A new lignan glycoside and phenylethanoid glycosides from Strobilanthes cusia BREMEK.
Identifieur interne : 005490 ( Main/Exploration ); précédent : 005489; suivant : 005491A new lignan glycoside and phenylethanoid glycosides from Strobilanthes cusia BREMEK.
Auteurs : Tomonori Tanaka [Japon] ; Tsuyoshi Ikeda ; Miho Kaku ; Xing-Hua Zhu ; Masafumi Okawa ; Kazumi Yokomizo ; Masaru Uyeda ; Toshihiro NoharaSource :
- Chemical & pharmaceutical bulletin [ 0009-2363 ] ; 2004.
Descripteurs français
- KwdFr :
- Acanthaceae, Animaux, Antiviraux (), Antiviraux (isolement et purification), Antiviraux (pharmacologie), Cellules Vero, Herpèsvirus humain de type 1 (), Hétérosides (), Hétérosides (isolement et purification), Hétérosides (pharmacologie), Lignanes (), Lignanes (isolement et purification), Lignanes (pharmacologie), Médicaments issus de plantes chinoises (), Médicaments issus de plantes chinoises (isolement et purification), Médicaments issus de plantes chinoises (pharmacologie), Phénylpropionates (), Phénylpropionates (isolement et purification), Phénylpropionates (pharmacologie), Racines de plante, Spectroscopie par résonance magnétique, Stéréoisomérie.
- MESH :
- isolement et purification : Antiviraux, Hétérosides, Lignanes, Médicaments issus de plantes chinoises, Phénylpropionates.
- pharmacologie : Antiviraux, Hétérosides, Lignanes, Médicaments issus de plantes chinoises, Phénylpropionates.
- Acanthaceae, Animaux, Antiviraux, Cellules Vero, Herpèsvirus humain de type 1, Hétérosides, Lignanes, Médicaments issus de plantes chinoises, Phénylpropionates, Racines de plante, Spectroscopie par résonance magnétique, Stéréoisomérie.
English descriptors
- KwdEn :
- Acanthaceae, Animals, Antiviral Agents (chemistry), Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Chlorocebus aethiops, Drugs, Chinese Herbal (chemistry), Drugs, Chinese Herbal (isolation & purification), Drugs, Chinese Herbal (pharmacology), Glycosides (chemistry), Glycosides (isolation & purification), Glycosides (pharmacology), Herpesvirus 1, Human (drug effects), Lignans (chemistry), Lignans (isolation & purification), Lignans (pharmacology), Magnetic Resonance Spectroscopy, Phenylpropionates (chemistry), Phenylpropionates (isolation & purification), Phenylpropionates (pharmacology), Plant Roots, Stereoisomerism, Vero Cells.
- MESH :
- chemical , chemistry : Antiviral Agents, Drugs, Chinese Herbal, Glycosides, Lignans, Phenylpropionates.
- chemical , isolation & purification : Antiviral Agents, Drugs, Chinese Herbal, Glycosides, Lignans, Phenylpropionates.
- chemical , pharmacology : Antiviral Agents, Drugs, Chinese Herbal, Glycosides, Lignans, Phenylpropionates.
- drug effects : Herpesvirus 1, Human.
- Acanthaceae, Animals, Chlorocebus aethiops, Magnetic Resonance Spectroscopy, Plant Roots, Stereoisomerism, Vero Cells.
Abstract
The root of Strobilanthes cusia BREMEK. (Acanthaceae), popularly known as Da-Ching-Yeh, has been commonly used in traditional Chinese medicine. It is used to treat influenza, epidemic cerebrospinal meningitis, encephalitis B, viral pneumonia, mumps, and severe acute respiratory syndrome (SARS). In this study, we found a new lignan glycoside (6) and two new phenylethanoid glycosides (7, 8) together with five known compounds as chemical constituents of Strobilanthes cusia root. Some samples were examined for anti-herpes simplex virus type-1 (HSV-1) activity. Among the tested samples, lupeol showed anti-HSV-1 activity (EC(50): 11.7 microM) and showed 100% inhibition of virus plaque formation at 58.7 microM.
DOI: 10.1248/cpb.52.1242
PubMed: 15467245
Affiliations:
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first="Kazumi" last="Yokomizo">Kazumi Yokomizo</name></author><author><name sortKey="Uyeda, Masaru" sort="Uyeda, Masaru" uniqKey="Uyeda M" first="Masaru" last="Uyeda">Masaru Uyeda</name></author><author><name sortKey="Nohara, Toshihiro" sort="Nohara, Toshihiro" uniqKey="Nohara T" first="Toshihiro" last="Nohara">Toshihiro Nohara</name></author></analytic><series><title level="j">Chemical & pharmaceutical bulletin</title><idno type="ISSN">0009-2363</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acanthaceae</term><term>Animals</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (isolation & purification)</term><term>Antiviral Agents (pharmacology)</term><term>Chlorocebus aethiops</term><term>Drugs, Chinese Herbal (chemistry)</term><term>Drugs, Chinese Herbal (isolation & purification)</term><term>Drugs, Chinese Herbal (pharmacology)</term><term>Glycosides (chemistry)</term><term>Glycosides (isolation & purification)</term><term>Glycosides (pharmacology)</term><term>Herpesvirus 1, Human (drug effects)</term><term>Lignans (chemistry)</term><term>Lignans (isolation & purification)</term><term>Lignans (pharmacology)</term><term>Magnetic Resonance Spectroscopy</term><term>Phenylpropionates (chemistry)</term><term>Phenylpropionates (isolation & purification)</term><term>Phenylpropionates (pharmacology)</term><term>Plant Roots</term><term>Stereoisomerism</term><term>Vero Cells</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acanthaceae</term><term>Animaux</term><term>Antiviraux ()</term><term>Antiviraux (isolement et purification)</term><term>Antiviraux (pharmacologie)</term><term>Cellules Vero</term><term>Herpèsvirus humain de type 1 ()</term><term>Hétérosides ()</term><term>Hétérosides (isolement et purification)</term><term>Hétérosides (pharmacologie)</term><term>Lignanes ()</term><term>Lignanes (isolement et purification)</term><term>Lignanes (pharmacologie)</term><term>Médicaments issus de plantes chinoises ()</term><term>Médicaments issus de plantes chinoises (isolement et purification)</term><term>Médicaments issus de plantes chinoises (pharmacologie)</term><term>Phénylpropionates ()</term><term>Phénylpropionates (isolement et purification)</term><term>Phénylpropionates (pharmacologie)</term><term>Racines de plante</term><term>Spectroscopie par résonance magnétique</term><term>Stéréoisomérie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term><term>Drugs, Chinese Herbal</term><term>Glycosides</term><term>Lignans</term><term>Phenylpropionates</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antiviral Agents</term><term>Drugs, Chinese Herbal</term><term>Glycosides</term><term>Lignans</term><term>Phenylpropionates</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Drugs, Chinese Herbal</term><term>Glycosides</term><term>Lignans</term><term>Phenylpropionates</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Herpesvirus 1, Human</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antiviraux</term><term>Hétérosides</term><term>Lignanes</term><term>Médicaments issus de plantes chinoises</term><term>Phénylpropionates</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Hétérosides</term><term>Lignanes</term><term>Médicaments issus de plantes chinoises</term><term>Phénylpropionates</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acanthaceae</term><term>Animals</term><term>Chlorocebus aethiops</term><term>Magnetic Resonance Spectroscopy</term><term>Plant Roots</term><term>Stereoisomerism</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acanthaceae</term><term>Animaux</term><term>Antiviraux</term><term>Cellules Vero</term><term>Herpèsvirus humain de type 1</term><term>Hétérosides</term><term>Lignanes</term><term>Médicaments issus de plantes chinoises</term><term>Phénylpropionates</term><term>Racines de plante</term><term>Spectroscopie par résonance magnétique</term><term>Stéréoisomérie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The root of Strobilanthes cusia BREMEK. (Acanthaceae), popularly known as Da-Ching-Yeh, has been commonly used in traditional Chinese medicine. It is used to treat influenza, epidemic cerebrospinal meningitis, encephalitis B, viral pneumonia, mumps, and severe acute respiratory syndrome (SARS). In this study, we found a new lignan glycoside (6) and two new phenylethanoid glycosides (7, 8) together with five known compounds as chemical constituents of Strobilanthes cusia root. Some samples were examined for anti-herpes simplex virus type-1 (HSV-1) activity. Among the tested samples, lupeol showed anti-HSV-1 activity (EC(50): 11.7 microM) and showed 100% inhibition of virus plaque formation at 58.7 microM.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Ikeda, Tsuyoshi" sort="Ikeda, Tsuyoshi" uniqKey="Ikeda T" first="Tsuyoshi" last="Ikeda">Tsuyoshi Ikeda</name><name sortKey="Kaku, Miho" sort="Kaku, Miho" uniqKey="Kaku M" first="Miho" last="Kaku">Miho Kaku</name><name sortKey="Nohara, Toshihiro" sort="Nohara, Toshihiro" uniqKey="Nohara T" first="Toshihiro" last="Nohara">Toshihiro Nohara</name><name sortKey="Okawa, Masafumi" sort="Okawa, Masafumi" uniqKey="Okawa M" first="Masafumi" last="Okawa">Masafumi Okawa</name><name sortKey="Uyeda, Masaru" sort="Uyeda, Masaru" uniqKey="Uyeda M" first="Masaru" last="Uyeda">Masaru Uyeda</name><name sortKey="Yokomizo, Kazumi" sort="Yokomizo, Kazumi" uniqKey="Yokomizo K" first="Kazumi" last="Yokomizo">Kazumi Yokomizo</name><name sortKey="Zhu, Xing Hua" sort="Zhu, Xing Hua" uniqKey="Zhu X" first="Xing-Hua" last="Zhu">Xing-Hua Zhu</name></noCountry><country name="Japon"><noRegion><name sortKey="Tanaka, Tomonori" sort="Tanaka, Tomonori" uniqKey="Tanaka T" first="Tomonori" last="Tanaka">Tomonori Tanaka</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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