Helicobacter Hypothesis for Idiopathic Parkinsonism: Before and Beyond
Identifieur interne : 003472 ( Main/Merge ); précédent : 003471; suivant : 003473Helicobacter Hypothesis for Idiopathic Parkinsonism: Before and Beyond
Auteurs : R. John Dobbs [Royaume-Uni] ; Sylvia M. Dobbs [Royaume-Uni] ; Clive Weller [Royaume-Uni] ; André Charlett [Royaume-Uni] ; Ingvar T. Bjarnason ; Alan Curry [Royaume-Uni] ; David S. Ellis ; Mohammad A. A. Ibrahim ; Maria V. Mccrossan ; John O'Donohue ; Robert J. Owen [Royaume-Uni] ; Norman L. Oxlade [Royaume-Uni] ; Ashley B. Price [Royaume-Uni] ; Jeremy D. Sanderson [Royaume-Uni] ; Malur Sudhanva [Royaume-Uni] ; John Williams [Royaume-Uni]Source :
- Helicobacter [ 1083-4389 ] ; 2008-10.
Abstract
We challenge the concept of idiopathic parkinsonism (IP) as inevitably progressive neurodegeneration, proposing a natural history of sequential microbial insults with predisposing host response. Proof‐of‐principle that infection can contribute to IP was provided by case studies and a placebo‐controlled efficacy study of Helicobacter eradication. “Malignant” IP appears converted to “benign”, but marked deterioration accompanies failure. Similar benefit on brady/hypokinesia from eradicating “low‐density” infection favors autoimmunity. Although a minority of UK probands are urea breath test positive for Helicobacter, the predicted probability of having the parkinsonian label depends on the serum H. pylori antibody profile, with clinically relevant gradients between this “discriminant index” and disease burden and progression. In IP, H. pylori antibodies discriminate for persistently abnormal bowel function, and specific abnormal duodenal enterocyte mitochondrial morphology is described in relation to H. pylori infection. Slow intestinal transit manifests as constipation from the prodrome. Diarrhea may flag secondary small‐intestinal bacterial overgrowth. This, coupled with genetically determined intense inflammatory response, might explain evolution from brady/hypokinetic to rigidity‐predominant parkinsonism.
Url:
DOI: 10.1111/j.1523-5378.2008.00622.x
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001A74
- to stream Istex, to step Curation: 001A74
- to stream Istex, to step Checkpoint: 001044
Links to Exploration step
ISTEX:10F818C8BD5A032AC8DC172BBB282F700BF32882Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Helicobacter Hypothesis for Idiopathic Parkinsonism: Before and Beyond</title>
<author><name sortKey="Dobbs, R John" sort="Dobbs, R John" uniqKey="Dobbs R" first="R. John" last="Dobbs">R. John Dobbs</name>
</author>
<author><name sortKey="Dobbs, Sylvia M" sort="Dobbs, Sylvia M" uniqKey="Dobbs S" first="Sylvia M." last="Dobbs">Sylvia M. Dobbs</name>
</author>
<author><name sortKey="Weller, Clive" sort="Weller, Clive" uniqKey="Weller C" first="Clive" last="Weller">Clive Weller</name>
</author>
<author><name sortKey="Charlett, Andre" sort="Charlett, Andre" uniqKey="Charlett A" first="André" last="Charlett">André Charlett</name>
</author>
<author><name sortKey="Bjarnason, Ingvar T" sort="Bjarnason, Ingvar T" uniqKey="Bjarnason I" first="Ingvar T." last="Bjarnason">Ingvar T. Bjarnason</name>
</author>
<author><name sortKey="Curry, Alan" sort="Curry, Alan" uniqKey="Curry A" first="Alan" last="Curry">Alan Curry</name>
</author>
<author><name sortKey="Ellis, David S" sort="Ellis, David S" uniqKey="Ellis D" first="David S." last="Ellis">David S. Ellis</name>
</author>
<author><name sortKey="Ibrahim, Mohammad A A" sort="Ibrahim, Mohammad A A" uniqKey="Ibrahim M" first="Mohammad A. A." last="Ibrahim">Mohammad A. A. Ibrahim</name>
</author>
<author><name sortKey="Mccrossan, Maria V" sort="Mccrossan, Maria V" uniqKey="Mccrossan M" first="Maria V." last="Mccrossan">Maria V. Mccrossan</name>
</author>
<author><name sortKey="O Donohue, John" sort="O Donohue, John" uniqKey="O Donohue J" first="John" last="O'Donohue">John O'Donohue</name>
</author>
<author><name sortKey="Owen, Robert J" sort="Owen, Robert J" uniqKey="Owen R" first="Robert J." last="Owen">Robert J. Owen</name>
</author>
<author><name sortKey="Oxlade, Norman L" sort="Oxlade, Norman L" uniqKey="Oxlade N" first="Norman L." last="Oxlade">Norman L. Oxlade</name>
</author>
<author><name sortKey="Price, Ashley B" sort="Price, Ashley B" uniqKey="Price A" first="Ashley B." last="Price">Ashley B. Price</name>
</author>
<author><name sortKey="Sanderson, Jeremy D" sort="Sanderson, Jeremy D" uniqKey="Sanderson J" first="Jeremy D." last="Sanderson">Jeremy D. Sanderson</name>
</author>
<author><name sortKey="Sudhanva, Malur" sort="Sudhanva, Malur" uniqKey="Sudhanva M" first="Malur" last="Sudhanva">Malur Sudhanva</name>
</author>
<author><name sortKey="Williams, John" sort="Williams, John" uniqKey="Williams J" first="John" last="Williams">John Williams</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:10F818C8BD5A032AC8DC172BBB282F700BF32882</idno>
<date when="2008" year="2008">2008</date>
<idno type="doi">10.1111/j.1523-5378.2008.00622.x</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-847X1VG5-8/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001A74</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001A74</idno>
<idno type="wicri:Area/Istex/Curation">001A74</idno>
<idno type="wicri:Area/Istex/Checkpoint">001044</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001044</idno>
<idno type="wicri:doubleKey">1083-4389:2008:Dobbs R:helicobacter:hypothesis:for</idno>
<idno type="wicri:Area/Main/Merge">003472</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Helicobacter Hypothesis for Idiopathic Parkinsonism: Before and Beyond</title>
<author><name sortKey="Dobbs, R John" sort="Dobbs, R John" uniqKey="Dobbs R" first="R. John" last="Dobbs">R. John Dobbs</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation></affiliation>
</author>
<author><name sortKey="Dobbs, Sylvia M" sort="Dobbs, Sylvia M" uniqKey="Dobbs S" first="Sylvia M." last="Dobbs">Sylvia M. Dobbs</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation></affiliation>
</author>
<author><name sortKey="Weller, Clive" sort="Weller, Clive" uniqKey="Weller C" first="Clive" last="Weller">Clive Weller</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Charlett, Andre" sort="Charlett, Andre" uniqKey="Charlett A" first="André" last="Charlett">André Charlett</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation></affiliation>
</author>
<author><name sortKey="Bjarnason, Ingvar T" sort="Bjarnason, Ingvar T" uniqKey="Bjarnason I" first="Ingvar T." last="Bjarnason">Ingvar T. Bjarnason</name>
<affiliation><wicri:noCountry code="no comma">Departments of Gastroenterology and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Curry, Alan" sort="Curry, Alan" uniqKey="Curry A" first="Alan" last="Curry">Alan Curry</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Electronmicroscopy, Health Protection Agency North‐West, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ellis, David S" sort="Ellis, David S" uniqKey="Ellis D" first="David S." last="Ellis">David S. Ellis</name>
<affiliation><wicri:noCountry code="no comma">Electronmicroscopy and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ibrahim, Mohammad A A" sort="Ibrahim, Mohammad A A" uniqKey="Ibrahim M" first="Mohammad A. A." last="Ibrahim">Mohammad A. A. Ibrahim</name>
<affiliation><wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mccrossan, Maria V" sort="Mccrossan, Maria V" uniqKey="Mccrossan M" first="Maria V." last="Mccrossan">Maria V. Mccrossan</name>
<affiliation><wicri:noCountry code="no comma">Electronmicroscopy and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="O Donohue, John" sort="O Donohue, John" uniqKey="O Donohue J" first="John" last="O'Donohue">John O'Donohue</name>
<affiliation><wicri:noCountry code="no comma">Departments of Gastroenterology and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Owen, Robert J" sort="Owen, Robert J" uniqKey="Owen R" first="Robert J." last="Owen">Robert J. Owen</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Helicobacter Reference Unit, Health Protection Agency, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oxlade, Norman L" sort="Oxlade, Norman L" uniqKey="Oxlade N" first="Norman L." last="Oxlade">Norman L. Oxlade</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Section of Clinical Neuropharmacology, Institute of Psychiatry, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Price, Ashley B" sort="Price, Ashley B" uniqKey="Price A" first="Ashley B." last="Price">Ashley B. Price</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Department of Histopathology, Northwick Park and St. Mark's Hospitals, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sanderson, Jeremy D" sort="Sanderson, Jeremy D" uniqKey="Sanderson J" first="Jeremy D." last="Sanderson">Jeremy D. Sanderson</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Gastroenterology, Guy's and St Thomas's Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sudhanva, Malur" sort="Sudhanva, Malur" uniqKey="Sudhanva M" first="Malur" last="Sudhanva">Malur Sudhanva</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>South London Specialist Virology Centre, Health Protection Agency Regional Laboratory, Kings College Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Williams, John" sort="Williams, John" uniqKey="Williams J" first="John" last="Williams">John Williams</name>
<affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country>
<wicri:regionArea>Diagnostic Parasitology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Helicobacter</title>
<title level="j" type="alt">HELICOBACTER</title>
<idno type="ISSN">1083-4389</idno>
<idno type="eISSN">1523-5378</idno>
<imprint><biblScope unit="vol">13</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="309">309</biblScope>
<biblScope unit="page" to="322">322</biblScope>
<biblScope unit="page-count">14</biblScope>
<publisher>Blackwell Publishing Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="2008-10">2008-10</date>
</imprint>
<idno type="ISSN">1083-4389</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1083-4389</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We challenge the concept of idiopathic parkinsonism (IP) as inevitably progressive neurodegeneration, proposing a natural history of sequential microbial insults with predisposing host response. Proof‐of‐principle that infection can contribute to IP was provided by case studies and a placebo‐controlled efficacy study of Helicobacter eradication. “Malignant” IP appears converted to “benign”, but marked deterioration accompanies failure. Similar benefit on brady/hypokinesia from eradicating “low‐density” infection favors autoimmunity. Although a minority of UK probands are urea breath test positive for Helicobacter, the predicted probability of having the parkinsonian label depends on the serum H. pylori antibody profile, with clinically relevant gradients between this “discriminant index” and disease burden and progression. In IP, H. pylori antibodies discriminate for persistently abnormal bowel function, and specific abnormal duodenal enterocyte mitochondrial morphology is described in relation to H. pylori infection. Slow intestinal transit manifests as constipation from the prodrome. Diarrhea may flag secondary small‐intestinal bacterial overgrowth. This, coupled with genetically determined intense inflammatory response, might explain evolution from brady/hypokinetic to rigidity‐predominant parkinsonism.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003472 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 003472 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:10F818C8BD5A032AC8DC172BBB282F700BF32882 |texte= Helicobacter Hypothesis for Idiopathic Parkinsonism: Before and Beyond }}
This area was generated with Dilib version V0.6.33. |