Molecular evolution and multilocus sequence typing of 145 strains of SARS-CoV
Identifieur interne : 004A29 ( Main/Merge ); précédent : 004A28; suivant : 004A30Molecular evolution and multilocus sequence typing of 145 strains of SARS-CoV
Auteurs : Zhi-Gang Wang [République populaire de Chine] ; Zhi-Hua Zheng [République populaire de Chine] ; Lei Shang [République populaire de Chine] ; Lan-Juan Li [République populaire de Chine] ; Li-Ming Cong [République populaire de Chine] ; Ming-Guang Feng [République populaire de Chine] ; Yun Luo [République populaire de Chine] ; Su-Yun Cheng [République populaire de Chine] ; Yan-Jun Zhang [République populaire de Chine] ; Miao-Gui Ru [République populaire de Chine] ; Zan-Xin Wang [République populaire de Chine] ; Qi-Yu Bao [République populaire de Chine]Source :
- Febs Letters [ 0014-5793 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- classification : SARS Virus.
- genetics : SARS Virus.
- pathogenicity : SARS Virus.
- Base Sequence, Databases, Nucleic Acid, Evolution, Molecular, Genotype, Humans, Molecular Sequence Data, Phylogeny, Polymorphism, Genetic, Selection, Genetic, Sequence Analysis, DNA.
Abstract
In this study, we have identified 876 polymorphism sites in 145 complete or partial genomes of SARS-CoV available in the NCBI GenBank. One hundred and seventy-four of these sites existed in two or more SARS-CoV genome sequences. According to the sequence polymorphism, all SARS-CoVs can be divided into three groups: (I) group 1, animal-origin viruses (such as SARS-CoV SZ1, SZ3, SZ13 and SZ16); (II) group 2, all viruses with clinical origin during first epidemic; and (III) group 3, SARS-CoV GD03T0013. According to 10 special loci, group 2 again can be divided into genotypes C and T, which can be further divided into sub-genotypes C1–C4 and T1–T4. Positive Darwinian selections were identified between any pair of these three groups. Genotype C gives neutral selection. Genotype T, however, shows negative selection. By comparing the death rates of SARS patients in the different regions, it was found that the death rate caused by the viruses of the genotype C was lower than that of the genotype T. SARS-CoVs might originate from an unknown ancestor.
Url:
DOI: 10.1016/j.febslet.2005.07.075
PubMed: 16112670
PubMed Central: 7118731
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PMC:7118731Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>In this study, we have identified 876 polymorphism sites in 145 complete or partial genomes of SARS-CoV available in the NCBI GenBank. One hundred and seventy-four of these sites existed in two or more SARS-CoV genome sequences. According to the sequence polymorphism, all SARS-CoVs can be divided into three groups: (I) group 1, animal-origin viruses (such as SARS-CoV SZ1, SZ3, SZ13 and SZ16); (II) group 2, all viruses with clinical origin during first epidemic; and (III) group 3, SARS-CoV GD03T0013. According to 10 special loci, group 2 again can be divided into genotypes C and T, which can be further divided into sub-genotypes C1–C4 and T1–T4. Positive Darwinian selections were identified between any pair of these three groups. Genotype C gives neutral selection. Genotype T, however, shows negative selection. By comparing the death rates of SARS patients in the different regions, it was found that the death rate caused by the viruses of the genotype C was lower than that of the genotype T. SARS-CoVs might originate from an unknown ancestor.</p>
</div>
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