Efficacy of severe acute respiratory syndrome vaccine based on a nonhuman primate adenovirus in the presence of immunity against human adenovirus.
Identifieur interne : 003F11 ( Main/Exploration ); précédent : 003F10; suivant : 003F12Efficacy of severe acute respiratory syndrome vaccine based on a nonhuman primate adenovirus in the presence of immunity against human adenovirus.
Auteurs : Yan Zhi [États-Unis] ; Joanita Figueredo ; Gary P. Kobinger ; Heather Hagan ; Roberto Calcedo ; James R. Miller ; Guangping Gao ; James M. WilsonSource :
- Human gene therapy [ 1043-0342 ] ; 2006.
Descripteurs français
- KwdFr :
- Adulte, Adénovirus humains (immunologie), Adénovirus simiens (immunologie), Animaux, Anticorps antiviraux (biosynthèse), Anticorps antiviraux (sang), Anticorps hétérophiles (biosynthèse), Humains, Lymphocytes T (immunologie), Modèles animaux, Pan troglodytes (virologie), Souris, Souris de lignée BALB C, Souris de lignée C57BL, Spécificité des anticorps, Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (immunologie), Vaccins à virosomes (immunologie), Vecteurs génétiques, Virus du SRAS (immunologie).
- MESH :
- biosynthèse : Anticorps antiviraux, Anticorps hétérophiles.
- immunologie : Adénovirus humains, Adénovirus simiens, Lymphocytes T, Syndrome respiratoire aigu sévère, Vaccins à virosomes, Virus du SRAS.
- sang : Anticorps antiviraux.
- virologie : Pan troglodytes.
- Adulte, Animaux, Humains, Modèles animaux, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Spécificité des anticorps, Syndrome respiratoire aigu sévère, Vecteurs génétiques.
English descriptors
- KwdEn :
- Adenoviruses, Human (immunology), Adenoviruses, Simian (immunology), Adult, Animals, Antibodies, Heterophile (biosynthesis), Antibodies, Viral (biosynthesis), Antibodies, Viral (blood), Antibody Specificity, Genetic Vectors, Humans, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Models, Animal, Pan troglodytes (virology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (prevention & control), T-Lymphocytes (immunology), Vaccines, Virosome (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Heterophile, Antibodies, Viral.
- chemical , blood : Antibodies, Viral.
- immunology : Adenoviruses, Human, Adenoviruses, Simian, SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocytes, Vaccines, Virosome.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : Pan troglodytes.
- Adult, Animals, Antibody Specificity, Genetic Vectors, Humans, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Models, Animal.
Abstract
Replication-deficient human adenovirus type 5 (AdH5) vectors can induce strong transgene product-specific cellular and humoral responses. However, many adult humans have neutralizing antibodies (NAbs) against AdH5 as a result of natural infection with this virus. Therefore, a chimpanzee adenovirus C7 (AdC7) vector was developed to circumvent interference by preexisting immunity to AdH5. This study evaluated the impact of preexisting immunity to human adenovirus on the efficacy of adenovirus-based vaccines against the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). Efficacy was assessed after intramuscular injection of the vector into mice and was measured as the frequency of SARS-CoV-specific T cells and NAbs against SARS-CoV. Immunogenicity of the AdH5-based vaccine was significantly attenuated or completely abolished when the preexisting anti-AdH5 NAb titer was higher than 40. Because 27% of human serum samples from the United States tested so far have an anti-AdH5 NAb titer higher than 40, our results suggested that a significant percentage of humans with preexisting anti-AdH5 immunity would not be candidates for vaccination with an AdH5-based genetic vaccine. In contrast, preexisting anti-AdH5 NAbs have a minimal effect on the potency of the AdC7-based genetic vaccine. Taken together, our studies warrant the further development of AdC7 as a vaccine carrier for human trials.
DOI: 10.1089/hum.2006.17.500
PubMed: 16716107
Affiliations:
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Kobinger</name></author><author><name sortKey="Hagan, Heather" sort="Hagan, Heather" uniqKey="Hagan H" first="Heather" last="Hagan">Heather Hagan</name></author><author><name sortKey="Calcedo, Roberto" sort="Calcedo, Roberto" uniqKey="Calcedo R" first="Roberto" last="Calcedo">Roberto Calcedo</name></author><author><name sortKey="Miller, James R" sort="Miller, James R" uniqKey="Miller J" first="James R" last="Miller">James R. Miller</name></author><author><name sortKey="Gao, Guangping" sort="Gao, Guangping" uniqKey="Gao G" first="Guangping" last="Gao">Guangping Gao</name></author><author><name sortKey="Wilson, James M" sort="Wilson, James M" uniqKey="Wilson J" first="James M" last="Wilson">James M. Wilson</name></author></analytic><series><title level="j">Human gene therapy</title><idno type="ISSN">1043-0342</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviruses, Human (immunology)</term><term>Adenoviruses, Simian (immunology)</term><term>Adult</term><term>Animals</term><term>Antibodies, Heterophile (biosynthesis)</term><term>Antibodies, Viral (biosynthesis)</term><term>Antibodies, Viral (blood)</term><term>Antibody Specificity</term><term>Genetic Vectors</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C57BL</term><term>Models, Animal</term><term>Pan troglodytes (virology)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>T-Lymphocytes (immunology)</term><term>Vaccines, Virosome (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adénovirus humains (immunologie)</term><term>Adénovirus simiens (immunologie)</term><term>Animaux</term><term>Anticorps antiviraux (biosynthèse)</term><term>Anticorps antiviraux (sang)</term><term>Anticorps hétérophiles (biosynthèse)</term><term>Humains</term><term>Lymphocytes T (immunologie)</term><term>Modèles animaux</term><term>Pan troglodytes (virologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C57BL</term><term>Spécificité des anticorps</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Vaccins à virosomes (immunologie)</term><term>Vecteurs génétiques</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Heterophile</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps hétérophiles</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Adénovirus humains</term><term>Adénovirus simiens</term><term>Lymphocytes T</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccins à virosomes</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Adenoviruses, Human</term><term>Adenoviruses, Simian</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>T-Lymphocytes</term><term>Vaccines, Virosome</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Pan troglodytes</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pan troglodytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Animals</term><term>Antibody Specificity</term><term>Genetic Vectors</term><term>Humans</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C57BL</term><term>Models, Animal</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Animaux</term><term>Humains</term><term>Modèles animaux</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C57BL</term><term>Spécificité des anticorps</term><term>Syndrome respiratoire aigu sévère</term><term>Vecteurs génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Replication-deficient human adenovirus type 5 (AdH5) vectors can induce strong transgene product-specific cellular and humoral responses. However, many adult humans have neutralizing antibodies (NAbs) against AdH5 as a result of natural infection with this virus. Therefore, a chimpanzee adenovirus C7 (AdC7) vector was developed to circumvent interference by preexisting immunity to AdH5. This study evaluated the impact of preexisting immunity to human adenovirus on the efficacy of adenovirus-based vaccines against the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). Efficacy was assessed after intramuscular injection of the vector into mice and was measured as the frequency of SARS-CoV-specific T cells and NAbs against SARS-CoV. Immunogenicity of the AdH5-based vaccine was significantly attenuated or completely abolished when the preexisting anti-AdH5 NAb titer was higher than 40. Because 27% of human serum samples from the United States tested so far have an anti-AdH5 NAb titer higher than 40, our results suggested that a significant percentage of humans with preexisting anti-AdH5 immunity would not be candidates for vaccination with an AdH5-based genetic vaccine. In contrast, preexisting anti-AdH5 NAbs have a minimal effect on the potency of the AdC7-based genetic vaccine. Taken together, our studies warrant the further development of AdC7 as a vaccine carrier for human trials.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Calcedo, Roberto" sort="Calcedo, Roberto" uniqKey="Calcedo R" first="Roberto" last="Calcedo">Roberto Calcedo</name><name sortKey="Figueredo, Joanita" sort="Figueredo, Joanita" uniqKey="Figueredo J" first="Joanita" last="Figueredo">Joanita Figueredo</name><name sortKey="Gao, Guangping" sort="Gao, Guangping" uniqKey="Gao G" first="Guangping" last="Gao">Guangping Gao</name><name sortKey="Hagan, Heather" sort="Hagan, Heather" uniqKey="Hagan H" first="Heather" last="Hagan">Heather Hagan</name><name sortKey="Kobinger, Gary P" sort="Kobinger, Gary P" uniqKey="Kobinger G" first="Gary P" last="Kobinger">Gary P. Kobinger</name><name sortKey="Miller, James R" sort="Miller, James R" uniqKey="Miller J" first="James R" last="Miller">James R. Miller</name><name sortKey="Wilson, James M" sort="Wilson, James M" uniqKey="Wilson J" first="James M" last="Wilson">James M. Wilson</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Zhi, Yan" sort="Zhi, Yan" uniqKey="Zhi Y" first="Yan" last="Zhi">Yan Zhi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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