Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice
Identifieur interne : 004651 ( Main/Merge ); précédent : 004650; suivant : 004652Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice
Auteurs : Nadine De Albuquerque [Canada] ; Ehtesham Baig [Canada] ; XUEZHONG MA [Canada] ; JIANHUA ZHANG [Canada] ; William He [Canada] ; Andrea Rowe [Canada] ; Marlena Habal [Canada] ; MINGFENG LIU [Canada] ; Itay Shalev [Canada] ; Gregory P. Downey [Canada] ; Reginald Gorczynski [Canada] ; Jagdish Butany [Canada] ; Julian Leibowitz [États-Unis] ; Susan R. Weiss [États-Unis] ; Ian D. Mcgilvray [Canada] ; M. James Phillips [Canada] ; Eleanor N. Fish [Canada] ; Gary A. Levy [Canada]Source :
- Journal of virology [ 0022-538X ] ; 2006.
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- Pascal (Inist)
English descriptors
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Abstract
Severe acute respiratory syndrome (SARS) is a life-threatening infectious disease which has been difficult to study and treat because of the lack of a readily available animal model. Intranasal infection of A/J mice with the coronavirus murine hepatitis virus strain 1 (MHV-1) produced pulmonary pathological features of SARS. All MHV-1-infected A/J mice developed progressive interstitial pneumonitis, including dense macrophage infiltrates, giant cells, and hyaline membranes, resulting in death of all animals. In contrast, other mouse strains developed only mild transitory disease. Infected A/J mice had significantly higher cytokine levels, particularly macrophage chemoattractant protein 1 (MCP-1/CCL-2), gamma interferon, and tumor necrosis factor alpha. Furthermore, FGL2/fibroleukin mRNA transcripts and protein and fibrin deposits were markedly increased in the lungs of infected A/J mice. These animals developed a less robust type I interferon response to MHV-1 infection than resistant C57BL/6J mice, and treatment with recombinant beta interferon improved survival. This study describes a potentially useful small animal model of human SARS, defines its pathogenesis, and suggests treatment strategies.
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice</title>
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<author><name sortKey="Xuezhong Ma" sort="Xuezhong Ma" uniqKey="Xuezhong Ma" last="Xuezhong Ma">XUEZHONG MA</name>
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<author><name sortKey="Jianhua Zhang" sort="Jianhua Zhang" uniqKey="Jianhua Zhang" last="Jianhua Zhang">JIANHUA ZHANG</name>
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</affiliation>
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<author><name sortKey="He, William" sort="He, William" uniqKey="He W" first="William" last="He">William He</name>
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<author><name sortKey="Mingfeng Liu" sort="Mingfeng Liu" uniqKey="Mingfeng Liu" last="Mingfeng Liu">MINGFENG LIU</name>
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<author><name sortKey="Shalev, Itay" sort="Shalev, Itay" uniqKey="Shalev I" first="Itay" last="Shalev">Itay Shalev</name>
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<author><name sortKey="Downey, Gregory P" sort="Downey, Gregory P" uniqKey="Downey G" first="Gregory P." last="Downey">Gregory P. Downey</name>
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<author><name sortKey="Gorczynski, Reginald" sort="Gorczynski, Reginald" uniqKey="Gorczynski R" first="Reginald" last="Gorczynski">Reginald Gorczynski</name>
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<author><name sortKey="Leibowitz, Julian" sort="Leibowitz, Julian" uniqKey="Leibowitz J" first="Julian" last="Leibowitz">Julian Leibowitz</name>
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<author><name sortKey="Phillips, M James" sort="Phillips, M James" uniqKey="Phillips M" first="M. James" last="Phillips">M. James Phillips</name>
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<author><name sortKey="Fish, Eleanor N" sort="Fish, Eleanor N" uniqKey="Fish E" first="Eleanor N." last="Fish">Eleanor N. Fish</name>
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<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Levy, Gary A" sort="Levy, Gary A" uniqKey="Levy G" first="Gary A." last="Levy">Gary A. Levy</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Medicine, University Health Network</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
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<sZ>9 aut.</sZ>
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</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Medicine, University Health Network</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>the Multi Organ Transplant Program, University Health Network</s1>
<s3>CAN</s3>
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<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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</inist:fA14>
<country>Canada</country>
<wicri:noRegion>the Multi Organ Transplant Program, University Health Network</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>University of Toronto</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
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<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Hepatitis A virus</term>
<term>Microbiology</term>
<term>Models</term>
<term>Mouse</term>
<term>Murine hepatitis virus</term>
<term>Severe acute respiratory syndrome</term>
<term>Strain</term>
<term>Virology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus hépatite murine</term>
<term>Virus hépatite A</term>
<term>Souris</term>
<term>Souche</term>
<term>Modèle</term>
<term>Microbiologie</term>
<term>Virologie</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a life-threatening infectious disease which has been difficult to study and treat because of the lack of a readily available animal model. Intranasal infection of A/J mice with the coronavirus murine hepatitis virus strain 1 (MHV-1) produced pulmonary pathological features of SARS. All MHV-1-infected A/J mice developed progressive interstitial pneumonitis, including dense macrophage infiltrates, giant cells, and hyaline membranes, resulting in death of all animals. In contrast, other mouse strains developed only mild transitory disease. Infected A/J mice had significantly higher cytokine levels, particularly macrophage chemoattractant protein 1 (MCP-1/CCL-2), gamma interferon, and tumor necrosis factor alpha. Furthermore, FGL2/fibroleukin mRNA transcripts and protein and fibrin deposits were markedly increased in the lungs of infected A/J mice. These animals developed a less robust type I interferon response to MHV-1 infection than resistant C57BL/6J mice, and treatment with recombinant beta interferon improved survival. This study describes a potentially useful small animal model of human SARS, defines its pathogenesis, and suggests treatment strategies.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Ontario</li>
<li>Pennsylvanie</li>
<li>Texas</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><noRegion><name sortKey="De Albuquerque, Nadine" sort="De Albuquerque, Nadine" uniqKey="De Albuquerque N" first="Nadine" last="De Albuquerque">Nadine De Albuquerque</name>
</noRegion>
<name sortKey="Baig, Ehtesham" sort="Baig, Ehtesham" uniqKey="Baig E" first="Ehtesham" last="Baig">Ehtesham Baig</name>
<name sortKey="Butany, Jagdish" sort="Butany, Jagdish" uniqKey="Butany J" first="Jagdish" last="Butany">Jagdish Butany</name>
<name sortKey="De Albuquerque, Nadine" sort="De Albuquerque, Nadine" uniqKey="De Albuquerque N" first="Nadine" last="De Albuquerque">Nadine De Albuquerque</name>
<name sortKey="Downey, Gregory P" sort="Downey, Gregory P" uniqKey="Downey G" first="Gregory P." last="Downey">Gregory P. Downey</name>
<name sortKey="Downey, Gregory P" sort="Downey, Gregory P" uniqKey="Downey G" first="Gregory P." last="Downey">Gregory P. Downey</name>
<name sortKey="Fish, Eleanor N" sort="Fish, Eleanor N" uniqKey="Fish E" first="Eleanor N." last="Fish">Eleanor N. Fish</name>
<name sortKey="Gorczynski, Reginald" sort="Gorczynski, Reginald" uniqKey="Gorczynski R" first="Reginald" last="Gorczynski">Reginald Gorczynski</name>
<name sortKey="Gorczynski, Reginald" sort="Gorczynski, Reginald" uniqKey="Gorczynski R" first="Reginald" last="Gorczynski">Reginald Gorczynski</name>
<name sortKey="Habal, Marlena" sort="Habal, Marlena" uniqKey="Habal M" first="Marlena" last="Habal">Marlena Habal</name>
<name sortKey="Habal, Marlena" sort="Habal, Marlena" uniqKey="Habal M" first="Marlena" last="Habal">Marlena Habal</name>
<name sortKey="He, William" sort="He, William" uniqKey="He W" first="William" last="He">William He</name>
<name sortKey="He, William" sort="He, William" uniqKey="He W" first="William" last="He">William He</name>
<name sortKey="Jianhua Zhang" sort="Jianhua Zhang" uniqKey="Jianhua Zhang" last="Jianhua Zhang">JIANHUA ZHANG</name>
<name sortKey="Jianhua Zhang" sort="Jianhua Zhang" uniqKey="Jianhua Zhang" last="Jianhua Zhang">JIANHUA ZHANG</name>
<name sortKey="Levy, Gary A" sort="Levy, Gary A" uniqKey="Levy G" first="Gary A." last="Levy">Gary A. Levy</name>
<name sortKey="Levy, Gary A" sort="Levy, Gary A" uniqKey="Levy G" first="Gary A." last="Levy">Gary A. Levy</name>
<name sortKey="Levy, Gary A" sort="Levy, Gary A" uniqKey="Levy G" first="Gary A." last="Levy">Gary A. Levy</name>
<name sortKey="Mcgilvray, Ian D" sort="Mcgilvray, Ian D" uniqKey="Mcgilvray I" first="Ian D." last="Mcgilvray">Ian D. Mcgilvray</name>
<name sortKey="Mcgilvray, Ian D" sort="Mcgilvray, Ian D" uniqKey="Mcgilvray I" first="Ian D." last="Mcgilvray">Ian D. Mcgilvray</name>
<name sortKey="Mcgilvray, Ian D" sort="Mcgilvray, Ian D" uniqKey="Mcgilvray I" first="Ian D." last="Mcgilvray">Ian D. Mcgilvray</name>
<name sortKey="Mingfeng Liu" sort="Mingfeng Liu" uniqKey="Mingfeng Liu" last="Mingfeng Liu">MINGFENG LIU</name>
<name sortKey="Mingfeng Liu" sort="Mingfeng Liu" uniqKey="Mingfeng Liu" last="Mingfeng Liu">MINGFENG LIU</name>
<name sortKey="Phillips, M James" sort="Phillips, M James" uniqKey="Phillips M" first="M. James" last="Phillips">M. James Phillips</name>
<name sortKey="Phillips, M James" sort="Phillips, M James" uniqKey="Phillips M" first="M. James" last="Phillips">M. James Phillips</name>
<name sortKey="Rowe, Andrea" sort="Rowe, Andrea" uniqKey="Rowe A" first="Andrea" last="Rowe">Andrea Rowe</name>
<name sortKey="Rowe, Andrea" sort="Rowe, Andrea" uniqKey="Rowe A" first="Andrea" last="Rowe">Andrea Rowe</name>
<name sortKey="Shalev, Itay" sort="Shalev, Itay" uniqKey="Shalev I" first="Itay" last="Shalev">Itay Shalev</name>
<name sortKey="Shalev, Itay" sort="Shalev, Itay" uniqKey="Shalev I" first="Itay" last="Shalev">Itay Shalev</name>
<name sortKey="Xuezhong Ma" sort="Xuezhong Ma" uniqKey="Xuezhong Ma" last="Xuezhong Ma">XUEZHONG MA</name>
<name sortKey="Xuezhong Ma" sort="Xuezhong Ma" uniqKey="Xuezhong Ma" last="Xuezhong Ma">XUEZHONG MA</name>
</country>
<country name="États-Unis"><region name="Texas"><name sortKey="Leibowitz, Julian" sort="Leibowitz, Julian" uniqKey="Leibowitz J" first="Julian" last="Leibowitz">Julian Leibowitz</name>
</region>
<name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R." last="Weiss">Susan R. Weiss</name>
</country>
</tree>
</affiliations>
</record>
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