Inactivation of SARS coronavirus by means of povidone-lodine, physical conditions and chemical reagents
Identifieur interne : 004663 ( Main/Merge ); précédent : 004662; suivant : 004664Inactivation of SARS coronavirus by means of povidone-lodine, physical conditions and chemical reagents
Auteurs : Hiroaki Kariwa [Japon] ; Nobuhiro Fujii [Japon] ; Ikuo Takashima [Japon]Source :
- Dermatology : (Basel) [ 1018-8665 ] ; 2006.
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- Pascal (Inist)
- Wicri :
- topic : Iode.
English descriptors
- KwdEn :
Abstract
The efficacy of several povidone-iodine (PVP-I) products, a number of other chemical agents and various physical conditions were evaluated for their ability to inactivate the severe acute respiratory syndrome coronavirus (SARS-CoV). Treatment of SARS-CoV with PVP-I products for 2 min reduced the virus infectivity from 1.17 x 106 TCID50/ml to below the detectable level. The efficacy of 70% ethanol was equivalent to that of PVP-I products. Fixation of SARS-CoV-infected Vero E6 cells with a fixative including formalin, glutaraldehyde, methanol and acetone for 5 min or longer eliminated all infectivity. Heating the virus at 56°C for 60 min or longer reduced the infectivity of the virus from 2.6 x 107 to undetectable levels. Irradiation with ultraviolet light at 134 μW/cm2 for 15 min reduced the infectivity from 3.8 x 107 to 180 TCID50/ml; however, prolonged irradiation (60 min) failed to eliminate the remaining virus, leaving 18.8 TCID50/ml.
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Pascal:06-0170112Le document en format XML
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<author><name sortKey="Fujii, Nobuhiro" sort="Fujii, Nobuhiro" uniqKey="Fujii N" first="Nobuhiro" last="Fujii">Nobuhiro Fujii</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Inactivation of SARS coronavirus by means of povidone-lodine, physical conditions and chemical reagents</title>
<author><name sortKey="Kariwa, Hiroaki" sort="Kariwa, Hiroaki" uniqKey="Kariwa H" first="Hiroaki" last="Kariwa">Hiroaki Kariwa</name>
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<author><name sortKey="Fujii, Nobuhiro" sort="Fujii, Nobuhiro" uniqKey="Fujii N" first="Nobuhiro" last="Fujii">Nobuhiro Fujii</name>
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<series><title level="j" type="main">Dermatology : (Basel)</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral</term>
<term>Biological activity</term>
<term>Coronavirus</term>
<term>In vitro</term>
<term>Iodine</term>
<term>Povidone</term>
<term>Severe acute respiratory syndrome</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
<term>Povidone</term>
<term>Coronavirus</term>
<term>Iode</term>
<term>In vitro</term>
<term>Activité biologique</term>
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<front><div type="abstract" xml:lang="en">The efficacy of several povidone-iodine (PVP-I) products, a number of other chemical agents and various physical conditions were evaluated for their ability to inactivate the severe acute respiratory syndrome coronavirus (SARS-CoV). Treatment of SARS-CoV with PVP-I products for 2 min reduced the virus infectivity from 1.17 x 10<sup>6</sup>
TCID<sub>50</sub>
/ml to below the detectable level. The efficacy of 70% ethanol was equivalent to that of PVP-I products. Fixation of SARS-CoV-infected Vero E6 cells with a fixative including formalin, glutaraldehyde, methanol and acetone for 5 min or longer eliminated all infectivity. Heating the virus at 56°C for 60 min or longer reduced the infectivity of the virus from 2.6 x 10<sup>7</sup>
to undetectable levels. Irradiation with ultraviolet light at 134 μW/cm<sup>2</sup>
for 15 min reduced the infectivity from 3.8 x 10<sup>7</sup>
to 180 TCID<sub>50</sub>
/ml; however, prolonged irradiation (60 min) failed to eliminate the remaining virus, leaving 18.8 TCID<sub>50</sub>
/ml.</div>
</front>
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<name sortKey="Fujii, Nobuhiro" sort="Fujii, Nobuhiro" uniqKey="Fujii N" first="Nobuhiro" last="Fujii">Nobuhiro Fujii</name>
<name sortKey="Takashima, Ikuo" sort="Takashima, Ikuo" uniqKey="Takashima I" first="Ikuo" last="Takashima">Ikuo Takashima</name>
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