviraux, Vaccins inactivés, Vaccins à ADN.
- Animaux, Cellules Vero, Souris, Syndrome respiratoire aigu sévère, Test ELISA.
English descriptors
- KwdEn :
- Animals, Chlorocebus aethiops, Enzyme-Linked Immunosorbent Assay, Mice, Severe Acute Respiratory Syndrome (prevention & control), Vaccines, DNA (immunology), Vaccines, Inactivated (administration & dosage), Vaccines, Inactivated (immunology), Vero Cells, Viral Vaccines (administration & dosage), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Vaccines, Inactivated, Viral Vaccines.
- chemical , immunology : Vaccines, DNA, Vaccines, Inactivated, Viral Vaccines.
- prevention & control : Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Enzyme-Linked Immunosorbent Assay, Mice, Vero Cells.
Abstract
We studied the immunogenicity of a DNA SARS-vaccine, a whole killed virus, or a whole killed and DNA vaccine combination. The DNA vaccine contained a plasmid encoding the SARS coronavirus (SARS-CoV) S protein under the control of the human CMV promoter and intron A. The whole killed virus vaccine was comprised of SARS-CoV, propagated in Vero-E6 cells, with subsequent β-propilactone inactivation and formulated with aluminum hydroxide adjuvant. Mice immunized twice with the DNA vaccine and once with the whole killed virus elicited higher antibody responses than mice immunized three times with the DNA vaccine or once with the whole killed virus vaccine. Mice immunized twice with the whole killed virus vaccine elicited higher antibody responses than mice immunized three times with the DNA vaccine or once with the whole killed virus vaccine. However, a combination of the vaccines induced T-helper type 1 (Th1) immune responses while the whole killed virus vaccine induced T helper type 2 (Th2) immune response. These results demonstrate that combination of the DNA vaccine and the whole killed virus vaccine can be used to enhance the magnitude and change the bias of the immune responses to SARS-CoV.
Url:
DOI: 10.1016/j.vaccine.2005.04.011
PubMed: 16005746
PubMed Central: 7115501
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PMC:7115501Le document en format XML
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Zakhartchouk</name><affiliation wicri:level="1"><nlm:aff id="aff1">Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Sask., Canada S7N 5E3</nlm:aff><country>Canada</country><wicri:regionArea>Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Sask.</wicri:regionArea><wicri:noRegion>Sask.</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Qiang" sort="Liu, Qiang" uniqKey="Liu Q" first="Qiang" last="Liu">Qiang Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Sask., Canada S7N 5E3</nlm:aff><country>Canada</country><wicri:regionArea>Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Sask.</wicri:regionArea><wicri:noRegion>Sask.</wicri:noRegion></affiliation></author><author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name><affiliation wicri:level="1"><nlm:aff id="aff2">BC Center for Disease Control, Vancouver, BC, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>BC Center for Disease Control, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Babiuk, Lorne A" sort="Babiuk, Lorne A" uniqKey="Babiuk L" first="Lorne A." last="Babiuk">Lorne A. Babiuk</name><affiliation wicri:level="1"><nlm:aff id="aff1">Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Sask., Canada S7N 5E3</nlm:aff><country>Canada</country><wicri:regionArea>Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Sask.</wicri:regionArea><wicri:noRegion>Sask.</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Mice</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Vaccines, DNA (immunology)</term><term>Vaccines, Inactivated (administration & dosage)</term><term>Vaccines, Inactivated (immunology)</term><term>Vero Cells</term><term>Viral Vaccines (administration & dosage)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Souris</term><term>Syndrome respiratoire aigu sévère ()</term><term>Test ELISA</term><term>Vaccins antiviraux (administration et posologie)</term><term>Vaccins antiviraux (immunologie)</term><term>Vaccins inactivés (administration et posologie)</term><term>Vaccins inactivés (immunologie)</term><term>Vaccins à ADN (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Vaccines, Inactivated</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Vaccines, DNA</term><term>Vaccines, Inactivated</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antiviraux</term><term>Vaccins inactivés</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antiviraux</term><term>Vaccins inactivés</term><term>Vaccins à ADN</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Mice</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Souris</term><term>Syndrome respiratoire aigu sévère</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We studied the immunogenicity of a DNA SARS-vaccine, a whole killed virus, or a whole killed and DNA vaccine combination. The DNA vaccine contained a plasmid encoding the SARS coronavirus (SARS-CoV) S protein under the control of the human CMV promoter and intron A. The whole killed virus vaccine was comprised of SARS-CoV, propagated in Vero-E6 cells, with subsequent β-propilactone inactivation and formulated with aluminum hydroxide adjuvant. Mice immunized twice with the DNA vaccine and once with the whole killed virus elicited higher antibody responses than mice immunized three times with the DNA vaccine or once with the whole killed virus vaccine. Mice immunized twice with the whole killed virus vaccine elicited higher antibody responses than mice immunized three times with the DNA vaccine or once with the whole killed virus vaccine. However, a combination of the vaccines induced T-helper type 1 (Th1) immune responses while the whole killed virus vaccine induced T helper type 2 (Th2) immune response. These results demonstrate that combination of the DNA vaccine and the whole killed virus vaccine can be used to enhance the magnitude and change the bias of the immune responses to SARS-CoV.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Christian, M D" uniqKey="Christian M">M.D. Christian</name></author><author><name sortKey="Poutanen, S M" uniqKey="Poutanen S">S.M. Poutanen</name></author><author><name sortKey="Loutfy, M R" uniqKey="Loutfy M">M.R. Loutfy</name></author><author><name sortKey="Muller, M P" uniqKey="Muller M">M.P. Muller</name></author><author><name sortKey="Low, D E" uniqKey="Low D">D.E. Low</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name></author><author><name sortKey="Oberste, M S" uniqKey="Oberste M">M.S. Oberste</name></author><author><name sortKey="Monroe, S S" uniqKey="Monroe S">S.S. 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Wang</name></author><author><name sortKey="Sin, W Y" uniqKey="Sin W">W.Y. Sin</name></author><author><name sortKey="Xu, G B" uniqKey="Xu G">G.B. Xu</name></author><author><name sortKey="Yang, H H" uniqKey="Yang H">H.H. Yang</name></author><author><name sortKey="Wong, T Y" uniqKey="Wong T">T.Y. Wong</name></author><author><name sortKey="Pang, X W" uniqKey="Pang X">X.W. Pang</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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