SrasV1, Main, Exploration, bibRecord, 004D57

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

Identifieur interne : 004D57 ( Main/Exploration ); précédent : 004D56; suivant : 004D58

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

Auteurs : FANG LI [États-Unis] ; WENHUI LI [États-Unis] ; Michael Farzan [États-Unis] ; Stephen C. Harrison [États-Unis]

Source :

Science : (Washington, D.C.) [ 0036-8075 ] ; 2005.

RBID : Pascal:05-0468606

Descripteurs français

Pascal (Inist)
- Virus syndrome respiratoire aigu sévère, Récepteur biologique, Protéine, Spicule, Site fixation, Analyse structurale, Relation structure propriété.

English descriptors

KwdEn :
- Binding site, Biological receptor, Property structure relationship, Protein, Severe acute respiratory syndrome virus, Spicule, Structural analysis.

Abstract

The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the RBD bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase. The atomic details at the interface between the two proteins clarify the importance of residue changes that facilitate efficient cross-species infection and human-to-human transmission. The structure of the RBD suggests ways to make truncated disulfide-stabilized RBD variants for use in the design of coronavirus vaccines.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000588
to stream PascalFrancis, to step Curation: 000402
to stream PascalFrancis, to step Checkpoint: 000566
to stream Main, to step Merge: 005086
to stream Main, to step Curation: 004D57

Le document en format XML

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<s3>USA</s3>
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<term>Récepteur biologique</term>
<term>Protéine</term>
<term>Spicule</term>
<term>Site fixation</term>
<term>Analyse structurale</term>
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<front><div type="abstract" xml:lang="en">The spike protein (S) of SARS coronavirus (SARS-CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the RBD bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the N-terminal lobe of the peptidase. The atomic details at the interface between the two proteins clarify the importance of residue changes that facilitate efficient cross-species infection and human-to-human transmission. The structure of the RBD suggests ways to make truncated disulfide-stabilized RBD variants for use in the design of coronavirus vaccines.</div>
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<region><li>Massachusetts</li>
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<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Fang Li" sort="Fang Li" uniqKey="Fang Li" last="Fang Li">FANG LI</name>
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<name sortKey="Farzan, Michael" sort="Farzan, Michael" uniqKey="Farzan M" first="Michael" last="Farzan">Michael Farzan</name>
<name sortKey="Harrison, Stephen C" sort="Harrison, Stephen C" uniqKey="Harrison S" first="Stephen C." last="Harrison">Stephen C. Harrison</name>
<name sortKey="Harrison, Stephen C" sort="Harrison, Stephen C" uniqKey="Harrison S" first="Stephen C." last="Harrison">Stephen C. Harrison</name>
<name sortKey="Wenhui Li" sort="Wenhui Li" uniqKey="Wenhui Li" last="Wenhui Li">WENHUI LI</name>
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Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri