Toward Automated Oligosaccharide Synthesis
Identifieur interne : 002195 ( Main/Exploration ); précédent : 002194; suivant : 002196Toward Automated Oligosaccharide Synthesis
Auteurs : Che-Hsiung Hsu [Taïwan] ; Shang-Cheng Hung [Taïwan] ; Chung-Yi Wu [Taïwan] ; Chi-Huey Wong [Taïwan, États-Unis]Source :
- Angewandte Chemie International Edition [ 1433-7851 ] ; 2011-12-09.
English descriptors
- Teeft :
- Ac2o, Acad, Academia, Acceptor, Acetal, Adjuvant, Angew, Anomeric, Biochem, Biol, Biotechnol, Blixt, Building blocks, Buskas, Carbohydr, Carbohydrate, Chem, Chemoenzymatic, Chemoenzymatic synthesis, Coli, Combinatorial, Commun, Crich, Curr, Danishefsky, Demchenko, Deprotection, Derivative, Disaccharide, Donor, Drug discovery, Dwek, Engl, Epitope, Equiv, Ester, Globo, Glycan, Glycan microarrays, Glycans, Glycobiology, Glycoconjugate, Glycoconjugates, Glycopeptide, Glycopeptides, Glycoprotein, Glycoside, Glycosidic, Glycosyl, Glycosyl donor, Glycosylation, Glycosyltransferases, Gmbh, Heparan, Heparin, Hexasaccharide, Huang, Hydroxy, Ichikawa, Immune, Immunogen, Immunogenic, Immunol, Kgaa, Kinase, Kulkarni, Kunz, Lett, Liang, Linker, Livingston, Microarray, Microarrays, Moiety, Monosaccharide, Muc1, Natl, Neu5, Nishimura, Oligomannose, Oligosaccharide, Oligosaccharide synthesis, Opin, Orthogonal, Paulson, Peptide, Polymer, Polysaccharide, Proc, Programmable, Programmable synthesis, Promoter, Ragupathi, Reactive, Receptor, Recombinant, Regeneration, Regioselective, Regioselective protection, Rrvs, Saccharide, Samain, Scanlan, Seeberger, Sialic, Sialosides, Sialyl, Sialylated, Stereoselective, Sulfate, Tacas, Takahashi, Tanaka, Tetrahedron, Tetrahedron lett, Tfoh, Thioglycoside, Thioglycosides, Tmsotf, Trisaccharide, Vaccine, Verlag, Verlag gmbh, Virol, Wang, Weinheim, Weinheim angew, Withers, Wong, Yamada, Yamamoto, Zhang.
Abstract
Carbohydrates have been shown to play important roles in biological processes. The pace of development in carbohydrate research is, however, relatively slow due to the problems associated with the complexity of carbohydrate structures and the lack of general synthetic methods and tools available for the study of this class of biomolecules. Recent advances in synthesis have demonstrated that many of these problems can be circumvented. In this Review, we describe the methods developed to tackle the problems of carbohydrate‐mediated biological processes, with particular focus on the issue related to the development of the automated synthesis of oligosaccharides. Further applications of carbohydrate microarrays and vaccines to human diseases are also highlighted.
Sweet dreams: Carbohydrates play important roles in biological processes. The pace of carbohydrate research is, however, relatively slow due, amongst other things, to the lack of general synthetic methods. Current developments in the automated synthesis of oligosaccharides can help overcome many of these problems and to pave the way for biomedical applications.
Url:
DOI: 10.1002/anie.201100125
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002051
- to stream Istex, to step Curation: 002051
- to stream Istex, to step Checkpoint: 000693
- to stream Main, to step Merge: 002223
- to stream Main, to step Curation: 002195
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Toward Automated Oligosaccharide Synthesis</title><author><name sortKey="Hsu, Che Siung" sort="Hsu, Che Siung" uniqKey="Hsu C" first="Che-Hsiung" last="Hsu">Che-Hsiung Hsu</name></author><author><name sortKey="Hung, Shang Heng" sort="Hung, Shang Heng" uniqKey="Hung S" first="Shang-Cheng" last="Hung">Shang-Cheng Hung</name></author><author><name sortKey="Wu, Chung I" sort="Wu, Chung I" uniqKey="Wu C" first="Chung-Yi" last="Wu">Chung-Yi Wu</name></author><author><name sortKey="Wong, Chi Uey" sort="Wong, Chi Uey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E00CD11961ED26FAF947E421500418F0F5FBDAA7</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/anie.201100125</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-R9C932RQ-J/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002051</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002051</idno><idno type="wicri:Area/Istex/Curation">002051</idno><idno type="wicri:Area/Istex/Checkpoint">000693</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000693</idno><idno type="wicri:doubleKey">1433-7851:2011:Hsu C:toward:automated:oligosaccharide</idno><idno type="wicri:Area/Main/Merge">002223</idno><idno type="wicri:Area/Main/Curation">002195</idno><idno type="wicri:Area/Main/Exploration">002195</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Toward Automated Oligosaccharide Synthesis</title><author><name sortKey="Hsu, Che Siung" sort="Hsu, Che Siung" uniqKey="Hsu C" first="Che-Hsiung" last="Hsu">Che-Hsiung Hsu</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang</wicri:regionArea><wicri:noRegion>Nankang</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Chemical Biology and Molecular Biophysics, Taiwan International Graduate Program</wicri:regionArea><wicri:noRegion>Taiwan International Graduate Program</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Institute of Bioinformatics and Structural Biology, National Tsing‐Hua University</wicri:regionArea><wicri:noRegion>National Tsing‐Hua University</wicri:noRegion></affiliation></author><author><name sortKey="Hung, Shang Heng" sort="Hung, Shang Heng" uniqKey="Hung S" first="Shang-Cheng" last="Hung">Shang-Cheng Hung</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang</wicri:regionArea><wicri:noRegion>Nankang</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Taïwan</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Correspondence address: The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang</wicri:regionArea><wicri:noRegion>Nankang</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Chung I" sort="Wu, Chung I" uniqKey="Wu C" first="Chung-Yi" last="Wu">Chung-Yi Wu</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang</wicri:regionArea><wicri:noRegion>Nankang</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Taïwan</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Correspondence address: The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang</wicri:regionArea><wicri:noRegion>Nankang</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Chi Uey" sort="Wong, Chi Uey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang</wicri:regionArea><wicri:noRegion>Nankang</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla</wicri:cityArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Taïwan</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Taïwan</country><wicri:regionArea>Correspondence address: The Genomics Research Center, Academia Sinica, Taiwan, 128 Academia Road, Section 2, Nankang</wicri:regionArea><wicri:noRegion>Nankang</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Angewandte Chemie International Edition</title><title level="j" type="alt">ANGEWANDTE CHEMIE INTERNATIONAL EDITION</title><idno type="ISSN">1433-7851</idno><idno type="eISSN">1521-3773</idno><imprint><biblScope unit="vol">50</biblScope><biblScope unit="issue">50</biblScope><biblScope unit="page" from="11872">11872</biblScope><biblScope unit="page" to="11923">11923</biblScope><biblScope unit="page-count">52</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2011-12-09">2011-12-09</date></imprint><idno type="ISSN">1433-7851</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1433-7851</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Ac2o</term><term>Acad</term><term>Academia</term><term>Acceptor</term><term>Acetal</term><term>Adjuvant</term><term>Angew</term><term>Anomeric</term><term>Biochem</term><term>Biol</term><term>Biotechnol</term><term>Blixt</term><term>Building blocks</term><term>Buskas</term><term>Carbohydr</term><term>Carbohydrate</term><term>Chem</term><term>Chemoenzymatic</term><term>Chemoenzymatic synthesis</term><term>Coli</term><term>Combinatorial</term><term>Commun</term><term>Crich</term><term>Curr</term><term>Danishefsky</term><term>Demchenko</term><term>Deprotection</term><term>Derivative</term><term>Disaccharide</term><term>Donor</term><term>Drug discovery</term><term>Dwek</term><term>Engl</term><term>Epitope</term><term>Equiv</term><term>Ester</term><term>Globo</term><term>Glycan</term><term>Glycan microarrays</term><term>Glycans</term><term>Glycobiology</term><term>Glycoconjugate</term><term>Glycoconjugates</term><term>Glycopeptide</term><term>Glycopeptides</term><term>Glycoprotein</term><term>Glycoside</term><term>Glycosidic</term><term>Glycosyl</term><term>Glycosyl donor</term><term>Glycosylation</term><term>Glycosyltransferases</term><term>Gmbh</term><term>Heparan</term><term>Heparin</term><term>Hexasaccharide</term><term>Huang</term><term>Hydroxy</term><term>Ichikawa</term><term>Immune</term><term>Immunogen</term><term>Immunogenic</term><term>Immunol</term><term>Kgaa</term><term>Kinase</term><term>Kulkarni</term><term>Kunz</term><term>Lett</term><term>Liang</term><term>Linker</term><term>Livingston</term><term>Microarray</term><term>Microarrays</term><term>Moiety</term><term>Monosaccharide</term><term>Muc1</term><term>Natl</term><term>Neu5</term><term>Nishimura</term><term>Oligomannose</term><term>Oligosaccharide</term><term>Oligosaccharide synthesis</term><term>Opin</term><term>Orthogonal</term><term>Paulson</term><term>Peptide</term><term>Polymer</term><term>Polysaccharide</term><term>Proc</term><term>Programmable</term><term>Programmable synthesis</term><term>Promoter</term><term>Ragupathi</term><term>Reactive</term><term>Receptor</term><term>Recombinant</term><term>Regeneration</term><term>Regioselective</term><term>Regioselective protection</term><term>Rrvs</term><term>Saccharide</term><term>Samain</term><term>Scanlan</term><term>Seeberger</term><term>Sialic</term><term>Sialosides</term><term>Sialyl</term><term>Sialylated</term><term>Stereoselective</term><term>Sulfate</term><term>Tacas</term><term>Takahashi</term><term>Tanaka</term><term>Tetrahedron</term><term>Tetrahedron lett</term><term>Tfoh</term><term>Thioglycoside</term><term>Thioglycosides</term><term>Tmsotf</term><term>Trisaccharide</term><term>Vaccine</term><term>Verlag</term><term>Verlag gmbh</term><term>Virol</term><term>Wang</term><term>Weinheim</term><term>Weinheim angew</term><term>Withers</term><term>Wong</term><term>Yamada</term><term>Yamamoto</term><term>Zhang</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Carbohydrates have been shown to play important roles in biological processes. The pace of development in carbohydrate research is, however, relatively slow due to the problems associated with the complexity of carbohydrate structures and the lack of general synthetic methods and tools available for the study of this class of biomolecules. Recent advances in synthesis have demonstrated that many of these problems can be circumvented. In this Review, we describe the methods developed to tackle the problems of carbohydrate‐mediated biological processes, with particular focus on the issue related to the development of the automated synthesis of oligosaccharides. Further applications of carbohydrate microarrays and vaccines to human diseases are also highlighted.</div><div type="abstract" xml:lang="en">Sweet dreams: Carbohydrates play important roles in biological processes. The pace of carbohydrate research is, however, relatively slow due, amongst other things, to the lack of general synthetic methods. Current developments in the automated synthesis of oligosaccharides can help overcome many of these problems and to pave the way for biomedical applications.</div></front></TEI><affiliations><list><country><li>Taïwan</li><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="Taïwan"><noRegion><name sortKey="Hsu, Che Siung" sort="Hsu, Che Siung" uniqKey="Hsu C" first="Che-Hsiung" last="Hsu">Che-Hsiung Hsu</name></noRegion><name sortKey="Hsu, Che Siung" sort="Hsu, Che Siung" uniqKey="Hsu C" first="Che-Hsiung" last="Hsu">Che-Hsiung Hsu</name><name sortKey="Hsu, Che Siung" sort="Hsu, Che Siung" uniqKey="Hsu C" first="Che-Hsiung" last="Hsu">Che-Hsiung Hsu</name><name sortKey="Hung, Shang Heng" sort="Hung, Shang Heng" uniqKey="Hung S" first="Shang-Cheng" last="Hung">Shang-Cheng Hung</name><name sortKey="Hung, Shang Heng" sort="Hung, Shang Heng" uniqKey="Hung S" first="Shang-Cheng" last="Hung">Shang-Cheng Hung</name><name sortKey="Hung, Shang Heng" sort="Hung, Shang Heng" uniqKey="Hung S" first="Shang-Cheng" last="Hung">Shang-Cheng Hung</name><name sortKey="Wong, Chi Uey" sort="Wong, Chi Uey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name><name sortKey="Wong, Chi Uey" sort="Wong, Chi Uey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name><name sortKey="Wong, Chi Uey" sort="Wong, Chi Uey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name><name sortKey="Wu, Chung I" sort="Wu, Chung I" uniqKey="Wu C" first="Chung-Yi" last="Wu">Chung-Yi Wu</name><name sortKey="Wu, Chung I" sort="Wu, Chung I" uniqKey="Wu C" first="Chung-Yi" last="Wu">Chung-Yi Wu</name><name sortKey="Wu, Chung I" sort="Wu, Chung I" uniqKey="Wu C" first="Chung-Yi" last="Wu">Chung-Yi Wu</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Wong, Chi Uey" sort="Wong, Chi Uey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name></region><name sortKey="Wong, Chi Uey" sort="Wong, Chi Uey" uniqKey="Wong C" first="Chi-Huey" last="Wong">Chi-Huey Wong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002195 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002195 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E00CD11961ED26FAF947E421500418F0F5FBDAA7
|texte= Toward Automated Oligosaccharide Synthesis
}}
| This area was generated with Dilib version V0.6.33. |  |