SrasV1, Main, Exploration, bibRecordById, pubmed:18063358

Human monoclonal antibodies by immortalization of memory B cells.

Identifieur interne : 003687 ( Main/Exploration ); précédent : 003686; suivant : 003688

Human monoclonal antibodies by immortalization of memory B cells.

Auteurs : Antonio Lanzavecchia [Suisse] ; Davide Corti ; Federica Sallusto

Source :

Current opinion in biotechnology [ 0958-1669 ] ; 2007.

RBID : pubmed:18063358

Descripteurs français

KwdFr :
- Anticorps monoclonaux (immunologie), Humains, Lymphocytes B (immunologie), Modèles immunologiques, Sous-type H5N1 du virus de la grippe A (immunologie), Virus du SRAS (immunologie).
MESH :
- immunologie : Anticorps monoclonaux, Lymphocytes B, Sous-type H5N1 du virus de la grippe A, Virus du SRAS.
- Humains, Modèles immunologiques.

English descriptors

KwdEn :
- Antibodies, Monoclonal (immunology), B-Lymphocytes (immunology), Humans, Influenza A Virus, H5N1 Subtype (immunology), Models, Immunological, SARS Virus (immunology).
MESH :
- chemical , immunology : Antibodies, Monoclonal.
- immunology : B-Lymphocytes, Influenza A Virus, H5N1 Subtype, SARS Virus.
- Humans, Models, Immunological.

Abstract

The administration of hyper immune sera to prevent or treat life-threatening infections is a remarkable milestone in medicine and biotechnology that has been achieved more than a century ago. Yet, the therapeutic use of monoclonal antibodies in this field has developed slowly over the last decades. Here we compare and contrast current methods to generate human monoclonal antibodies and highlight the advantages of exploiting the human antibody repertoire using a novel method that allows efficient immortalization and cloning of human memory B cells. This method, which has been successfully applied to isolate broadly neutralizing antibodies against SARS and H5N1 influenza viruses, is expected to accelerate the development of therapeutics in the field of infectious diseases not only by providing neutralizing antibodies for passive serotherapy, but also by generating relevant information for vaccine design.

DOI: 10.1016/j.copbio.2007.10.011
PubMed: 18063358

Affiliations:

Suisse

Le document en format XML

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<front><div type="abstract" xml:lang="en">The administration of hyper immune sera to prevent or treat life-threatening infections is a remarkable milestone in medicine and biotechnology that has been achieved more than a century ago. Yet, the therapeutic use of monoclonal antibodies in this field has developed slowly over the last decades. Here we compare and contrast current methods to generate human monoclonal antibodies and highlight the advantages of exploiting the human antibody repertoire using a novel method that allows efficient immortalization and cloning of human memory B cells. This method, which has been successfully applied to isolate broadly neutralizing antibodies against SARS and H5N1 influenza viruses, is expected to accelerate the development of therapeutics in the field of infectious diseases not only by providing neutralizing antibodies for passive serotherapy, but also by generating relevant information for vaccine design.</div>
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Human monoclonal antibodies by immortalization of memory B cells.

Human monoclonal antibodies by immortalization of memory B cells.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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