Enhancement of cytotoxicity against Vero E6 cells persistently infected with SARS-CoV by Mycoplasma fermentans
Identifieur interne : 003A17 ( Main/Exploration ); précédent : 003A16; suivant : 003A18Enhancement of cytotoxicity against Vero E6 cells persistently infected with SARS-CoV by Mycoplasma fermentans
Auteurs : T. Mizutani [Japon] ; S. Fukushi [Japon] ; T. Kenri [Japon] ; Y. Sasaki [Japon] ; K. Ishii [Japon] ; D. Endoh [Japon] ; A. Zamoto [Japon] ; M. Saijo [Japon] ; I. Kurane [Japon] ; S. Morikawa [Japon]Source :
- Archives of Virology [ 0304-8608 ] ; 2007-05-01.
Descripteurs français
- KwdFr :
- Animaux, Apoptose, Cellules Vero (anatomopathologie), Cellules Vero (microbiologie), Effet cytopathogène viral, Infections à Mycoplasma (), Infections à Mycoplasma (microbiologie), Mycoplasma fermentans (physiologie), Syndrome respiratoire aigu sévère (), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (physiologie).
- MESH :
- anatomopathologie : Cellules Vero.
- microbiologie : Cellules Vero, Infections à Mycoplasma.
- physiologie : Mycoplasma fermentans, Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Apoptose, Effet cytopathogène viral, Infections à Mycoplasma, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Animals, Apoptosis, Chlorocebus aethiops, Cytopathogenic Effect, Viral, Mycoplasma Infections (complications), Mycoplasma Infections (microbiology), Mycoplasma fermentans (physiology), SARS Virus (physiology), Severe Acute Respiratory Syndrome (complications), Severe Acute Respiratory Syndrome (virology), Vero Cells (microbiology), Vero Cells (pathology).
- MESH :
- complications : Mycoplasma Infections, Severe Acute Respiratory Syndrome.
- microbiology : Mycoplasma Infections, Vero Cells.
- pathology : Vero Cells.
- physiology : Mycoplasma fermentans, SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Apoptosis, Chlorocebus aethiops, Cytopathogenic Effect, Viral.
Abstract
Summary.: We previously reported that cells with persistent severe acute respiratory syndrome coronavirus (SARS-CoV) infection were established after apoptotic events. In the present study, we investigated the cytopathic effects of dual infection with SARS-CoV and Mycoplasma fermentans on Vero E6 cells. Dual infection completely killed cells and prevented the establishment of persistent SARS-CoV infection. M. fermentans induced inhibition of cell proliferation, but the cells remained alive. Apoptosis was induced easily in M. fermentans-infected cells, indicating that they were primed for apoptosis. These results indicated that M. fermentans enhances apoptosis in surviving cells that have escaped from SARS-CoV-induced apoptosis.
Url:
DOI: 10.1007/s00705-006-0924-7
Affiliations:
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In the present study, we investigated the cytopathic effects of dual infection with SARS-CoV and Mycoplasma fermentans on Vero E6 cells. Dual infection completely killed cells and prevented the establishment of persistent SARS-CoV infection. M. fermentans induced inhibition of cell proliferation, but the cells remained alive. Apoptosis was induced easily in M. fermentans-infected cells, indicating that they were primed for apoptosis. These results indicated that M. fermentans enhances apoptosis in surviving cells that have escaped from SARS-CoV-induced apoptosis.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Mizutani, T" sort="Mizutani, T" uniqKey="Mizutani T" first="T." last="Mizutani">T. Mizutani</name></region><name sortKey="Endoh, D" sort="Endoh, D" uniqKey="Endoh D" first="D." last="Endoh">D. Endoh</name><name sortKey="Fukushi, S" sort="Fukushi, S" uniqKey="Fukushi S" first="S." last="Fukushi">S. Fukushi</name><name sortKey="Ishii, K" sort="Ishii, K" uniqKey="Ishii K" first="K." last="Ishii">K. Ishii</name><name sortKey="Kenri, T" sort="Kenri, T" uniqKey="Kenri T" first="T." last="Kenri">T. Kenri</name><name sortKey="Kurane, I" sort="Kurane, I" uniqKey="Kurane I" first="I." last="Kurane">I. Kurane</name><name sortKey="Morikawa, S" sort="Morikawa, S" uniqKey="Morikawa S" first="S." last="Morikawa">S. Morikawa</name><name sortKey="Saijo, M" sort="Saijo, M" uniqKey="Saijo M" first="M." last="Saijo">M. Saijo</name><name sortKey="Sasaki, Y" sort="Sasaki, Y" uniqKey="Sasaki Y" first="Y." last="Sasaki">Y. Sasaki</name><name sortKey="Zamoto, A" sort="Zamoto, A" uniqKey="Zamoto A" first="A." last="Zamoto">A. Zamoto</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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