Coronaviruses post-SARS: update on replication and pathogenesis
Identifieur interne : 002B51 ( Main/Exploration ); précédent : 002B50; suivant : 002B52Coronaviruses post-SARS: update on replication and pathogenesis
Auteurs : Stanley Perlman ; Jason NetlandSource :
- Nature Reviews. Microbiology [ 1740-1526 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus (immunologie), Coronavirus (pathogénicité), Humains, Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Modèles biologiques, Réplication virale (physiologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie).
- MESH :
- immunologie : Coronavirus, Infections à coronavirus, Syndrome respiratoire aigu sévère.
- pathogénicité : Coronavirus.
- physiologie : Réplication virale.
- virologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Animaux, Humains, Modèles biologiques.
English descriptors
- KwdEn :
- MESH :
- immunology : Coronavirus, Coronavirus Infections, Severe Acute Respiratory Syndrome.
- pathogenicity : Coronavirus.
- physiology : Virus Replication.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Animals, Humans, Models, Biological.
Abstract
Coronaviruses are positive strand RNA viruses that cause disease in humans, and domestic and companion animals. They are most notorious for causing severe acute respiratory syndrome (SARS) outbreaks in 2002–2003. All coronaviruses follow the same basic strategy of replication. All coronaviruses encode 15 or 16 replicase related proteins, 4 or 5 structural proteins and 1–8 group-specific or accessory proteins. Many of the replicase proteins are assembled into replication machinery in double-membrane vesicles (DMVs) and on a reticular network of membranes that are derived from the endoplasmic reticulum. Coronaviruses are readily transmitted across species. This phenomenon was illustrated when the SARS-coronavirus crossed species from bats to intermediate hosts, such as palm civets, and then to humans. It also explains the large number of species, including humans, that are infected with viruses closely related to bovine coronavirus. In many coronavirus infections, disease severity increases during virus clearance, suggesting that the host immune response is both protective and pathogenic. Furthermore, inhibition of specific aspects of the immune response results in less severe disease and less tissue destruction, without diminishing the kinetics of virus clearance. Like all successful viruses, coronaviruses have evolved both passive and active mechanisms to evade the interferon response. Replication in DMVs may contribute to passive evasion of the innate immune response by making double-stranded RNA inaccessible to cellular sensors.
Url:
DOI: 10.1038/nrmicro2147
PubMed: 19430490
PubMed Central: 2830095
Affiliations:
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Microbiology</title><idno type="ISSN">1740-1526</idno><idno type="eISSN">1740-1534</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus (immunology)</term><term>Coronavirus (pathogenicity)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Models, Biological</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Virus Replication (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Coronavirus (immunologie)</term><term>Coronavirus (pathogénicité)</term><term>Humains</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (virologie)</term><term>Modèles biologiques</term><term>Réplication virale (physiologie)</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus</term><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus</term><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Réplication virale</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Models, Biological</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Modèles biologiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Key Points</title><p id="Par3"><list list-type="bullet"><list-item><p id="Par4">Coronaviruses are positive strand RNA viruses that cause disease in humans, and domestic and companion animals. They are most notorious for causing severe acute respiratory syndrome (SARS) outbreaks in 2002–2003. All coronaviruses follow the same basic strategy of replication.</p></list-item><list-item><p id="Par5">All coronaviruses encode 15 or 16 replicase related proteins, 4 or 5 structural proteins and 1–8 group-specific or accessory proteins. Many of the replicase proteins are assembled into replication machinery in double-membrane vesicles (DMVs) and on a reticular network of membranes that are derived from the endoplasmic reticulum.</p></list-item><list-item><p id="Par6">Coronaviruses are readily transmitted across species. This phenomenon was illustrated when the SARS-coronavirus crossed species from bats to intermediate hosts, such as palm civets, and then to humans. It also explains the large number of species, including humans, that are infected with viruses closely related to bovine coronavirus.</p></list-item><list-item><p id="Par7">In many coronavirus infections, disease severity increases during virus clearance, suggesting that the host immune response is both protective and pathogenic. Furthermore, inhibition of specific aspects of the immune response results in less severe disease and less tissue destruction, without diminishing the kinetics of virus clearance.</p></list-item><list-item><p id="Par8">Like all successful viruses, coronaviruses have evolved both passive and active mechanisms to evade the interferon response. Replication in DMVs may contribute to passive evasion of the innate immune response by making double-stranded RNA inaccessible to cellular sensors.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barcena, M" uniqKey="Barcena M">M Barcena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neuman, Bw" uniqKey="Neuman B">BW Neuman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Masters, Ps" uniqKey="Masters P">PS Masters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lissenberg, A" uniqKey="Lissenberg A">A Lissenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemmila, E" uniqKey="Hemmila E">E Hemmila</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofmann, H" uniqKey="Hofmann H">H Hofmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuba, K" uniqKey="Kuba K">K Kuba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imai, Y" uniqKey="Imai Y">Y Imai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ning, Q" uniqKey="Ning Q">Q Ning</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name></author><author><name sortKey="Chen, Yg" uniqKey="Chen Y">YG Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dediego, Ml" uniqKey="Dediego M">ML DeDiego</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuo, L" uniqKey="Kuo L">L Kuo</name></author><author><name sortKey="Masters, Ps" uniqKey="Masters P">PS Masters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ortego, J" uniqKey="Ortego J">J Ortego</name></author><author><name sortKey="Ceriani, Je" uniqKey="Ceriani J">JE Ceriani</name></author><author><name sortKey="Patino, C" uniqKey="Patino C">C Patino</name></author><author><name sortKey="Plana, J" uniqKey="Plana J">J Plana</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madan, V" uniqKey="Madan V">V Madan</name></author><author><name sortKey="Garcia Mde, J" uniqKey="Garcia Mde J">J Garcia Mde</name></author><author><name sortKey="Sanz, Ma" uniqKey="Sanz M">MA Sanz</name></author><author><name sortKey="Carrasco, L" uniqKey="Carrasco L">L Carrasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mckinlay, C" uniqKey="Mckinlay C">C McKinlay</name></author><author><name sortKey="Gage, P" uniqKey="Gage P">P Gage</name></author><author><name sortKey="Ewart, G" uniqKey="Ewart G">G Ewart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ontiveros, E" uniqKey="Ontiveros E">E Ontiveros</name></author><author><name sortKey="Kuo, L" uniqKey="Kuo L">L Kuo</name></author><author><name sortKey="Masters, Ps" uniqKey="Masters P">PS Masters</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author><author><name sortKey="Masters, Ps" uniqKey="Masters P">PS Masters</name></author><author><name sortKey="Shen, X" uniqKey="Shen X">X Shen</name></author><author><name sortKey="Weiss, S" uniqKey="Weiss S">S Weiss</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fischer, F" uniqKey="Fischer F">F Fischer</name></author><author><name sortKey="Peng, D" uniqKey="Peng D">D Peng</name></author><author><name sortKey="Hingley, St" uniqKey="Hingley S">ST Hingley</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author><author><name sortKey="Masters, Ps" uniqKey="Masters P">PS Masters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Peters, Cj" uniqKey="Peters C">CJ Peters</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito, N" uniqKey="Ito N">N Ito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schaecher, Sr" uniqKey="Schaecher S">SR Schaecher</name></author><author><name sortKey="Mackenzie, Jm" uniqKey="Mackenzie J">JM Mackenzie</name></author><author><name sortKey="Pekosz, A" uniqKey="Pekosz A">A Pekosz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neuman, Bw" uniqKey="Neuman B">BW Neuman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sawicki, Sg" uniqKey="Sawicki S">SG Sawicki</name></author><author><name sortKey="Sawicki, Dl" uniqKey="Sawicki D">DL Sawicki</name></author><author><name sortKey="Siddell, Sg" uniqKey="Siddell S">SG Siddell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anand, K" uniqKey="Anand K">K Anand</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author><author><name sortKey="Wadhwani, P" uniqKey="Wadhwani P">P Wadhwani</name></author><author><name sortKey="Mesters, Jr" uniqKey="Mesters J">JR Mesters</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R Hilgenfeld</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhai, Y" uniqKey="Zhai Y">Y Zhai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A Chatterjee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joseph, Js" uniqKey="Joseph J">JS Joseph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joseph, Js" uniqKey="Joseph J">JS Joseph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peti, W" uniqKey="Peti W">W Peti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saikatendu, Ks" uniqKey="Saikatendu K">KS Saikatendu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Almeida, Ms" uniqKey="Almeida M">MS Almeida</name></author><author><name sortKey="Johnson, Ma" uniqKey="Johnson M">MA Johnson</name></author><author><name sortKey="Herrmann, T" uniqKey="Herrmann T">T Herrmann</name></author><author><name sortKey="Geralt, M" uniqKey="Geralt M">M Geralt</name></author><author><name sortKey="Wuthrich, K" uniqKey="Wuthrich K">K Wuthrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serrano, P" uniqKey="Serrano P">P Serrano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ricagno, S" uniqKey="Ricagno S">S Ricagno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, D" uniqKey="Su D">D Su</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imbert, I" uniqKey="Imbert I">I Imbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ratia, K" uniqKey="Ratia K">K Ratia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deming, Dj" uniqKey="Deming D">DJ Deming</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Egloff, Mp" uniqKey="Egloff M">MP Egloff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckerle, Ld" uniqKey="Eckerle L">LD Eckerle</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Sperry, Sm" uniqKey="Sperry S">SM Sperry</name></author><author><name sortKey="Choi, L" uniqKey="Choi L">L Choi</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ivanov, Ka" uniqKey="Ivanov K">KA Ivanov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decroly, E" uniqKey="Decroly E">E Decroly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prentice, E" uniqKey="Prentice E">E Prentice</name></author><author><name sortKey="Jerome, Wg" uniqKey="Jerome W">WG Jerome</name></author><author><name sortKey="Yoshimori, T" uniqKey="Yoshimori T">T Yoshimori</name></author><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N Mizushima</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bechill, J" uniqKey="Bechill J">J Bechill</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author><author><name sortKey="Brewer, Jw" uniqKey="Brewer J">JW Brewer</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knoops, K" uniqKey="Knoops K">K Knoops</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Van Tol, H" uniqKey="Van Tol H">H van Tol</name></author><author><name sortKey="Roos, N" uniqKey="Roos N">N Roos</name></author><author><name sortKey="Pedersen, Kw" uniqKey="Pedersen K">KW Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clementz, Ma" uniqKey="Clementz M">MA Clementz</name></author><author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A Kanjanahaluethai</name></author><author><name sortKey="O Brien, Te" uniqKey="O Brien T">TE O'Brien</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A Kanjanahaluethai</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author><author><name sortKey="Jukneliene, D" uniqKey="Jukneliene D">D Jukneliene</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oostra, M" uniqKey="Oostra M">M Oostra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oostra, M" uniqKey="Oostra M">M Oostra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garbino, J" uniqKey="Garbino J">J Garbino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, J" uniqKey="Gu J">J Gu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Hoek, L" uniqKey="Van Der Hoek L">L van der Hoek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K Pyrc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Hoek, L" uniqKey="Van Der Hoek L">L van der Hoek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="Nakamura, K" uniqKey="Nakamura K">K Nakamura</name></author><author><name sortKey="Schellen, P" uniqKey="Schellen P">P Schellen</name></author><author><name sortKey="Volders, H" uniqKey="Volders H">H Volders</name></author><author><name sortKey="Haijema, Bj" uniqKey="Haijema B">BJ Haijema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot Mijnes, Jd" uniqKey="De Groot Mijnes J">JD de Groot-Mijnes</name></author><author><name sortKey="Van Dun, Jm" uniqKey="Van Dun J">JM van Dun</name></author><author><name sortKey="Van Der Most, Rg" uniqKey="Van Der Most R">RG van der Most</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vennema, H" uniqKey="Vennema H">H Vennema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chinese, Smec" uniqKey="Chinese S">SMEC Chinese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, Hd" uniqKey="Song H">HD Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T Sheahan</name></author><author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name></author><author><name sortKey="Donaldson, E" uniqKey="Donaldson E">E Donaldson</name></author><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Baric, R" uniqKey="Baric R">R Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Dt" uniqKey="Leung D">DT Leung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Becker, Mm" uniqKey="Becker M">MM Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, W" uniqKey="Ren W">W Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijgen, L" uniqKey="Vijgen L">L Vijgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alekseev, Kp" uniqKey="Alekseev K">KP Alekseev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, L" uniqKey="Jin L">L Jin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lorusso, A" uniqKey="Lorusso A">A Lorusso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dominguez, Sr" uniqKey="Dominguez S">SR Dominguez</name></author><author><name sortKey="O Shea, Tj" uniqKey="O Shea T">TJ O'Shea</name></author><author><name sortKey="Oko, Lm" uniqKey="Oko L">LM Oko</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gloza Rausch, F" uniqKey="Gloza Rausch F">F Gloza-Rausch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dong, Bq" uniqKey="Dong B">BQ Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mihindukulasuriya, Ka" uniqKey="Mihindukulasuriya K">KA Mihindukulasuriya</name></author><author><name sortKey="Wu, G" uniqKey="Wu G">G Wu</name></author><author><name sortKey="St Leger, J" uniqKey="St Leger J">J St Leger</name></author><author><name sortKey="Nordhausen, Rw" uniqKey="Nordhausen R">RW Nordhausen</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Dandekar, Aa" uniqKey="Dandekar A">AA Dandekar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bergmann, Cc" uniqKey="Bergmann C">CC Bergmann</name></author><author><name sortKey="Lane, Te" uniqKey="Lane T">TE Lane</name></author><author><name sortKey="Stohlman, Sa" uniqKey="Stohlman S">SA Stohlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Savarin, C" uniqKey="Savarin C">C Savarin</name></author><author><name sortKey="Bergmann, Cc" uniqKey="Bergmann C">CC Bergmann</name></author><author><name sortKey="Hinton, Dr" uniqKey="Hinton D">DR Hinton</name></author><author><name sortKey="Ransohoff, Rm" uniqKey="Ransohoff R">RM Ransohoff</name></author><author><name sortKey="Stohlman, Sa" uniqKey="Stohlman S">SA Stohlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Ts" uniqKey="Kim T">TS Kim</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Ts" uniqKey="Kim T">TS Kim</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williamson, Js" uniqKey="Williamson J">JS Williamson</name></author><author><name sortKey="Stohlman, Sa" uniqKey="Stohlman S">SA Stohlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anghelina, D" uniqKey="Anghelina D">D Anghelina</name></author><author><name sortKey="Pewe, L" uniqKey="Pewe L">L Pewe</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deming, D" uniqKey="Deming D">D Deming</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Versteeg, Ga" uniqKey="Versteeg G">GA Versteeg</name></author><author><name sortKey="Bredenbeek, Pj" uniqKey="Bredenbeek P">PJ Bredenbeek</name></author><author><name sortKey="Van Den Worm, Sh" uniqKey="Van Den Worm S">SH van den Worm</name></author><author><name sortKey="Spaan, Wj" uniqKey="Spaan W">WJ Spaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spiegel, M" uniqKey="Spiegel M">M Spiegel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, R" uniqKey="He R">R He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kopecky Bromberg, Sa" uniqKey="Kopecky Bromberg S">SA Kopecky-Bromberg</name></author><author><name sortKey="Martinez Sobrido, L" uniqKey="Martinez Sobrido L">L Martinez-Sobrido</name></author><author><name sortKey="Frieman, M" uniqKey="Frieman M">M Frieman</name></author><author><name sortKey="Baric, Ra" uniqKey="Baric R">RA Baric</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ye, Y" uniqKey="Ye Y">Y Ye</name></author><author><name sortKey="Hauns, K" uniqKey="Hauns K">K Hauns</name></author><author><name sortKey="Langland, Jo" uniqKey="Langland J">JO Langland</name></author><author><name sortKey="Jacobs, Bl" uniqKey="Jacobs B">BL Jacobs</name></author><author><name sortKey="Hogue, Bg" uniqKey="Hogue B">BG Hogue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wathelet, Mg" uniqKey="Wathelet M">MG Wathelet</name></author><author><name sortKey="Orr, M" uniqKey="Orr M">M Orr</name></author><author><name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zust, R" uniqKey="Zust R">R Zust</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frieman, M" uniqKey="Frieman M">M Frieman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hussain, S" uniqKey="Hussain S">S Hussain</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamitani, W" uniqKey="Kamitani W">W Kamitani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devaraj, Sg" uniqKey="Devaraj S">SG Devaraj</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cameron, Mj" uniqKey="Cameron M">MJ Cameron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rempel, Jd" uniqKey="Rempel J">JD Rempel</name></author><author><name sortKey="Murray, Sj" uniqKey="Murray S">SJ Murray</name></author><author><name sortKey="Meisner, J" uniqKey="Meisner J">J Meisner</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ireland, Dd" uniqKey="Ireland D">DD Ireland</name></author><author><name sortKey="Stohlman, Sa" uniqKey="Stohlman S">SA Stohlman</name></author><author><name sortKey="Hinton, Dr" uniqKey="Hinton D">DR Hinton</name></author><author><name sortKey="Atkinson, R" uniqKey="Atkinson R">R Atkinson</name></author><author><name sortKey="Bergmann, Cc" uniqKey="Bergmann C">CC Bergmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cervantes Barragan, L" uniqKey="Cervantes Barragan L">L Cervantes-Barragan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roth Cross, Jk" uniqKey="Roth Cross J">JK Roth-Cross</name></author><author><name sortKey="Bender, Sj" uniqKey="Bender S">SJ Bender</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cervantes Barragan, L" uniqKey="Cervantes Barragan L">L Cervantes-Barragan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, L" uniqKey="He L">L He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Ck" uniqKey="Li C">CK Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, J" uniqKey="Gu J">J Gu</name></author><author><name sortKey="Korteweg, C" uniqKey="Korteweg C">C Korteweg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Netland, J" uniqKey="Netland J">J Netland</name></author><author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name></author><author><name sortKey="Moore, S" uniqKey="Moore S">S Moore</name></author><author><name sortKey="Cassell, M" uniqKey="Cassell M">M Cassell</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Dt" uniqKey="Lee D">DT Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagata, N" uniqKey="Nagata N">N Nagata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagata, N" uniqKey="Nagata N">N Nagata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Lang, A" uniqKey="De Lang A">A de Lang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baas, T" uniqKey="Baas T">T Baas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morahan, G" uniqKey="Morahan G">G Morahan</name></author><author><name sortKey="Balmer, L" uniqKey="Balmer L">L Balmer</name></author><author><name sortKey="Monley, D" uniqKey="Monley D">D Monley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stockman, Lj" uniqKey="Stockman L">LJ Stockman</name></author><author><name sortKey="Bellamy, R" uniqKey="Bellamy R">R Bellamy</name></author><author><name sortKey="Garner, P" uniqKey="Garner P">P Garner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gosert, R" uniqKey="Gosert R">R Gosert</name></author><author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A Kanjanahaluethai</name></author><author><name sortKey="Egger, D" uniqKey="Egger D">D Egger</name></author><author><name sortKey="Bienz, K" uniqKey="Bienz K">K Bienz</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Ostermann, J" uniqKey="Ostermann J">J Ostermann</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Netland, Jason" sort="Netland, Jason" uniqKey="Netland J" first="Jason" last="Netland">Jason Netland</name><name 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