Evaluation of a recombinant nucleocapsid protein‐based assay for Anti‐SARS‐CoV IgG detection
Identifieur interne : 004C14 ( Main/Exploration ); précédent : 004C13; suivant : 004C15Evaluation of a recombinant nucleocapsid protein‐based assay for Anti‐SARS‐CoV IgG detection
Auteurs : Paul K. S. Chan [République populaire de Chine, Hong Kong] ; Esther Y. M. Liu [République populaire de Chine] ; Danny T. M. Leung [République populaire de Chine] ; Jo L. K. Cheung [République populaire de Chine] ; C. H. Ma [République populaire de Chine] ; Frankie C. H. Tam [République populaire de Chine] ; Mamie Hui [République populaire de Chine] ; John S. Tam [République populaire de Chine] ; Pak Leong Lim [République populaire de Chine]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2005-02.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Anticorps antiviraux (sang), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Immunoglobuline G (sang), Mâle, Protéines nucléocapside (immunologie), Protéines recombinantes (immunologie), Sensibilité et spécificité, Syndrome respiratoire aigu sévère (immunologie), Test ELISA (), Virus du SRAS (immunologie).
- MESH :
- Pascal (Inist)
- MESH :
- Wicri :
- topic : Enzyme.
English descriptors
- KwdEn :
- Adolescent, Adult, Antibodies, Viral (blood), Child, Child, Preschool, Coronavirus, Detection, Diagnosis, Enzyme, Enzyme immunoassay, Enzyme-Linked Immunosorbent Assay (methods), Female, Humans, IgG, Immunoglobulin G (blood), Male, Nucleocapsid, Nucleocapsid Proteins (immunology), Recombinant Proteins (immunology), Recombinant protein, SARS Virus (immunology), Sensitivity and Specificity, Serology, Severe Acute Respiratory Syndrome (immunology), Severe acute respiratory syndrome.
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin G.
- chemical , immunology : Nucleocapsid Proteins, Recombinant Proteins.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- methods : Enzyme-Linked Immunosorbent Assay.
- Teeft :
- Adolescent, Adult, Antibody response, Assay, Chan, Child, Child, Preschool, Chinese university, Clin, Clin diagn, Coronavirus, Coronavirus nucleocapsid protein, Early samples, Elisarstm, Enzyme immunoassay, Female, Hong kong, Humans, Iggene, Immunoassay, Male, Novel coronavirus, Nucleocapsid, Nucleocapsid protein, Peiris, Recombinant, Respiratory syndrome, Respiratory syndrome coronavirus, Sars, Sars patients, Sensitivity and Specificity, Serum samples, Syndrome, Wales hospital, Wang.
Abstract
A high throughput accurate assay for anti‐SARS‐CoV IgG detection is needed for large‐scale epidemiological studies. The evaluation of a commercial recombinant nucleocapsid protein‐based microtitre plate enzyme immunoassay, ELISARS™ is described. The results on 150 sera from SARS patients and 450 sera from non‐SARS controls showed that this assay had a high level of sensitivity (96.2% for late serum samples) and specificity (97.8%). The performance and setup of this assay fulfills the requirement as a screening test for large‐scale studies. A vast majority of SARS patients developed antibodies against the nucleocapsid protein. In some patients (10/45), a high level of anti‐nucleocapsid antibody appeared very early in the course of the illness. In contrast, a minority (4 of 105 patients) never developed these antibodies. The implication of differences in antibody response to the nucleocapsid protein deserves further investigation. J. Med. Virol. 75:181–184, 2005. © 2004 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.20254
Affiliations:
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Ma</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Tam, Frankie C H" sort="Tam, Frankie C H" uniqKey="Tam F" first="Frankie C. H." last="Tam">Frankie C. H. 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Tam</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Lim, Pak Leong" sort="Lim, Pak Leong" uniqKey="Lim P" first="Pak Leong" last="Lim">Pak Leong Lim</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Clinical Immunology Unit, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">75</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="181">181</biblScope><biblScope unit="page" to="184">184</biblScope><biblScope unit="page-count">4</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-02">2005-02</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antibodies, Viral (blood)</term><term>Child</term><term>Child, Preschool</term><term>Coronavirus</term><term>Detection</term><term>Diagnosis</term><term>Enzyme</term><term>Enzyme immunoassay</term><term>Enzyme-Linked Immunosorbent Assay (methods)</term><term>Female</term><term>Humans</term><term>IgG</term><term>Immunoglobulin G (blood)</term><term>Male</term><term>Nucleocapsid</term><term>Nucleocapsid Proteins (immunology)</term><term>Recombinant Proteins (immunology)</term><term>Recombinant protein</term><term>SARS Virus (immunology)</term><term>Sensitivity and Specificity</term><term>Serology</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Anticorps antiviraux (sang)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Immunoglobuline G (sang)</term><term>Mâle</term><term>Protéines nucléocapside (immunologie)</term><term>Protéines recombinantes (immunologie)</term><term>Sensibilité et spécificité</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Test ELISA ()</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Nucleocapsid Proteins</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Protéines nucléocapside</term><term>Protéines recombinantes</term><term>Syndrome respiratoire aigu sévère</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Immunoglobuline G</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Diagnostic</term><term>Détection</term><term>Enzyme</term><term>IgG</term><term>Méthode immunoenzymatique</term><term>Nucléocapside</term><term>Protéine recombinante</term><term>Syndrome respiratoire aigu sévère</term><term>Sérologie</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antibody response</term><term>Assay</term><term>Chan</term><term>Child</term><term>Child, Preschool</term><term>Chinese university</term><term>Clin</term><term>Clin diagn</term><term>Coronavirus</term><term>Coronavirus nucleocapsid protein</term><term>Early samples</term><term>Elisarstm</term><term>Enzyme immunoassay</term><term>Female</term><term>Hong kong</term><term>Humans</term><term>Iggene</term><term>Immunoassay</term><term>Male</term><term>Novel coronavirus</term><term>Nucleocapsid</term><term>Nucleocapsid protein</term><term>Peiris</term><term>Recombinant</term><term>Respiratory syndrome</term><term>Respiratory syndrome coronavirus</term><term>Sars</term><term>Sars patients</term><term>Sensitivity and Specificity</term><term>Serum samples</term><term>Syndrome</term><term>Wales hospital</term><term>Wang</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sensibilité et spécificité</term><term>Test ELISA</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enzyme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A high throughput accurate assay for anti‐SARS‐CoV IgG detection is needed for large‐scale epidemiological studies. The evaluation of a commercial recombinant nucleocapsid protein‐based microtitre plate enzyme immunoassay, ELISARS™ is described. The results on 150 sera from SARS patients and 450 sera from non‐SARS controls showed that this assay had a high level of sensitivity (96.2% for late serum samples) and specificity (97.8%). The performance and setup of this assay fulfills the requirement as a screening test for large‐scale studies. A vast majority of SARS patients developed antibodies against the nucleocapsid protein. In some patients (10/45), a high level of anti‐nucleocapsid antibody appeared very early in the course of the illness. In contrast, a minority (4 of 105 patients) never developed these antibodies. The implication of differences in antibody response to the nucleocapsid protein deserves further investigation. J. Med. Virol. 75:181–184, 2005. © 2004 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name></noRegion><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name><name sortKey="Cheung, Jo L K" sort="Cheung, Jo L K" uniqKey="Cheung J" first="Jo L. K." last="Cheung">Jo L. K. Cheung</name><name sortKey="Hui, Mamie" sort="Hui, Mamie" uniqKey="Hui M" first="Mamie" last="Hui">Mamie Hui</name><name sortKey="Hui, Mamie" sort="Hui, Mamie" uniqKey="Hui M" first="Mamie" last="Hui">Mamie Hui</name><name sortKey="Leung, Danny T M" sort="Leung, Danny T M" uniqKey="Leung D" first="Danny T. M." last="Leung">Danny T. M. Leung</name><name sortKey="Lim, Pak Leong" sort="Lim, Pak Leong" uniqKey="Lim P" first="Pak Leong" last="Lim">Pak Leong Lim</name><name sortKey="Liu, Esther Y M" sort="Liu, Esther Y M" uniqKey="Liu E" first="Esther Y. M." last="Liu">Esther Y. M. Liu</name><name sortKey="Ma, C H" sort="Ma, C H" uniqKey="Ma C" first="C. H." last="Ma">C. H. Ma</name><name sortKey="Tam, Frankie C H" sort="Tam, Frankie C H" uniqKey="Tam F" first="Frankie C. H." last="Tam">Frankie C. H. Tam</name><name sortKey="Tam, John S" sort="Tam, John S" uniqKey="Tam J" first="John S." last="Tam">John S. Tam</name><name sortKey="Tam, John S" sort="Tam, John S" uniqKey="Tam J" first="John S." last="Tam">John S. Tam</name></country><country name="Hong Kong"><noRegion><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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