Structural Insight Into the Viral 3C-Like Protease Inhibitors: Comparative SAR/QSAR Approaches
Identifieur interne : 000D70 ( Main/Merge ); précédent : 000D69; suivant : 000D71Structural Insight Into the Viral 3C-Like Protease Inhibitors: Comparative SAR/QSAR Approaches
Auteurs : Nilanjan Adhikari [Inde] ; Sandip K. Baidya [Inde] ; Achintya Saha [Inde] ; Tarun Jha [Inde]Source :
- Viral Proteases and Their Inhibitors ; 2017.
Abstract
Severe acute respiratory syndrome (SARS), caused by SARS-coronavirus (SARS-CoV), is a dreadful infection worldwide having economic and medical importance and a global threat for health. It was turned into an epidemic in South China followed by a chain of infections across three generations. A number of pathogeneses in human may occur due to the virus. This infection has not been taken into account before the SARS outbreak, and still it is a neglected one. Therefore, there is an urgent need to develop small molecule antivirals to combat the SARS-CoV. No vaccines are available till date though a number of SARS-CoV 3C-like and 3C protease inhibitors were reported. In this chapter, quantitative structure–activity relationship technique is used for development of anti-SARS and anti-HRV drugs and outcome discussed in details. This approach may be a useful strategy to design novel and potential anti-SARS drugs to combat these dreadful viral diseases.
Url:
DOI: 10.1016/B978-0-12-809712-0.00011-3
PubMed: NONE
PubMed Central: 7150231
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000985
- to stream Pmc, to step Curation: 000985
- to stream Pmc, to step Checkpoint: 000584
- to stream Ncbi, to step Merge: 004060
- to stream Ncbi, to step Curation: 004060
- to stream Ncbi, to step Checkpoint: 004060
Links to Exploration step
PMC:7150231Le document en format XML
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Baidya</name><affiliation wicri:level="1"><nlm:aff id="aff1">Jadavpur University, Kolkata, West Bengal, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Jadavpur University, Kolkata, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Saha, Achintya" sort="Saha, Achintya" uniqKey="Saha A" first="Achintya" last="Saha">Achintya Saha</name><affiliation wicri:level="1"><nlm:aff id="aff2">University of Calcutta, Kolkata, West Bengal, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>University of Calcutta, Kolkata, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author><author><name sortKey="Jha, Tarun" sort="Jha, Tarun" uniqKey="Jha T" first="Tarun" last="Jha">Tarun Jha</name><affiliation wicri:level="1"><nlm:aff id="aff1">Jadavpur University, Kolkata, West Bengal, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Jadavpur University, Kolkata, West Bengal</wicri:regionArea><wicri:noRegion>West Bengal</wicri:noRegion></affiliation></author></analytic><series><title level="j">Viral Proteases and Their Inhibitors</title><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Severe acute respiratory syndrome (SARS), caused by SARS-coronavirus (SARS-CoV), is a dreadful infection worldwide having economic and medical importance and a global threat for health. 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