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Kexia Yan [République populaire de Chine] ; Wenjie Tan ; Huijuan Wang ; Yue Wang ; Xiangmin Zhang ; Yan Li ; Li Ruan | SARS-CoV spike proteins expressed by the vaccinia virus Tiantan strain: secreted sq protein induces robust neutralization antibody in mice. |
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Benoît Callendret [France] ; Valérie Lorin [France] ; Pierre Charneau [France] ; Philippe Marianneau [France] ; Hugues Contamin [France] ; Jean-Michel Betton [France] ; Sylvie Van Der Werf [France] ; Nicolas Escriou [France] | Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS |
| 003988 (2007) |
Lei Ba [États-Unis] ; Christopher E. Yi [États-Unis] ; Linqi Zhang [États-Unis] ; David D. Ho [États-Unis] ; Zhiwei Chen [États-Unis] | Heterologous MVA-S prime Ad5-S boost regimen induces high and persistent levels of neutralizing antibody response against SARS coronavirus |
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Yuxian He [États-Unis] ; Jingjing Li ; Wenhui Li ; Sara Lustigman ; Michael Farzan ; Shibo Jiang | Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein. |
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Shuetsu Fukushi [Japon] ; Tetsuya Mizutani [Japon] ; Masayuki Saijo [Japon] ; Ichiro Kurane [Japon] ; Fumihiro Taguchi [Japon] ; Masato Tashiro [Japon] ; Shigeru Morikawa [Japon] | Evaluation of a novel vesicular stomatitis virus pseudotype‐based assay for detection of neutralizing antibody responses to SARS‐CoV |
| 004684 (2005) |
Yuxian He [États-Unis] ; Hong Lu ; Pamela Siddiqui ; Yusen Zhou ; Shibo Jiang | Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies. |
| 004939 (2005) |
Ran-Yi Liu [République populaire de Chine] ; Li-Zhi Wu ; Bi-Jun Huang ; Jia-Ling Huang ; Yan-Ling Zhang ; Miao-La Ke ; Jun-Mei Wang ; Wei-Ping Tan ; Ru-Hua Zhang ; Han-Kui Chen ; Yi-Xin Zeng ; Wenlin Huang | Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats. |
| 004F28 (2004) |
Yun Zhang [République populaire de Chine] ; Fan Yang ; Yan-Han Li ; Wen-Hui Li ; Xin-Ming Tu ; Qiang Wei ; Hua Zhu ; Li Liu ; Heng Wang ; Chuan Qin ; Guo-Yong Yuan ; Wei He ; Shu-Hui Wang | [Potent neutralization antibody elicited in mice by SARS-associated coronavirus spike protein S1 domain]. |
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Heike Hofmann [Allemagne] ; Kim Hattermann [Allemagne] ; Andrea Marzi [Allemagne] ; Thomas Gramberg [Allemagne] ; Martina Geier [Allemagne] ; Mandy Krumbiegel [Allemagne] ; Seraphin Kuate [Allemagne] ; Klaus Überla [Allemagne] ; Matthias Niedrig [Allemagne] ; Stefan Pöhlmann [Allemagne] | S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients |
| 005A75 (2004) |
Tsanan Giroglou [Allemagne] ; Jindrich Jr Cinatl [Allemagne] ; Holger Rabenau [Allemagne] ; Christian Drosten [Allemagne] ; Harald Schwalbe [Allemagne] ; Hans Wilhelm Doerr [Allemagne] ; Dorothee Von Laer [Allemagne] | Retroviral vectors pseudotyped with severe acute respiratory syndrome coronavirus S protein |
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Fumihiro Taguchi ; Yohko K. Shimazaki | Functional analysis of an epitope in the S2 subunit of the murine coronavirus spike protein: involvement in fusion activity. |
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Kuan-Hsun Lin [Taïwan] ; Chuen-Fu Lin ; Shyan-Song Chiou ; Ai-Ping Hsu ; Min-Shiuh Lee ; Chao-Chin Chang ; Tien-Jye Chang ; Jui-Hung Shien ; Wei-Li Hsu | Application of purified recombinant antigenic spike fragments to the diagnosis of avian infectious bronchitis virus infection. |
| 002385 (2011) |
Ye V. Liu [États-Unis] ; Michael J. Massare [États-Unis] ; Dale L. Barnard [États-Unis] ; Thomas Kort [États-Unis] ; Margret Nathan [États-Unis] ; LEI WANG [États-Unis] ; Gale Smith [États-Unis] | Chimeric severe acute respiratory syndrome coronavirus (SARS-CoV) S glycoprotein and influenza matrix 1 efficiently form virus-like particles (VLPs) that protect mice against challenge with SARS-CoV |
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Yanbo Lv ; Zhihua Ruan ; Li Wang ; Bing Ni ; Yuzhang Wu | Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV |
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Che-Man Chan [Hong Kong] ; Patrick C Y. Woo ; Susanna K P. Lau ; Herman Tse ; Hong-Lin Chen ; Feng Li ; Bo-Jian Zheng ; Ling Chen ; Jian-Dong Huang ; Kwok-Yung Yuen | Spike protein, S, of human coronavirus HKU1: role in viral life cycle and application in antibody detection. |
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Wei Wang ; Linbai Ye ; Li Ye ; Baozong Li ; Bo Gao ; Yingchun Zeng ; Lingbao Kong ; Xiaonan Fang ; Hong Zheng ; Zhenghui Wu ; Yinglong She | Up-regulation of IL-6 and TNF-α induced by SARS-coronavirus spike protein in murine macrophages via NF-κB pathway |
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Yuxian He ; Jingjing Li ; Shibo Jiang | A single amino acid substitution (R441A) in the receptor-binding domain of SARS coronavirus spike protein disrupts the antigenic structure and binding activity |
| 004612 (2005) |
Fang Li [États-Unis] ; Wenhui Li ; Michael Farzan ; Stephen C. Harrison | Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. |
| 004739 (2005) |
Qigai He ; Ivanus Manopo ; Liqun Lu ; Bernard P. Leung ; Hiok Hee Chng ; Ai Ee Ling ; Li Lian Chee ; Shzu-Wei Chan ; Eng Eong Ooi ; Yeo Lee Sin ; Brenda Ang ; Jimmy Kwang | Novel Immunofluorescence Assay Using Recombinant Nucleocapsid-Spike Fusion Protein as Antigen To Detect Antibodies against Severe Acute Respiratory Syndrome Coronavirus |
| 005007 (2004) |
Xiao Dong Wu [République populaire de Chine] ; Bo Shang ; Rui Fu Yang ; Hao Yu ; Zhi Hai Ma ; Xu Shen ; Yong Yong Ji ; Ying Lin ; Ya Di Wu ; Guo Mei Lin ; Lin Tian ; Xiao Qing Gan ; Sheng Yang ; Wei Hong Jiang ; Er Hei Dai ; Xiao Yi Wang ; Hua Liang Jiang ; You Hua Xie ; Xue Liang Zhu ; Gang Pei ; Lin Li ; Jia Rui Wu ; Bing Sun | The spike protein of severe acute respiratory syndrome (SARS) is cleaved in virus infected Vero-E6 cells. |
| 005041 (2004) |
Hyun Chul Song ; Mi-Young Seo ; Konrad Stadler ; Byoung J. Yoo ; Qui-Lim Choo ; Stephen R. Coates ; Yasushi Uematsu ; Takashi Harada ; Catherine E. Greer ; John M. Polo ; Piero Pileri ; Markus Eickmann ; Rino Rappuoli ; Sergio Abrignani ; Michael Houghton ; Jang H. Han | Synthesis and Characterization of a Native, Oligomeric Form of Recombinant Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein |
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Tin-Yun Ho [Taïwan] ; Shih-Lu Wu ; Shin-Ei Cheng ; Yen-Chiao Wei ; Shan-Ping Huang ; Chien-Yun Hsiang | Antigenicity and receptor-binding ability of recombinant SARS coronavirus spike protein. |
| 005586 (2004) |
Yong Xiu Yao [Royaume-Uni] ; Junyuan Ren [Royaume-Uni] ; Paul Heinen [Royaume-Uni] ; Maria Zambon [Royaume-Uni] ; Ian M. Jones [Royaume-Uni] | Cleavage and Serum Reactivity of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein |
| 006107 (2003) |
Yan Ren ; Zhengfeng Zhou ; Jinxiu Liu ; Liang Lin ; Shuting Li ; Hao Wang ; Ji Xia ; Zhe Zhao ; Jie Wen ; Cuiqi Zhou ; Jingqiang Wang ; Jianning Yin ; Ningzhi Xu ; Siqi Liu | A Strategy for Searching Antigenic Regions in the SARS-CoV Spike Protein |
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| 001918 (2013) |
Jie Li [États-Unis] ; Laura Ulitzky ; Erica Silberstein ; Deborah R. Taylor ; Raphael Viscidi | Immunogenicity and protection efficacy of monomeric and trimeric recombinant SARS coronavirus spike protein subunit vaccine candidates. |
| 001D12 (2012) |
Hatem A. Elshabrawy [États-Unis] ; Melissa M. Coughlin ; Susan C. Baker ; Bellur S. Prabhakar | Human monoclonal antibodies against highly conserved HR1 and HR2 domains of the SARS-CoV spike protein are more broadly neutralizing. |
| 001D33 (2012) |
Kazuya Shirato ; Miyuki Kawase ; Oshi Watanabe [Japon] ; Chika Hirokawa [Japon] ; Shutoku Matsuyama ; Hidekazu Nishimura [Japon] ; Fumihiro Taguchi [Japon] | Differences in neutralizing antigenicity between laboratory and clinical isolates of HCoV-229E isolated in Japan in 2004-2008 depend on the S1 region sequence of the spike protein. |
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Liu Di-Qiu ; Qiao Xin-Yuan ; Ge Jun-Wei ; Tang Li-Jie ; Jiang Yan-Ping ; Li Yi-Jing | Construction and characterization of Lactobacillus pentosus expressing the D antigenic site of the spike protein of Transmissible gastroenteritis virus. |
| 002522 (2010) |
Yu-Xuan Hou [République populaire de Chine] ; Cheng Peng ; Zheng-Gang Han ; Peng Zhou ; Ji-Guo Chen ; Zheng-Li Shi | Immunogenicity of the spike glycoprotein of bat SARS-like coronavirus. |
| 002653 (2010) |
Barry Rockx [États-Unis] ; Eric Donaldson ; Matthew Frieman ; Timothy Sheahan ; Davide Corti [Suisse] ; Antonio Lanzavecchia [Suisse] ; Ralph S. Baric | Escape from Human Monoclonal Antibody Neutralization Affects In Vitro and In Vivo Fitness of Severe Acute Respiratory Syndrome Coronavirus |
| 002A40 (2009) |
Lanying Du [États-Unis] ; Guangyu Zhao [République populaire de Chine] ; Chris C. S. Chan [République populaire de Chine] ; Shihui Sun [République populaire de Chine] ; Min Chen [République populaire de Chine] ; Zhonghua Liu [États-Unis] ; Hongxiang Guo [États-Unis] ; Yuxian He [États-Unis] ; Yusen Zhou [République populaire de Chine] ; Bo-Jian Zheng [République populaire de Chine] ; Shibo Jiang [États-Unis] | Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity |
| 002A62 (2009) |
Lijie Tang [République populaire de Chine] ; Yijing Li | Oral immunization of mice with recombinant Lactococcus lactis expressing porcine transmissible gastroenteritis virus spike glycoprotein. |
| 003034 (2008) |
Sagar U. Kapadia [États-Unis] ; Ian D. Simon ; John K. Rose | SARS vaccine based on a replication-defective recombinant vesicular stomatitis virus is more potent than one based on a replication-competent vector. |
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Kumari G. Lokugamage [États-Unis] ; Naoko Yoshikawa-Iwata ; Naoto Ito ; Douglas M. Watts ; Philip R. Wyde ; Nan Wang ; Patrick Newman ; Chien-Te Kent Tseng ; C J Peters ; Shinji Makino | Chimeric coronavirus-like particles carrying severe acute respiratory syndrome coronavirus (SCoV) S protein protect mice against challenge with SCoV. |
| 003484 (2008) |
Timothy Sheahan [États-Unis] ; Barry Rockx [États-Unis] ; Eric Donaldson [États-Unis] ; Davide Corti [Suisse] ; Ralph Baric [États-Unis] | Pathways of Cross-Species Transmission of Synthetically Reconstructed Zoonotic Severe Acute Respiratory Syndrome Coronavirus |
| 003519 (2008) |
Yu-Ya Mitsuki [Japon] ; Kazuo Ohnishi [Japon] ; Hirotaka Takagi [Japon] ; Masamichi Oshima [Japon] ; Takuya Yamamoto [Japon] ; Fuminori Mizukoshi [Japon] ; Kazutaka Terahara [Japon] ; Kazuo Kobayashi [Japon] ; Naoki Yamamoto [Japon] ; Shoji Yamaoka [Japon] ; Yasuko Tsunetsugu-Yokota [Japon] | A single amino acid substitution in the Sl and S2 Spike protein domains determines the neutralization escape phenotype of SARS-CoV |
| 003523 (2008) |
Julie E. Martin [États-Unis] ; Mark K. Louder [États-Unis] ; Lasonji A. Holman [États-Unis] ; Ingelise J. Gordon [États-Unis] ; Mary E. Enama [États-Unis] ; Brenda D. Larkin [États-Unis] ; Charla A. Andrews [États-Unis] ; Leatrice Vogel [États-Unis] ; Richard A. Koup [États-Unis] ; Mario Roederer [États-Unis] ; Robert T. Bailer [États-Unis] ; Phillip L. Gomez [États-Unis] ; Martha Nason [États-Unis] ; John R. Mascola [États-Unis] ; Gary J. Nabel [États-Unis] ; Barney S. Graham [États-Unis] | A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial |
| 003589 (2007) |
D B Sun [République populaire de Chine] ; L. Feng ; H Y Shi ; J F Chen ; S W Liu ; H Y Chen ; Y F Wang | Spike protein region (aa 636789) of porcine epidemic diarrhea virus is essential for induction of neutralizing antibodies. |
| 003654 (2007) |
Li Liu ; Qing Fang ; Fei Deng ; Hanzhong Wang ; Christopher E. Yi ; Lei Ba ; Wenjie Yu ; Richard D. Lin ; Taisheng Li ; Zhihong Hu ; David D. Ho ; Linqi Zhang ; Zhiwei Chen | Natural Mutations in the Receptor Binding Domain of Spike Glycoprotein Determine the Reactivity of Cross-Neutralization between Palm Civet Coronavirus and Severe Acute Respiratory Syndrome Coronavirus▿ |
| 003708 (2007) |
Seraphin Kuate [Allemagne] ; Jindrich Cinatl [Allemagne] ; Hans Wilhelm Doerr [Allemagne] ; Klaus Überla [Allemagne] | Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies |
| 003746 (2007) |
Yuan Zhang [République populaire de Chine] ; Nan Zheng ; Yang Zhong | Computational characterization and design of SARS coronavirus receptor recognition and antibody neutralization. |
| 003C76 (2006) |
Brian Tripet [États-Unis] ; Daniel J. Kao ; Scott A. Jeffers ; Kathryn V. Holmes ; Robert S. Hodges | Template-based coiled-coil antigens elicit neutralizing antibodies to the SARS-coronavirus. |
| 003C93 (2006) |
William C. Hwang [États-Unis] ; Yaqiong Lin ; Eugenio Santelli ; Jianhua Sui ; Lukasz Jaroszewski ; Boguslaw Stec ; Michael Farzan ; Wayne A. Marasco ; Robert C. Liddington | Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R. |
| 003D26 (2006) |
Masahiro Kitabatake [Japon] ; Shingo Inoue [Japon] ; Fumihiko Yasui [Japon] ; Shoji Yokochi [Japon] ; Masaaki Arai [Japon] ; Kouichi Morita [Japon] ; Hisatoshi Shida [Japon] ; Minoru Kidokoro [Japon] ; Fukashi Murai [Japon] ; Mai Quynh Le [Viêt Nam] ; Kyosuke Mizuno [Japon] ; Kouji Matsushima [Japon] ; Michinori Kohara [Japon] | SARS-CoV spike protein-expressing recombinant vaccinia virus efficiently induces neutralizing antibodies in rabbits pre-immunized with vaccinia virus |
| 003E15 (2006) |
Kuo-Ming Lip ; Shuo Shen ; Xiaoming Yang ; Choong-Tat Keng ; Aihua Zhang ; Hsueh-Ling Janice Oh ; Zhi-Hong Li ; Le-Ann Hwang ; Chih-Fong Chou ; Burtram C. Fielding ; Timothy H P. Tan ; Josef Mayrhofer ; Falko G. Falkner ; Jianlin Fu ; Seng Gee Lim ; Wanjin Hong ; Yee-Joo Tan | Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus. |
| 003E24 (2006) |
Natalia Tarnovitski [Israël] ; Leslie J. Matthews ; Jianhua Sui ; Jonathan M. Gershoni ; Wayne A. Marasco | Mapping a neutralizing epitope on the SARS coronavirus spike protein: computational prediction based on affinity-selected peptides. |
| 003E74 (2006) |
Jan Ter Meulen ; Edward N. Van Den Brink ; Leo L. M. Poon ; Wilfred E. Marissen ; Cynthia S. W. Leung ; Freek Cox ; Chung Y. Cheung ; Arjen Q. Bakker ; Johannes A. Bogaards ; Els Van Deventer ; Wolfgang Preiser ; Hans Wilhelm Doerr ; Vincent T. Chow ; John De Kruif ; Joseph S. M. Peiris ; Jaap Goudsmit | Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants |
| 004364 (2006) |
Mo Liu [République populaire de Chine] ; Chunfang Gu [République populaire de Chine] ; Jianguo Wu [République populaire de Chine] ; Ying Zhu [République populaire de Chine] | Amino acids 1 to 422 of the spike protein of SARS associated coronavirus are required for induction of cyclooxygenase-2 |
| 004442 (2006) |
Yi-Ping Shih [Taïwan] ; Chia-Yen Chen [Taïwan] ; Shih-Jen Liu [Taïwan] ; Kuan-Hsuan Chen [Taïwan] ; Yuan-Ming Lee [Taïwan] ; Yu-Chan Chao [Taïwan] ; Yi-Ming Arthur Chen [Taïwan] | Identifying epitopes responsible for neutralizing antibody and DC-SIGN binding on the spike glycoprotein of the severe acute respiratory syndrome coronavirus |
| 004469 (2006) |
Raymond H. See [Canada] ; Alexander N. Zakhartchouk [Canada] ; Martin Petric [Canada] ; David J. Lawrence [Canada] ; Catherine P. Y. Mok [Canada] ; Robert J. Hogan [États-Unis] ; Thomas Rowe [États-Unis] ; Lois A. Zitzow [États-Unis] ; Karuna P. Karunakaran [Canada] ; Mary M. Hilt [Canada] ; Frank L. Graham [Canada] ; Ludvik Prevec [Canada] ; James B. Mahony [Canada] ; Chetna Sharon [Canada] ; Thierry C. Auperin [Canada] ; James M. Rini [Canada] ; Aubrey J. Tingle [Canada] ; David W. Scheifele [Canada] ; Danuta M. Skowronski [Canada] ; David M. Patrick [Canada] ; Thomas G. Voss [États-Unis] ; Lorne A. Babiuk [Canada] ; Jack Gauldie [Canada] ; Rachel L. Roper [États-Unis] ; Robert C. Brunham [Canada] ; B. Brett Finlay [Canada] | Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus |
| 004682 (2005) |
Zhiwei Chen ; Linqi Zhang ; Chuan Qin ; Lei Ba ; Christopher E. Yi ; Fengwen Zhang ; Qiang Wei ; Tian He ; Wenjie Yu ; Jian Yu ; Hong Gao ; Xinming Tu ; Agegnehu Gettie ; Michael Farzan ; Kwok-Yung Yuen ; David D. Ho | Recombinant Modified Vaccinia Virus Ankara Expressing the Spike Glycoprotein of Severe Acute Respiratory Syndrome Coronavirus Induces Protective Neutralizing Antibodies Primarily Targeting the Receptor Binding Region |
| 004743 (2005) |
Himani Bisht [États-Unis] ; Anjeanette Roberts ; Leatrice Vogel ; Kanta Subbarao ; Bernard Moss | Neutralizing antibody and protective immunity to SARS coronavirus infection of mice induced by a soluble recombinant polypeptide containing an N-terminal segment of the spike glycoprotein. |
| 004767 (2005) |
Nigel J. Temperton [Royaume-Uni] ; Paul K. Chan [République populaire de Chine] ; Graham Simmons [États-Unis] ; Maria C. Zambon [Royaume-Uni] ; Richard S. Tedder [Royaume-Uni] ; Yasuhiro Takeuchi [Royaume-Uni] ; Robin A. Weiss [Royaume-Uni] | Longitudinally Profiling Neutralizing Antibody Response to SARS Coronavirus with Pseudotypes |
| 004802 (2005) |
Shixia Wang [États-Unis] ; Te-Hui W. Chou ; Pavlo V. Sakhatskyy ; Song Huang ; John M. Lawrence ; Hong Cao ; Xiaoyun Huang ; Shan Lu | Identification of two neutralizing regions on the severe acute respiratory syndrome coronavirus spike glycoprotein produced from the mammalian expression system. |
| 004807 (2005) |
Yuxian He [États-Unis] ; Qingyu Zhu [République populaire de Chine] ; Shuwen Liu [États-Unis] ; Yusen Zhou [République populaire de Chine] ; Baoan Yang [République populaire de Chine] ; Jiaming Li [République populaire de Chine] ; Shibo Jiang [États-Unis] | Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: importance for designing SARS vaccines |
| 004844 (2005) |
Te-Hui W. Chou [États-Unis] ; Shixia Wang [États-Unis] ; Pavlo V. Sakhatskyy [États-Unis] ; Innocent Mboudoudjeck [États-Unis] ; John M. Lawrence [États-Unis] ; Song Huang [États-Unis] ; Scott Coley [États-Unis] ; Baoan Yang [République populaire de Chine] ; Jiaming Li [République populaire de Chine] ; Qingyu Zhu [République populaire de Chine] ; Shan Lu [États-Unis] | Epitope mapping and biological function analysis of antibodies produced by immunization of mice with an inactivated Chinese isolate of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) |
| 004D63 (2005) |
Christopher E. Yi [États-Unis] ; LEI BA [États-Unis] ; LINQI ZHANG [États-Unis] ; David D. Ho [États-Unis] ; ZHIWEI CHEN [États-Unis] | Single amino acid substitutions in the severe acute respiratory syndrome coronavirus spike glycoprotein determine viral entry and immunogenicity of a major neutralizing domain |
| 004D72 (2005) |
Patrick C. Y. Woo [Hong Kong] ; Susanna K. P. Lau [Hong Kong] ; Hoi-Wah Tsoi [Hong Kong] ; Zhi-Wei Chen [États-Unis] ; Beatrice H. L. Wong [Hong Kong] ; LINQI ZHANG [États-Unis] ; Jim K. H. Chan [Hong Kong] ; Lei-Po Wong [Hong Kong] ; WEI HE [République populaire de Chine] ; CHI MA [République populaire de Chine] ; Kwok-Hung Chan [Hong Kong] ; David D. Ho [États-Unis] ; Kwok-Yung Yuen [Hong Kong] | SARS coronavirus spike polypeptide DNA vaccine priming with recombinant spike polypeptide from Escherichia coli as booster induces high titer of neutralizing antibody against SARS coronavirus |
| 004E80 (2005) |
Choong-Tat Keng [Singapour] ; AIHUA ZHANG [République populaire de Chine] ; SHUO SHEN [Singapour] ; Kuo-Ming Lip [Singapour] ; Burtram C. Fielding [Singapour] ; Timothy H. P. Tan [Singapour] ; Chih-Fong Chou [Singapour] ; CHAY BOON LOH [Singapour] ; SIFANG WANG [Singapour] ; JIANLIN FU [Singapour] ; XIAOMING YANG [République populaire de Chine] ; SENG GEE LIM [Singapour] ; WANJIN HONG [Singapour] ; Yee-Joo Tan [Singapour] | Amino acids 1055 to 1192 in the S2 region of severe acute respiratory syndrome coronavirus S protein induce neutralizing antibodies : Implications for the development of vaccines and antiviral agents |
| 004E84 (2005) |
Milosz Faber [États-Unis] ; Elaine W. Lamirande [États-Unis] ; Anjeanette Roberts [États-Unis] ; Amy B. Rice [États-Unis] ; Hilary Koprowski [États-Unis] ; Bernhard Dietzschold [États-Unis] ; Matthias J. Schnell [États-Unis] | A single immunization with a rhabdovirus-based vector expressing severe acute respiratory syndrome coronavirus (SARS-CoV) S protein results in the production of high levels of SARs-CoV-neutralizing antibodies |
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Ursula J. Buchholz [États-Unis] ; Alexander Bukreyev ; Lijuan Yang ; Elaine W. Lamirande ; Brian R. Murphy ; Kanta Subbarao ; Peter L. Collins | Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity. |
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Elisabetta Traggiai [Suisse] ; Stephan Becker ; Kanta Subbarao ; Larissa Kolesnikova ; Yasushi Uematsu ; Maria Rita Gismondo ; Brian R. Murphy ; Rino Rappuoli ; Antonio Lanzavecchia | An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. |
| 005475 (2004) |
Tong Zhou ; Hong Wang ; Danlin Luo ; Thomas Rowe ; Zheng Wang ; Robert J. Hogan ; Shihong Qiu ; Robert J. Bunzel ; Guoqiang Huang ; Vinod Mishra ; Thomas G. Voss ; Robert Kimberly ; Ming Luo | An Exposed Domain in the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Induces Neutralizing Antibodies |
| 006471 (2000) |
L. Kuo [États-Unis] ; G J Godeke ; M J Raamsman ; P S Masters ; P J Rottier | Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: crossing the host cell species barrier. |
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C. Smerdou [Espagne] ; I M Anton ; J. Plana ; R. Curtiss ; L. Enjuanes | A continuous epitope from transmissible gastroenteritis virus S protein fused to E. coli heat-labile toxin B subunit expressed by attenuated Salmonella induces serum and secretory immunity. |
| 001812 (2013) |
Rui-Ping Wu [République populaire de Chine] ; Jia-Zi Meng ; Yu-Xian He | [Construction and screening of SARS-CoV S protein-specific phage displayed antigen library]. |
| 001832 (2013) |
Huihui Mou [Pays-Bas] ; V Stalin Raj ; Frank J M. Van Kuppeveld ; Peter J M. Rottier ; Bart L. Haagmans ; Berend Jan Bosch | The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies. |
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Qianqian Yao [République populaire de Chine] ; Paul S. Masters ; Rong Ye | Negatively charged residues in the endodomain are critical for specific assembly of spike protein into murine coronavirus. |
| 001A05 (2013) |
Qiong Zhao [République populaire de Chine] ; Jiayi Zhu ; Weijuan Zhu ; Xunliang Li ; Ye Tao ; Xiaonan Lv ; Xue Wang ; Jiechao Yin ; Cheng He ; Xiaofeng Ren | A monoclonal antibody against transmissible gastroenteritis virus generated via immunization of a DNA plasmid bearing TGEV S1 gene. |
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Byoung-Shik Shim [Corée du Sud] ; Konrad Stadler ; Huan Huu Nguyen ; Cheol-Heui Yun ; Dong Wook Kim ; Jun Chang ; Cecil Czerkinsky ; Man Ki Song | Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain. |
| 001C71 (2012) |
Jun Huang [République populaire de Chine] ; Yingnan Cao [République populaire de Chine] ; Xianzhang Bu [République populaire de Chine] ; Changyou Wu [République populaire de Chine] | Residue analysis of a CTL epitope of SARS-CoV spike protein by IFN-gamma production and bioinformatics prediction |
| 001C82 (2012) |
Xiaorong Zhang [République populaire de Chine] ; Yantao Wu ; Yezhen Huang ; Xiufan Liu | Protection conferred by a recombinant Marek's disease virus that expresses the spike protein from infectious bronchitis virus in specific pathogen-free chicken. |
| 001D09 (2012) |
Siqingaowa Suo [République populaire de Chine] ; Yudong Ren ; Guangxing Li ; Dante Zarlenga ; Ri-E Bu ; Dingding Su ; Xunliang Li ; Pengchong Li ; Fandan Meng ; Chao Wang ; Xiaofeng Ren | Immune responses induced by DNA vaccines bearing Spike gene of PEDV combined with porcine IL-18. |
| 001D15 (2012) |
Di-Qiu Liu [République populaire de Chine] ; Jun-Wei Ge ; Xin-Yuan Qiao ; Yan-Ping Jiang ; Song-Mei Liu ; Yi-Jing Li | High-level mucosal and systemic immune responses induced by oral administration with Lactobacillus-expressed porcine epidemic diarrhea virus (PEDV) S1 region combined with Lactobacillus-expressed N protein. |
| 001D22 (2012) |
Yutaka Terada [Japon] ; Yuto Shiozaki [Japon] ; Hiroshi Shimoda [Japon] ; Hassan Youssef Abdel Hamid Mahmoud [Japon] ; Keita Noguchi [Japon] ; Yumiko Nagao [Japon] ; Masayuki Shimojima [Japon] ; Hiroyuki Iwata [Japon] ; Takuya Mizuno [Japon] ; Masaru Okuda [Japon] ; Masahiro Morimoto [Japon] ; Toshiharu Hayashi [Japon] ; Yoshikazu Tanaka [Japon] ; Masami Mochizuki [Japon] ; Ken Maeda [Japon] | Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats. |
| 002062 (2011) |
Lanying Du [États-Unis] ; Xiujuan Zhang ; Jixiang Liu ; Shibo Jiang | Protocol for recombinant RBD-based SARS vaccines: protein preparation, animal vaccination and neutralization detection. |
| 002077 (2011) |
Kazuya Shirato [Japon] ; Madoka Maejima ; Shutoku Matsuyama ; Makoto Ujike ; Ayako Miyazaki ; Natsumi Takeyama ; Hidetoshi Ikeda ; Fumihiro Taguchi | Mutation in the cytoplasmic retrieval signal of porcine epidemic diarrhea virus spike (S) protein is responsible for enhanced fusion activity. |
| 002114 (2011) |
Tohru Miyoshi-Akiyama [Japon] ; Isao Ishida ; Masaya Fukushi ; Keina Yamaguchi ; Yusuke Matsuoka ; Takashi Ishihara ; Masayoshi Tsukahara ; Seisuke Hatakeyama ; Norikazu Itoh ; Aki Morisawa ; Yoshiyuki Yoshinaka ; Naoki Yamamoto ; Zhang Lianfeng ; Qin Chuan ; Teruo Kirikae ; Takehiko Sasazuki | Fully human monoclonal antibody directed to proteolytic cleavage site in severe acute respiratory syndrome (SARS) coronavirus S protein neutralizes the virus in a rhesus macaque SARS model. |
| 002117 (2011) |
Ilona Glowacka [Allemagne] ; Stephanie Bertram ; Marcel A. Müller ; Paul Allen ; Elizabeth Soilleux ; Susanne Pfefferle ; Imke Steffen ; Theodros Solomon Tsegaye ; Yuxian He ; Kerstin Gnirss ; Daniela Niemeyer ; Heike Schneider ; Christian Drosten ; Stefan Pöhlmann | Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response. |
| 002147 (2011) |
Han-Xin Lin [Canada] ; Yan Feng ; Xinming Tu ; Xuesen Zhao ; Chih-Heng Hsieh ; Lauren Griffin ; Murray Junop ; Chengsheng Zhang | Characterization of the spike protein of human coronavirus NL63 in receptor binding and pseudotype virus entry. |
| 002150 (2011) |
Juan Reguera [Espagne] ; Desiderio Ordo O [Espagne] ; César Santiago [Espagne] ; Luis Enjuanes [Espagne] ; José M. Casasnovas [Espagne] | Antigenic modules in the N-terminal S1 region of the transmissible gastroenteritis virus spike protein. |
| 002227 (2011) |
Jung-Eun Park [Corée du Sud] ; Deu John M. Cruz [Corée du Sud] ; Hyun-Jin Shin [Corée du Sud] | Receptor-bound porcine epidemic diarrhea virus spike protein cleaved by trypsin induces membrane fusion |
| 002277 (2011) |
Yi-Ning Chen [États-Unis] ; Ching Ching Wu [États-Unis] ; Tsang Long Lin [États-Unis] | Identification and characterization of a neutralizing-epitope-containing spike protein fragment in turkey coronavirus |
| 002405 (2010) |
Wei-Min Zhou [République populaire de Chine] ; Wen-Ling Wang ; Wen-Jie Tan ; Ling-Lin Zhang ; Xiao Yin ; Rou-Jian Lu ; Hui-Juan Wang | [Development of serological detection assays for human coronavirus HKU1 infection and its application]. |
| 002479 (2010) |
Chao Wang [République populaire de Chine] ; Xiaofeng Ren | Preparation and characterization of polyclonal antibody against severe acute respiratory syndrome-associated coronavirus spike protein. |
| 002493 (2010) |
Jody D. Berry [États-Unis, Canada] ; Kevin Hay [États-Unis] ; James M. Rini [États-Unis] ; Meng Yu ; Linfa Wang ; Francis A. Plummer [États-Unis, Canada] ; Cindi R. Corbett [États-Unis, Canada] ; Anton Andonov [États-Unis, Canada] | Neutralizing epitopes of the SARS-CoV S-protein cluster independent of repertoire, antigen structure or mAb technology |
| 002547 (2010) |
Sandrine Belouzard [États-Unis] ; Ikenna Madu ; Gary R. Whittaker | Elastase-mediated activation of the severe acute respiratory syndrome coronavirus spike protein at discrete sites within the S2 domain. |
| 002589 (2010) |
Yanchen Zhou [États-Unis] ; Kai Lu ; Susanne Pfefferle ; Stephanie Bertram ; Ilona Glowacka ; Christian Drosten ; Stefan Pöhlmann ; Graham Simmons | A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms. |
| 002981 (2009) |
Shutoku Matsuyama [Japon] ; Fumihiro Taguchi | Two-step conformational changes in a coronavirus envelope glycoprotein mediated by receptor binding and proteolysis. |
| 002A09 (2009) |
John E. Pak [Canada] ; Chetna Sharon ; Malathy Satkunarajah ; Thierry C. Auperin ; Cheryl M. Cameron ; David J. Kelvin ; Jayaraman Seetharaman ; Alan Cochrane ; Francis A. Plummer ; Jody D. Berry ; James M. Rini | Structural insights into immune recognition of the severe acute respiratory syndrome coronavirus S protein receptor binding domain. |
| 002A26 (2009) |
Hong-Long Ji [États-Unis] ; Weifeng Song ; Zhiqian Gao ; Xue-Feng Su ; Hong-Guang Nie ; Yi Jiang ; Ji-Bin Peng ; Yu-Xian He ; Ying Liao ; Yong-Jian Zhou ; Albert Tousson ; Sadis Matalon | SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms. |
| 002A68 (2009) |
Jeroen Corver [Pays-Bas] ; Rene Broer ; Puck Van Kasteren ; Willy Spaan | Mutagenesis of the transmembrane domain of the SARS coronavirus spike glycoprotein: refinement of the requirements for SARS coronavirus cell entry. |
| 002B01 (2009) |
Ying Guo [États-Unis] ; Jennifer Tisoncik ; Susanna Mcreynolds ; Michael Farzan ; Bellur S. Prabhakar ; Thomas Gallagher ; Lijun Rong ; Michael Caffrey | Identification of a new region of SARS-CoV S protein critical for viral entry. |
| 002C15 (2009) |
Junbao Yang [États-Unis] ; Eddie James [États-Unis] ; Michelle Roti [États-Unis] ; Laurie Huston [États-Unis] ; John A. Gebe [États-Unis] ; William W. Kwok [États-Unis] | Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals |
| 002E43 (2009) |
W. P. Poh [Singapour] ; T. Narasaraju [Singapour] ; N. A. Pereira [Singapour] ; F. Zhong [Singapour] ; M. C. Phoon [Singapour] ; P. A. Macary [Singapour] ; S. H. Wong [Singapour] ; J. Lu [Singapour] ; D. R. Koh [Singapour] ; Vincent T. K. Chow [Singapour] | Characterization of cytotoxic T‐lymphocyte epitopes and immune responses to SARS coronavirus spike DNA vaccine expressing the RGD‐integrin‐binding motif |
| 002F91 (2008) |
Feng Mu [République populaire de Chine] ; Dongsheng Niu [République populaire de Chine] ; Jingsong Mu [République populaire de Chine] ; Bo He [République populaire de Chine] ; Weiguo Han [République populaire de Chine] ; Baoxing Fan [République populaire de Chine] ; Shengyong Huang [République populaire de Chine] ; Yan Qiu [République populaire de Chine] ; Bo You [République populaire de Chine] ; Weijun Chen [République populaire de Chine] | The expression and antigenicity of a truncated spike-nucleocapsid fusion protein of severe acute respiratory syndrome-associated coronavirus |
| 003009 (2008) |
Sarmistha Basak [Canada] ; Xiaolei Hao ; Andrew Chen ; Michel Chrétien ; Ajoy Basak | Structural and biochemical investigation of heptad repeat derived peptides of human SARS corona virus (hSARS-CoV) spike protein. |
| 003010 (2008) |
Fang Li [États-Unis] | Structural Analysis of Major Species Barriers between Humans and Palm Civets for Severe Acute Respiratory Syndrome Coronavirus Infections▿ |
| 003036 (2008) |
Hongliang Wang [République populaire de Chine] ; Peng Yang [République populaire de Chine] ; Kangtai Liu [République populaire de Chine] ; Feng Guo [République populaire de Chine] ; Yanli Zhang [République populaire de Chine] ; Gongyi Zhang [États-Unis] ; Chengyu Jiang [République populaire de Chine] | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway |
