Programmed ribosomal frameshifting in HIV-1 and the SARS–CoV
Identifieur interne : 004981 ( Main/Merge ); précédent : 004980; suivant : 004982Programmed ribosomal frameshifting in HIV-1 and the SARS–CoV
Auteurs : Ian Brierley [Royaume-Uni] ; Francisco J. Dos Ramos [Royaume-Uni]Source :
- Virus Research [ 0168-1702 ] ; 2005.
Descripteurs français
- KwdFr :
- ARN viral (génétique), ARN viral (métabolisme), Biosynthèse des protéines, Conformation d'acide nucléique, Données de séquences moléculaires, Décalage ribosomique du cadre de lecture, Humains, Régulation de l'expression des gènes viraux, Séquence nucléotidique, Séquences régulatrices de l'acide ribonucléique, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (métabolisme), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (physiologie), Virus du SRAS (génétique), Virus du SRAS (métabolisme), Virus du SRAS (physiologie).
- MESH :
- génétique : ARN viral, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Virus du SRAS.
- métabolisme : ARN viral, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Virus du SRAS.
- physiologie : VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Virus du SRAS.
- Biosynthèse des protéines, Conformation d'acide nucléique, Données de séquences moléculaires, Décalage ribosomique du cadre de lecture, Humains, Régulation de l'expression des gènes viraux, Séquence nucléotidique, Séquences régulatrices de l'acide ribonucléique.
English descriptors
- KwdEn :
- Base Sequence, Frameshifting, Ribosomal, Gene Expression Regulation, Viral, HIV-1 (genetics), HIV-1 (metabolism), HIV-1 (physiology), Humans, Molecular Sequence Data, Nucleic Acid Conformation, Protein Biosynthesis, RNA, Viral (genetics), RNA, Viral (metabolism), Regulatory Sequences, Ribonucleic Acid, SARS Virus (genetics), SARS Virus (metabolism), SARS Virus (physiology).
- MESH :
- chemical , genetics : RNA, Viral.
- genetics : HIV-1, SARS Virus.
- metabolism : HIV-1, RNA, Viral, SARS Virus.
- physiology : HIV-1, SARS Virus.
- Base Sequence, Frameshifting, Ribosomal, Gene Expression Regulation, Viral, Humans, Molecular Sequence Data, Nucleic Acid Conformation, Protein Biosynthesis, Regulatory Sequences, Ribonucleic Acid.
Abstract
Ribosomal frameshifting is a mechanism of gene expression used by several RNA viruses to express replicase enzymes. This article focuses on frameshifting in two human pathogens, the retrovirus human immunodeficiency virus type 1 (HIV-1) and the coronavirus responsible for severe acute respiratory syndrome (SARS). The nature of the frameshift signals of HIV-1 and the SARS–CoV will be described and the impact of this knowledge on models of frameshifting will be considered. The role of frameshifting in the replication cycle of the two pathogens and potential antiviral therapies targeting frameshifting will also be discussed.
Url:
DOI: 10.1016/j.virusres.2005.10.008
PubMed: 16310880
PubMed Central: 7114087
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PMC:7114087Le document en format XML
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<term>Frameshifting, Ribosomal</term>
<term>Gene Expression Regulation, Viral</term>
<term>HIV-1 (genetics)</term>
<term>HIV-1 (metabolism)</term>
<term>HIV-1 (physiology)</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
<term>Nucleic Acid Conformation</term>
<term>Protein Biosynthesis</term>
<term>RNA, Viral (genetics)</term>
<term>RNA, Viral (metabolism)</term>
<term>Regulatory Sequences, Ribonucleic Acid</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (metabolism)</term>
<term>SARS Virus (physiology)</term>
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<term>ARN viral (métabolisme)</term>
<term>Biosynthèse des protéines</term>
<term>Conformation d'acide nucléique</term>
<term>Données de séquences moléculaires</term>
<term>Décalage ribosomique du cadre de lecture</term>
<term>Humains</term>
<term>Régulation de l'expression des gènes viraux</term>
<term>Séquence nucléotidique</term>
<term>Séquences régulatrices de l'acide ribonucléique</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (métabolisme)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (physiologie)</term>
<term>Virus du SRAS (génétique)</term>
<term>Virus du SRAS (métabolisme)</term>
<term>Virus du SRAS (physiologie)</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>HIV-1</term>
<term>SARS Virus</term>
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<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
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<term>Frameshifting, Ribosomal</term>
<term>Gene Expression Regulation, Viral</term>
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<term>Molecular Sequence Data</term>
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<term>Données de séquences moléculaires</term>
<term>Décalage ribosomique du cadre de lecture</term>
<term>Humains</term>
<term>Régulation de l'expression des gènes viraux</term>
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<front><div type="abstract" xml:lang="en"><p>Ribosomal frameshifting is a mechanism of gene expression used by several RNA viruses to express replicase enzymes. This article focuses on frameshifting in two human pathogens, the retrovirus human immunodeficiency virus type 1 (HIV-1) and the coronavirus responsible for severe acute respiratory syndrome (SARS). The nature of the frameshift signals of HIV-1 and the SARS–CoV will be described and the impact of this knowledge on models of frameshifting will be considered. The role of frameshifting in the replication cycle of the two pathogens and potential antiviral therapies targeting frameshifting will also be discussed.</p>
</div>
</front>
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</TEI>
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