Evolutional insights on uncharacterized SARS coronavirus genes
Identifieur interne : 005360 ( Main/Exploration ); précédent : 005359; suivant : 005361Evolutional insights on uncharacterized SARS coronavirus genes
Auteurs : Alex Inberg ; Michal LinialSource :
- Febs Letters [ 0014-5793 ] ; 2004.
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- MESH :
English descriptors
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- MESH :
Abstract
The complete genome of the severe acute respiratory syndrome coronavirus (SARS‐CoV) and many of its variants has been determined by several laboratories. The genome contains fourteen predicted open reading frames (ORFs). However, a function had been clearly assigned for only six of these ORFs, in the viral replication, transcription and structural constituents. The others are herein referred to as uncharacterized ORFs (UC‐ORFs). Here, we try to provide a relational insight on those UC‐ORFs, suggesting that a number of them are remotely related to structural proteins of coronaviruses and other viruses infecting mammalian hosts. Surprisingly, several of the UC‐ORFs exhibit considerable similarity with other SARS‐CoV ORFs. These observations may provide clues on the evolution and genome dynamics of the SARS‐CoV.
Url:
DOI: 10.1016/j.febslet.2004.09.076
PubMed: 15527778
PubMed Central: 7125658
Affiliations:
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<term>Données de séquences moléculaires</term>
<term>Gènes viraux</term>
<term>Similitude de séquences d'acides aminés</term>
<term>Séquence d'acides aminés</term>
<term>Virus du SRAS (génétique)</term>
<term>Évolution biologique</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term>
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<front><div type="abstract" xml:lang="en"><p>The complete genome of the severe acute respiratory syndrome coronavirus (SARS‐CoV) and many of its variants has been determined by several laboratories. The genome contains fourteen predicted open reading frames (ORFs). However, a function had been clearly assigned for only six of these ORFs, in the viral replication, transcription and structural constituents. The others are herein referred to as uncharacterized ORFs (UC‐ORFs). Here, we try to provide a relational insight on those UC‐ORFs, suggesting that a number of them are remotely related to structural proteins of coronaviruses and other viruses infecting mammalian hosts. Surprisingly, several of the UC‐ORFs exhibit considerable similarity with other SARS‐CoV ORFs. These observations may provide clues on the evolution and genome dynamics of the SARS‐CoV.</p>
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