Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease.
Identifieur interne : 000077 ( Main/Merge ); précédent : 000076; suivant : 000078Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease.
Auteurs : Mahmoud Kandeel [Égypte] ; Mohammed Al-Nazawi [Arabie saoudite]Source :
- Life sciences [ 1879-0631 ] ; 2020.
Abstract
In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual screening study by of FDA approved drugs dataset. In addition, a knowledge gap in relations of COVID-19 with the previously known fatal Coronaviruses (CoVs) epidemics, SARS and MERS CoVs, was covered by investigation of sequence statistics and phylogenetics.
DOI: 10.1016/j.lfs.2020.117627
PubMed: 32251634
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<front><div type="abstract" xml:lang="en">In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual screening study by of FDA approved drugs dataset. In addition, a knowledge gap in relations of COVID-19 with the previously known fatal Coronaviruses (CoVs) epidemics, SARS and MERS CoVs, was covered by investigation of sequence statistics and phylogenetics.</div>
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