Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the SARS coronavirus and stimulates robust immune responses in macaques.
Identifieur interne : 003927 ( Main/Merge ); précédent : 003926; suivant : 003928Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the SARS coronavirus and stimulates robust immune responses in macaques.
Auteurs : Gary P. Kobinger [Canada] ; Joanita M. Figueredo ; Thomas Rowe ; Yan Zhi ; Guangping Gao ; Julio C. Sanmiguel ; Peter Bell ; Nelson A. Wivel ; Lois A. Zitzow ; Douglas B. Flieder ; Robert J. Hogan ; James M. WilsonSource :
- Vaccine [ 0264-410X ] ; 2007.
Descripteurs français
- KwdFr :
- Adenoviridae (immunologie), Administration par voie nasale, Animaux, Antigènes viraux (immunologie), Furets, Humains, Lymphocytes B (immunologie), Lymphocytes T (immunologie), Macaca mulatta, Modèles animaux de maladie humaine, Pneumopathie infectieuse (), Pneumopathie infectieuse (immunologie), Poumon (anatomopathologie), Poumon (immunologie), Poumon (virologie), Rappel de vaccin (), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Vaccination (), Vaccins antiviraux (administration et posologie), Vaccins antiviraux (immunologie), Virus du SRAS (croissance et développement), Virus du SRAS (immunologie).
- MESH :
- administration et posologie : Vaccins antiviraux.
- anatomopathologie : Poumon.
- croissance et développement : Virus du SRAS.
- immunologie : Adenoviridae, Antigènes viraux, Lymphocytes B, Lymphocytes T, Pneumopathie infectieuse, Poumon, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Virus du SRAS.
- virologie : Poumon.
- Administration par voie nasale, Animaux, Furets, Humains, Macaca mulatta, Modèles animaux de maladie humaine, Pneumopathie infectieuse, Rappel de vaccin, Syndrome respiratoire aigu sévère, Vaccination.
English descriptors
- KwdEn :
- Adenoviridae (immunology), Administration, Intranasal, Animals, Antigens, Viral (immunology), B-Lymphocytes (immunology), Disease Models, Animal, Ferrets, Humans, Immunization, Secondary (methods), Lung (immunology), Lung (pathology), Lung (virology), Macaca mulatta, Pneumonia (immunology), Pneumonia (prevention & control), SARS Virus (growth & development), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), T-Lymphocytes (immunology), Vaccination (methods), Viral Vaccines (administration & dosage), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Viral Vaccines.
- chemical , immunology : Antigens, Viral, Viral Vaccines.
- growth & development : SARS Virus.
- immunology : Adenoviridae, B-Lymphocytes, Lung, Pneumonia, SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocytes.
- methods : Immunization, Secondary, Vaccination.
- pathology : Lung.
- prevention & control : Pneumonia, Severe Acute Respiratory Syndrome.
- virology : Lung.
- Administration, Intranasal, Animals, Disease Models, Animal, Ferrets, Humans, Macaca mulatta.
Abstract
A ferret model of severe acute respiratory syndrome (SARS)-CoV infection was used to evaluate the efficacy of an adenovirus vaccine. Animals were subjected to heterologous prime-boost using vectors from human serotype 5 and chimpanzee derived adenoviruses (human AdHu5 and chimpanzee AdC7) expressing spike protein followed by intranasal challenge with SARS-CoV. Vaccination led to a substantial reduction in viral load and prevented the severe pneumonia seen in unvaccinated animals. The same prime-boost strategy was effective in rhesus macaques in eliciting SARS-CoV specific immune responses. These data indicate that a heterologous adenovirus-based prime-boost vaccine strategy could safely stimulate strong immunity that may be needed for complete protection against SARS-CoV infection.
DOI: 10.1016/j.vaccine.2007.04.065
PubMed: 17559989
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001D91
- to stream PubMed, to step Curation: 001D91
- to stream PubMed, to step Checkpoint: 001E79
- to stream Ncbi, to step Merge: 001992
- to stream Ncbi, to step Curation: 001992
- to stream Ncbi, to step Checkpoint: 001992
Links to Exploration step
pubmed:17559989Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the SARS coronavirus and stimulates robust immune responses in macaques.</title><author><name sortKey="Kobinger, Gary P" sort="Kobinger, Gary P" uniqKey="Kobinger G" first="Gary P" last="Kobinger">Gary P. Kobinger</name><affiliation wicri:level="4"><nlm:affiliation>Special Pathogens Program, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Special Pathogens Program, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Department of Medical Microbiology, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Figueredo, Joanita M" sort="Figueredo, Joanita M" uniqKey="Figueredo J" first="Joanita M" last="Figueredo">Joanita M. Figueredo</name></author><author><name sortKey="Rowe, Thomas" sort="Rowe, Thomas" uniqKey="Rowe T" first="Thomas" last="Rowe">Thomas Rowe</name></author><author><name sortKey="Zhi, Yan" sort="Zhi, Yan" uniqKey="Zhi Y" first="Yan" last="Zhi">Yan Zhi</name></author><author><name sortKey="Gao, Guangping" sort="Gao, Guangping" uniqKey="Gao G" first="Guangping" last="Gao">Guangping Gao</name></author><author><name sortKey="Sanmiguel, Julio C" sort="Sanmiguel, Julio C" uniqKey="Sanmiguel J" first="Julio C" last="Sanmiguel">Julio C. Sanmiguel</name></author><author><name sortKey="Bell, Peter" sort="Bell, Peter" uniqKey="Bell P" first="Peter" last="Bell">Peter Bell</name></author><author><name sortKey="Wivel, Nelson A" sort="Wivel, Nelson A" uniqKey="Wivel N" first="Nelson A" last="Wivel">Nelson A. Wivel</name></author><author><name sortKey="Zitzow, Lois A" sort="Zitzow, Lois A" uniqKey="Zitzow L" first="Lois A" last="Zitzow">Lois A. Zitzow</name></author><author><name sortKey="Flieder, Douglas B" sort="Flieder, Douglas B" uniqKey="Flieder D" first="Douglas B" last="Flieder">Douglas B. Flieder</name></author><author><name sortKey="Hogan, Robert J" sort="Hogan, Robert J" uniqKey="Hogan R" first="Robert J" last="Hogan">Robert J. Hogan</name></author><author><name sortKey="Wilson, James M" sort="Wilson, James M" uniqKey="Wilson J" first="James M" last="Wilson">James M. Wilson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17559989</idno><idno type="pmid">17559989</idno><idno type="doi">10.1016/j.vaccine.2007.04.065</idno><idno type="wicri:Area/PubMed/Corpus">001D91</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D91</idno><idno type="wicri:Area/PubMed/Curation">001D91</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001D91</idno><idno type="wicri:Area/PubMed/Checkpoint">001E79</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001E79</idno><idno type="wicri:Area/Ncbi/Merge">001992</idno><idno type="wicri:Area/Ncbi/Curation">001992</idno><idno type="wicri:Area/Ncbi/Checkpoint">001992</idno><idno type="wicri:doubleKey">0264-410X:2007:Kobinger G:adenovirus:based:vaccine</idno><idno type="wicri:Area/Main/Merge">003927</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the SARS coronavirus and stimulates robust immune responses in macaques.</title><author><name sortKey="Kobinger, Gary P" sort="Kobinger, Gary P" uniqKey="Kobinger G" first="Gary P" last="Kobinger">Gary P. Kobinger</name><affiliation wicri:level="4"><nlm:affiliation>Special Pathogens Program, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Special Pathogens Program, National Microbiology Laboratory, Health Canada, Canadian Science Centre for Human and Animal Health, Department of Medical Microbiology, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Figueredo, Joanita M" sort="Figueredo, Joanita M" uniqKey="Figueredo J" first="Joanita M" last="Figueredo">Joanita M. Figueredo</name></author><author><name sortKey="Rowe, Thomas" sort="Rowe, Thomas" uniqKey="Rowe T" first="Thomas" last="Rowe">Thomas Rowe</name></author><author><name sortKey="Zhi, Yan" sort="Zhi, Yan" uniqKey="Zhi Y" first="Yan" last="Zhi">Yan Zhi</name></author><author><name sortKey="Gao, Guangping" sort="Gao, Guangping" uniqKey="Gao G" first="Guangping" last="Gao">Guangping Gao</name></author><author><name sortKey="Sanmiguel, Julio C" sort="Sanmiguel, Julio C" uniqKey="Sanmiguel J" first="Julio C" last="Sanmiguel">Julio C. Sanmiguel</name></author><author><name sortKey="Bell, Peter" sort="Bell, Peter" uniqKey="Bell P" first="Peter" last="Bell">Peter Bell</name></author><author><name sortKey="Wivel, Nelson A" sort="Wivel, Nelson A" uniqKey="Wivel N" first="Nelson A" last="Wivel">Nelson A. Wivel</name></author><author><name sortKey="Zitzow, Lois A" sort="Zitzow, Lois A" uniqKey="Zitzow L" first="Lois A" last="Zitzow">Lois A. Zitzow</name></author><author><name sortKey="Flieder, Douglas B" sort="Flieder, Douglas B" uniqKey="Flieder D" first="Douglas B" last="Flieder">Douglas B. Flieder</name></author><author><name sortKey="Hogan, Robert J" sort="Hogan, Robert J" uniqKey="Hogan R" first="Robert J" last="Hogan">Robert J. Hogan</name></author><author><name sortKey="Wilson, James M" sort="Wilson, James M" uniqKey="Wilson J" first="James M" last="Wilson">James M. Wilson</name></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae (immunology)</term><term>Administration, Intranasal</term><term>Animals</term><term>Antigens, Viral (immunology)</term><term>B-Lymphocytes (immunology)</term><term>Disease Models, Animal</term><term>Ferrets</term><term>Humans</term><term>Immunization, Secondary (methods)</term><term>Lung (immunology)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Macaca mulatta</term><term>Pneumonia (immunology)</term><term>Pneumonia (prevention & control)</term><term>SARS Virus (growth & development)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>T-Lymphocytes (immunology)</term><term>Vaccination (methods)</term><term>Viral Vaccines (administration & dosage)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae (immunologie)</term><term>Administration par voie nasale</term><term>Animaux</term><term>Antigènes viraux (immunologie)</term><term>Furets</term><term>Humains</term><term>Lymphocytes B (immunologie)</term><term>Lymphocytes T (immunologie)</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Pneumopathie infectieuse ()</term><term>Pneumopathie infectieuse (immunologie)</term><term>Poumon (anatomopathologie)</term><term>Poumon (immunologie)</term><term>Poumon (virologie)</term><term>Rappel de vaccin ()</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Vaccination ()</term><term>Vaccins antiviraux (administration et posologie)</term><term>Vaccins antiviraux (immunologie)</term><term>Virus du SRAS (croissance et développement)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Adenoviridae</term><term>Antigènes viraux</term><term>Lymphocytes B</term><term>Lymphocytes T</term><term>Pneumopathie infectieuse</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccins antiviraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Adenoviridae</term><term>B-Lymphocytes</term><term>Lung</term><term>Pneumonia</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization, Secondary</term><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pneumonia</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Disease Models, Animal</term><term>Ferrets</term><term>Humans</term><term>Macaca mulatta</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Furets</term><term>Humains</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Pneumopathie infectieuse</term><term>Rappel de vaccin</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A ferret model of severe acute respiratory syndrome (SARS)-CoV infection was used to evaluate the efficacy of an adenovirus vaccine. Animals were subjected to heterologous prime-boost using vectors from human serotype 5 and chimpanzee derived adenoviruses (human AdHu5 and chimpanzee AdC7) expressing spike protein followed by intranasal challenge with SARS-CoV. Vaccination led to a substantial reduction in viral load and prevented the severe pneumonia seen in unvaccinated animals. The same prime-boost strategy was effective in rhesus macaques in eliciting SARS-CoV specific immune responses. These data indicate that a heterologous adenovirus-based prime-boost vaccine strategy could safely stimulate strong immunity that may be needed for complete protection against SARS-CoV infection.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003927 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003927 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Merge
|type= RBID
|clé= pubmed:17559989
|texte= Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the SARS coronavirus and stimulates robust immune responses in macaques.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:17559989" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |