SrasV1, Main, Merge, bibRecord, 001290

MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels.

Identifieur interne : 001290 ( Main/Merge ); précédent : 001289; suivant : 001291

MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels.

Auteurs : Wahyu Surya [Singapour] ; Yan Li [Singapour] ; Carmina Verdià-Bàguena [Espagne] ; Vicente M. Aguilella [Espagne] ; Jaume Torres [Singapour]

Source :

Virus research [ 1872-7492 ] ; 2015.

RBID : pubmed:25733052

Descripteurs français

English descriptors

KwdEn :
- Humans, Ion Channels (chemistry), Ion Channels (metabolism), Middle East Respiratory Syndrome Coronavirus (chemistry), Middle East Respiratory Syndrome Coronavirus (physiology), Protein Conformation, Protein Multimerization, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (metabolism).
MESH :
- chemical , chemistry : Ion Channels, Viral Envelope Proteins.
- chemical , metabolism : Ion Channels, Viral Envelope Proteins.
- chemistry : Middle East Respiratory Syndrome Coronavirus.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- Humans, Protein Conformation, Protein Multimerization.

Abstract

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified pathogen able of human transmission that causes a mortality of almost 40%. As in the case of SARS-CoV, MERS virus lacking E protein represents a potential vaccine. In both cases, abolishment of channel activity may be a contributor to the attenuation observed in E-deleted viruses. Herein, we report that purified MERS-CoV E protein, like SARS-CoV E protein, is almost fully α-helical, has a single α-helical transmembrane domain, and forms pentameric ion channels in lipid bilayers. Based on these similarities, and the proposed involvement of channel activity as virulence factor in SARS-CoV E protein, MERS-CoV E protein may constitute a potential drug target.

DOI: 10.1016/j.virusres.2015.02.023
PubMed: 25733052

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000E51
to stream PubMed, to step Curation: 000E51
to stream PubMed, to step Checkpoint: 000D96
to stream Ncbi, to step Merge: 002A40
to stream Ncbi, to step Curation: 002A40
to stream Ncbi, to step Checkpoint: 002A40

Links to Exploration step

pubmed:25733052

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels.</title>
<author><name sortKey="Surya, Wahyu" sort="Surya, Wahyu" uniqKey="Surya W" first="Wahyu" last="Surya">Wahyu Surya</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>School of Biological Sciences, Nanyang Technological University</wicri:regionArea>
<wicri:noRegion>Nanyang Technological University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>School of Biological Sciences, Nanyang Technological University</wicri:regionArea>
<wicri:noRegion>Nanyang Technological University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verdia Baguena, Carmina" sort="Verdia Baguena, Carmina" uniqKey="Verdia Baguena C" first="Carmina" last="Verdià-Bàguena">Carmina Verdià-Bàguena</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Physics, Laboratory of Molecular Biophysics, Universitat Jaume I, 12071 Castellón, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Physics, Laboratory of Molecular Biophysics, Universitat Jaume I, 12071 Castellón</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté valencienne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aguilella, Vicente M" sort="Aguilella, Vicente M" uniqKey="Aguilella V" first="Vicente M" last="Aguilella">Vicente M. Aguilella</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Physics, Laboratory of Molecular Biophysics, Universitat Jaume I, 12071 Castellón, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Physics, Laboratory of Molecular Biophysics, Universitat Jaume I, 12071 Castellón</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté valencienne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torres, Jaume" sort="Torres, Jaume" uniqKey="Torres J" first="Jaume" last="Torres">Jaume Torres</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, Singapore. Electronic address: jtorres@ntu.edu.sg.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>School of Biological Sciences, Nanyang Technological University</wicri:regionArea>
<wicri:noRegion>Nanyang Technological University</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:25733052</idno>
<idno type="pmid">25733052</idno>
<idno type="doi">10.1016/j.virusres.2015.02.023</idno>
<idno type="wicri:Area/PubMed/Corpus">000E51</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E51</idno>
<idno type="wicri:Area/PubMed/Curation">000E51</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E51</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000D96</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D96</idno>
<idno type="wicri:Area/Ncbi/Merge">002A40</idno>
<idno type="wicri:Area/Ncbi/Curation">002A40</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002A40</idno>
<idno type="wicri:Area/Main/Merge">001290</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels.</title>
<author><name sortKey="Surya, Wahyu" sort="Surya, Wahyu" uniqKey="Surya W" first="Wahyu" last="Surya">Wahyu Surya</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>School of Biological Sciences, Nanyang Technological University</wicri:regionArea>
<wicri:noRegion>Nanyang Technological University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Yan" sort="Li, Yan" uniqKey="Li Y" first="Yan" last="Li">Yan Li</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>School of Biological Sciences, Nanyang Technological University</wicri:regionArea>
<wicri:noRegion>Nanyang Technological University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verdia Baguena, Carmina" sort="Verdia Baguena, Carmina" uniqKey="Verdia Baguena C" first="Carmina" last="Verdià-Bàguena">Carmina Verdià-Bàguena</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Physics, Laboratory of Molecular Biophysics, Universitat Jaume I, 12071 Castellón, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Physics, Laboratory of Molecular Biophysics, Universitat Jaume I, 12071 Castellón</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté valencienne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aguilella, Vicente M" sort="Aguilella, Vicente M" uniqKey="Aguilella V" first="Vicente M" last="Aguilella">Vicente M. Aguilella</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Physics, Laboratory of Molecular Biophysics, Universitat Jaume I, 12071 Castellón, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Physics, Laboratory of Molecular Biophysics, Universitat Jaume I, 12071 Castellón</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Communauté valencienne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torres, Jaume" sort="Torres, Jaume" uniqKey="Torres J" first="Jaume" last="Torres">Jaume Torres</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Biological Sciences, Nanyang Technological University, Singapore. Electronic address: jtorres@ntu.edu.sg.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>School of Biological Sciences, Nanyang Technological University</wicri:regionArea>
<wicri:noRegion>Nanyang Technological University</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Virus research</title>
<idno type="eISSN">1872-7492</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term>
<term>Ion Channels (chemistry)</term>
<term>Ion Channels (metabolism)</term>
<term>Middle East Respiratory Syndrome Coronavirus (chemistry)</term>
<term>Middle East Respiratory Syndrome Coronavirus (physiology)</term>
<term>Protein Conformation</term>
<term>Protein Multimerization</term>
<term>Viral Envelope Proteins (chemistry)</term>
<term>Viral Envelope Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Canaux ioniques ()</term>
<term>Canaux ioniques (métabolisme)</term>
<term>Conformation des protéines</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term>
<term>Humains</term>
<term>Multimérisation de protéines</term>
<term>Protéines de l'enveloppe virale ()</term>
<term>Protéines de l'enveloppe virale (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Ion Channels</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Ion Channels</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Canaux ioniques</term>
<term>Protéines de l'enveloppe virale</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Protein Conformation</term>
<term>Protein Multimerization</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Canaux ioniques</term>
<term>Conformation des protéines</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Humains</term>
<term>Multimérisation de protéines</term>
<term>Protéines de l'enveloppe virale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified pathogen able of human transmission that causes a mortality of almost 40%. As in the case of SARS-CoV, MERS virus lacking E protein represents a potential vaccine. In both cases, abolishment of channel activity may be a contributor to the attenuation observed in E-deleted viruses. Herein, we report that purified MERS-CoV E protein, like SARS-CoV E protein, is almost fully α-helical, has a single α-helical transmembrane domain, and forms pentameric ion channels in lipid bilayers. Based on these similarities, and the proposed involvement of channel activity as virulence factor in SARS-CoV E protein, MERS-CoV E protein may constitute a potential drug target. </div>
</front>
</TEI>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001290 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001290 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:25733052
   |texte=   MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i   -Sk "pubmed:25733052" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels.

MERS coronavirus envelope protein has a single transmembrane domain that forms pentameric ion channels.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki