Anti-severe acute respiratory syndrome coronavirus immune responses : The role played by Vγ9Vδ2 T cells
Identifieur interne : 004709 ( Main/Merge ); précédent : 004708; suivant : 004710Anti-severe acute respiratory syndrome coronavirus immune responses : The role played by Vγ9Vδ2 T cells
Auteurs : Fabrizio Poccia [Italie] ; Chiara Agrati [Italie] ; Concetta Castilletti [Italie] ; Licia Bordi [Italie] ; Cristiana Gioia [Italie] ; Douglas Horejsh [Italie] ; Giuseppe Ippolito [Italie] ; Paul K. S. Chan [Hong Kong] ; David S. C. Hui [Hong Kong] ; Joseph J. Y. Sung [Hong Kong] ; Maria Rosaria Capobianchi [Italie] ; Miroslav Malkovsky [États-Unis]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2006.
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Abstract
Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus (SARS-CoV) strain. Analyses ofT cell repertoires in health care workers who survived SARS-CoV infection during the 2003 outbreak revealed that their effector memory Vγ9Vδ2 T cell populations were selectively expanded ∼3 months after the onset of disease. No such expansion of their αβ T cell pools was detected. The expansion of the Vγ9Vδ2 T cell population was associated with higher anti-SARS-CoV immunoglobulin G titers. In addition, in vitro experiments demonstrated that stimulated Vγ9Vδ2 T cells display an interferon-γ-dependent anti-SARS-CoV activity and are able to directly kill SARS-CoV-infected target cells. These findings are compatible with the possibility that Vγ9Vδ2 T cells play a protective role during SARS.
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type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Malkovsky, Miroslav" sort="Malkovsky, Miroslav" uniqKey="Malkovsky M" first="Miroslav" last="Malkovsky">Miroslav Malkovsky</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medical Microbiology and Immunology, University of Wisconsin Medical School</s1><s2>Madison</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Madison</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0319267</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 06-0319267 INIST</idno><idno type="RBID">Pascal:06-0319267</idno><idno type="wicri:Area/PascalFrancis/Corpus">000483</idno><idno type="wicri:Area/PascalFrancis/Curation">000507</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000508</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000508</idno><idno type="wicri:doubleKey">0022-1899:2006:Poccia F:anti:severe:acute</idno><idno type="wicri:Area/Main/Merge">004709</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Anti-severe acute respiratory syndrome coronavirus immune responses : The role played by Vγ9Vδ2 T cells</title><author><name sortKey="Poccia, Fabrizio" sort="Poccia, Fabrizio" uniqKey="Poccia F" first="Fabrizio" last="Poccia">Fabrizio Poccia</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unit of Cellular Immunology, National Institute for Infectious Diseases "Lazzaro Spallanzani," Istituto di Ricovero e Cura a Carattere Scientifico</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Agrati, Chiara" sort="Agrati, Chiara" uniqKey="Agrati C" first="Chiara" last="Agrati">Chiara Agrati</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unit of Cellular Immunology, National Institute for Infectious Diseases "Lazzaro Spallanzani," Istituto di Ricovero e Cura a Carattere Scientifico</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Castilletti, Concetta" sort="Castilletti, Concetta" uniqKey="Castilletti C" first="Concetta" last="Castilletti">Concetta Castilletti</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani," Istituto di Ricovero e Cura a Carattere Scientifico</s1><s2>Rome</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bordi, Licia" sort="Bordi, Licia" uniqKey="Bordi L" first="Licia" last="Bordi">Licia Bordi</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani," Istituto di Ricovero e Cura a Carattere Scientifico</s1><s2>Rome</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Gioia, Cristiana" sort="Gioia, Cristiana" uniqKey="Gioia C" first="Cristiana" last="Gioia">Cristiana Gioia</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Unit of Cellular Immunology, National Institute for Infectious Diseases "Lazzaro Spallanzani," Istituto di Ricovero e Cura a Carattere Scientifico</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Horejsh, Douglas" sort="Horejsh, Douglas" uniqKey="Horejsh D" first="Douglas" last="Horejsh">Douglas Horejsh</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani," Istituto di Ricovero e Cura a Carattere Scientifico</s1><s2>Rome</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Epidemiology, National Institute for Infectious Diseases "Lazzaro Spallanzani," Istituto di Ricovero e Cura a Carattere Scientifico</s1><s2>Rome</s2><s3>ITA</s3><sZ>7 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S. C." last="Hui">David S. C. Hui</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Centre for Emerging Infectious Diseases, School of Public Health, Faculty of Medicine, Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Capobianchi, Maria Rosaria" sort="Capobianchi, Maria Rosaria" uniqKey="Capobianchi M" first="Maria Rosaria" last="Capobianchi">Maria Rosaria Capobianchi</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratory of Virology, National Institute for Infectious Diseases "Lazzaro Spallanzani," Istituto di Ricovero e Cura a Carattere Scientifico</s1><s2>Rome</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Malkovsky, Miroslav" sort="Malkovsky, Miroslav" uniqKey="Malkovsky M" first="Miroslav" last="Malkovsky">Miroslav Malkovsky</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medical Microbiology and Immunology, University of Wisconsin Medical School</s1><s2>Madison</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Madison</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term><term>Immune response</term><term>Infection</term><term>Microbiology</term><term>Severe acute respiratory syndrome</term><term>T-Lymphocyte</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Réponse immune</term><term>Lymphocyte T</term><term>Microbiologie</term><term>Infection</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus (SARS-CoV) strain. Analyses ofT cell repertoires in health care workers who survived SARS-CoV infection during the 2003 outbreak revealed that their effector memory Vγ9Vδ2 T cell populations were selectively expanded ∼3 months after the onset of disease. No such expansion of their αβ T cell pools was detected. The expansion of the Vγ9Vδ2 T cell population was associated with higher anti-SARS-CoV immunoglobulin G titers. In addition, in vitro experiments demonstrated that stimulated Vγ9Vδ2 T cells display an interferon-γ-dependent anti-SARS-CoV activity and are able to directly kill SARS-CoV-infected target cells. These findings are compatible with the possibility that Vγ9Vδ2 T cells play a protective role during SARS.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>Italie</li><li>États-Unis</li></country><region><li>Latium</li></region><settlement><li>Rome</li><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="Italie"><region name="Latium"><name sortKey="Poccia, Fabrizio" sort="Poccia, Fabrizio" uniqKey="Poccia F" first="Fabrizio" last="Poccia">Fabrizio Poccia</name></region><name sortKey="Agrati, Chiara" sort="Agrati, Chiara" uniqKey="Agrati C" first="Chiara" last="Agrati">Chiara Agrati</name><name sortKey="Bordi, Licia" sort="Bordi, Licia" uniqKey="Bordi L" first="Licia" last="Bordi">Licia Bordi</name><name sortKey="Capobianchi, Maria Rosaria" sort="Capobianchi, Maria Rosaria" uniqKey="Capobianchi M" first="Maria Rosaria" last="Capobianchi">Maria Rosaria Capobianchi</name><name sortKey="Castilletti, Concetta" sort="Castilletti, Concetta" uniqKey="Castilletti C" first="Concetta" last="Castilletti">Concetta Castilletti</name><name sortKey="Gioia, Cristiana" sort="Gioia, Cristiana" uniqKey="Gioia C" first="Cristiana" last="Gioia">Cristiana Gioia</name><name sortKey="Horejsh, Douglas" sort="Horejsh, Douglas" uniqKey="Horejsh D" first="Douglas" last="Horejsh">Douglas Horejsh</name><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name></country><country name="Hong Kong"><noRegion><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name></noRegion><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S. C." last="Hui">David S. C. Hui</name><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name></country><country name="États-Unis"><noRegion><name sortKey="Malkovsky, Miroslav" sort="Malkovsky, Miroslav" uniqKey="Malkovsky M" first="Miroslav" last="Malkovsky">Miroslav Malkovsky</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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