Specific epitopes of the structural and hypothetical proteins elicit variable humoral responses in SARS patients
Identifieur interne : 004171 ( Main/Exploration ); précédent : 004170; suivant : 004172Specific epitopes of the structural and hypothetical proteins elicit variable humoral responses in SARS patients
Auteurs : S C S. Chow [République populaire de Chine] ; C Y S. Ho [Hong Kong] ; T T Y. Tam [République populaire de Chine] ; C. Wu [États-Unis] ; T. Cheung [République populaire de Chine] ; P K S. Chan [Hong Kong] ; M H L. Ng [Hong Kong] ; P K Hui [Hong Kong] ; H K Ng [Hong Kong] ; D M Y. Au [République populaire de Chine] ; A W I. Lo [Hong Kong]Source :
- Journal of Clinical Pathology [ 0021-9746 ] ; 2006-05.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (immunologie), Antigènes viraux (génétique), Antigènes viraux (immunologie), Cartographie épitopique, Génome viral, Humains, Production d'anticorps, Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), Protéines virales structurales (génétique), Protéines virales structurales (immunologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Séquençage par oligonucléotides en batterie, Virus du SRAS (génétique), Épitopes (génétique), Épitopes (immunologie).
- MESH :
- génétique : Antigènes viraux, Protéines de l'enveloppe virale, Protéines virales structurales, Virus du SRAS, Épitopes.
- immunologie : Anticorps antiviraux, Antigènes viraux, Protéines de l'enveloppe virale, Protéines virales structurales, Syndrome respiratoire aigu sévère, Épitopes.
- virologie : Syndrome respiratoire aigu sévère.
- Cartographie épitopique, Génome viral, Humains, Production d'anticorps, Séquençage par oligonucléotides en batterie.
English descriptors
- KwdEn :
- Antibodies, Viral (immunology), Antibody Formation, Antigens, Viral (genetics), Antigens, Viral (immunology), Epitope Mapping, Epitopes (genetics), Epitopes (immunology), Genome, Viral, Humans, KLH, keyhole limpet haemocyanin, ORF, open reading frame, Oligonucleotide Array Sequence Analysis, SARS, SARS Virus (genetics), SARS, severe acute respiratory syndrome, Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology), Viral Structural Proteins (genetics), Viral Structural Proteins (immunology), antibody, coronavirus, peptide chip.
- MESH :
- chemical , genetics : Antigens, Viral, Epitopes, Viral Envelope Proteins, Viral Structural Proteins.
- chemical , immunology : Antibodies, Viral, Antigens, Viral, Epitopes, Viral Envelope Proteins, Viral Structural Proteins.
- genetics : SARS Virus.
- immunology : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Teeft :
- Additional sars patients, Administrative region, Amino acids, Antibody Formation, Antibody responses, Antigenic, Antigenic sites, Average fluorescence signals, Average fluorescence units, Cellular pathology, Chinese university, Clin, Clin chem, Clin microbiol, Clin pathol, Coronavirus, Different patients, Different sars patients, Different time intervals, Empty triangles, Epitope, Epitope Mapping, Fluorescence signals, Fourth panel, Functional receptor, Genome, Genome, Viral, Genomic locations, Hong kong, Humans, Humoral, Humoral responses, Hypothetical proteins, Important epitopes, Individual epitope, Individual patient, Infectious disease, Keyhole limpet haemocyanin, Lower panel, Lower panels, Membrane protein, Negative controls, Nucleocapsid, Nucleocapsid protein, Odds ratio, Odds ratios, Oligonucleotide Array Sequence Analysis, Open reading frames, Peptide, Peptide chip, Peptide chip platform, Perkin elmer, Potential antigenic epitopes, Potential epitopes, Potential markers, Putative proteins, Respiratory syndrome, Respiratory syndrome coronavirus, Sars, Sars control, Sars coronavirus, Sars patients, Sars3a, Second panel, Serial samples, Specific antigenic sites, Specific epitopes, Specific humoral responses, Spike, Spike protein, Structural proteins, Syndrome, Temporal changes, Third panel, Time interval, Time intervals, Upper panel, Vaccine development, Variable antibody responses, Viral, Viral infection.
Abstract
Background: Severe acute respiratory syndrome (SARS) is an infectious disease which was caused by a novel coronavirus (SARS-CoV). SARS has caused an outbreak in the world during 2003 and 2004, with 8098 individuals being infected and a death toll of 774 in 28 regions around the world. Specific humoral responses to viral infection remain unclear. Objective: To analyse the antigenicity of the SARS-CoV genome and identify potential antigenic epitopes in the structural proteins. Methods: Potential antigenic epitopes were identified in the structural proteins (nucleocapsid, membrane, spike, and small envelope proteins) and hypothetical proteins (SARS3a, 3b, 6, 7a, and 9b) that are specific for SARS-CoV. A peptide chip platform was created and the profiles of antibodies to these epitopes were investigated in 59 different SARS patients’ sera obtained 6–103 days after the onset of the illness. Serial sera from five additional patients were also studied. Results: Epitopes at the N-terminus of the membrane protein and the C-terminus of nucleocapsid protein elicited strong antibody responses. Epitopes on the spike protein were only moderately immunogenic but the effects were persistent. Antibodies were also detected for some putative proteins, noticeably the C-termini of SARS3a and SARS6. Conclusions: Important epitopes of the SARS-CoV genome that may serve as potential markers for the viral infection are identified. These specific antigenic sites may also be important for vaccine development against this new fatal infectious disease.
Url:
- https://api.istex.fr/ark:/67375/NVC-F8W6FJVF-M/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860290
DOI: 10.1136/jcp.2005.029868
Affiliations:
- Hong Kong, République populaire de Chine, États-Unis
- Californie
- Sha Tin
- Université chinoise de Hong Kong
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Le document en format XML
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Chow</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Century Biotech Ltd, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Ho, C Y S" sort="Ho, C Y S" uniqKey="Ho C" first="C Y S" last="Ho">C Y S. Ho</name><affiliation wicri:level="4"><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Tam, T T Y" sort="Tam, T T Y" uniqKey="Tam T" first="T T Y" last="Tam">T T Y. Tam</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Century Biotech Ltd, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Wu, C" sort="Wu, C" uniqKey="Wu C" first="C" last="Wu">C. Wu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Abgent Inc, San Diego, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Cheung, T" sort="Cheung, T" uniqKey="Cheung T" first="T" last="Cheung">T. Cheung</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Century Biotech Ltd, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P K S" last="Chan">P K S. Chan</name><affiliation wicri:level="4"><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Ng, M H L" sort="Ng, M H L" uniqKey="Ng M" first="M H L" last="Ng">M H L. Ng</name><affiliation wicri:level="4"><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Hui, P K" sort="Hui, P K" uniqKey="Hui P" first="P K" last="Hui">P K Hui</name><affiliation wicri:level="1"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Pathology, Kwong Wah Hospital</wicri:regionArea><wicri:noRegion>Kwong Wah Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Ng, H K" sort="Ng, H K" uniqKey="Ng H" first="H K" last="Ng">H K Ng</name><affiliation wicri:level="4"><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Au, D M Y" sort="Au, D M Y" uniqKey="Au D" first="D M Y" last="Au">D M Y. Au</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Century Biotech Ltd, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Lo, A W I" sort="Lo, A W I" uniqKey="Lo A" first="A W I" last="Lo">A W I. Lo</name><affiliation wicri:level="4"><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Clinical Pathology</title><title level="j" type="abbrev">J Clin Pathol</title><idno type="ISSN">0021-9746</idno><idno type="eISSN">1472-4146</idno><imprint><publisher>BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><date type="published" when="2006-05">2006-05</date><biblScope unit="volume">59</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="468">468</biblScope></imprint><idno type="ISSN">0021-9746</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0021-9746</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (immunology)</term><term>Antibody Formation</term><term>Antigens, Viral (genetics)</term><term>Antigens, Viral (immunology)</term><term>Epitope Mapping</term><term>Epitopes (genetics)</term><term>Epitopes (immunology)</term><term>Genome, Viral</term><term>Humans</term><term>KLH, keyhole limpet haemocyanin</term><term>ORF, open reading frame</term><term>Oligonucleotide Array Sequence Analysis</term><term>SARS</term><term>SARS Virus (genetics)</term><term>SARS, severe acute respiratory syndrome</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Envelope Proteins (genetics)</term><term>Viral Envelope Proteins (immunology)</term><term>Viral Structural Proteins (genetics)</term><term>Viral Structural Proteins (immunology)</term><term>antibody</term><term>coronavirus</term><term>peptide chip</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (immunologie)</term><term>Antigènes viraux (génétique)</term><term>Antigènes viraux (immunologie)</term><term>Cartographie épitopique</term><term>Génome viral</term><term>Humains</term><term>Production d'anticorps</term><term>Protéines de l'enveloppe virale (génétique)</term><term>Protéines de l'enveloppe virale (immunologie)</term><term>Protéines virales structurales (génétique)</term><term>Protéines virales structurales (immunologie)</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Séquençage par oligonucléotides en batterie</term><term>Virus du SRAS (génétique)</term><term>Épitopes (génétique)</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Viral</term><term>Epitopes</term><term>Viral Envelope Proteins</term><term>Viral Structural Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Antigens, Viral</term><term>Epitopes</term><term>Viral Envelope Proteins</term><term>Viral Structural Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes viraux</term><term>Protéines de l'enveloppe virale</term><term>Protéines virales structurales</term><term>Virus du SRAS</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Antigènes viraux</term><term>Protéines de l'enveloppe virale</term><term>Protéines virales structurales</term><term>Syndrome respiratoire aigu sévère</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Additional sars patients</term><term>Administrative region</term><term>Amino acids</term><term>Antibody Formation</term><term>Antibody responses</term><term>Antigenic</term><term>Antigenic sites</term><term>Average fluorescence signals</term><term>Average fluorescence units</term><term>Cellular pathology</term><term>Chinese university</term><term>Clin</term><term>Clin chem</term><term>Clin microbiol</term><term>Clin pathol</term><term>Coronavirus</term><term>Different patients</term><term>Different sars patients</term><term>Different time intervals</term><term>Empty triangles</term><term>Epitope</term><term>Epitope Mapping</term><term>Fluorescence signals</term><term>Fourth panel</term><term>Functional receptor</term><term>Genome</term><term>Genome, Viral</term><term>Genomic locations</term><term>Hong kong</term><term>Humans</term><term>Humoral</term><term>Humoral responses</term><term>Hypothetical proteins</term><term>Important epitopes</term><term>Individual epitope</term><term>Individual patient</term><term>Infectious disease</term><term>Keyhole limpet haemocyanin</term><term>Lower panel</term><term>Lower panels</term><term>Membrane protein</term><term>Negative controls</term><term>Nucleocapsid</term><term>Nucleocapsid protein</term><term>Odds ratio</term><term>Odds ratios</term><term>Oligonucleotide Array Sequence Analysis</term><term>Open reading frames</term><term>Peptide</term><term>Peptide chip</term><term>Peptide chip platform</term><term>Perkin elmer</term><term>Potential antigenic epitopes</term><term>Potential epitopes</term><term>Potential markers</term><term>Putative proteins</term><term>Respiratory syndrome</term><term>Respiratory syndrome coronavirus</term><term>Sars</term><term>Sars control</term><term>Sars coronavirus</term><term>Sars patients</term><term>Sars3a</term><term>Second panel</term><term>Serial samples</term><term>Specific antigenic sites</term><term>Specific epitopes</term><term>Specific humoral responses</term><term>Spike</term><term>Spike protein</term><term>Structural proteins</term><term>Syndrome</term><term>Temporal changes</term><term>Third panel</term><term>Time interval</term><term>Time intervals</term><term>Upper panel</term><term>Vaccine development</term><term>Variable antibody responses</term><term>Viral</term><term>Viral infection</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cartographie épitopique</term><term>Génome viral</term><term>Humains</term><term>Production d'anticorps</term><term>Séquençage par oligonucléotides en batterie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Severe acute respiratory syndrome (SARS) is an infectious disease which was caused by a novel coronavirus (SARS-CoV). SARS has caused an outbreak in the world during 2003 and 2004, with 8098 individuals being infected and a death toll of 774 in 28 regions around the world. Specific humoral responses to viral infection remain unclear. Objective: To analyse the antigenicity of the SARS-CoV genome and identify potential antigenic epitopes in the structural proteins. Methods: Potential antigenic epitopes were identified in the structural proteins (nucleocapsid, membrane, spike, and small envelope proteins) and hypothetical proteins (SARS3a, 3b, 6, 7a, and 9b) that are specific for SARS-CoV. A peptide chip platform was created and the profiles of antibodies to these epitopes were investigated in 59 different SARS patients’ sera obtained 6–103 days after the onset of the illness. Serial sera from five additional patients were also studied. Results: Epitopes at the N-terminus of the membrane protein and the C-terminus of nucleocapsid protein elicited strong antibody responses. Epitopes on the spike protein were only moderately immunogenic but the effects were persistent. Antibodies were also detected for some putative proteins, noticeably the C-termini of SARS3a and SARS6. Conclusions: Important epitopes of the SARS-CoV genome that may serve as potential markers for the viral infection are identified. These specific antigenic sites may also be important for vaccine development against this new fatal infectious disease.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Californie</li></region><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Chow, S C S" sort="Chow, S C S" uniqKey="Chow S" first="S C S" last="Chow">S C S. Chow</name></noRegion><name sortKey="Au, D M Y" sort="Au, D M Y" uniqKey="Au D" first="D M Y" last="Au">D M Y. Au</name><name sortKey="Cheung, T" sort="Cheung, T" uniqKey="Cheung T" first="T" last="Cheung">T. Cheung</name><name sortKey="Tam, T T Y" sort="Tam, T T Y" uniqKey="Tam T" first="T T Y" last="Tam">T T Y. Tam</name></country><country name="Hong Kong"><noRegion><name sortKey="Ho, C Y S" sort="Ho, C Y S" uniqKey="Ho C" first="C Y S" last="Ho">C Y S. Ho</name></noRegion><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P K S" last="Chan">P K S. Chan</name><name sortKey="Hui, P K" sort="Hui, P K" uniqKey="Hui P" first="P K" last="Hui">P K Hui</name><name sortKey="Lo, A W I" sort="Lo, A W I" uniqKey="Lo A" first="A W I" last="Lo">A W I. Lo</name><name sortKey="Ng, H K" sort="Ng, H K" uniqKey="Ng H" first="H K" last="Ng">H K Ng</name><name sortKey="Ng, M H L" sort="Ng, M H L" uniqKey="Ng M" first="M H L" last="Ng">M H L. Ng</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Wu, C" sort="Wu, C" uniqKey="Wu C" first="C" last="Wu">C. 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