Production of an anti-severe acute respiratory syndrome (SARS) coronavirus human monoclonal antibody Fab fragment by using a combinatorial immunoglobulin gene library derived from patients who recovered from SARS.
Identifieur interne : 003F43 ( Main/Merge ); précédent : 003F42; suivant : 003F44Production of an anti-severe acute respiratory syndrome (SARS) coronavirus human monoclonal antibody Fab fragment by using a combinatorial immunoglobulin gene library derived from patients who recovered from SARS.
Auteurs : Jinye Liu [République populaire de Chine] ; Hongxia Shao ; Yanlin Tao ; Bin Yang ; Lisheng Qian ; Xiaoli Yang ; Brian Cao ; Gengxi Hu ; Hiroshi Tachibana ; Xunjia ChengSource :
- Clinical and vaccine immunology : CVI [ 1556-6811 ] ; 2006.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (génétique), Anticorps antiviraux (immunologie), Anticorps monoclonaux (), Anticorps monoclonaux (génétique), Anticorps monoclonaux (métabolisme), Banque génomique, Coronavirus (immunologie), Données de séquences moléculaires, Fragments Fab d'immunoglobuline (), Fragments Fab d'immunoglobuline (génétique), Fragments Fab d'immunoglobuline (métabolisme), Humains, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Séquence d'acides aminés, Techniques de chimie combinatoire.
- MESH :
- génétique : Anticorps antiviraux, Anticorps monoclonaux, Fragments Fab d'immunoglobuline.
- immunologie : Anticorps antiviraux, Coronavirus, Syndrome respiratoire aigu sévère.
- métabolisme : Anticorps monoclonaux, Fragments Fab d'immunoglobuline.
- virologie : Syndrome respiratoire aigu sévère.
- Anticorps monoclonaux, Banque génomique, Données de séquences moléculaires, Fragments Fab d'immunoglobuline, Humains, Séquence d'acides aminés, Techniques de chimie combinatoire.
English descriptors
- KwdEn :
- Amino Acid Sequence, Antibodies, Monoclonal (chemistry), Antibodies, Monoclonal (genetics), Antibodies, Monoclonal (metabolism), Antibodies, Viral (genetics), Antibodies, Viral (immunology), Combinatorial Chemistry Techniques, Coronavirus (immunology), Genomic Library, Humans, Immunoglobulin Fab Fragments (chemistry), Immunoglobulin Fab Fragments (genetics), Immunoglobulin Fab Fragments (metabolism), Molecular Sequence Data, Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , chemistry : Antibodies, Monoclonal, Immunoglobulin Fab Fragments.
- chemical , genetics : Antibodies, Monoclonal, Antibodies, Viral, Immunoglobulin Fab Fragments.
- chemical , immunology : Antibodies, Viral.
- chemical , metabolism : Antibodies, Monoclonal, Immunoglobulin Fab Fragments.
- immunology : Coronavirus, Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Combinatorial Chemistry Techniques, Genomic Library, Humans, Molecular Sequence Data.
Abstract
A combinatorial human immunoglobulin gene library was constructed from the peripheral lymphocytes of two patients who recovered from severe acute respiratory syndrome (SARS). The library was screened for the production of Fab antibody fragments to a recombinant spike protein of SARS-associated coronavirus (SARS-CoV). One Fab clone, AS3-3, reacted with the spike protein in an enzyme-linked immunosorbent assay. The dissociation constant of AS3-3 was 1.98 x 10(-8) M. Immunofluorescent microscopy revealed that it reacted with SARS-CoV-infected cells. The library seems to be a potent tool for the production of human antibodies to SARS-CoV.
DOI: 10.1128/CVI.13.5.594-597.2006
PubMed: 16682481
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002243
- to stream PubMed, to step Curation: 002243
- to stream PubMed, to step Checkpoint: 002056
- to stream Ncbi, to step Merge: 001494
- to stream Ncbi, to step Curation: 001494
- to stream Ncbi, to step Checkpoint: 001494
Links to Exploration step
pubmed:16682481Le document en format XML
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<term>Antibodies, Monoclonal (genetics)</term>
<term>Antibodies, Monoclonal (metabolism)</term>
<term>Antibodies, Viral (genetics)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Combinatorial Chemistry Techniques</term>
<term>Coronavirus (immunology)</term>
<term>Genomic Library</term>
<term>Humans</term>
<term>Immunoglobulin Fab Fragments (chemistry)</term>
<term>Immunoglobulin Fab Fragments (genetics)</term>
<term>Immunoglobulin Fab Fragments (metabolism)</term>
<term>Molecular Sequence Data</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
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<term>Anticorps monoclonaux (génétique)</term>
<term>Anticorps monoclonaux (métabolisme)</term>
<term>Banque génomique</term>
<term>Coronavirus (immunologie)</term>
<term>Données de séquences moléculaires</term>
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<term>Fragments Fab d'immunoglobuline (génétique)</term>
<term>Fragments Fab d'immunoglobuline (métabolisme)</term>
<term>Humains</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Séquence d'acides aminés</term>
<term>Techniques de chimie combinatoire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Immunoglobulin Fab Fragments</term>
</keywords>
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<term>Antibodies, Viral</term>
<term>Immunoglobulin Fab Fragments</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Immunoglobulin Fab Fragments</term>
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<term>Anticorps monoclonaux</term>
<term>Fragments Fab d'immunoglobuline</term>
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<term>Severe Acute Respiratory Syndrome</term>
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<term>Combinatorial Chemistry Techniques</term>
<term>Genomic Library</term>
<term>Humans</term>
<term>Molecular Sequence Data</term>
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<term>Banque génomique</term>
<term>Données de séquences moléculaires</term>
<term>Fragments Fab d'immunoglobuline</term>
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<term>Séquence d'acides aminés</term>
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<front><div type="abstract" xml:lang="en">A combinatorial human immunoglobulin gene library was constructed from the peripheral lymphocytes of two patients who recovered from severe acute respiratory syndrome (SARS). The library was screened for the production of Fab antibody fragments to a recombinant spike protein of SARS-associated coronavirus (SARS-CoV). One Fab clone, AS3-3, reacted with the spike protein in an enzyme-linked immunosorbent assay. The dissociation constant of AS3-3 was 1.98 x 10(-8) M. Immunofluorescent microscopy revealed that it reacted with SARS-CoV-infected cells. The library seems to be a potent tool for the production of human antibodies to SARS-CoV.</div>
</front>
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