Severe acute respiratory syndrome epidemic in Taiwan, 2003.
Identifieur interne : 004628 ( Main/Exploration ); précédent : 004627; suivant : 004629Severe acute respiratory syndrome epidemic in Taiwan, 2003.
Auteurs : Po Ren Hsueh [Taïwan] ; Pan Chyr YangSource :
- Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi [ 1684-1182 ] ; 2005.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Animaux, Antiviraux (usage thérapeutique), Contrôle des maladies contagieuses, Femelle, Flambées de maladies, Génome viral, Humains, Infection croisée (épidémiologie), Mâle, Réservoirs d'agents pathogènes, Sujet âgé, Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Taïwan (épidémiologie), Virus du SRAS (génétique), Épidémiologie moléculaire.
- MESH :
- génétique : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Antiviraux.
- virologie : Syndrome respiratoire aigu sévère.
- épidémiologie : Infection croisée, Syndrome respiratoire aigu sévère, Taïwan.
- Adulte, Adulte d'âge moyen, Animaux, Contrôle des maladies contagieuses, Femelle, Flambées de maladies, Génome viral, Humains, Mâle, Réservoirs d'agents pathogènes, Sujet âgé, Épidémiologie moléculaire.
- Wicri :
- geographic : Taïwan.
English descriptors
- KwdEn :
- Adult, Aged, Animals, Antiviral Agents (therapeutic use), Communicable Disease Control, Cross Infection (epidemiology), Disease Outbreaks, Disease Reservoirs, Female, Genome, Viral, Humans, Male, Middle Aged, Molecular Epidemiology, SARS Virus (genetics), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (virology), Taiwan (epidemiology).
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- geographic , epidemiology : Taiwan.
- drug therapy : Severe Acute Respiratory Syndrome.
- epidemiology : Cross Infection, Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Adult, Aged, Animals, Communicable Disease Control, Disease Outbreaks, Disease Reservoirs, Female, Genome, Viral, Humans, Male, Middle Aged, Molecular Epidemiology.
Abstract
In Taiwan, since the first case of severe acute respiratory syndrome (SARS) was identified on February 25, 2003, a total of 3032 cases of suspected or probable SARS were reported prior to July 5, 2003. Among these cases, 664 cases were classified as probable SARS based on the clinical case definitions and 346 had a positive result for the SARS-associated coronavirus (SARS-CoV). The epidemic in Taiwan could be divided into 2 distinct stages. In stage I (late-February to mid-April) patients had traceable contact with infected patients or travel histories to known affected areas of SARS. By contrast, patients in stage II (mid-April to June) acquired infection via intra-hospital or inter-hospital transmission. The mortality rate directly attributable to SARS during the 2 stages of the outbreak in Taiwan was 11% (37 patients). Phylogenetic analysis of sequences of SARS-CoV strains in Taiwan and other countries showed that Taiwanese strains were closely related to those isolated from patients in Hong Kong and Guangdong. The nonspecific initial symptoms and signs of the illness, the absence of reliable diagnostic tests, as well as the initial lack of strict infection control measures in hospitals and effective national control policies contributed to the island-wide spread of the SARS epidemic in Taiwan. Development of an effective strategy to prepare for future outbreaks will require the implementation of an active coordinated clinical reporting system, international collaboration to identify cases in the early stage, development of laboratory tools for early diagnosis, a robust system of prepared isolation, and adequate quarantine facilities.
PubMed: 15843851
Affiliations:
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Among these cases, 664 cases were classified as probable SARS based on the clinical case definitions and 346 had a positive result for the SARS-associated coronavirus (SARS-CoV). The epidemic in Taiwan could be divided into 2 distinct stages. In stage I (late-February to mid-April) patients had traceable contact with infected patients or travel histories to known affected areas of SARS. By contrast, patients in stage II (mid-April to June) acquired infection via intra-hospital or inter-hospital transmission. The mortality rate directly attributable to SARS during the 2 stages of the outbreak in Taiwan was 11% (37 patients). Phylogenetic analysis of sequences of SARS-CoV strains in Taiwan and other countries showed that Taiwanese strains were closely related to those isolated from patients in Hong Kong and Guangdong. The nonspecific initial symptoms and signs of the illness, the absence of reliable diagnostic tests, as well as the initial lack of strict infection control measures in hospitals and effective national control policies contributed to the island-wide spread of the SARS epidemic in Taiwan. Development of an effective strategy to prepare for future outbreaks will require the implementation of an active coordinated clinical reporting system, international collaboration to identify cases in the early stage, development of laboratory tools for early diagnosis, a robust system of prepared isolation, and adequate quarantine facilities.</div></front></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><noCountry><name sortKey="Yang, Pan Chyr" sort="Yang, Pan Chyr" uniqKey="Yang P" first="Pan Chyr" last="Yang">Pan Chyr Yang</name></noCountry><country name="Taïwan"><noRegion><name sortKey="Hsueh, Po Ren" sort="Hsueh, Po Ren" uniqKey="Hsueh P" first="Po Ren" last="Hsueh">Po Ren Hsueh</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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