SrasV1, Main, Exploration, bibRecordById, Pascal:09-0466845

Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a

Identifieur interne : 002F32 ( Main/Exploration ); précédent : 002F31; suivant : 002F33

Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a

Auteurs : Shunsuke Kohyama [Japon] ; Satoshi Ohno [Japon] ; Tatsuya Suda [Japon] ; Maiko Taneichi [Japon] ; Shoichi Yokoyama [Japon] ; Masahito Mori [Japon] ; Akiharu Kobavashi [Japon] ; Hidenori Havashi [Japon] ; Tetsuva Uchida [Japon] ; Masanori Matsui [Japon]

Source :

Antiviral research [ 0166-3542 ] ; 2009.

RBID : Pascal:09-0466845

Descripteurs français

Pascal (Inist)
- Induction, Lymphocyte T cytotoxique, Syndrome respiratoire aigu sévère, Virus syndrome respiratoire aigu sévère, Immunisation, Vaccin, Vaccination, Liposome, Polyprotéine, Prévention, Immunoprophylaxie, Immunité cellulaire, Composé conjugué, Protéine non structurale.
Wicri :
- topic : Vaccin, Vaccination.

English descriptors

KwdEn :
- Cellular immunity, Conjugated compound, Cytotoxic T lymphocyte, Immunization, Immunoprophylaxis, Induction, Liposome, Polyprotein, Prevention, Severe acute respiratory syndrome, Severe acute respiratory syndrome virus, Vaccination, Vaccine.

Abstract

Spike and nucleocapsid are structural proteins of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and major targets for cytotoxic T lymphocytes (CTLs). In contrast, non-structural proteins encoded by two-thirds of viral genome are poorly characterized for cell-mediated immunity. We previously demonstrated that nucleocapsid-derived peptides chemically coupled to the surface of liposomes effectively elicited SARS-CoV-specific CTLs in mice. Here, we attempted to identify HLA-A^*0201-restricted CTL epitopes derived from a non-structural polyprotein 1a (ppla) of SARS-CoV, and investigated whether liposomal peptides derived from pp1a were effective for CTL induction. Out of 30 peptides predicted on computational algorithms, nine peptides could significantly induce interferon gamma (IFN-γ)-producing CD8⁺ T cells in mice. These peptides were coupled to the surface of liposomes, and inoculated into mice. Six liposomal peptides effectively induced IFN-γ-producing CD8⁺ T cells and seven liposomal peptides including the six peptides primed CTLs showing in vivo killing activities. Further, CTLs induced by the seven liposomal peptides lysed an HLA-A^*0201 positive cell line expressing naturally processed, ppla-derived peptides. Of note, one of the liposomal peptides induced high numbers of long-lasting memory CTLs. These data suggest that surface-linked liposomal peptides derived from ppla might offer an efficient CTL-based vaccine against SARS.

Affiliations:

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Le document en format XML

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<author><name sortKey="Kobavashi, Akiharu" sort="Kobavashi, Akiharu" uniqKey="Kobavashi A" first="Akiharu" last="Kobavashi">Akiharu Kobavashi</name>
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<author><name sortKey="Havashi, Hidenori" sort="Havashi, Hidenori" uniqKey="Havashi H" first="Hidenori" last="Havashi">Hidenori Havashi</name>
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<author><name sortKey="Uchida, Tetsuva" sort="Uchida, Tetsuva" uniqKey="Uchida T" first="Tetsuva" last="Uchida">Tetsuva Uchida</name>
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<author><name sortKey="Matsui, Masanori" sort="Matsui, Masanori" uniqKey="Matsui M" first="Masanori" last="Matsui">Masanori Matsui</name>
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<series><title level="j" type="main">Antiviral research</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cellular immunity</term>
<term>Conjugated compound</term>
<term>Cytotoxic T lymphocyte</term>
<term>Immunization</term>
<term>Immunoprophylaxis</term>
<term>Induction</term>
<term>Liposome</term>
<term>Polyprotein</term>
<term>Prevention</term>
<term>Severe acute respiratory syndrome</term>
<term>Severe acute respiratory syndrome virus</term>
<term>Vaccination</term>
<term>Vaccine</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Induction</term>
<term>Lymphocyte T cytotoxique</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Virus syndrome respiratoire aigu sévère</term>
<term>Immunisation</term>
<term>Vaccin</term>
<term>Vaccination</term>
<term>Liposome</term>
<term>Polyprotéine</term>
<term>Prévention</term>
<term>Immunoprophylaxie</term>
<term>Immunité cellulaire</term>
<term>Composé conjugué</term>
<term>Protéine non structurale</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term>
<term>Vaccination</term>
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<front><div type="abstract" xml:lang="en">Spike and nucleocapsid are structural proteins of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and major targets for cytotoxic T lymphocytes (CTLs). In contrast, non-structural proteins encoded by two-thirds of viral genome are poorly characterized for cell-mediated immunity. We previously demonstrated that nucleocapsid-derived peptides chemically coupled to the surface of liposomes effectively elicited SARS-CoV-specific CTLs in mice. Here, we attempted to identify HLA-A<sup>*</sup>
0201-restricted CTL epitopes derived from a non-structural polyprotein 1a (ppla) of SARS-CoV, and investigated whether liposomal peptides derived from pp1a were effective for CTL induction. Out of 30 peptides predicted on computational algorithms, nine peptides could significantly induce interferon gamma (IFN-γ)-producing CD8<sup>+</sup>
 T cells in mice. These peptides were coupled to the surface of liposomes, and inoculated into mice. Six liposomal peptides effectively induced IFN-γ-producing CD8<sup>+</sup>
 T cells and seven liposomal peptides including the six peptides primed CTLs showing in vivo killing activities. Further, CTLs induced by the seven liposomal peptides lysed an HLA-A<sup>*</sup>
0201 positive cell line expressing naturally processed, ppla-derived peptides. Of note, one of the liposomal peptides induced high numbers of long-lasting memory CTLs. These data suggest that surface-linked liposomal peptides derived from ppla might offer an efficient CTL-based vaccine against SARS.</div>
</front>
</TEI>
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<name sortKey="Havashi, Hidenori" sort="Havashi, Hidenori" uniqKey="Havashi H" first="Hidenori" last="Havashi">Hidenori Havashi</name>
<name sortKey="Kobavashi, Akiharu" sort="Kobavashi, Akiharu" uniqKey="Kobavashi A" first="Akiharu" last="Kobavashi">Akiharu Kobavashi</name>
<name sortKey="Kohyama, Shunsuke" sort="Kohyama, Shunsuke" uniqKey="Kohyama S" first="Shunsuke" last="Kohyama">Shunsuke Kohyama</name>
<name sortKey="Matsui, Masanori" sort="Matsui, Masanori" uniqKey="Matsui M" first="Masanori" last="Matsui">Masanori Matsui</name>
<name sortKey="Mori, Masahito" sort="Mori, Masahito" uniqKey="Mori M" first="Masahito" last="Mori">Masahito Mori</name>
<name sortKey="Ohno, Satoshi" sort="Ohno, Satoshi" uniqKey="Ohno S" first="Satoshi" last="Ohno">Satoshi Ohno</name>
<name sortKey="Ohno, Satoshi" sort="Ohno, Satoshi" uniqKey="Ohno S" first="Satoshi" last="Ohno">Satoshi Ohno</name>
<name sortKey="Suda, Tatsuya" sort="Suda, Tatsuya" uniqKey="Suda T" first="Tatsuya" last="Suda">Tatsuya Suda</name>
<name sortKey="Taneichi, Maiko" sort="Taneichi, Maiko" uniqKey="Taneichi M" first="Maiko" last="Taneichi">Maiko Taneichi</name>
<name sortKey="Uchida, Tetsuva" sort="Uchida, Tetsuva" uniqKey="Uchida T" first="Tetsuva" last="Uchida">Tetsuva Uchida</name>
<name sortKey="Yokoyama, Shoichi" sort="Yokoyama, Shoichi" uniqKey="Yokoyama S" first="Shoichi" last="Yokoyama">Shoichi Yokoyama</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a
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Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a

Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a

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