Interferon: ten stories in one. A short review of some of the highlights in the history of an almost quinquagenarian.
Identifieur interne : 004780 ( Main/Exploration ); précédent : 004779; suivant : 004781Interferon: ten stories in one. A short review of some of the highlights in the history of an almost quinquagenarian.
Auteurs : E. De Clercq [Belgique]Source :
- Acta microbiologica et immunologica Hungarica [ 1217-8950 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- histoire : Antiviraux, Interférons.
- usage thérapeutique : Antiviraux, Interférons.
- Animaux, Histoire du 20ème siècle, Humains, Souris.
English descriptors
- KwdEn :
- MESH :
- chemical , history : Antiviral Agents, Interferons.
- chemical , therapeutic use : Antiviral Agents, Interferons.
- Animals, History, 20th Century, Humans, Mice.
Abstract
This short review article on some pertinent observations in the unfolding story of interferon is dedicated to Professor Ilona Béládi on the occasion of her 80th birthday. This by no means covers the whole story on interferon. It just highlights some of the more striking findings made with interferon (or its inducers) over a time span of almost 50 years since its original discovery (in 1957) by Isaacs and Lindenmann. These observations concern (i) the induction of interferon by synthetic polyanions such as polyacrylic acid and polymethacrylic acid; (ii) the prolonged antiviral activity shown by polyacrylic acid in vivo; (iii) the interferon-inducing ability of double-stranded RNAs such as poly(I) x poly(C) and (iv) mismatched derivatives thereof (i.e. ampligen); (v) the cloning and expression of interferon-beta, and (vi) its usefulness in the treatment of multiple sclerosis; (vii) the potential of (pegylated) interferon-alpha in the treatment of hepatitis C and (viii) the therapy/prophylaxis of SARS; (ix) the efficacy of interferon (inducers) in the experimental treatment of flavivirus encephalitis and enterovirus myocarditis; and, finally, (x) the role of interferon in the activity shown by S-adenosylhomocysteine inhibitors such as 3-deazaneplanocin A against experimental Ebola virus infections in mice.
DOI: 10.1556/AMicr.52.2005.2.6
PubMed: 16400870
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002385
- to stream PubMed, to step Curation: 002385
- to stream PubMed, to step Checkpoint: 002644
- to stream Ncbi, to step Merge: 001331
- to stream Ncbi, to step Curation: 001331
- to stream Ncbi, to step Checkpoint: 001331
- to stream Main, to step Merge: 004A60
- to stream Main, to step Curation: 004780
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interferon: ten stories in one. A short review of some of the highlights in the history of an almost quinquagenarian.</title><author><name sortKey="De Clercq, E" sort="De Clercq, E" uniqKey="De Clercq E" first="E" last="De Clercq">E. De Clercq</name><affiliation wicri:level="1"><nlm:affiliation>Rega Institute for Medical Research, KU Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, KU Leuven</wicri:regionArea><wicri:noRegion>KU Leuven</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16400870</idno><idno type="pmid">16400870</idno><idno type="doi">10.1556/AMicr.52.2005.2.6</idno><idno type="wicri:Area/PubMed/Corpus">002385</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002385</idno><idno type="wicri:Area/PubMed/Curation">002385</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002385</idno><idno type="wicri:Area/PubMed/Checkpoint">002644</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002644</idno><idno type="wicri:Area/Ncbi/Merge">001331</idno><idno type="wicri:Area/Ncbi/Curation">001331</idno><idno type="wicri:Area/Ncbi/Checkpoint">001331</idno><idno type="wicri:doubleKey">1217-8950:2005:De Clercq E:interferon:ten:stories</idno><idno type="wicri:Area/Main/Merge">004A60</idno><idno type="wicri:Area/Main/Curation">004780</idno><idno type="wicri:Area/Main/Exploration">004780</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interferon: ten stories in one. A short review of some of the highlights in the history of an almost quinquagenarian.</title><author><name sortKey="De Clercq, E" sort="De Clercq, E" uniqKey="De Clercq E" first="E" last="De Clercq">E. De Clercq</name><affiliation wicri:level="1"><nlm:affiliation>Rega Institute for Medical Research, KU Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Rega Institute for Medical Research, KU Leuven</wicri:regionArea><wicri:noRegion>KU Leuven</wicri:noRegion></affiliation></author></analytic><series><title level="j">Acta microbiologica et immunologica Hungarica</title><idno type="ISSN">1217-8950</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (history)</term><term>Antiviral Agents (therapeutic use)</term><term>History, 20th Century</term><term>Humans</term><term>Interferons (history)</term><term>Interferons (therapeutic use)</term><term>Mice</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (histoire)</term><term>Antiviraux (usage thérapeutique)</term><term>Histoire du 20ème siècle</term><term>Humains</term><term>Interférons (histoire)</term><term>Interférons (usage thérapeutique)</term><term>Souris</term></keywords><keywords scheme="MESH" type="chemical" qualifier="history" xml:lang="en"><term>Antiviral Agents</term><term>Interferons</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Interferons</term></keywords><keywords scheme="MESH" qualifier="histoire" xml:lang="fr"><term>Antiviraux</term><term>Interférons</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Interférons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>History, 20th Century</term><term>Humans</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Histoire du 20ème siècle</term><term>Humains</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This short review article on some pertinent observations in the unfolding story of interferon is dedicated to Professor Ilona Béládi on the occasion of her 80th birthday. This by no means covers the whole story on interferon. It just highlights some of the more striking findings made with interferon (or its inducers) over a time span of almost 50 years since its original discovery (in 1957) by Isaacs and Lindenmann. These observations concern (i) the induction of interferon by synthetic polyanions such as polyacrylic acid and polymethacrylic acid; (ii) the prolonged antiviral activity shown by polyacrylic acid in vivo; (iii) the interferon-inducing ability of double-stranded RNAs such as poly(I) x poly(C) and (iv) mismatched derivatives thereof (i.e. ampligen); (v) the cloning and expression of interferon-beta, and (vi) its usefulness in the treatment of multiple sclerosis; (vii) the potential of (pegylated) interferon-alpha in the treatment of hepatitis C and (viii) the therapy/prophylaxis of SARS; (ix) the efficacy of interferon (inducers) in the experimental treatment of flavivirus encephalitis and enterovirus myocarditis; and, finally, (x) the role of interferon in the activity shown by S-adenosylhomocysteine inhibitors such as 3-deazaneplanocin A against experimental Ebola virus infections in mice.</div></front></TEI><affiliations><list><country><li>Belgique</li></country></list><tree><country name="Belgique"><noRegion><name sortKey="De Clercq, E" sort="De Clercq, E" uniqKey="De Clercq E" first="E" last="De Clercq">E. De Clercq</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004780 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004780 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:16400870
|texte= Interferon: ten stories in one. A short review of some of the highlights in the history of an almost quinquagenarian.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:16400870" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |