Changes of Plasma Amino Acid Profile in Hemodialysis Patients
Identifieur interne : 005942 ( Main/Exploration ); précédent : 005941; suivant : 005943Changes of Plasma Amino Acid Profile in Hemodialysis Patients
Auteurs : Y. S. Shin [Corée du Sud] ; H. M. Cho [Corée du Sud] ; Y. O. Kim [Corée du Sud] ; Y. S. Kim [Corée du Sud] ; Y. S. Chang [Corée du Sud] ; M. D. Lee [Corée du Sud] ; B. K. Bang [Corée du Sud]Source :
- Hemodialysis International [ 1492-7535 ] ; 2004-01.
Abstract
Healthy nutritional status is crucial for obtaining favorable hemodialysis (HD) and transplantation results in chronic renal failure (CRF), because there is a high incidence of malnutrition in these patients. In addition, there is a remarkable loss of amino acids (AAs) during HD. Purpose: This study examined changes in the serum AA profiles of pre‐ and post‐HD in order to plan a strategy for providing nutritional support to patients on HD. Method: Twenty‐nine stable male patients on HD were enrolled in this study. The criteria for patient selection were urine output less than 200 mL/day, 3 times HD a week, and HD treatment for more than 12 months. Results: Total plasma AA concentrations of pre‐ and post‐HD were 2948.4 ± 543.1 and 2279.2 ± 400.8 mol/L, the difference being highly significant (p < 0.0001). There was also a significant decrease in the level of essential AAs (EAAs, 774.4 ± 163.8 vs. 643.4 ± 142.5 μmol/L, p < 0.0005) and non‐EAAs (2019.0 ± 411.7 vs. 1539.6 ± 278.3 μmol/L, p < 0.0001) after HD. The ratio of the EAAs to the non‐EAAs increased after HD (0.39 ± 0.07 vs. 0.42 ± 0.07 μmol/L). The level of branched chain AAs (BCAAs) of pre‐ and post‐HD was 323.3 ± 73.7 vs. 286.7 ± 71.2 μmol/L and that of aromatic AAs (AAAs) was 180.9 ± 56.2 vs. 137.5 ± 42.6 μmol/L (p < 0.0005), and the BCCA to AAA ratio increased after HD (1.8 ± 0.41 vs. 2.2 ± 0.57 μmol/L, p = 0.01). Among the abnormal AAs which appear in CRF, the concentrations of β‐aminobutyric acid, citrulline, 1‐methyl histidine, phophoserine, and taurine decreased significantly after HD. Conclusion: Patients revealed a large loss of AAs including abnormal‐appearing AAs during HD. The ratios of EAA to non‐EAA and BCAA to AAA increase significantly, which indicates the beneficial effect of HD on the metabolic recovery of the AA profile. But replacing AAs, especially EAAs with high BCAAs, is essential for maintaining nutritional status to compensate the significant loss of AAs during HD.
Url:
DOI: 10.1111/j.1492-7535.2004.0085bk.x
Affiliations:
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Bang</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Internal Medicine and General Surgery, The Catholic University of Korea, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Hemodialysis International</title><title level="j" type="alt">HEMODIALYSIS INTERNATIONAL</title><idno type="ISSN">1492-7535</idno><idno type="eISSN">1542-4758</idno><imprint><biblScope unit="vol">8</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="102">102</biblScope><biblScope unit="page" to="102">102</biblScope><biblScope unit="page-count">100</biblScope><publisher>Blackwell Science Inc</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2004-01">2004-01</date></imprint><idno type="ISSN">1492-7535</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1492-7535</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Healthy nutritional status is crucial for obtaining favorable hemodialysis (HD) and transplantation results in chronic renal failure (CRF), because there is a high incidence of malnutrition in these patients. In addition, there is a remarkable loss of amino acids (AAs) during HD. Purpose: This study examined changes in the serum AA profiles of pre‐ and post‐HD in order to plan a strategy for providing nutritional support to patients on HD. Method: Twenty‐nine stable male patients on HD were enrolled in this study. The criteria for patient selection were urine output less than 200 mL/day, 3 times HD a week, and HD treatment for more than 12 months. Results: Total plasma AA concentrations of pre‐ and post‐HD were 2948.4 ± 543.1 and 2279.2 ± 400.8 mol/L, the difference being highly significant (p < 0.0001). There was also a significant decrease in the level of essential AAs (EAAs, 774.4 ± 163.8 vs. 643.4 ± 142.5 μmol/L, p < 0.0005) and non‐EAAs (2019.0 ± 411.7 vs. 1539.6 ± 278.3 μmol/L, p < 0.0001) after HD. The ratio of the EAAs to the non‐EAAs increased after HD (0.39 ± 0.07 vs. 0.42 ± 0.07 μmol/L). The level of branched chain AAs (BCAAs) of pre‐ and post‐HD was 323.3 ± 73.7 vs. 286.7 ± 71.2 μmol/L and that of aromatic AAs (AAAs) was 180.9 ± 56.2 vs. 137.5 ± 42.6 μmol/L (p < 0.0005), and the BCCA to AAA ratio increased after HD (1.8 ± 0.41 vs. 2.2 ± 0.57 μmol/L, p = 0.01). Among the abnormal AAs which appear in CRF, the concentrations of β‐aminobutyric acid, citrulline, 1‐methyl histidine, phophoserine, and taurine decreased significantly after HD. Conclusion: Patients revealed a large loss of AAs including abnormal‐appearing AAs during HD. The ratios of EAA to non‐EAA and BCAA to AAA increase significantly, which indicates the beneficial effect of HD on the metabolic recovery of the AA profile. But replacing AAs, especially EAAs with high BCAAs, is essential for maintaining nutritional status to compensate the significant loss of AAs during HD.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Shin, Y S" sort="Shin, Y S" uniqKey="Shin Y" first="Y. S." last="Shin">Y. S. Shin</name></region><name sortKey="Bang, B K" sort="Bang, B K" uniqKey="Bang B" first="B. K." last="Bang">B. K. Bang</name><name sortKey="Chang, Y S" sort="Chang, Y S" uniqKey="Chang Y" first="Y. S." last="Chang">Y. S. Chang</name><name sortKey="Cho, H M" sort="Cho, H M" uniqKey="Cho H" first="H. M." last="Cho">H. M. Cho</name><name sortKey="Kim, Y O" sort="Kim, Y O" uniqKey="Kim Y" first="Y. O." last="Kim">Y. O. Kim</name><name sortKey="Kim, Y S" sort="Kim, Y S" uniqKey="Kim Y" first="Y. S." last="Kim">Y. S. Kim</name><name sortKey="Lee, M D" sort="Lee, M D" uniqKey="Lee M" first="M. D." last="Lee">M. D. Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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