Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the SARS coronavirus and stimulates robust immune responses in macaques.
Identifieur interne : 003927 ( Main/Merge ); précédent : 003926; suivant : 003928Adenovirus-based vaccine prevents pneumonia in ferrets challenged with the SARS coronavirus and stimulates robust immune responses in macaques.
Auteurs : Gary P. Kobinger [Canada] ; Joanita M. Figueredo ; Thomas Rowe ; Yan Zhi ; Guangping Gao ; Julio C. Sanmiguel ; Peter Bell ; Nelson A. Wivel ; Lois A. Zitzow ; Douglas B. Flieder ; Robert J. Hogan ; James M. WilsonSource :
- Vaccine [ 0264-410X ] ; 2007.
Descripteurs français
- KwdFr :
- Adenoviridae (immunologie), Administration par voie nasale, Animaux, Antigènes viraux (immunologie), Furets, Humains, Lymphocytes B (immunologie), Lymphocytes T (immunologie), Macaca mulatta, Modèles animaux de maladie humaine, Pneumopathie infectieuse (), Pneumopathie infectieuse (immunologie), Poumon (anatomopathologie), Poumon (immunologie), Poumon (virologie), Rappel de vaccin (), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Vaccination (), Vaccins antiviraux (administration et posologie), Vaccins antiviraux (immunologie), Virus du SRAS (croissance et développement), Virus du SRAS (immunologie).
- MESH :
- administration et posologie : Vaccins antiviraux.
- anatomopathologie : Poumon.
- croissance et développement : Virus du SRAS.
- immunologie : Adenoviridae, Antigènes viraux, Lymphocytes B, Lymphocytes T, Pneumopathie infectieuse, Poumon, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Virus du SRAS.
- virologie : Poumon.
- Administration par voie nasale, Animaux, Furets, Humains, Macaca mulatta, Modèles animaux de maladie humaine, Pneumopathie infectieuse, Rappel de vaccin, Syndrome respiratoire aigu sévère, Vaccination.
English descriptors
- KwdEn :
- Adenoviridae (immunology), Administration, Intranasal, Animals, Antigens, Viral (immunology), B-Lymphocytes (immunology), Disease Models, Animal, Ferrets, Humans, Immunization, Secondary (methods), Lung (immunology), Lung (pathology), Lung (virology), Macaca mulatta, Pneumonia (immunology), Pneumonia (prevention & control), SARS Virus (growth & development), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), T-Lymphocytes (immunology), Vaccination (methods), Viral Vaccines (administration & dosage), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Viral Vaccines.
- chemical , immunology : Antigens, Viral, Viral Vaccines.
- growth & development : SARS Virus.
- immunology : Adenoviridae, B-Lymphocytes, Lung, Pneumonia, SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocytes.
- methods : Immunization, Secondary, Vaccination.
- pathology : Lung.
- prevention & control : Pneumonia, Severe Acute Respiratory Syndrome.
- virology : Lung.
- Administration, Intranasal, Animals, Disease Models, Animal, Ferrets, Humans, Macaca mulatta.
Abstract
A ferret model of severe acute respiratory syndrome (SARS)-CoV infection was used to evaluate the efficacy of an adenovirus vaccine. Animals were subjected to heterologous prime-boost using vectors from human serotype 5 and chimpanzee derived adenoviruses (human AdHu5 and chimpanzee AdC7) expressing spike protein followed by intranasal challenge with SARS-CoV. Vaccination led to a substantial reduction in viral load and prevented the severe pneumonia seen in unvaccinated animals. The same prime-boost strategy was effective in rhesus macaques in eliciting SARS-CoV specific immune responses. These data indicate that a heterologous adenovirus-based prime-boost vaccine strategy could safely stimulate strong immunity that may be needed for complete protection against SARS-CoV infection.
DOI: 10.1016/j.vaccine.2007.04.065
PubMed: 17559989
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pubmed:17559989Le document en format XML
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<term>Animals</term>
<term>Antigens, Viral (immunology)</term>
<term>B-Lymphocytes (immunology)</term>
<term>Disease Models, Animal</term>
<term>Ferrets</term>
<term>Humans</term>
<term>Immunization, Secondary (methods)</term>
<term>Lung (immunology)</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Macaca mulatta</term>
<term>Pneumonia (immunology)</term>
<term>Pneumonia (prevention & control)</term>
<term>SARS Virus (growth & development)</term>
<term>SARS Virus (immunology)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (prevention & control)</term>
<term>T-Lymphocytes (immunology)</term>
<term>Vaccination (methods)</term>
<term>Viral Vaccines (administration & dosage)</term>
<term>Viral Vaccines (immunology)</term>
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<term>Administration par voie nasale</term>
<term>Animaux</term>
<term>Antigènes viraux (immunologie)</term>
<term>Furets</term>
<term>Humains</term>
<term>Lymphocytes B (immunologie)</term>
<term>Lymphocytes T (immunologie)</term>
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<term>Pneumopathie infectieuse (immunologie)</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (immunologie)</term>
<term>Poumon (virologie)</term>
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<term>Syndrome respiratoire aigu sévère ()</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
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<term>Syndrome respiratoire aigu sévère</term>
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<front><div type="abstract" xml:lang="en">A ferret model of severe acute respiratory syndrome (SARS)-CoV infection was used to evaluate the efficacy of an adenovirus vaccine. Animals were subjected to heterologous prime-boost using vectors from human serotype 5 and chimpanzee derived adenoviruses (human AdHu5 and chimpanzee AdC7) expressing spike protein followed by intranasal challenge with SARS-CoV. Vaccination led to a substantial reduction in viral load and prevented the severe pneumonia seen in unvaccinated animals. The same prime-boost strategy was effective in rhesus macaques in eliciting SARS-CoV specific immune responses. These data indicate that a heterologous adenovirus-based prime-boost vaccine strategy could safely stimulate strong immunity that may be needed for complete protection against SARS-CoV infection.</div>
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