Unraveling the complexities of the interferon response during SARS-CoV infection
Identifieur interne : 002A21 ( Main/Merge ); précédent : 002A20; suivant : 002A22Unraveling the complexities of the interferon response during SARS-CoV infection
Auteurs : Anna De Lang ; Tracey Baas ; Saskia L. Smits ; Michael G. Katze ; Albert Dme Osterhaus ; Bart L. HaagmansSource :
- Future virology [ 1746-0794 ] ; 2009.
Abstract
Viruses employ different strategies to circumvent the antiviral actions of the innate immune response. SARS coronavirus (SARS-CoV), a virus that causes severe lung damage, encodes an array of proteins able to inhibit induction and signaling of type-I interferons. However, recent studies have demonstrated that interferons are produced during SARS-CoV infection in humans and macaques. Furthermore, nuclear translocation of activated STAT1 and a range of interferon-stimulated genes could be demonstrated in the lungs of SARS-CoV-infected macaques. In line with these observations, plasmacytoid dendritic cells have been shown to produce interferons upon SARS-CoV infection
Url:
DOI: 10.2217/17460794.4.1.71
PubMed: 19885368
PubMed Central: 2680287
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<front><div type="abstract" xml:lang="en"><p id="P1">Viruses employ different strategies to circumvent the antiviral actions of the innate immune response. SARS coronavirus (SARS-CoV), a virus that causes severe lung damage, encodes an array of proteins able to inhibit induction and signaling of type-I interferons. However, recent studies have demonstrated that interferons are produced during SARS-CoV infection in humans and macaques. Furthermore, nuclear translocation of activated STAT1 and a range of interferon-stimulated genes could be demonstrated in the lungs of SARS-CoV-infected macaques. In line with these observations, plasmacytoid dendritic cells have been shown to produce interferons upon SARS-CoV infection <italic>in vitro</italic>
. Given the pivotal role of interferons during viral infections, (differential) induction of interferons may affect the outcome of the infection. Therefore, the functional implication of interferon production during SARS-CoV infection remains to be re-investigated.</p>
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