SrasV1, Main, Exploration, bibRecord, 004564

Variation analysis of the severe acute respiratory syndrome coronavirus putative non-structural protein 2 gene and construction of three-dimensional model.

Identifieur interne : 004564 ( Main/Exploration ); précédent : 004563; suivant : 004565

Variation analysis of the severe acute respiratory syndrome coronavirus putative non-structural protein 2 gene and construction of three-dimensional model.

Auteurs : Jia-Hai Lu [République populaire de Chine] ; Ding-Mei Zhang ; Guo-Ling Wang ; Zhong-Min Guo ; Chuan-Hai Zhang ; Bing-Yan Tan ; Li-Ping Ouyang ; Li Lin ; Yi-Min Liu ; Wei-Qing Chen ; Wen-Hua Ling ; Xin-Bing Yu ; Nan-Shan Zhong

Source :

Chinese medical journal [ 0366-6999 ] ; 2005.

RBID : pubmed:15899130

Descripteurs français

KwdFr :
- Animaux, Cellules COS, Cysteine endopeptidases (), Cysteine endopeptidases (biosynthèse), Cysteine endopeptidases (génétique), Diffraction des rayons X, Humains, Modèles moléculaires, Protéines recombinantes (biosynthèse), RT-PCR, Syndrome respiratoire aigu sévère (traitement médicamenteux), Variation génétique, Virus du SRAS (), Virus du SRAS (génétique).
MESH :
- biosynthèse : Cysteine endopeptidases, Protéines recombinantes.
- génétique : Cysteine endopeptidases, Virus du SRAS.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- Animaux, Cellules COS, Cysteine endopeptidases, Diffraction des rayons X, Humains, Modèles moléculaires, RT-PCR, Variation génétique, Virus du SRAS.

English descriptors

KwdEn :
- Animals, COS Cells, Cysteine Endopeptidases (biosynthesis), Cysteine Endopeptidases (chemistry), Cysteine Endopeptidases (genetics), Genetic Variation, Humans, Models, Molecular, Recombinant Proteins (biosynthesis), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (chemistry), SARS Virus (genetics), Severe Acute Respiratory Syndrome (drug therapy), X-Ray Diffraction.
MESH :
- chemical , biosynthesis : Cysteine Endopeptidases, Recombinant Proteins.
- chemical , chemistry : Cysteine Endopeptidases.
- chemical , genetics : Cysteine Endopeptidases.
- chemistry : SARS Virus.
- drug therapy : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- Animals, COS Cells, Genetic Variation, Humans, Models, Molecular, Reverse Transcriptase Polymerase Chain Reaction, X-Ray Diffraction.

Abstract

The rapid transmission and high mortality rate made severe acute respiratory syndrome (SARS) a global threat for which no efficacious therapy is available now. Without sufficient knowledge about the SARS coronavirus (SARS-CoV), it is impossible to define the candidate for the anti-SARS targets. The putative non-structural protein 2 (nsp2) (3CL(pro), following the nomenclature by Gao et al, also known as nsp5 in Snidjer et al) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development, so we carried on this study to have an insight into putative polymerase nsp2 of SARS-CoV Guangdong (GD) strain.

PubMed: 15899130

Affiliations:

Le document en format XML

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<term>Cysteine Endopeptidases (genetics)</term>
<term>Genetic Variation</term>
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<term>SARS Virus (genetics)</term>
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<term>Cysteine endopeptidases (biosynthèse)</term>
<term>Cysteine endopeptidases (génétique)</term>
<term>Diffraction des rayons X</term>
<term>Humains</term>
<term>Modèles moléculaires</term>
<term>Protéines recombinantes (biosynthèse)</term>
<term>RT-PCR</term>
<term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term>
<term>Variation génétique</term>
<term>Virus du SRAS ()</term>
<term>Virus du SRAS (génétique)</term>
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<term>Recombinant Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cysteine Endopeptidases</term>
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<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Cysteine endopeptidases</term>
<term>Protéines recombinantes</term>
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<term>COS Cells</term>
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<term>Humans</term>
<term>Models, Molecular</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>X-Ray Diffraction</term>
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<term>Cellules COS</term>
<term>Cysteine endopeptidases</term>
<term>Diffraction des rayons X</term>
<term>Humains</term>
<term>Modèles moléculaires</term>
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<front><div type="abstract" xml:lang="en">The rapid transmission and high mortality rate made severe acute respiratory syndrome (SARS) a global threat for which no efficacious therapy is available now. Without sufficient knowledge about the SARS coronavirus (SARS-CoV), it is impossible to define the candidate for the anti-SARS targets. The putative non-structural protein 2 (nsp2) (3CL(pro), following the nomenclature by Gao et al, also known as nsp5 in Snidjer et al) of SARS-CoV plays an important role in viral transcription and replication, and is an attractive target for anti-SARS drug development, so we carried on this study to have an insight into putative polymerase nsp2 of SARS-CoV Guangdong (GD) strain.</div>
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Variation analysis of the severe acute respiratory syndrome coronavirus putative non-structural protein 2 gene and construction of three-dimensional model.

Variation analysis of the severe acute respiratory syndrome coronavirus putative non-structural protein 2 gene and construction of three-dimensional model.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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