The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6
Identifieur interne : 002A03 ( Main/Exploration ); précédent : 002A02; suivant : 002A04The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6
Auteurs : Shu-Chiun Sung [Taïwan] ; Che-Yi Chao [Taïwan] ; King-Song Jeng [Taïwan] ; Jyh-Yuan Yang [Taïwan] ; Michael M. C. Lai [Taïwan]Source :
- Virology [ 0042-6822 ] ; 2009.
Descripteurs français
- KwdFr :
- Alignement de séquences, Animaux, Cadres ouverts de lecture (génétique), Cellules HeLa, Cellules Vero, Données de séquences moléculaires, Facteur de transcription ATF-6 (métabolisme), Humains, Protéines virales régulatrices ou accessoires (génétique), Protéines virales régulatrices ou accessoires (métabolisme), Régulation positive, Réticulum endoplasmique (métabolisme), Réticulum endoplasmique (virologie), Séquence d'acides aminés, Transport de protéines, Virus du SRAS (métabolisme).
- MESH :
- génétique : Cadres ouverts de lecture, Protéines virales régulatrices ou accessoires.
- métabolisme : Facteur de transcription ATF-6, Protéines virales régulatrices ou accessoires, Réticulum endoplasmique, Virus du SRAS.
- virologie : Réticulum endoplasmique.
- Alignement de séquences, Animaux, Cellules HeLa, Cellules Vero, Données de séquences moléculaires, Humains, Régulation positive, Séquence d'acides aminés, Transport de protéines.
English descriptors
- KwdEn :
- Activating Transcription Factor 6 (metabolism), Amino Acid Sequence, Animals, Chlorocebus aethiops, Endoplasmic Reticulum (metabolism), Endoplasmic Reticulum (virology), HeLa Cells, Humans, Molecular Sequence Data, Open Reading Frames (genetics), Protein Transport, SARS Virus (metabolism), Sequence Alignment, Up-Regulation, Vero Cells, Viral Regulatory and Accessory Proteins (genetics), Viral Regulatory and Accessory Proteins (metabolism).
- MESH :
- chemical , genetics : Viral Regulatory and Accessory Proteins.
- chemical , metabolism : Activating Transcription Factor 6, Viral Regulatory and Accessory Proteins.
- genetics : Open Reading Frames.
- metabolism : Endoplasmic Reticulum, SARS Virus.
- virology : Endoplasmic Reticulum.
- Amino Acid Sequence, Animals, Chlorocebus aethiops, HeLa Cells, Humans, Molecular Sequence Data, Protein Transport, Sequence Alignment, Up-Regulation, Vero Cells.
Abstract
The 8ab protein of SARS-CoV is a group-specific accessory protein, which is lost when the virus was transmitted from animals to humans due to a 29-nucleotide deletion in the ORF8ab region. Here we found that 8ab protein is associated with ER membrane at luminal surface. 8ab protein was found to up-regulate the synthesis of endogenous ER-resident chaperons involved in protein folding through the activation of the transcription factor ATF6, while it showed no effect on the CHOP induction and XBP1 splicing associated with the unfolded protein response (UPR). When ectopically expressed in mammalian cells, 8ab induced the proteolysis of ATF6 and the translocation of its cleaved DNA-binding and transcription-activation domains from the ER to the nucleus. Finally, we showed that 8ab binds to the luminal domain of ATF6. These findings suggest that 8ab could modulate the UPR by activating ATF6 to facilitate protein folding and processing. Thus, the loss of 8ab in SARS-CoV through viral evolution in animals may play a role in its pathogenicity.
Url:
DOI: 10.1016/j.virol.2009.02.021
PubMed: 19304306
PubMed Central: 7103415
Affiliations:
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Here we found that 8ab protein is associated with ER membrane at luminal surface. 8ab protein was found to up-regulate the synthesis of endogenous ER-resident chaperons involved in protein folding through the activation of the transcription factor ATF6, while it showed no effect on the CHOP induction and XBP1 splicing associated with the unfolded protein response (UPR). When ectopically expressed in mammalian cells, 8ab induced the proteolysis of ATF6 and the translocation of its cleaved DNA-binding and transcription-activation domains from the ER to the nucleus. Finally, we showed that 8ab binds to the luminal domain of ATF6. These findings suggest that 8ab could modulate the UPR by activating ATF6 to facilitate protein folding and processing. Thus, the loss of 8ab in SARS-CoV through viral evolution in animals may play a role in its pathogenicity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chan, C P" uniqKey="Chan C">C.P. 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Mori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yount, B" uniqKey="Yount B">B. Yount</name></author><author><name sortKey="Roberts, R S" uniqKey="Roberts R">R.S. Roberts</name></author><author><name sortKey="Sims, A C" uniqKey="Sims A">A.C. Sims</name></author><author><name sortKey="Deming, D" uniqKey="Deming D">D. Deming</name></author><author><name sortKey="Frieman, M B" uniqKey="Frieman M">M.B. Frieman</name></author><author><name sortKey="Sparks, J" uniqKey="Sparks J">J. Sparks</name></author><author><name sortKey="Denison, M R" uniqKey="Denison M">M.R. Denison</name></author><author><name sortKey="Davis, N" uniqKey="Davis N">N. Davis</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zinszner, H" uniqKey="Zinszner H">H. Zinszner</name></author><author><name sortKey="Kuroda, M" uniqKey="Kuroda M">M. Kuroda</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Batchvarova, N" uniqKey="Batchvarova N">N. Batchvarova</name></author><author><name sortKey="Lightfoot, R T" uniqKey="Lightfoot R">R.T. Lightfoot</name></author><author><name sortKey="Remotti, H" uniqKey="Remotti H">H. Remotti</name></author><author><name sortKey="Stevens, J L" uniqKey="Stevens J">J.L. Stevens</name></author><author><name sortKey="Ron, D" uniqKey="Ron D">D. Ron</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Sung, Shu Chiun" sort="Sung, Shu Chiun" uniqKey="Sung S" first="Shu-Chiun" last="Sung">Shu-Chiun Sung</name></noRegion><name sortKey="Chao, Che Yi" sort="Chao, Che Yi" uniqKey="Chao C" first="Che-Yi" last="Chao">Che-Yi Chao</name><name sortKey="Jeng, King Song" sort="Jeng, King Song" uniqKey="Jeng K" first="King-Song" last="Jeng">King-Song Jeng</name><name sortKey="Lai, Michael M C" sort="Lai, Michael M C" uniqKey="Lai M" first="Michael M. C." last="Lai">Michael M. C. Lai</name><name sortKey="Lai, Michael M C" sort="Lai, Michael M C" uniqKey="Lai M" first="Michael M. C." last="Lai">Michael M. C. Lai</name><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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