Orchitis : A complication of severe acute respiratory syndrome (SARS)
Identifieur interne : 004425 ( Main/Exploration ); précédent : 004424; suivant : 004426Orchitis : A complication of severe acute respiratory syndrome (SARS)
Auteurs : JIAN XU [République populaire de Chine] ; LIHUA QI [République populaire de Chine] ; XIAOCHUN CHI [République populaire de Chine] ; JINGJING YANG [République populaire de Chine] ; XIAOHONG WEI [République populaire de Chine] ; ENCONG GONG [République populaire de Chine] ; Suatcheng Peh [République populaire de Chine] ; JIANG GU [République populaire de Chine]Source :
- Biology of reproduction [ 0006-3363 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
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Abstract
Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3+ T lymphocytes and CD68+ macrophages increased significantly in the interstitial tissue compared with the control group (P < 0.05). SARS viral genomic sequences were not detected in the testes by in situ hybridization. Immunohistochemistry demonstrated abundant IgG precipitation in the seminiferous epithelium of SARS testes, indicating possible immune response as the cause for the damage. Our findings indicated that orchitis is a complication of SARS. It further suggests that the reproductive functions should be followed and evaluated in recovered male SARS patients.
Affiliations:
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type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Lihua Qi" sort="Lihua Qi" uniqKey="Lihua Qi" last="Lihua Qi">LIHUA QI</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University</s1><s2>Beijing 100083</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Xiaochun Chi" sort="Xiaochun Chi" uniqKey="Xiaochun Chi" last="Xiaochun Chi">XIAOCHUN CHI</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University</s1><s2>Beijing 100083</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Jingjing Yang" sort="Jingjing Yang" uniqKey="Jingjing Yang" last="Jingjing Yang">JINGJING YANG</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University</s1><s2>Beijing 100083</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Xiaohong Wei" sort="Xiaohong Wei" uniqKey="Xiaohong Wei" last="Xiaohong Wei">XIAOHONG WEI</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Anatomy, Histology, and Embryology, School of Basic Medical Sciences, Peking University</s1><s2>Beijing 100083</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Encong Gong" sort="Encong Gong" uniqKey="Encong Gong" last="Encong Gong">ENCONG GONG</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, School of Basic Medical Sciences, Peking University</s1><s2>Beijing 100083</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Peh, Suatcheng" sort="Peh, Suatcheng" uniqKey="Peh S" first="Suatcheng" last="Peh">Suatcheng Peh</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, School of Basic Medical Sciences, Peking University</s1><s2>Beijing 100083</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author><author><name sortKey="Jiang Gu" sort="Jiang Gu" uniqKey="Jiang Gu" last="Jiang Gu">JIANG GU</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Pathology, School of Basic Medical Sciences, Peking University</s1><s2>Beijing 100083</s2><s3>CHN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName><orgName type="university">Université de Pékin</orgName><placeName><settlement type="city">Pékin</settlement><region type="capitale">Pékin</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Biology of reproduction</title><title level="j" type="abbreviated">Biol. reprod.</title><idno type="ISSN">0006-3363</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Biology of reproduction</title><title level="j" type="abbreviated">Biol. reprod.</title><idno type="ISSN">0006-3363</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term><term>Human</term><term>In vitro</term><term>Morphological analysis</term><term>Orchitis</term><term>Severe acute respiratory syndrome virus</term><term>Spermatogenesis</term><term>Testicle</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus syndrome respiratoire aigu sévère</term><term>Testicule</term><term>Anatomopathologie</term><term>Analyse morphologique</term><term>Spermatogenèse</term><term>Orchite</term><term>Homme</term><term>In vitro</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3+ T lymphocytes and CD68+ macrophages increased significantly in the interstitial tissue compared with the control group (P < 0.05). SARS viral genomic sequences were not detected in the testes by in situ hybridization. Immunohistochemistry demonstrated abundant IgG precipitation in the seminiferous epithelium of SARS testes, indicating possible immune response as the cause for the damage. Our findings indicated that orchitis is a complication of SARS. It further suggests that the reproductive functions should be followed and evaluated in recovered male SARS patients.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Pékin</li></region><settlement><li>Pékin</li></settlement><orgName><li>Université de Pékin</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Jian Xu" sort="Jian Xu" uniqKey="Jian Xu" last="Jian Xu">JIAN XU</name></noRegion><name sortKey="Encong Gong" sort="Encong Gong" uniqKey="Encong Gong" last="Encong Gong">ENCONG GONG</name><name sortKey="Jiang Gu" sort="Jiang Gu" uniqKey="Jiang Gu" last="Jiang Gu">JIANG GU</name><name sortKey="Jingjing Yang" sort="Jingjing Yang" uniqKey="Jingjing Yang" last="Jingjing Yang">JINGJING YANG</name><name sortKey="Lihua Qi" sort="Lihua Qi" uniqKey="Lihua Qi" last="Lihua Qi">LIHUA QI</name><name sortKey="Peh, Suatcheng" sort="Peh, Suatcheng" uniqKey="Peh S" first="Suatcheng" last="Peh">Suatcheng Peh</name><name sortKey="Xiaochun Chi" sort="Xiaochun Chi" uniqKey="Xiaochun Chi" last="Xiaochun Chi">XIAOCHUN CHI</name><name sortKey="Xiaohong Wei" sort="Xiaohong Wei" uniqKey="Xiaohong Wei" last="Xiaohong Wei">XIAOHONG WEI</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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