The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1 : a review
Identifieur interne : 004624 ( Main/Merge ); précédent : 004623; suivant : 004625The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1 : a review
Auteurs : Wai-Fu Ng [Hong Kong] ; Ka-Fai To [Hong Kong] ; William W. L. Lam [Hong Kong] ; Tak-Keung Ng [Hong Kong] ; Kam-Cheong Lee [Hong Kong]Source :
- Human pathology [ 0046-8177 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
The pathology of 2 zoonotic human viral infections that recently emerged, severe acute respiratory syndrome (SARS) due to coronavirus (SARS-CoV) and avian influenza A subtype H5N1, is reviewed and compared based on the literature and the cases examined by the authors. Pneumocytes are the primary target of infection resulting in diffuse alveolar damage. Systemic cytokine activation results in hemophagocytic syndrome, lymphoid depletion, and skeletal muscle fiber necrosis. Severe acute respiratory syndrome induces a more fibrocellular intra-alveolar organization with a "bronchiolitis obliterans organizing pneumonia"-like pattern and presence of multinucleated histiocytes and pneumocytes. H5N1 causes a more fulminant and nccrotizing diffuse alveolar damage with patchy and interstitial paucicellular fibrosis. Severe acute respiratory syndrome associated coronavirus persists in the lung up to the second month, whereas H5N1 persists in the lung up to the third week. Severe acute respiratory syndrome associated coronavirus disseminates to blood, urine, feces, gastrointestinal tract, and liver. There is recent report of possible cerebral involvement by H5N1 and its isolation in the blood, gastrointestinal tract, and cerebrospinal fluid. More pathologic studies are urgently needed.
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Lam</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, Princess Margaret Hospital, Kowloon West Cluster Hospitals</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Pathology, Princess Margaret Hospital, Kowloon West Cluster Hospitals</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Tak Keung" sort="Ng, Tak Keung" uniqKey="Ng T" first="Tak-Keung" last="Ng">Tak-Keung Ng</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, Princess Margaret Hospital, Kowloon West Cluster Hospitals</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Pathology, Princess Margaret Hospital, Kowloon West Cluster Hospitals</wicri:noRegion></affiliation></author><author><name sortKey="Lee, Kam Cheong" sort="Lee, Kam Cheong" uniqKey="Lee K" first="Kam-Cheong" last="Lee">Kam-Cheong Lee</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology, Princess Margaret Hospital, Kowloon West Cluster Hospitals</s1><s3>HKG</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Department of Pathology, Princess Margaret Hospital, Kowloon West Cluster Hospitals</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Human pathology</title><title level="j" type="abbreviated">Human pathol.</title><idno type="ISSN">0046-8177</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Human pathology</title><title level="j" type="abbreviated">Human pathol.</title><idno type="ISSN">0046-8177</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term><term>Avian influenza</term><term>Bibliographic review</term><term>Comparative study</term><term>Coronavirus</term><term>Influenzavirus A(H5N1)</term><term>Lesion</term><term>Pulmonary alveolus</term><term>Review</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Etude comparative</term><term>Anatomopathologie</term><term>Syndrome respiratoire aigu sévère</term><term>Alvéole pulmonaire</term><term>Coronavirus</term><term>Article synthèse</term><term>Revue bibliographique</term><term>Lésion</term><term>Grippe aviaire</term><term>Influenzavirus A(H5N1)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathology of 2 zoonotic human viral infections that recently emerged, severe acute respiratory syndrome (SARS) due to coronavirus (SARS-CoV) and avian influenza A subtype H5N1, is reviewed and compared based on the literature and the cases examined by the authors. Pneumocytes are the primary target of infection resulting in diffuse alveolar damage. Systemic cytokine activation results in hemophagocytic syndrome, lymphoid depletion, and skeletal muscle fiber necrosis. Severe acute respiratory syndrome induces a more fibrocellular intra-alveolar organization with a "bronchiolitis obliterans organizing pneumonia"-like pattern and presence of multinucleated histiocytes and pneumocytes. H5N1 causes a more fulminant and nccrotizing diffuse alveolar damage with patchy and interstitial paucicellular fibrosis. Severe acute respiratory syndrome associated coronavirus persists in the lung up to the second month, whereas H5N1 persists in the lung up to the third week. Severe acute respiratory syndrome associated coronavirus disseminates to blood, urine, feces, gastrointestinal tract, and liver. There is recent report of possible cerebral involvement by H5N1 and its isolation in the blood, gastrointestinal tract, and cerebrospinal fluid. More pathologic studies are urgently needed.</div></front></TEI><affiliations><list><country><li>Hong Kong</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="Hong Kong"><noRegion><name sortKey="Ng, Wai Fu" sort="Ng, Wai Fu" uniqKey="Ng W" first="Wai-Fu" last="Ng">Wai-Fu Ng</name></noRegion><name sortKey="Lam, William W L" sort="Lam, William W L" uniqKey="Lam W" first="William W. L." last="Lam">William W. L. Lam</name><name sortKey="Lee, Kam Cheong" sort="Lee, Kam Cheong" uniqKey="Lee K" first="Kam-Cheong" last="Lee">Kam-Cheong Lee</name><name sortKey="Ng, Tak Keung" sort="Ng, Tak Keung" uniqKey="Ng T" first="Tak-Keung" last="Ng">Tak-Keung Ng</name><name sortKey="To, Ka Fai" sort="To, Ka Fai" uniqKey="To K" first="Ka-Fai" last="To">Ka-Fai To</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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