SARS coronavirus anti-infectives.
Identifieur interne : 003F07 ( Main/Merge ); précédent : 003F06; suivant : 003F08SARS coronavirus anti-infectives.
Auteurs : Tommy R. Tong [Hong Kong]Source :
- Recent patents on anti-infective drug discovery [ 1574-891X ] ; 2006.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (pharmacologie), Antiviraux (usage thérapeutique), DNA-directed RNA polymerases (antagonistes et inhibiteurs), Helicase (antagonistes et inhibiteurs), Humains, Inhibiteurs de protéases (pharmacologie), Interférons (pharmacologie), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (pathogénicité).
- MESH :
- antagonistes et inhibiteurs : DNA-directed RNA polymerases, Helicase.
- pathogénicité : Virus du SRAS.
- pharmacologie : Anticorps monoclonaux, Inhibiteurs de protéases, Interférons.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Antiviraux.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Humains, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (pharmacology), Antiviral Agents (therapeutic use), DNA Helicases (antagonists & inhibitors), DNA-Directed RNA Polymerases (antagonists & inhibitors), Humans, Interferons (pharmacology), Protease Inhibitors (pharmacology), SARS Virus (drug effects), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , antagonists & inhibitors : DNA Helicases, DNA-Directed RNA Polymerases.
- chemical , pharmacology : Antibodies, Monoclonal, Interferons, Protease Inhibitors.
- chemical , therapeutic use : Antiviral Agents.
- drug effects : SARS Virus.
- drug therapy : Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Humans.
Abstract
Severe acute respiratory syndrome (SARS) emerged in late 2002 and was controlled in July 2003 by public health measures. Its causative agent, SARS coronavirus (SARS-CoV) jumped from an animal reservoir to humans and has the potential to re-emerge. Following the sequencing of the genetic code and the deciphering of some of the functions of its proteins, including the cellular receptors and host proteins that participate in the life cycle of the virus, promising lead drugs and new uses of old drugs have been discovered. Patent applications for cathepsin L inhibitors have taken new relevance because of the role of cathepsin L in the entry of SARS-CoV into host cells. Likewise, patent applications for SARS-CoV protease inhibitors and interferon and mismatched dsRNA also need to be watched for potential application in treatment and prevention of SARS-CoV. Here, we review the recent advances and inventions that target SARS-CoV infection in humans.
DOI: 10.2174/157489106778777637
PubMed: 18221155
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pubmed:18221155Le document en format XML
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<term>Antibodies, Monoclonal (pharmacology)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>DNA Helicases (antagonists & inhibitors)</term>
<term>DNA-Directed RNA Polymerases (antagonists & inhibitors)</term>
<term>Humans</term>
<term>Interferons (pharmacology)</term>
<term>Protease Inhibitors (pharmacology)</term>
<term>SARS Virus (drug effects)</term>
<term>SARS Virus (pathogenicity)</term>
<term>Severe Acute Respiratory Syndrome (drug therapy)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
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<term>Anticorps monoclonaux (pharmacologie)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>DNA-directed RNA polymerases (antagonistes et inhibiteurs)</term>
<term>Helicase (antagonistes et inhibiteurs)</term>
<term>Humains</term>
<term>Inhibiteurs de protéases (pharmacologie)</term>
<term>Interférons (pharmacologie)</term>
<term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (pathogénicité)</term>
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<term>DNA-Directed RNA Polymerases</term>
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<term>Interferons</term>
<term>Protease Inhibitors</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
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<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>DNA-directed RNA polymerases</term>
<term>Helicase</term>
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<term>Inhibiteurs de protéases</term>
<term>Interférons</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) emerged in late 2002 and was controlled in July 2003 by public health measures. Its causative agent, SARS coronavirus (SARS-CoV) jumped from an animal reservoir to humans and has the potential to re-emerge. Following the sequencing of the genetic code and the deciphering of some of the functions of its proteins, including the cellular receptors and host proteins that participate in the life cycle of the virus, promising lead drugs and new uses of old drugs have been discovered. Patent applications for cathepsin L inhibitors have taken new relevance because of the role of cathepsin L in the entry of SARS-CoV into host cells. Likewise, patent applications for SARS-CoV protease inhibitors and interferon and mismatched dsRNA also need to be watched for potential application in treatment and prevention of SARS-CoV. Here, we review the recent advances and inventions that target SARS-CoV infection in humans.</div>
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