Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors
Identifieur interne : 004667 ( Main/Merge ); précédent : 004666; suivant : 004668Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors
Auteurs : HUI LI [États-Unis] ; John Tatlock [États-Unis] ; Angelica Linton [États-Unis] ; Javier Gonzalez [États-Unis] ; Allen Borchardt [États-Unis] ; Peter Dragovich [États-Unis] ; Tanya Jewell [États-Unis] ; Tom Prins [États-Unis] ; RU ZHOU [États-Unis] ; Julie Blazel [États-Unis] ; Hans Parge [États-Unis] ; Robert Love [États-Unis] ; Michael Hickey [États-Unis] ; Chau Doan [États-Unis] ; Stephanie Shi [États-Unis] ; Rohit Duggal [États-Unis] ; Cristina Lewis [États-Unis] ; Shella Fuhrman [États-Unis]Source :
- Bioorganic & medicinal chemistry letters : (Print) [ 0960-894X ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Optimisation, Virus hépatite C, DNA-directed RNA polymerase, Inhibiteur enzyme, Composé non nucléoside, Criblage, Structure cristalline, Site fixation, Changement conformation, Relation structure activité, Pyranone dérivé, Cyclopentane dérivé, Lactone, Antiviral, Composé benzénique, Halogène Composé organique, RNA-directed RNA polymerase, Pyrane dérivé, NS5B polymerase, Pyran-2-one(3-[4-amino-2-(t-butyl)-5-méthylphénylsulfanyl]-6-cyclopentyl-5,6-dihydro-4-hydroxy-6-[4-hydroxyphénéthyl]), Pyrane-2,4-dione dérivé, Protéine NS5B.
English descriptors
- KwdEn :
- Antiviral, Benzenic compound, Binding site, Conformational changes, Crystalline structure, Cyclopentane derivatives, DNA-directed RNA polymerase, Enzyme inhibitor, Halogen Organic compounds, Hepatitis C virus, Lactone, Non nucleoside compound, Optimization, Pyran derivatives, Pyranone derivatives, RNA-directed RNA polymerase, Screening, Structure activity relation.
Abstract
A novel class of non-nucleoside HCV NS5B polymerase inhibitors has been identified from screening. A co-crystal structure revealed an allosteric binding site in the protein that required a unique conformational change to accommodate inhibitor binding. Herein we report the structure-activity relationships (SARs) of this novel class of dihydropyrone-containing compounds that show potent inhibitory activities against the HCV RNA polymerase in biochemical assays.
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Links to Exploration step
Pascal:07-0028982Le document en format XML
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Inc., 1 DNA Way</s1><s2>South San Francisco, CA 94098</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fuhrman, Shella" sort="Fuhrman, Shella" uniqKey="Fuhrman S" first="Shella" last="Fuhrman">Shella Fuhrman</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">07-0028982</idno><date when="2006">2006</date><idno type="stanalyst">PASCAL 07-0028982 INIST</idno><idno type="RBID">Pascal:07-0028982</idno><idno type="wicri:Area/PascalFrancis/Corpus">000426</idno><idno type="wicri:Area/PascalFrancis/Curation">000563</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000466</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000466</idno><idno type="wicri:doubleKey">0960-894X:2006:Hui Li:identification:and:structure</idno><idno type="wicri:Area/Main/Merge">004667</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors</title><author><name sortKey="Hui Li" sort="Hui Li" uniqKey="Hui Li" last="Hui Li">HUI LI</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tatlock, John" sort="Tatlock, John" uniqKey="Tatlock J" first="John" last="Tatlock">John Tatlock</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Linton, Angelica" sort="Linton, Angelica" uniqKey="Linton A" first="Angelica" last="Linton">Angelica Linton</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gonzalez, Javier" sort="Gonzalez, Javier" uniqKey="Gonzalez J" first="Javier" last="Gonzalez">Javier Gonzalez</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Borchardt, Allen" sort="Borchardt, Allen" uniqKey="Borchardt A" first="Allen" last="Borchardt">Allen Borchardt</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dragovich, Peter" sort="Dragovich, Peter" uniqKey="Dragovich P" first="Peter" last="Dragovich">Peter Dragovich</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Anadys Pharmaceuticals, 3115 Merryfield Row</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jewell, Tanya" sort="Jewell, Tanya" uniqKey="Jewell T" first="Tanya" last="Jewell">Tanya Jewell</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Prins, Tom" sort="Prins, Tom" uniqKey="Prins T" first="Tom" last="Prins">Tom Prins</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Anadys Pharmaceuticals, 3115 Merryfield Row</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ru Zhou" sort="Ru Zhou" uniqKey="Ru Zhou" last="Ru Zhou">RU ZHOU</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Blazel, Julie" sort="Blazel, Julie" uniqKey="Blazel J" first="Julie" last="Blazel">Julie Blazel</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Anadys Pharmaceuticals, 3115 Merryfield Row</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Parge, Hans" sort="Parge, Hans" uniqKey="Parge H" first="Hans" last="Parge">Hans Parge</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Love, Robert" sort="Love, Robert" uniqKey="Love R" first="Robert" last="Love">Robert Love</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hickey, Michael" sort="Hickey, Michael" uniqKey="Hickey M" first="Michael" last="Hickey">Michael Hickey</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Doan, Chau" sort="Doan, Chau" uniqKey="Doan C" first="Chau" last="Doan">Chau Doan</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Shi, Stephanie" sort="Shi, Stephanie" uniqKey="Shi S" first="Stephanie" last="Shi">Stephanie Shi</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Duggal, Rohit" sort="Duggal, Rohit" uniqKey="Duggal R" first="Rohit" last="Duggal">Rohit Duggal</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lewis, Cristina" sort="Lewis, Cristina" uniqKey="Lewis C" first="Cristina" last="Lewis">Cristina Lewis</name><affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Genentecb. Inc., 1 DNA Way</s1><s2>South San Francisco, CA 94098</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fuhrman, Shella" sort="Fuhrman, Shella" uniqKey="Fuhrman S" first="Shella" last="Fuhrman">Shella Fuhrman</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Dr</s1><s2>San Diego, CA 92121</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Bioorganic & medicinal chemistry letters : (Print)</title><title level="j" type="abbreviated">Bioorg. med. chem. lett. : (Print)</title><idno type="ISSN">0960-894X</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Bioorganic & medicinal chemistry letters : (Print)</title><title level="j" type="abbreviated">Bioorg. med. chem. lett. : (Print)</title><idno type="ISSN">0960-894X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral</term><term>Benzenic compound</term><term>Binding site</term><term>Conformational changes</term><term>Crystalline structure</term><term>Cyclopentane derivatives</term><term>DNA-directed RNA polymerase</term><term>Enzyme inhibitor</term><term>Halogen Organic compounds</term><term>Hepatitis C virus</term><term>Lactone</term><term>Non nucleoside compound</term><term>Optimization</term><term>Pyran derivatives</term><term>Pyranone derivatives</term><term>RNA-directed RNA polymerase</term><term>Screening</term><term>Structure activity relation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Optimisation</term><term>Virus hépatite C</term><term>DNA-directed RNA polymerase</term><term>Inhibiteur enzyme</term><term>Composé non nucléoside</term><term>Criblage</term><term>Structure cristalline</term><term>Site fixation</term><term>Changement conformation</term><term>Relation structure activité</term><term>Pyranone dérivé</term><term>Cyclopentane dérivé</term><term>Lactone</term><term>Antiviral</term><term>Composé benzénique</term><term>Halogène Composé organique</term><term>RNA-directed RNA polymerase</term><term>Pyrane dérivé</term><term>NS5B polymerase</term><term>Pyran-2-one(3-[4-amino-2-(t-butyl)-5-méthylphénylsulfanyl]-6-cyclopentyl-5,6-dihydro-4-hydroxy-6-[4-hydroxyphénéthyl])</term><term>Pyrane-2,4-dione dérivé</term><term>Protéine NS5B</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A novel class of non-nucleoside HCV NS5B polymerase inhibitors has been identified from screening. A co-crystal structure revealed an allosteric binding site in the protein that required a unique conformational change to accommodate inhibitor binding. Herein we report the structure-activity relationships (SARs) of this novel class of dihydropyrone-containing compounds that show potent inhibitory activities against the HCV RNA polymerase in biochemical assays.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Hui Li" sort="Hui Li" uniqKey="Hui Li" last="Hui Li">HUI LI</name></region><name sortKey="Blazel, Julie" sort="Blazel, Julie" uniqKey="Blazel J" first="Julie" last="Blazel">Julie Blazel</name><name sortKey="Borchardt, Allen" sort="Borchardt, Allen" uniqKey="Borchardt A" first="Allen" last="Borchardt">Allen Borchardt</name><name sortKey="Doan, Chau" sort="Doan, Chau" uniqKey="Doan C" first="Chau" last="Doan">Chau Doan</name><name sortKey="Dragovich, Peter" sort="Dragovich, Peter" uniqKey="Dragovich P" first="Peter" last="Dragovich">Peter Dragovich</name><name sortKey="Duggal, Rohit" sort="Duggal, Rohit" uniqKey="Duggal R" first="Rohit" last="Duggal">Rohit Duggal</name><name sortKey="Fuhrman, Shella" sort="Fuhrman, Shella" uniqKey="Fuhrman S" first="Shella" last="Fuhrman">Shella Fuhrman</name><name sortKey="Gonzalez, Javier" sort="Gonzalez, Javier" uniqKey="Gonzalez J" first="Javier" last="Gonzalez">Javier Gonzalez</name><name sortKey="Hickey, Michael" sort="Hickey, Michael" uniqKey="Hickey M" first="Michael" last="Hickey">Michael Hickey</name><name sortKey="Jewell, Tanya" sort="Jewell, Tanya" uniqKey="Jewell T" first="Tanya" last="Jewell">Tanya Jewell</name><name sortKey="Lewis, Cristina" sort="Lewis, Cristina" uniqKey="Lewis C" first="Cristina" last="Lewis">Cristina Lewis</name><name sortKey="Linton, Angelica" sort="Linton, Angelica" uniqKey="Linton A" first="Angelica" last="Linton">Angelica Linton</name><name sortKey="Love, Robert" sort="Love, Robert" uniqKey="Love R" first="Robert" last="Love">Robert Love</name><name sortKey="Parge, Hans" sort="Parge, Hans" uniqKey="Parge H" first="Hans" last="Parge">Hans Parge</name><name sortKey="Prins, Tom" sort="Prins, Tom" uniqKey="Prins T" first="Tom" last="Prins">Tom Prins</name><name sortKey="Ru Zhou" sort="Ru Zhou" uniqKey="Ru Zhou" last="Ru Zhou">RU ZHOU</name><name sortKey="Shi, Stephanie" sort="Shi, Stephanie" uniqKey="Shi S" first="Stephanie" last="Shi">Stephanie Shi</name><name sortKey="Tatlock, John" sort="Tatlock, John" uniqKey="Tatlock J" first="John" last="Tatlock">John Tatlock</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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