An indolent case of severe acute respiratory syndrome.
Identifieur interne : 005472 ( Main/Exploration ); précédent : 005471; suivant : 005473An indolent case of severe acute respiratory syndrome.
Auteurs : Man-Fai Lam [République populaire de Chine] ; Gaik C. Ooi ; Bing Lam ; James C. Ho ; Wing H. Seto ; Pak L. Ho ; Poon C. Wong ; Raymond Liang ; Wah K. Lam ; Kenneth W. TsangSource :
- American journal of respiratory and critical care medicine [ 1073-449X ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Antibactériens, Association de médicaments (administration et posologie), Femelle, Humains, Indice de gravité médicale, Leucémie aigüe myéloïde (), Leucémie aigüe myéloïde (diagnostic), Radiographie thoracique, Sujet immunodéprimé, Syndrome respiratoire aigu sévère (diagnostic), Syndrome respiratoire aigu sévère (traitement médicamenteux), Tomodensitométrie, Transplantation de moelle osseuse (immunologie), Virus du SRAS (isolement et purification), Études de suivi, Évaluation des risques.
- MESH :
- administration et posologie : Association de médicaments.
- diagnostic : Leucémie aigüe myéloïde, Syndrome respiratoire aigu sévère.
- immunologie : Transplantation de moelle osseuse.
- isolement et purification : Virus du SRAS.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- Adulte d'âge moyen, Antibactériens, Femelle, Humains, Indice de gravité médicale, Leucémie aigüe myéloïde, Radiographie thoracique, Sujet immunodéprimé, Tomodensitométrie, Études de suivi, Évaluation des risques.
English descriptors
- KwdEn :
- Anti-Bacterial Agents, Bone Marrow Transplantation (immunology), Drug Therapy, Combination (administration & dosage), Female, Follow-Up Studies, Humans, Immunocompromised Host, Leukemia, Myeloid, Acute (diagnosis), Leukemia, Myeloid, Acute (therapy), Middle Aged, Radiography, Thoracic, Risk Assessment, SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (drug therapy), Severity of Illness Index, Tomography, X-Ray Computed.
- MESH :
- chemical : Anti-Bacterial Agents.
- administration & dosage : Drug Therapy, Combination.
- diagnosis : Leukemia, Myeloid, Acute, Severe Acute Respiratory Syndrome.
- drug therapy : Severe Acute Respiratory Syndrome.
- immunology : Bone Marrow Transplantation.
- isolation & purification : SARS Virus.
- therapy : Leukemia, Myeloid, Acute.
- Female, Follow-Up Studies, Humans, Immunocompromised Host, Middle Aged, Radiography, Thoracic, Risk Assessment, Severity of Illness Index, Tomography, X-Ray Computed.
Abstract
Severe acute respiratory syndrome (SARS) is a highly contagious and typically rapidly progressive form of atypical pneumonia, which spread from Asia to many parts of the world in early 2003. Clinical diagnosis of SARS requires the presence of unremitting fever and progressive pneumonia despite antibiotic therapy, particularly in the presence of lymphopenia and raised transaminase levels. We report the case of a woman who had undergone a successful allogeneic bone marrow transplant for acute myeloid leukemia. She presented initially with fever and a normal chest radiograph. Her indolent clinical course of SARS was punctuated by resolution of fever, but there was progressive radiologic deterioration and increasing serum antibody titer against SARS coronavirus. Treatment with oral prednisolone and ribavirin normalized her lymphopenia, altered transaminases, chest radiograph and high-resolution computed tomography appearances rapidly. Our experience should alert other clinicians in recognizing this atypical indolent presentation of SARS, to protect health care workers and the community at large and to ensure that these patients are properly treated.
DOI: 10.1164/rccm.200306-754CR
PubMed: 14695107
Affiliations:
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Le document en format XML
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Ooi</name></author><author><name sortKey="Lam, Bing" sort="Lam, Bing" uniqKey="Lam B" first="Bing" last="Lam">Bing Lam</name></author><author><name sortKey="Ho, James C" sort="Ho, James C" uniqKey="Ho J" first="James C" last="Ho">James C. Ho</name></author><author><name sortKey="Seto, Wing H" sort="Seto, Wing H" uniqKey="Seto W" first="Wing H" last="Seto">Wing H. Seto</name></author><author><name sortKey="Ho, Pak L" sort="Ho, Pak L" uniqKey="Ho P" first="Pak L" last="Ho">Pak L. Ho</name></author><author><name sortKey="Wong, Poon C" sort="Wong, Poon C" uniqKey="Wong P" first="Poon C" last="Wong">Poon C. Wong</name></author><author><name sortKey="Liang, Raymond" sort="Liang, Raymond" uniqKey="Liang R" first="Raymond" last="Liang">Raymond Liang</name></author><author><name sortKey="Lam, Wah K" sort="Lam, Wah K" uniqKey="Lam W" first="Wah K" last="Lam">Wah K. Lam</name></author><author><name sortKey="Tsang, Kenneth W" sort="Tsang, Kenneth W" uniqKey="Tsang K" first="Kenneth W" last="Tsang">Kenneth W. 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Ooi</name></author><author><name sortKey="Lam, Bing" sort="Lam, Bing" uniqKey="Lam B" first="Bing" last="Lam">Bing Lam</name></author><author><name sortKey="Ho, James C" sort="Ho, James C" uniqKey="Ho J" first="James C" last="Ho">James C. Ho</name></author><author><name sortKey="Seto, Wing H" sort="Seto, Wing H" uniqKey="Seto W" first="Wing H" last="Seto">Wing H. Seto</name></author><author><name sortKey="Ho, Pak L" sort="Ho, Pak L" uniqKey="Ho P" first="Pak L" last="Ho">Pak L. Ho</name></author><author><name sortKey="Wong, Poon C" sort="Wong, Poon C" uniqKey="Wong P" first="Poon C" last="Wong">Poon C. Wong</name></author><author><name sortKey="Liang, Raymond" sort="Liang, Raymond" uniqKey="Liang R" first="Raymond" last="Liang">Raymond Liang</name></author><author><name sortKey="Lam, Wah K" sort="Lam, Wah K" uniqKey="Lam W" first="Wah K" last="Lam">Wah K. Lam</name></author><author><name sortKey="Tsang, Kenneth W" sort="Tsang, Kenneth W" uniqKey="Tsang K" first="Kenneth W" last="Tsang">Kenneth W. Tsang</name></author></analytic><series><title level="j">American journal of respiratory and critical care medicine</title><idno type="ISSN">1073-449X</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Bone Marrow Transplantation (immunology)</term><term>Drug Therapy, Combination (administration & dosage)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunocompromised Host</term><term>Leukemia, Myeloid, Acute (diagnosis)</term><term>Leukemia, Myeloid, Acute (therapy)</term><term>Middle Aged</term><term>Radiography, Thoracic</term><term>Risk Assessment</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Severity of Illness Index</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Antibactériens</term><term>Association de médicaments (administration et posologie)</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Leucémie aigüe myéloïde ()</term><term>Leucémie aigüe myéloïde (diagnostic)</term><term>Radiographie thoracique</term><term>Sujet immunodéprimé</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term><term>Tomodensitométrie</term><term>Transplantation de moelle osseuse (immunologie)</term><term>Virus du SRAS (isolement et purification)</term><term>Études de suivi</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Drug Therapy, Combination</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Association de médicaments</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Leukemia, Myeloid, Acute</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Leucémie aigüe myéloïde</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Transplantation de moelle osseuse</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bone Marrow Transplantation</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Leukemia, Myeloid, Acute</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunocompromised Host</term><term>Middle Aged</term><term>Radiography, Thoracic</term><term>Risk Assessment</term><term>Severity of Illness Index</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Antibactériens</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Leucémie aigüe myéloïde</term><term>Radiographie thoracique</term><term>Sujet immunodéprimé</term><term>Tomodensitométrie</term><term>Études de suivi</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is a highly contagious and typically rapidly progressive form of atypical pneumonia, which spread from Asia to many parts of the world in early 2003. Clinical diagnosis of SARS requires the presence of unremitting fever and progressive pneumonia despite antibiotic therapy, particularly in the presence of lymphopenia and raised transaminase levels. We report the case of a woman who had undergone a successful allogeneic bone marrow transplant for acute myeloid leukemia. She presented initially with fever and a normal chest radiograph. Her indolent clinical course of SARS was punctuated by resolution of fever, but there was progressive radiologic deterioration and increasing serum antibody titer against SARS coronavirus. Treatment with oral prednisolone and ribavirin normalized her lymphopenia, altered transaminases, chest radiograph and high-resolution computed tomography appearances rapidly. Our experience should alert other clinicians in recognizing this atypical indolent presentation of SARS, to protect health care workers and the community at large and to ensure that these patients are properly treated.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Ho, James C" sort="Ho, James C" uniqKey="Ho J" first="James C" last="Ho">James C. Ho</name><name sortKey="Ho, Pak L" sort="Ho, Pak L" uniqKey="Ho P" first="Pak L" last="Ho">Pak L. Ho</name><name sortKey="Lam, Bing" sort="Lam, Bing" uniqKey="Lam B" first="Bing" last="Lam">Bing Lam</name><name sortKey="Lam, Wah K" sort="Lam, Wah K" uniqKey="Lam W" first="Wah K" last="Lam">Wah K. Lam</name><name sortKey="Liang, Raymond" sort="Liang, Raymond" uniqKey="Liang R" first="Raymond" last="Liang">Raymond Liang</name><name sortKey="Ooi, Gaik C" sort="Ooi, Gaik C" uniqKey="Ooi G" first="Gaik C" last="Ooi">Gaik C. Ooi</name><name sortKey="Seto, Wing H" sort="Seto, Wing H" uniqKey="Seto W" first="Wing H" last="Seto">Wing H. Seto</name><name sortKey="Tsang, Kenneth W" sort="Tsang, Kenneth W" uniqKey="Tsang K" first="Kenneth W" last="Tsang">Kenneth W. Tsang</name><name sortKey="Wong, Poon C" sort="Wong, Poon C" uniqKey="Wong P" first="Poon C" last="Wong">Poon C. Wong</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Lam, Man Fai" sort="Lam, Man Fai" uniqKey="Lam M" first="Man-Fai" last="Lam">Man-Fai Lam</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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