Experimental infection of macaques with the human reovirus BYD1 strain: an animal model for the study of the severe acute respiratory syndrome.
Identifieur interne : 004836 ( Main/Exploration ); précédent : 004835; suivant : 004837Experimental infection of macaques with the human reovirus BYD1 strain: an animal model for the study of the severe acute respiratory syndrome.
Auteurs : Cheng He [République populaire de Chine] ; Wanyong Pang ; Xinhao Yong ; Hong Zhu ; Ming Lei ; Qing DuanSource :
- DNA and cell biology [ 1044-5498 ] ; 2005.
Descripteurs français
- KwdFr :
- Alvéoles pulmonaires (anatomopathologie), Animaux, Anticorps antiviraux (sang), Cellules Vero, Femelle, Fièvre (anatomopathologie), Humains, Infections à Reoviridae (anatomopathologie), Infections à Reoviridae (immunologie), Lignée cellulaire tumorale, Macaca, Modèles animaux de maladie humaine, Mâle, Noeuds lymphatiques (anatomopathologie), Poumon (anatomopathologie), Rate (anatomopathologie), Reoviridae (immunologie), Reoviridae (isolement et purification), Reoviridae (pathogénicité), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie).
- MESH :
- anatomopathologie : Alvéoles pulmonaires, Fièvre, Infections à Reoviridae, Noeuds lymphatiques, Poumon, Rate, Syndrome respiratoire aigu sévère.
- immunologie : Infections à Reoviridae, Reoviridae, Syndrome respiratoire aigu sévère.
- isolement et purification : Reoviridae.
- pathogénicité : Reoviridae.
- sang : Anticorps antiviraux.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Cellules Vero, Femelle, Humains, Lignée cellulaire tumorale, Macaca, Modèles animaux de maladie humaine, Mâle.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Cell Line, Tumor, Chlorocebus aethiops, Disease Models, Animal, Female, Fever (pathology), Humans, Lung (pathology), Lymph Nodes (pathology), Macaca, Male, Pulmonary Alveoli (pathology), Reoviridae (immunology), Reoviridae (isolation & purification), Reoviridae (pathogenicity), Reoviridae Infections (immunology), Reoviridae Infections (pathology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Spleen (pathology), Vero Cells.
- MESH :
- chemical , blood : Antibodies, Viral.
- immunology : Reoviridae, Reoviridae Infections, Severe Acute Respiratory Syndrome.
- isolation & purification : Reoviridae.
- pathogenicity : Reoviridae.
- pathology : Fever, Lung, Lymph Nodes, Pulmonary Alveoli, Reoviridae Infections, Severe Acute Respiratory Syndrome, Spleen.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Cell Line, Tumor, Chlorocebus aethiops, Disease Models, Animal, Female, Humans, Macaca, Male, Vero Cells.
Abstract
Experimental studies were performed to determine the role of a newly isolated reovirus (ReoV) from a severe acute respiratory syndrome (SARS) patient in the etiology of this newly described serious respiratory syndrome. Four cynomologus macaques were inoculated with this reovirus (BYD1) in an attempt to replicate the infection and pathology observed in SARS. The body temperature of the infected monkeys was monitored three times a day, and blood and fecal samples were periodically collected for specific immunology determinations. On days 7 and 33 after inoculation, necropsies for pathological accessment and pathogen isolation were performed. The four infected macaques developed a fever on days 3 and 4 after inoculation, and maintainted a febrile state for 4-6 days. The highest temperature in the animals recorded was 40.4 degrees C. After a recovery phase, the macaques developed a second febrile condition. Antibody titers against the reovirus injected by the intravenous route occurred in higher number than those in the nasal cavity. Four macaque monkeys demonstrated diffuse alveolar damage, characterized by hemorrhagic pneumonia, serosanguineous exudates, formation of hyaline membranes, and type II pneumocyte hyperplasia, which were similar to those that have been noted in SARS patients. Lymphocytes decreased in the cortex of the lymph node and in the white pulp of the spleen. ReoV was detected in pneumonic tissue by virus isolation and RT-PCR. The macaques infected with the newly isolated reovirus developed a fever, diffuse alveolar damage and pulmonary interstitial inflammation similar to that noted in SARS patients. This evidence demonstrates that ReoV might have a primary role in the etiology of SARS.
DOI: 10.1089/dna.2005.24.491
PubMed: 16101346
Affiliations:
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Le document en format XML
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Four cynomologus macaques were inoculated with this reovirus (BYD1) in an attempt to replicate the infection and pathology observed in SARS. The body temperature of the infected monkeys was monitored three times a day, and blood and fecal samples were periodically collected for specific immunology determinations. On days 7 and 33 after inoculation, necropsies for pathological accessment and pathogen isolation were performed. The four infected macaques developed a fever on days 3 and 4 after inoculation, and maintainted a febrile state for 4-6 days. The highest temperature in the animals recorded was 40.4 degrees C. After a recovery phase, the macaques developed a second febrile condition. Antibody titers against the reovirus injected by the intravenous route occurred in higher number than those in the nasal cavity. Four macaque monkeys demonstrated diffuse alveolar damage, characterized by hemorrhagic pneumonia, serosanguineous exudates, formation of hyaline membranes, and type II pneumocyte hyperplasia, which were similar to those that have been noted in SARS patients. Lymphocytes decreased in the cortex of the lymph node and in the white pulp of the spleen. ReoV was detected in pneumonic tissue by virus isolation and RT-PCR. The macaques infected with the newly isolated reovirus developed a fever, diffuse alveolar damage and pulmonary interstitial inflammation similar to that noted in SARS patients. This evidence demonstrates that ReoV might have a primary role in the etiology of SARS.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Duan, Qing" sort="Duan, Qing" uniqKey="Duan Q" first="Qing" last="Duan">Qing Duan</name><name sortKey="Lei, Ming" sort="Lei, Ming" uniqKey="Lei M" first="Ming" last="Lei">Ming Lei</name><name sortKey="Pang, Wanyong" sort="Pang, Wanyong" uniqKey="Pang W" first="Wanyong" last="Pang">Wanyong Pang</name><name sortKey="Yong, Xinhao" sort="Yong, Xinhao" uniqKey="Yong X" first="Xinhao" last="Yong">Xinhao Yong</name><name sortKey="Zhu, Hong" sort="Zhu, Hong" uniqKey="Zhu H" first="Hong" last="Zhu">Hong Zhu</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="He, Cheng" sort="He, Cheng" uniqKey="He C" first="Cheng" last="He">Cheng He</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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