Potential antivirals and antiviral strategies against SARS coronavirus infections
Identifieur interne : 001599 ( Main/Exploration ); précédent : 001598; suivant : 001600Potential antivirals and antiviral strategies against SARS coronavirus infections
Auteurs : Erik De ClercqSource :
- Expert Review of Anti-Infective Therapy [ 1478-7210 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (), Antiviraux (administration et posologie), Antiviraux (métabolisme), Humains, Syndrome respiratoire aigu sévère (métabolisme), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Systèmes de délivrance de médicaments (), Systèmes de délivrance de médicaments (tendances), Virus du SRAS (), Virus du SRAS (métabolisme).
- MESH :
- administration et posologie : Antiviraux.
- métabolisme : Antiviraux, Syndrome respiratoire aigu sévère, Virus du SRAS.
- tendances : Systèmes de délivrance de médicaments.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Antiviraux, Humains, Systèmes de délivrance de médicaments, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (administration & dosage), Antiviral Agents (chemistry), Antiviral Agents (metabolism), Drug Delivery Systems (methods), Drug Delivery Systems (trends), Humans, SARS Virus (chemistry), SARS Virus (drug effects), SARS Virus (metabolism), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (metabolism), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , administration & dosage : Antiviral Agents.
- chemical , chemistry : Antiviral Agents.
- chemical , metabolism : Antiviral Agents.
- chemistry : SARS Virus.
- drug effects : SARS Virus.
- drug therapy : Severe Acute Respiratory Syndrome.
- metabolism : SARS Virus, Severe Acute Respiratory Syndrome.
- methods : Drug Delivery Systems.
- trends : Drug Delivery Systems.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Humans.
Abstract
There are a number of antivirals as well as antiviral strategies that could be envisaged to prevent or treat severe acute respiratory syndrome (SARS) (or similar) coronavirus (CoV) infections. Targets for the prophylactic or therapeutic interventions include interaction of the spike (S) glycoprotein (S1 domain) with the host cell receptor, fusion of the S2 domain with the host cell membrane, processing of the replicase polyproteins by the virus-encoded proteases (3C-like cysteine protease [3CLpro] and papain-like cysteine protease) and other virus-encoded enzymes such as the NTPase/helicase and RNA-dependent RNA polymerase. Human monoclonal antibody blocking S1 may play an important role in the immunoprophylaxis of SARS. Fusion inhibitors reminiscent of enfuvirtide in the case of HIV may also be developed for SARS-CoV. Various peptidomimetic and nonpeptidic inhibitors of 3CLpro have been described, the best ones inhibiting SARS-CoV replication with a selectivity index greater than 1000. Human interferons, in particular α- and β-interferon, as well as short interfering RNAs could further be pursued for the control of SARS. Various other compounds, often with an ill-defined mode of action but selectivity indexes up to 100, have been reported to exhibit
Url:
DOI: 10.1586/14787210.4.2.291
PubMed: 16597209
PubMed Central: 7105749
Affiliations:
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Le document en format XML
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type="wicri:Area/Main/Exploration">001599</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Potential antivirals and antiviral strategies against SARS coronavirus infections</title><author><name sortKey="De Clercq, Erik" sort="De Clercq, Erik" uniqKey="De Clercq E" first="Erik" last="De Clercq">Erik De Clercq</name><affiliation><nlm:aff id="AFF0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Expert Review of Anti-Infective Therapy</title><idno type="ISSN">1478-7210</idno><idno type="eISSN">1744-8336</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (administration & dosage)</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (metabolism)</term><term>Drug Delivery Systems (methods)</term><term>Drug Delivery Systems (trends)</term><term>Humans</term><term>SARS Virus (chemistry)</term><term>SARS Virus (drug effects)</term><term>SARS Virus (metabolism)</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Severe Acute Respiratory Syndrome (metabolism)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (administration et posologie)</term><term>Antiviraux (métabolisme)</term><term>Humains</term><term>Syndrome respiratoire aigu sévère (métabolisme)</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Systèmes de délivrance de médicaments ()</term><term>Systèmes de délivrance de médicaments (tendances)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Delivery Systems</term></keywords><keywords scheme="MESH" 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SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>There are a number of antivirals as well as antiviral strategies that could be envisaged to prevent or treat severe acute respiratory syndrome (SARS) (or similar) coronavirus (CoV) infections. Targets for the prophylactic or therapeutic interventions include interaction of the spike (S) glycoprotein (S1 domain) with the host cell receptor, fusion of the S2 domain with the host cell membrane, processing of the replicase polyproteins by the virus-encoded proteases (3C-like cysteine protease [3CLpro] and papain-like cysteine protease) and other virus-encoded enzymes such as the NTPase/helicase and RNA-dependent RNA polymerase. Human monoclonal antibody blocking S1 may play an important role in the immunoprophylaxis of SARS. Fusion inhibitors reminiscent of enfuvirtide in the case of HIV may also be developed for SARS-CoV. Various peptidomimetic and nonpeptidic inhibitors of 3CLpro have been described, the best ones inhibiting SARS-CoV replication with a selectivity index greater than 1000. Human interferons, in particular α- and β-interferon, as well as short interfering RNAs could further be pursued for the control of SARS. Various other compounds, often with an ill-defined mode of action but selectivity indexes up to 100, have been reported to exhibit <italic>in vitro</italic> activity against SARS-CoV: valinomycin, glycopeptide antibiotics, plant lectins, hesperetin, glycyrrhizin, aurintricarboxylic acid, chloroquine, niclosamide, nelfinavir and calpain inhibitors.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris" uniqKey="Peiris">Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee" uniqKey="Lee">Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek" uniqKey="Ksiazek">Ksiazek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten" uniqKey="Drosten">Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuiken" 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